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Hire Subodh S.
United States
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PhD Virologist | Expert in Antiviral Drug Discovery, HTS Assays, and Kinetic Data Analysis
Profile Summary
Subject Matter Expertise
Services
Writing
Technical Writing
Research
Scientific and Technical Research
Consulting
Scientific and Technical Consulting
Data & AI
Statistical Analysis
Work Experience
Senior Scientist
Lychee Biosciences
July 2024 - Present 
Research Scientist III
University of Arizona
July 2021 - Present
Post Doc Research Associate I
University of Arizona
November 2020 - Present
Post Doctoral Fellow
Wadsworth Center
August 2018 - October 2020
Post Doctoral Fellow
Wayne State University
July 2014 - August 2018
Graduate Student
University of Alberta
September 2008 - September 2013
Project Assistant
National insitute of Immunology
January 2006 - August 2008
Education
PhD (Department of Surgery)
University of Alberta
September 2008 - September 2013
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Mengtong Cao, Carl W. Trieshmann, Subodh Kumar Samrat, Hongmin Li, Yifei Wu, Steven P. Maher, Angela A. Bae, Zhong-Ru Xie, Robert J. Hogan, Y. George Zheng (2025). Assay development and screening of inhibitors targeting the SARS-CoV-2 2′-O-methyltransferase NSP16 . Pharmaceutical Science Advances.
Samrat SK, Kumar P, Liu Y, Chen K, Lee H, Li Z, Chen Y, Li H (2024). An ISG15-Based High-Throughput Screening Assay for Identification and Characterization of SARS-CoV-2 Inhibitors Targeting Papain-like Protease . Viruses.
Subodh Kumar Samrat, Qamar Bashir, Yiding Huang, Carl William Trieshmann, Anil Mathew Tharappel, Ran Zhang, Ke Chen, Y. Geoge Zheng, Zhong Li, Hongmin Li (2023). Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase . ACS Infectious Diseases.
Samrat SK, Bashir Q, Zhang R, Huang Y, Liu Y, Wu X, Brown T, Wang W, George Zheng Y, Zhang QY, et al. (2023). A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases . Emerging microbes & infections.
Liang W, Gu M, Zhu L, Yan Z, Schenten D, Herrick S, Li H, Samrat SK, Zhu J, Chen Y (2023). The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression . Signal transduction and targeted therapy.
Samrat SK, Xu J, Xie X, Gianti E, Chen H, Zou J, Pattis JG, Elokely K, Lee H, Li Z, et al. (2022). Allosteric inhibitors of the main protease of SARS-CoV-2 . Antiviral research.
Samrat SK, Xu J, Li Z, Zhou J, Li H (2022). Antiviral Agents against Flavivirus Protease: Prospect and Future Direction . Pathogens (Basel, Switzerland).
Li Z, Xu J, Lang Y, Wu X, Hu S, Samrat SK, Tharappel AM, Kuo L, Butler D, Song Y, et al. (2021). In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus . Acta pharmaceutica Sinica. B.
(2020). Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo . Emerging microbes & infections.
(2020). Targeting Crucial Host Factors of SARS-CoV-2 . ACS infectious diseases.
(2020). JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo . ACS infectious diseases.
(2020). Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development . Virus research.
(2020). Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection . Journal of virology.
Fada, B.J., Kaadi, E., Samrat, S.K., Zheng, Y., Gu, H.(2020). Effect of SUMO-SIM interaction on the ICP0-mediated degradation of PML isoform II and its associated proteins in herpes simplex virus 1 infection . Journal of Virology. 94. (12).
Li, Z., Xu, J., Lang, Y., Fan, X., Kuo, L., D'Brant, L., Hu, S., Samrat, S.K., Trudeau, N., Tharappel, A.M., et al.(2020). JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both in Vitro and in Vivo . ACS Infectious Diseases. 6. (10). p. 2616-2628.
Tharappel, A.M., Samrat, S.K., Li, Z., Li, H.(2020). Targeting Crucial Host Factors of SARS-CoV-2 . ACS Infectious Diseases. 6. (11). p. 2844-2865.
Li, Z., Lang, Y., Sakamuru, S., Samrat, S., Trudeau, N., Kuo, L., Rugenstein, N., Tharappel, A., D'Brant, L., Koetzner, C.A., et al.(2020). Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo . Emerging Microbes and Infections. 9. (1). p. 2404-2416.
Samrat, S.K., Tharappel, A.M., Li, Z., Li, H.(2020). Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development . Virus Research. 288.
(2018). Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy . Journal of visualized experiments : JoVE.
(2018). Characterization of Elements Regulating the Nuclear-to-Cytoplasmic Translocation of ICP0 in Late Herpes Simplex Virus 1 Infection . Journal of virology.
Samrat, S.K., Ha, B.L., Zheng, Y., Gu, H.(2018). Characterization of elements regulating the nuclear-to-cytoplasmic translocation of ICP0 in late herpes simplex virus 1 infection . Journal of Virology. 92. (2).
Samrat, S.K., Gu, H.(2018). Temporal analysis of the nuclear-to-cytoplasmic translocation of a herpes simplex virus 1 protein by immunofluorescent confocal microscopy . Journal of Visualized Experiments. 2018. (141).
(2016). A Tale of Two PMLs: Elements Regulating a Differential Substrate Recognition by the ICP0 E3 Ubiquitin Ligase of Herpes Simplex Virus 1 . Journal of virology.
(2016). Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines . PloS one.
Zheng, Y., Samrat, S.K., Gu, H.(2016). A tale of two PMLs: Elements regulating a differential substrate recognition by the ICP0 E3 ubiquitin ligase of herpes simplex virus . Journal of Virology. 90. (23). p. 10875-10885.
Singh, S., Vedi, S., Samrat, S.K., Li, W., Kumar, R., Agrawal, B.(2016). Heterologous immunity between adenoviruses and hepatitis C virus: A new paradigm in HCV immunity and vaccines . PLoS ONE. 11. (1).
(2015). Immunization with Recombinant Adenoviral Vectors Expressing HCV Core or F Proteins Leads to T Cells with Reduced Effector Molecules Granzyme B and IFN-γ: A Potential New Strategy for Immune Evasion in HCV Infection . Viral immunology.
Samrat, S.K., Vedi, S., Singh, S., Li, W., Kumar, R., Agrawal, B.(2015). Immunization with Recombinant Adenoviral Vectors Expressing HCV Core or F Proteins Leads to T Cells with Reduced Effector Molecules Granzyme B and IFN-γ: A Potential New Strategy for Immune Evasion in HCV Infection . Viral Immunology. 28. (6). p. 309-324.
(2014). Co-incubation with core proteins of HBV and HCV leads to modulation of human dendritic cells . Viral immunology.
(2014). Recombinant adenoviral vector expressing HCV NS4 induces protective immune responses in a mouse model of Vaccinia-HCV virus infection: a dose and route conundrum . Vaccine.
(2014). Alternate reading frame protein (F protein) of hepatitis C virus: paradoxical effects of activation and apoptosis on human dendritic cells lead to stimulation of T cells . PloS one.
Samrat, S.K., Li, W., Singh, S., Kumar, R., Agrawal, B.(2014). Alternate reading frame protein (F protein) of hepatitis C virus: Paradoxical effects of activation and apoptosis on human dendritic cells lead to stimulation of T cells . PLoS ONE. 9. (1).
Agrawal, A., Samrat, S.K., Agrawal, B., Tyrrell, D.L.J., Kumar, R.(2014). Co-incubation with core proteins of HBV and HCV leads to modulation of human dendritic cells . Viral Immunology. 27. (8). p. 412-417.
Singh, S., Vedi, S., Li, W., Samrat, S.K., Kumar, R., Agrawal, B.(2014). Recombinant adenoviral vector expressing HCV NS4 induces protective immune responses in a mouse model of Vaccinia-HCV virus infection: A dose and route conundrum . Vaccine. 32. (23). p. 2712-2721.
(2010). Genetic and functional analysis of HIV-1 Rev Responsive Element (RRE) sequences from North-India . AIDS research and therapy.
Sharma, Y., Neogi, U., Sood, V., Banerjee, S., Samrat, S., Wanchu, A., Singh, S., Banerjea, A.C.(2010). Genetic and functional analysis of HIV-1 Rev Responsive Element (RRE) sequences from North-India . AIDS Research and Therapy. 7.
(2009). Global HIV-1 molecular epidemiology with special reference to genetic analysis of HIV-1 subtypes circulating in North India: functional and pathogenic implications of genetic variation. Indian journal of experimental biology.
(2008). Dissecting the functional role of polyketide synthases in Dictyostelium discoideum: biosynthesis of the differentiation regulating factor 4-methyl-5-pentylbenzene-1,3-diol . The Journal of biological chemistry.
Ghosh, R., Chhabra, A., Phatale, P.A., Samrat, S.K., Sharma, J., Gosain, A., Mohanty, D., Saran, S., Gokhale, R.S.(2008). Dissecting the functional role of polyketide synthases in Dictyostelium discoideum: Biosynthesis of the differentiation regulating factor 4-methyl-5-pentylbenzene-1,3-diol . Journal of Biological Chemistry. 283. (17). p. 11348-11354.
(2006). Isolation and characterization of a novel banana rhizosphere bacterium as fungal antagonist and microbial adjuvant in micropropagation of banana . Journal of applied microbiology.
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