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USD 60 /hr
Hire Dr. Simon C.
United States
USD 60 /hr
I am a biochemist who with deep knowledge of molecular interactions, gene expression, and biomolecular condensates.
Profile Summary
Subject Matter Expertise
Services
Writing
Technical Writing,
Copywriting,
Newswriting
Research
Market Research,
User Research,
Meta-Research,
Feasibility Study,
Fact Checking,
Gap Analysis,
Gray Literature Search,
Systematic Literature Review,
Secondary Data Collection
Consulting
Digital Strategy Consulting,
Scientific and Technical Consulting
Data & AI
Statistical Analysis,
Data Visualization,
Big Data Analytics,
Data Insights
Product Development
Product Evaluation,
Prototyping
Work Experience
Postdoctoral Researcher
UT Southwestern Medical Center
June 2017 - Present
Postdoctoral Researcher
University of Texas Southwestern Medical Center
June 2017 - Present 
Postdoctoral Researcher
University of Utah
September 2016 - May 2017
Education
PhD
University of Utah
August 2009 - August 2016
PhD (Oncological Sciences)
University of Utah
August 2009 - August 2016
BA (Chemistry)
Willamette University
August 2005 - May 2009
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
(2021). Using quantitative reconstitution to investigate multi-component condensates . RNA (New York, N.Y.).
Simon L. Currie, Steven L. Warner, Hariprasad Vankayalapati, Xiaohui Liu, Sunil Sharma, David J. Bearss, Barbara J. Graves(2019). Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors . SLAS DISCOVERY: Advancing the Science of Drug Discovery. 24. (1). p. 77--85. {SAGE} Publications
Bethany J. Madison, Kathleen A. Clark, Niraja Bhachech, Peter C. Hollenhorst, Barbara J. Graves, Simon L. Currie(2018). Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN–FOS at composite DNA sites . Journal of Biological Chemistry. 293. (48). p. 18624--18635. Elsevier {BV}
(2017). Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs . The Journal of biological chemistry.
(2017). ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain . Journal of molecular biology.
Simon L. Currie, Desmond K. W. Lau, Jedediah J. Doane, Frank G. Whitby, Mark Okon, Lawrence P. McIntosh, Barbara J. Graves(2017). Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5 . Nucleic Acids Research. 45. (5). p. 2223--2241. Oxford University Press ({OUP})
Huang, F., Ramakrishnan, S., Pokhrel, S., Pflueger, C., Parnell, T.J., Kasten, M.M., Currie, S.L., Bhachech, N., Horikoshi, M., Graves, B.J., et al.(2015). Interaction of the Jhd2 histone H3 Lys-4 demethylase with chromatin is controlled by histone H2A surfaces and restricted by H2B ubiquitination . Journal of Biological Chemistry. 290. (48). p. 28760-28777.
Desjardins, G., Meeker, C.A., Bhachech, N., Currie, S.L., Okon, M., Graves, B.J., McIntosh, L.P.(2014). Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor . Proceedings of the National Academy of Sciences of the United States of America. 111. (30). p. 11019-11024.
OTHER
Simon L. Currie, Jedediah J. Doane, Kathryn S. Evans, Niraja Bhachech, Bethany J. Madison, Desmond K. W. Lau, Lawrence P. McIntosh, Jack J. Skalicky, Kathleen A. Clark, Barbara J. Graves(2017). ETV4 and AP1 transcription factors form multivalent interactions with three sites on the MED25 activator-interacting domain . Cold Spring Harbor Laboratory
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