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★★★★★

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USD 75 /hr

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☆☆☆☆☆

Hire Dr. Shuai Z.

United States

USD 75 /hr

Chemical biologist and synthetic chemist with 15+ years of academic and industry experience

Profile Summary

Well trained chemist with 12+ years of research experience in organic synthesis, medicinal chemistry, and chemical biology. Deep expertise in synthetic methodology, fluorescent probes, super-resolution microscopy, targeted protein degradation, and high throughput experimentation. Fluent in molecule modeling, structure-guided design, bioconjugation chemistry/linker-ligand selection, DNA-encoded library, and ADME optimization. Experienced in regulatory affairs and non-clinical drug development.

Subject Matter Expertise

• ★ Organic Chemistry
• ★ Chemical Biology
• ★ Medicinal Chemistry
• ☆ Catalysis
• ☆ Analytical Chemistry
• ☆ Crystallography
• ☆ X-Ray Crystallography
• ☆ Spectroscopy
• ☆ UV Spectroscopy
• ☆ Fluorescence Spectroscopy
• ☆ IR Spectroscopy
• ☆ NMR Spectroscopy
• ☆ Mass Spectrometry
• ☆ Molecular Imaging
• ☆ Liquid Chromatography/HPLC
• ☆ Gas Chromatography
• ☆ Organometallic Chemistry
• ☆ Retrosynthesis
• ☆ Biotechnology & Bioengineering
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Structure-Activity Relationship (SAR) Studies

Services

• Writing
• Research
• Product Development

Writing Technical Writing, General Proofreading & Editing, Translation

Research Scientific and Technical Research, Systematic Literature Review

Product Development Manufacturing, Quality Assurance & Control (QA/QC)

Work Experience

Scientist II

Lycia Therapeutics

May 2023 - Present

Postdoctoral Associate

University of California, Berkeley

May 2020 - April 2023

Education

PhD (Department of Chemistry)

University of Pennsylvania

August 2015 - Present

Master of Art (Department of Chemistry)

Washington University in Saint Louis

August 2013 - May 2015

Bachelor of Science (Department of Chemistry)

Zhejiang University

September 2009 - June 2013

Certifications

• Python for Everyone

  Coursera/University of Michigan

  February 2026 - Present

Publications

JOURNAL ARTICLE

Shuai Zheng, Leah T. Roe, Isabel M. Piper, Carly K. Schissel, Taylor L. Dover, Bhavana Shah, Noah X. Hamlish, Arjun M. Garapaty, Diondra A. Dilworth, Nicole Wong, et al. (2025). Site-selective protein editing by backbone extension acyl rearrangements . Nature Chemical Biology.

Shuai Zheng, Lauren Lesiak, Neville Dadina, Marianne Schelvis, Alanna Schepartz (2024). A Bright, Photostable, and Far-Red Dye That Enables Multicolor, Time-Lapse, and Super-Resolution Imaging of Acidic Organelles . ACS Central Science.

Shuai Zheng, Neville Dadina, Deepto Mozumdar, Lauren Lesiak, Kayli N. Martinez, Evan W. Miller, Alanna Schepartz (2024). Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe . Nature Chemical Biology.

N. Dadina, J. Tyson, S. Zheng, L. Lesiak, A. Schepartz (2021). Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes . Current Opinion in Chemical Biology.

Shuai Zheng, Jonathan Tyson, Kevin Hu, Phylicia Kidd, Neville Dadina, Ling Chu, Derek Toomre, Joerg Bewersdorf, Alanna Schepartz (2021). Extremely Bright, Near-IR Emitting Spontaneously Blinking Fluorophores Enable Ratiometric Multicolor Nanoscopy in Live Cells . ACS Central Science.

Shuai Zheng, Shuo-Qing Zhang, Borna Saeednia, Jiawang Zhou, Jessica M. Anna, Xin Hong, Gary A. Molander(2020). Diastereoselective olefin amidoacylation via photoredox PCET/nickel-dual catalysis: reaction scope and mechanistic insights . Chemical Science. 11. (16). p. 4131--4137. Royal Society of Chemistry ({RSC})

Shuai Zheng, Zheng-Jun Wang, Eugénie Romero, Jennifer K. Matsui, Gary A. Molander(2019). Regioselective Single-Electron Tsuji–Trost Reaction of Allylic Alcohols: A Photoredox/Nickel Dual Catalytic Approach . Organic Letters. 21. (16). p. 6543--6547. American Chemical Society ({ACS})

Shuai Zheng, Álvaro Gutiérrez-Bonet, Gary A. Molander(2019). Merging Photoredox PCET with Ni-Catalyzed Cross-Coupling: Cascade Amidoarylation of Unactivated Olefins . Chem. 5. (2). p. 339--352. Elsevier {BV}

Shuai Zheng, Zheng-Jun Wang, Jennifer K. Matsui, Zhipeng Lu, Gary A. Molander(2019). Desulfonative photoredox alkylation of N-heteroaryl sulfones – an acid-free approach for substituted heteroarene synthesis . Chemical Science. Royal Society of Chemistry ({RSC})

(2018). Divergent Pathways Involving 1,3-Dipolar Addition and N−N Bond Splitting of an Organic Azide across a Zirconium Methylidene . Angewandte Chemie International Edition.

Shuai Zheng, David N. Primer, Gary A. Molander(2017). Nickel/Photoredox-Catalyzed Amidation via Alkylsilicates and Isocyanates . ACS Catalysis. 7. (11). p. 7957--7961. American Chemical Society ({ACS})

Shuai Zheng, Wen Zhou, Jason W. Schultz, Nigam P. Rath, Liviu M. Mirica(2016). Aromatic Cyanoalkylation through Double C–H Activation Mediated by Ni(III) . Journal of the American Chemical Society. 138. (18). p. 5777--5780. American Chemical Society ({ACS})

Shuai Zheng, Wen Zhou, Michael B. Watson, Nigam P. Rath, Liviu M. Mirica(2016). Ligand effects on the properties of Ni(iii) complexes: aerobically-induced aromatic cyanation at room temperature . Dalton Trans. 45. (40). p. 15886--15893. Royal Society of Chemistry ({RSC})

Shuai Zheng, Jin Han, Yaochen Zheng, Sipei Li, Tiannan Hu, Aijin Tang, Chao Gao(2014). Water soluble octa-functionalized POSS: all-click chemistry synthesis and efficient host–guest encapsulation . Chem. Commun. 50. (63). p. 8712--8714. Royal Society of Chemistry ({RSC})

PREPRINT

Shuai Zheng, Leah T. Roe, Carly K. Schissel, Taylor L. Dover, Bhavana Shah, Noah X. Hamlish, Diondra A. Dilworth, Nicole Wong, Zhongqi Zhang, Abhishek Chatterjee, et al. (2023). Backbone extension acyl rearrangements enable cellular synthesis of proteins with internal β²-peptide linkages .

Shuai Zheng, Lauren Lesiak, Neville Dadina, Marianne Schelvis, Alanna Schepartz (2023). A Bright, Photostable Dye that Enables Multicolor, Time Lapse, and Super-Resolution Imaging of Acidic Organelles .

Long-term, super-resolution HIDE imaging of the inner mitochondrial membrane in live cells with a cell-permeant lipid probe <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> .