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Academic PI & Immunology Advisor | Innate Immune Modulation in Cancer & Chronic Inflammation
Profile Summary
Subject Matter Expertise
Services
Consulting
Scientific and Technical Consulting
Work Experience
Associate Professor
Albert Einstein College of Medicine
July 2025 - Present 
Assistant Professor
Albert Einstein College of Medicine
November 2019 - June 2025
Postdoctoral Fellow
University of Wisconsin Madison
October 2014 - October 2019
PhD Student
Instituto de Medicina Molecular
May 2010 - September 2014
PhD Student
Universidad de Murcia
May 2010 - September 2014
Research Fellow
Instituto de Medicina Molecular
October 2007 - April 2010
Education
PhD (Instituto de Bioquimica)
Universidade de Lisboa Faculdade de Medicina
May 2010 - September 2014
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Sofia de Oliveira, Cassia Michael, Joaquín Cantón-Sandoval, María Feliz-Norberto, Pablo Scharf (2025). Metainflammation alters neutrophil function and migration in vivo in response to tissue injury . Journal of Leukocyte Biology.
Sofia de Oliveira, Cassia Michael, Juliana Moreira Mendonça-Gomes, Clinton Walton DePaolo, Antonio Di Cristofano (2024). A zebrafish xenotransplant model of anaplastic thyroid cancer to study tumor microenvironment and innate immune cell interactions in vivo . Endocrine-Related Cancer.
Sofia de Oliveira, Cassia Michael (2023). Exploring the dynamic behavior of leukocytes with zebrafish . Current Opinion in Cell Biology.
Hernández-Silva, D., Cantón-Sandoval, J., Martínez-Navarro, F.J., Pérez-Sánchez, H., de Oliveira, S., Mulero, V., Alcaraz-Pérez, F., Cayuela, M.L.(2022). Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation . International Journal of Molecular Sciences. 23. (18).
Therapeutic targeting of the inflammasome in myeloid malignancies <head>
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</head> . Blood Cancer Journal.
Joshua T. Weinreb and Noura Ghazale and Kith Pradhan and Varun Gupta and Kathryn S. Potts and Brad Tricomi and Noah J. Daniels and Richard A. Padgett and Sofia De Oliveira and Amit Verma and Teresa V. Bowman(2021). Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production . Developmental Cell. 56. (5). p. 627--640.e5. Elsevier {BV}
Michael, C., Martínez-Navarro, F.J., de Oliveira, S.(2021). Analysis of liver microenvironment during early progression of non-alcoholic fatty liver disease-associated hepatocellular carcinoma in zebrafish . Journal of Visualized Experiments. 2021. (170).
Chakraborty, S., Shapiro, L.C., de Oliveira, S., Rivera-Pena, B., Verma, A., Shastri, A.(2021). Therapeutic targeting of the inflammasome in myeloid malignancies . Blood Cancer Journal. 11. (9).
Weinreb, J.T., Ghazale, N., Pradhan, K., Gupta, V., Potts, K.S., Tricomi, B., Daniels, N.J., Padgett, R.A., De Oliveira, S., Verma, A., et al.(2021). Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production . Developmental Cell. 56. (5). p. 627-640.e5.
Sofia de Oliveira, Ruth A. Houseright, Benjamin G. Korte, Anna Huttenlocher (2020). DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma . Disease Models & Mechanisms.
Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish @article {
title = {Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish},
journal = {Developmental & Comparative Immunology},
year = {2020},
month = {apr},
url = {http://dx.doi.org/10.1016/j.dci.2019.103583},
doi = {10.1016/j.dci.2019.103583}
} . Developmental & Comparative Immunology.
(2020). Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish . Developmental & Comparative Immunology.
(2020). DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma . Disease Models & Mechanisms.
De Oliveira, S., Houseright, R.A., Korte, B.G., Huttenlocher, A.(2020). DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma . DMM Disease Models and Mechanisms. 13. (4).
De Oliveira, S.(2020). First person . DMM Disease Models and Mechanisms. 13. (4).
Martínez-Navarro, F.J., Martínez-Morcillo, F.J., de Oliveira, S., Candel, S., Cabas, I., García-Ayala, A., Martínez-Menchón, T., Corbalán-Vélez, R., Mesa-del-Castillo, P., Cayuela, M.L., et al.(2020). Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish . Developmental and Comparative Immunology. 105.
(2019). Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish . Journal of Hepatology.
Road map for fibrolamellar carcinoma: progress and goals of a diversified approach</p> @article {
title = {Road map for fibrolamellar carcinoma: progress and goals of a diversified approach</p>},
journal = {Journal of Hepatocellular Carcinoma},
year = {2019},
month = {jan},
url = {http://dx.doi.org/10.2147/jhc.s194764},
doi = {10.2147/jhc.s194764}
} . Journal of Hepatocellular Carcinoma.
(2019). Road map for fibrolamellar carcinoma: progress and goals of a diversified approach</p> . Journal of Hepatocellular Carcinoma.
de Oliveira, S., Houseright, R.A., Graves, A.L., Golenberg, N., Korte, B.G., Miskolci, V., Huttenlocher, A.(2019). Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish . Journal of Hepatology. 70. (4). p. 710-721.
(2018). Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model . International Journal of Cancer.
Gabellini, C., Gómez-Abenza, E., Ibáñez-Molero, S., Tupone, M.G., Pérez-Oliva, A.B., de Oliveira, S., Del Bufalo, D., Mulero, V.(2018). Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model . International Journal of Cancer. 142. (3). p. 584-596.
(2016). Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion . Journal of Biological Chemistry.
(2016). Neutrophil migration in infection and wound repair: going forward in reverse . Nature Reviews Immunology.
(2016). TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity . The Journal of Immunology.
Galindo-Villegas, J., Montalban-Arques, A., Liarte, S., De Oliveira, S., Pardo-Pastor, C., Rubio-Moscardo, F., Meseguer, J., Valverde, M.A., Mulero, V.(2016). TRPV4-mediated detection of hyposmotic stress by skin keratinocytes activates developmental immunity . Journal of Immunology. 196. (2). p. 738-749.
Galindo-Villegas, J., Montalban-Arques, A., Liarte, S., De Oliveira, S., Pardo-Pastor, C., Rubio-Moscardo, F., Meseguer, J., Valverde, M.A., Mulero, V.(2016). Erratum: TRPV4-mediated detection of hyposmotic stress by skin keratinocytes activates developmental immunity (Journal of Immunology (2016) 196 (738-749)) . Journal of Immunology. 196. (8). p. 3494.
De Oliveira, S., Rosowski, E.E., Huttenlocher, A.(2016). Neutrophil migration in infection and wound repair: Going forward in reverse . Nature Reviews Immunology. 16. (6). p. 378-391.
Boateng, L.R., Bennin, D., De Oliveira, S., Huttenlocher, A.(2016). Mammalian actin-binding protein-1/hip-55 interacts with fhl2 and negatively regulates cell invasion . Journal of Biological Chemistry. 291. (27). p. 13987-13998.
(2015). Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish . Developmental & Comparative Immunology.
Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish @article {
title = {Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish},
journal = {Developmental & Comparative Immunology},
year = {2015},
month = {jun},
url = {http://dx.doi.org/10.1016/j.dci.2015.01.005},
doi = {10.1016/j.dci.2015.01.005}
} . Developmental & Comparative Immunology.
Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium @article {
title = {Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium},
journal = {Developmental & Comparative Immunology},
year = {2015},
month = {mar},
url = {http://dx.doi.org/10.1016/j.dci.2014.11.004},
doi = {10.1016/j.dci.2014.11.004}
} . Developmental & Comparative Immunology.
(2015). Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium . Developmental & Comparative Immunology.
(2015). Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications . The Journal of Immunology.
De Oliveira, S., Boudinot, P., Calado, Â., Mulero, V.(2015). Duox1-derived H<sub>2</sub>O<sub>2</sub> modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications . Journal of Immunology. 194. (4). p. 1523-1533.
de Oliveira, S., Lopez-Muñoz, A., Martínez-Navarro, F.J., Galindo-Villegas, J., Mulero, V., Calado, T.(2015). Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium . Developmental and Comparative Immunology. 49. (1). p. 44-48.
Candel, S., Sepulcre, M.P., Espín-Palazón, R., Tyrkalska, S.D., de Oliveira, S., Meseguer, J., Mulero, V.(2015). Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish . Developmental and Comparative Immunology. 50. (2). p. 155-165.
(2014). ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1–Derived H2O2 Production and NF-κB Activation . The Journal of Immunology.
(2014). Tnfa Signaling Through Tnfr2 Protects Skin Against Oxidative Stress–Induced Inflammation . PLoS Biology.
Candel, S., de Oliveira, S., López-Muñoz, A., García-Moreno, D., Espín-Palazón, R., Tyrkalska, S.D., Cayuela, M.L., Renshaw, S.A., Corbalán-Vélez, R., Vidal-Abarca, I., et al.(2014). Tnfa Signaling Through Tnfr2 Protects Skin Against Oxidative Stress-Induced Inflammation . PLoS Biology. 12. (5).
De Oliveira, S., López-Muñoz, A., Candel, S., Pelegrín, P., Calado, A., Mulero, V.(2014). ATP modulates acute inflammation in vivo through dual oxidase 1-derived H<sub>2</sub>O<sub>2</sub> production and NF-κB activation . Journal of Immunology. 192. (12). p. 5710-5719.
(2013). Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response . The Journal of Immunology.
De Oliveira, S., Reyes-Aldasoro, C.C., Candel, S., Renshaw, S.A., Mulero, V., Calado, A.(2013). Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response . Journal of Immunology. 190. (8). p. 4349-4359.
(2012). Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development . Proceedings of the National Academy of Sciences.
Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development @article {
title = {Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development},
journal = {Proceedings of the National Academy of Sciences},
year = {2012},
month = {sep},
url = {http://dx.doi.org/10.1073/pnas.1209920109},
doi = {10.1073/pnas.1209920109}
} . Proceedings of the National Academy of Sciences.
Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane @article {
title = {Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane},
journal = {Biochimica et Biophysica Acta (BBA) - Biomembranes},
year = {2012},
month = {mar},
url = {http://dx.doi.org/10.1016/j.bbamem.2011.10.028},
doi = {10.1016/j.bbamem.2011.10.028}
} . Biochimica et Biophysica Acta (BBA) - Biomembranes.
(2012). Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane . Biochimica et Biophysica Acta (BBA) - Biomembranes.
Erythrocyte as a biological sensor @article {
title = {Erythrocyte as a biological sensor},
journal = {Clinical Hemorheology and Microcirculation},
year = {2012},
url = {http://doi.org/10.3233/CH-2011-1512},
doi = {10.3233/CH-2011-1512}
} . Clinical Hemorheology and Microcirculation.
De Almeida, J.P.L., Oliveira, S., Saldanha, C.(2012). Erythrocyte as a biological sensor . Clinical Hemorheology and Microcirculation. 51. (1). p. 1-20.
(2012). Erythrocyte as a biological sensor . Clinical Hemorheology and Microcirculation.
De Oliveira, S., De Almeida, V.V., Calado, A., Rosário, H.S., Saldanha, C.(2012). Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane . Biochimica et Biophysica Acta - Biomembranes. 1818. (3). p. 481-490.
Galindo-Villegas, J., Garciá-Moreno, D., De Oliveira, S., Meseguer, J., Mulero, V.(2012). Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development . Proceedings of the National Academy of Sciences of the United States of America. 109. (39).
(2011). Variations on Fibrinogen-Erythrocyte Interactions during Cell Aging . PLoS ONE.
Carvalho, F.A., de Oliveira, S., Freitas, T., Gonçalves, S., Santos, N.C.(2011). Variations on fibrinogen-erythrocyte interactions during cell aging . PLoS ONE. 6. (3).
(2010). An overview about erythrocyte membrane . Clinical Hemorheology and Microcirculation.
De Oliveira, S., Saldanha, C.(2010). An overview about erythrocyte membrane . Clinical Hemorheology and Microcirculation. 44. (1). p. 63-74.
An overview about erythrocyte membrane @article {
title = {An overview about erythrocyte membrane},
journal = {Clinical Hemorheology and Microcirculation},
year = {2010},
url = {http://doi.org/10.3233/CH-2010-1253},
doi = {10.3233/CH-2010-1253}
} . Clinical Hemorheology and Microcirculation.
(2008). Modulation of erythrocyte deformability by PKC activity. Clinical hemorheology and microcirculation.
Modulation of erythrocyte deformability by PKC activity. @article {
title = {Modulation of erythrocyte deformability by PKC activity.},
journal = {Clinical hemorheology and microcirculation},
year = {2008},
month = {jan}
}. Clinical hemorheology and microcirculation.
De Oliveira, S., Silva-Herdade, A.S., Saldanha, C.(2008). Modulation of erythrocyte deformability by PKC activity . Clinical Hemorheology and Microcirculation. 39. (1-4). p. 363-373.
PREPRINT
Sofia de Oliveira, Carmen de Sena-Tomás, Leonor Rebola Lameira, Patrícia Naique Taborda, Alexandre Laborde, Michael Orger, Leonor Saúde (2024). Neutrophil immune profile controls spinal cord regeneration in zebrafish .
Sofia de Oliveira, Cassia Michael, Antonio Di Cristofano (2023). A zebrafish xenotransplant model of anaplastic thyroid cancer to study the tumor microenvironment and innate immune cell interactionsin vivo .
OTHER
Sofia de Oliveira, Maria Feliz-Norberto, Cassia Michael(2021). Neutrophil reverse migration from liver fuels neutrophilic inflammation to tissue injury in Nonalcoholic Steatohepatitis . Cold Spring Harbor Laboratory
Feliz-Norberto, M., Michael, C., de Oliveira, S.(2021). Neutrophil reverse migration from liver fuels neutrophilic inflammation to tissue injury in Nonalcoholic Steatohepatitis . bioRxiv.
(2019). DNAJB1-PRKACA fusion induces liver inflammation in zebrafish model of Fibrolamellar Hepatocellular Carcinoma . BioRxiv.
de Oliveira, S., Houseright, R.A., Korte, B.G., Huttenlocher, A.(2019). DNAJB1-PRKACA fusion induces liver inflammation in zebrafish model of Fibrolamellar Hepatocellular Carcinoma . bioRxiv.
Sofia de Oliveira, Ruth A. Houseright, Alyssa L. Graves, Netta Golenberg, Benjamin G. Korte, Veronika Miskolci, Anna Huttenlocher(2018). High cholesterol diet modulates macrophage polarization and liver inflammation during early hepatocellular carcinoma progression in zebrafish . Cold Spring Harbor Laboratory
de Oliveira, S., Houseright, R.A., Graves, A.L., Golenberg, N., Korte, B.G., Miskolci, V., Huttenlocher, A.(2018). High cholesterol diet modulates macrophage polarization and liver inflammation during early hepatocellular carcinoma progression in zebrafish . bioRxiv.
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