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Hire Steven B.
United States
USD 25 /hr
Laboratory scientist with 10+ of experience in RNA biology and genomics research
Profile Summary
Subject Matter Expertise
Services
Work Experience
Staff Research Associate IV
University of California San Diego
August 2013 - Present 
Education
Biotechnology
University of California Irvine
September 2010 - June 2012
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Waqar Arif, Bhoomika Mathur, Michael F. Saikali, Ullas V. Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M. Blue, Brian A. Yee, et al. (2023). Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death . Nature Communications.
Steven M. Blue, Brian A. Yee, Gabriel A. Pratt, Jasmine R. Mueller, Samuel S. Park, Alexander A. Shishkin, Anne C. Starner, Eric L. Van Nostrand, Gene W. Yeo(2022). Transcriptome-wide identification of RNA-binding protein binding sites using seCLIP-seq . Nature Protocols. Springer Science and Business Media {LLC}
Yue Qin, Edward L. Huttlin, Casper F. Winsnes, Maya L. Gosztyla, Ludivine Wacheul, Marcus R. Kelly, Steven M. Blue, Fan Zheng, Michael Chen, Leah V. Schaffer, et al.(2021). A multi-scale map of cell structure fusing protein images and interactions . Nature. Springer Science and Business Media {LLC}
Meredith Corley, Ryan A. Flynn, Steven M. Blue, Brian A. Yee, Howard Y. Chang, Gene W. Yeo(2021). fSHAPE, fSHAPE-eCLIP, and SHAPE-eCLIP probe transcript regions that interact with specific proteins . STAR Protocols. 2. (3). p. 100762. Elsevier {BV}
Van Nostrand, E.L., Freese, P., Pratt, G.A., Wang, X., Wei, X., Xiao, R., Blue, S.M., Chen, J.-Y., Cody, N.A.L., Dominguez, D., et al.(2021). Author Correction: A large-scale binding and functional map of human RNA-binding proteins (Nature, (2020), 583, 7818, (711-719), 10.1038/s41586-020-2077-3) . Nature. 589. (7842). p. E5.
Jourdain, A.A., Begg, B.E., Mick, E., Shah, H., Calvo, S.E., Skinner, O.S., Sharma, R., Blue, S.M., Yeo, G.W., Burge, C.B., et al.(2021). Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS . Molecular Cell. 81. (9). p. 1905-1919.e12.
Batra, R., Nelles, D.A., Roth, D.M., Krach, F., Nutter, C.A., Tadokoro, T., Thomas, J.D., Sznajder, Ł.J., Blue, S.M., Gutierrez, H.L., et al.(2021). The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1 . Nature Biomedical Engineering. 5. (2). p. 157-168.
Fenix, A.M., Miyaoka, Y., Bertero, A., Blue, S.M., Spindler, M.J., Tan, K.K.B., Perez-Bermejo, J.A., Chan, A.H., Mayerl, S.J., Nguyen, T.D., et al.(2021). Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies . Nature Communications. 12. (1).
Meredith Corley, Ryan A. Flynn, Byron Lee, Steven M. Blue, Howard Y. Chang, Gene W. Yeo(2020). Footprinting SHAPE-eCLIP Reveals Transcriptome-wide Hydrogen Bonds at RNA-Protein Interfaces . Molecular Cell. 80. (5). p. 903--914.e8. Elsevier {BV}
Jeevisha Bajaj, Michael Hamilton, Yutaka Shima, Kendall Chambers, Kyle Spinler, Eric L. Van Nostrand, Brian A. Yee, Steven M. Blue, Michael Chen, David Rizzeri, et al. (2020). An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia . Nature Cancer.
Van Nostrand, E.L., Freese, P., Pratt, G.A., Wang, X., Wei, X., Xiao, R., Blue, S.M., Chen, J.-Y., Cody, N.A.L., Dominguez, D., et al.(2020). A large-scale binding and functional map of human RNA-binding proteins . Nature. 583. (7818). p. 711-719.
Van Nostrand, E.L., Pratt, G.A., Yee, B.A., Wheeler, E.C., Blue, S.M., Mueller, J., Park, S.S., Garcia, K.E., Gelboin-Burkhart, C., Nguyen, T.B., et al.(2020). Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins . Genome Biology. 21. (1).
Corley, M., Flynn, R.A., Lee, B., Blue, S.M., Chang, H.Y., Yeo, G.W.(2020). Footprinting SHAPE-eCLIP Reveals Transcriptome-wide Hydrogen Bonds at RNA-Protein Interfaces . Molecular Cell. 80. (5). p. 903-914.e8.
Abascal, F., Acosta, R., Addleman, N.J., Adrian, J., Afzal, V., Aken, B., Akiyama, J.A., Jammal, O.A., Amrhein, H., Anderson, S.M., et al.(2020). Expanded encyclopaedias of DNA elements in the human and mouse genomes . Nature. 583. (7818). p. 699-710.
Abascal, F., Acosta, R., Addleman, N.J., Adrian, J., Afzal, V., Aken, B., Akiyama, J.A., Jammal, O.A., Amrhein, H., Anderson, S.M., et al.(2020). Perspectives on ENCODE . Nature. 583. (7818). p. 693-698.
Steven Blue(2019). Biotin-Labelling of Immunoprecipitated RNA (v1pre) . protocols.io.
(2017). Robust, Cost-Effective Profiling of RNA Binding Protein Targets with Single-end Enhanced Crosslinking and Immunoprecipitation (seCLIP) . Methods in molecular biology (Clifton, N.J.).
Batra, R., Nelles, D.A., Pirie, E., Blue, S.M., Marina, R.J., Wang, H., Chaim, I.A., Thomas, J.D., Zhang, N., Nguyen, V., et al.(2017). Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9 . Cell. 170. (5). p. 899-912.e10.
Van Nostrand, E.L., Nguyen, T.B., Gelboin-Burkhart, C., Wang, R., Blue, S.M., Pratt, G.A., Louie, A.L., Yeo, G.W.(2017). Erratum to: Robust, Cost-Effective Profiling of RNA Binding Protein Targets with Single-end Enhanced Crosslinking and Immunoprecipitation (seCLIP) . Methods in molecular biology (Clifton, N.J.). 1648. p. E1.
Van Nostrand, E.L., Gelboin-Burkhart, C., Wang, R., Pratt, G.A., Blue, S.M., Yeo, G.W.(2017). CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins . Methods. 118-119. p. 50-59.
(2016). CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins . Methods (San Diego, Calif.).
(2016). Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP) . Nature methods.
(2016). Resources for the Comprehensive Discovery of Functional RNA Elements . Molecular cell.
Sundararaman, B., Zhan, L., Blue, S.M., Stanton, R., Elkins, K., Olson, S., Wei, X., Van Nostrand, E.L., Pratt, G.A., Huelga, S.C., et al.(2016). Resources for the Comprehensive Discovery of Functional RNA Elements . Molecular Cell. 61. (6). p. 903-913.
Van Nostrand, E.L., Pratt, G.A., Shishkin, A.A., Gelboin-Burkhart, C., Fang, M.Y., Sundararaman, B., Blue, S.M., Nguyen, T.B., Surka, C., Elkins, K., et al.(2016). Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP) . Nature Methods. 13. (6). p. 508-514.
OTHER
Steven Blue, Aidan M. Fenix, Yuichiro Miyaoka, Alessandro Bertero, Matthew J. Spindler, Kenneth K. B. Tan, Juan Perez-Bermejo, Amanda H. Chan, Steven J. Mayer, Trieu Nguyen, et al.(2021). Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies . Cold Spring Harbor Laboratory
Fenix, A.M., Miyaoka, Y., Bertero, A., Blue, S., Spindler, M.J., Tan, K.K.B., Perez-Bermejo, J., Chan, A.H., Mayer, S.J., Nguyen, T., et al.(2021). Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein aggregates within processing bodies . bioRxiv.
Arif, W., Mathur, B., Saikali, M.F., Chembazhi, U.V., Blue, S.M., Yee, B.A., van Nostrand, E.L., Bangru, S., Hao, Q., Yeo, G.W., et al.(2021). Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology via R-loop induced DNA damage and cell death . bioRxiv.
Morgan, S.C., Aigner, S., Anderson, C., Belda-Ferre, P., de Hoff, P., Marotz, C.A., Sathe, S., Zeller, M., Ahmed, N., Audhya, X., et al.(2021). Automated, miniaturized, and scalable screening of healthcare workers, first responders, and students for SARS-CoV-2 in San Diego county . medRxiv.
Xiangduo Kong, Yen-Yun Chen, Jianhuang Lin, Ebony Flowers, Eric Van Nostrand, Steven M. Blue, Jonathan Chau, Christopher I-Hsing Ma, Isaiah Mohr, Ryan Thai, et al.(2019). The cohesin loader NIPBL interacts with pre-ribosomal RNA and treacle to regulate ribosomal RNA synthesis . Cold Spring Harbor Laboratory
Kong, X., Chen, Y.-Y., Lin, J., Flowers, E., Van Nostrand, E., Blue, S.M., Chau, J., Ma, C.I.-H., Mohr, I., Thai, R., et al.(2019). The cohesin loader NIPBL interacts with pre-ribosomal RNA and treacle to regulate ribosomal RNA synthesis . bioRxiv.
van Nostrand, E.L., Pratt, G.A., Yee, B.A., Wheeler, E., Blue, S.M., Mueller, J., Park, S.S., Garcia, K.E., Gelboin-Burkhart, C., Nguyen, T.B., et al.(2019). Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins . bioRxiv.
van Nostrand, E.L., Freese, P., Pratt, G.A., Wang, X., Wei, X., Xiao, R., Blue, S.M., Chen, J.-Y., Cody, N.A.L., Dominguez, D., et al.(2017). A large-scale binding and functional map of human RNA binding proteins . bioRxiv.
Batra, R., Nelles, D.A., Krach, F., Thomas, J.D., Snjader, L., Blue, S.M., Aigner, S., Swanson, M.S., Yeo, G.W.(2017). Reversal of molecular pathology by RNA-targeting Cas9 in a myotonic dystrophy mouse model . bioRxiv.
PREPRINT
Steven Blue, Eric Van Nostrand, Gene Yeo (2019). Biotin-Labelling of Immunoprecipitated RNA (v1pre) v1 .
BOOK CHAPTER
Van Nostrand, E.L., Nguyen, T.B., Gelboin-Burkhart, C., Wang, R., Blue, S.M., Pratt, G.A., Louie, A.L., Yeo, G.W.(2017). Robust, cost-effective profiling of RNA binding protein targets with single-end enhanced crosslinking and immunoprecipitation (SeCLIP) . Methods in Molecular Biology. 1648. p. 177-200.
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