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Hire Dr. Simon L.

United Kingdom

Profile Summary

Technical and Clinical Validation of immunoassays, bioassays and diagnostic devices. Immune Therapy Medical Science Liaisons and Project Management

Subject Matter Expertise

• ☆ Project Management

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

SeraDiaLogistics

- Present

Self Employed Project Management and Business Development

Freelance Consultancy

January 2004 - June 2016

Clinical Operations Study Manager

Roche Penzberg

February 2012 - December 2012

Scientific Project Manager and Medical Affairs

Fresenius Biotech

January 2004 - June 2009

Education

Post doctoral research

NEI-NIH Bethesda MD, Karolinska Institute Stockholm

January 1994 - January 2000

Phd , MsC and MPH

Hebrew University, Weizmann Institute- Yale University

September 1987 - January 1994

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Blankenstein, T., Lytton, S.D., Leidl, B., Atweh, E., Friese, K., Mylonas, I.(2015). Point-of-care (POC) diagnosis of bacterial vaginosis (BV) using VGTest™ ion mobility spectrometry (IMS) in a routine ambulatory care gynecology clinic . Archives of Gynecology and Obstetrics. 292. (2). p. 355-362.

Woynarowski, M., Woźniak, M., Cukrowska, B., Wierzbicka, A., Lytton, S.D.(2015). Autoantibody Profile of Adult Patients With Childhood Onset Type 2 Autoimmune Hepatitis . Journal of Clinical Laboratory Analysis.

Wall, J.R., Lahooti, H., El Kochairi, I., Lytton, S.D., Champion, B.(2014). Thyroid-stimulating immunoglobulins as measured in a reporter bioassay are not detected in patients with Hashimoto’s thyroiditis and ophthalmopathy or isolated upper eyelid retraction . Clinical Ophthalmology. 8. p. 2071-2076.

Lytton, S.D., Antiga, E., Pfeiffer, S., Matthias, T., Szaflarska-Poplawska, A., Ulaganathan, V.K., Placek, W., Fabbri, P., Hall, R., Caproni, M.(2013). Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease - Dermatitis herpetiformis . Clinica Chimica Acta. 415. p. 346-349.

Horai, R., Silver, P.B., Chen, J., Agarwal, R.K., Chong, W.P., Jittayasothorn, Y., Mattapallil, M.J., Nguyen, S., Natarajan, K., Villasmil, R., et al.(2013). Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen . Journal of Autoimmunity. 44. p. 21-33.

Shimony, O., Nagler, A., Gellman, Y.N., Refaeli, E., Rosenblum, N., Eshkar-Sebban, L., Yerushalmi, R., Shimoni, A., Lytton, S.D., Stanevsky, A., et al.(2012). Anti-T lymphocyte globulin (ATG) induces generation of regulatory T cells, at least part of them express activated CD44 . Journal of Clinical Immunology. 32. (1). p. 173-188.

Kahaly, G.J., Shimony, O., Gellman, Y.N., Lytton, S.D., Eshkar-Sebban, L., Rosenblum, N., Refaeli, E., Kassem, S., Ilany, J., Naor, D.(2011). Regulatory T-cells in Graves' orbitopathy: Baseline findings and immunomodulation by anti-T lymphocyte globulin . Journal of Clinical Endocrinology and Metabolism. 96. (2). p. 422-429.

Lytton, S.D., Li, Y., Olivo, P.D., Kohn, L.D., Kahaly, G.J.(2010). Novel chimeric thyroid-stimulating hormone-receptor bioassay for thyroid-stimulating immunoglobulin . Clinical and Experimental Immunology. 162. (3). p. 438-446.

Lytton, S.D., Ponto, K.A., Kanitz, M., Matheis, N., Kohn, L.D., Kahaly, G.J.(2010). A novel thyroid stimulating immunoglobulin bioassay is a functional indicator of activity and severity of graves' orbitopathy . Journal of Clinical Endocrinology and Metabolism. 95. (5). p. 2123-2131.

Lytton, S.D., Kahaly, G.J.(2010). Bioassays for TSH-receptor autoantibodies: An update . Autoimmunity Reviews. 10. (2). p. 116-122.

Karabekian, Z., Lytton, S.D., Silver, P.B., Sergeev, Y.V., Schneck, J.P., Caspi, R.R.(2005). Antigen/MHC class II/Ig dimers for study of uveitogenic T cells: IRBP p161-180 presented by both IA and IE molecules . Investigative Ophthalmology and Visual Science. 46. (10). p. 3769-3776.

Lytton, S.D., Fischer, W., Nagel, W., Haas, R., Beck, F.X.(2005). Production of ammonium by Helicobacter pylori mediates occludin processing and disruption tight junctions in Caco-2 cells . Microbiology. 151. (10). p. 3267-3276.

Grosse-Hovest, L., Müller, S., Minoia, R., Wolf, E., Zakhartchenko, V., Wenigerkind, H., Lassnig, C., Besenfelder, U., Müller, M., Lytton, S.D., et al.(2004). Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing . Proceedings of the National Academy of Sciences of the United States of America. 101. (18). p. 6858-6863.

Sahlin, M., Cho, K.-B., Pötsch, S., Lytton, S.D., Huque, Y., Gunther, M.R., Sjöberg, B.-M., Mason, R.P., Gräslund, A.(2002). Peroxyl adduct radicals formed in the iron/oxygen reconstitution reaction of mutant ribonucleotide reductase R2 proteins from Escherichia coli . Journal of Biological Inorganic Chemistry. 7. (1-2). p. 74-82.

Lytton, S.D., Berg, U., Nemeth, A., Ingelman-Sundberg, M.(2002). Autoantibodies against cytochrome P450s in sera of children treated with immunosuppressive drugs . Clinical and Experimental Immunology. 127. (2). p. 293-302.

Lytton, S.D., Helander, A., Zhang-Gouillon, Z.-Q., Stokkeland, K., Bordone, R., Aricò, S., Albano, E., French, S.W., Ingelman-Sundberg, M.(1999). Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics . Molecular Pharmacology. 55. (2). p. 223-233.

Eliasson, E., Stål, P., Oksanen, A., Lytton, S.(1998). Expression of autoantibodies to specific cytochromes P450 in a case of disulfiram hepatitis . Journal of Hepatology. 29. (5). p. 819-825.

Lytton, S.D., Loyevsky, M., Libman, J., Mester, B., Shanzer, A., Cabantchik, Z.I.(1994). The biochemical basis for the selective antimalarial action of iron chelators on Plasmodium falciparum parasitized cells . Advances in Experimental Medicine and Biology. 356. p. 385-397.

Lytton, S.D., Mester, B., Libman, J., Shanzer, A., Cabantchik, Z.L.(1994). Mode of action of iron (III) chelators as antimalarials: II. Evidence for differential effects on parasite iron-dependent nucleic acid synthesis . Blood. 84. (3). p. 910-915.

Loyevsky, M., Lytton, S.D., Mester, B., Libman, J., Shanzer, A., Cabantchik, Z.I.(1993). The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites . Journal of Clinical Investigation. 91. (1). p. 218-224.

Lytton, S.D., Loyevsky, M., Mester, B., Libman, J., Landau, I., Shanzer, A., Cabantchik, Z.I.(1993). In vivo antimalarial action of a lipophilic iron (III) chelator: Suppression of Plasmodium vinckei infection by reversed siderophore . American Journal of Hematology. 43. (3). p. 217-220.

Lytton, S.D., Mester, B., Dayan, I., Glickstein, H., Libman, J., Shanzer, A., Cabantchik, Z.I.(1993). Mode of action of iron (III) chelators as antimalarials: I. Membrane permeation properties and cytotoxic activity . Blood. 81. (1). p. 214-221.

Lytton, S.D., Mozes, E., Jaffe, C.L.(1993). Effect of macrophage infection by Leishmania on the proliferation of an antigen-specific T-cell line, TPB1, to a non-parasite antigen . Parasite Immunology. 15. (8). p. 489-492.

Lytton, S.D., Mester, B., Libman, J., Shanzer, A., Ioav Cabantchik, Z.(1992). Monitoring of iron(III) removal from biological sources using a fluorescent siderophore . Analytical Biochemistry. 205. (2). p. 326-333.

Shanzer, A., Libman, J., Lytton, S.D., Glickstein, H., Cabantchik, Z.I.(1991). Reversed siderophores act as antimalarial agents . Proceedings of the National Academy of Sciences of the United States of America. 88. (15). p. 6585-6589.

Lytton, S.D., Cabantchik, Z.I., Libman, J., Shanzer, A.(1991). Reversed siderophores as antimalarial agents. II. Selective scavenging of Fe(III) from parasitized erythrocytes by a fluorescent derivative of desferal . Molecular Pharmacology. 40. (4). p. 584-590.

BOOK

Lytton, S.D., Denton, C.P., Nutzenberger, A.M.(2007). Treatment of autoimmune disease with rabbit anti-T lymphocyte globulin: Clinical efficacy and potential mechanisms of action . Annals of the New York Academy of Sciences. 1110. p. 285-296.

Frost, N., Messer, G., Fierlbeck, G., Risler, T., Lytton, S.D.(2005). Treatment of pemphigus vulgaris with protein A immunoadsorption: Case report of long-term history showing favorable outcome . Annals of the New York Academy of Sciences. 1051. p. 591-596.