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USD 100 /hr

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☆☆☆☆☆

Hire Dr. Shekhar D.

India

USD 100 /hr

Expert in In Vitro Pharmacology | Technical Scientific Writing | 27+ Years Research Exp | 25 Publications | 800+ Citat

Profile Summary

I am an experienced biological researcher with over two decades of specialized expertise in in vitro pharmacology, focusing on assay development, screening, and mechanism of action studies. My work has contributed to advancing preclinical discovery across therapeutic areas, with a strong emphasis on robust experimental design, data analysis, and translational relevance. With 25 peer-reviewed publications in reputable scientific journals and over 800 citations, I bring deep scientific rigor and practical insight to research challenges. My background includes developing and validating in vitro assays, evaluating compound efficacy and toxicity, and interpreting complex pharmacological data to guide decision-making in early-stage development. I now focus on remote scientific consulting, offering strategic support in: Design and optimization of in vitro pharmacology assays Critical review of experimental plans and data interpretation Manuscript and grant writing/review/editing (particularly in pharmacology and cell biology) Scientific due diligence for early-stage biotech projects Training and mentoring researchers in best practices in in vitro methods

Subject Matter Expertise

• ★ Preclinical ADME/PK/PD
• ★ Preclinical Pharmacology
• ★ Scientific Proofreading & Editing
• ☆ Botany
• ☆ Phytochemistry
• ☆ Biochemistry
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Binding Assays
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Neuroscience
• ☆ Neuropharmacology
• ☆ Neurobiology
• ☆ Pharmacy
• ☆ Drug Discovery
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ Men's Health
• ☆ Erectile Dysfunction
• ☆ Endocrinology
• ☆ Diabetes
• ☆ Psychiatry
• ☆ Complementary & Alternative Medicine
• ☆ Quality Assurance & Quality Control (QA/QC)
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Literature Search
• ☆ Journal Selection
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ White Papers
• ☆ Spec Sheets
• ☆ Science Communication
• ☆ Literature Review
• ☆ Systematic Literature Review
• ☆ Proofreading & Editing
• ☆ Grant Writing
• ☆ Supplements

Services

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, General Proofreading & Editing

Research Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting, Regulatory Consulting

Product Development Stability/Shelf Life Testing, Quality Assurance & Control (QA/QC)

Work Experience

Manager

Natural Remedies Private Limited

July 2003 - Present

Education

PhD, Biochemistry

Marathwada University, Aurangabad, India

August 1995 - December 2001

Certifications

• -

  -

  January 2025 - January 2025

Publications

JOURNAL ARTICLE

Shekhar Dethe, Mannanthendil Kumaran Asha, Debnath Debraj, Anirban Bhaskar, Nithyanantham Muruganantham, Mundkinajeddu Deepak (2017). Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes . Journal of Dietary Supplements.

G. M. Gururaja, Deepak Mundkinajeddu, A. Senthil Kumar, Shekhar Michael Dethe, J. Joshua Allan, Amit Agarwal (2017). Evaluation of Cholesterol-lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar Rats . Pharmacognosy Research.

Shekhar Dethe, M Deepak, Amit Agarwal (2016). Elucidation of Molecular Mechanism(s) of Cognition Enhancing Activity of Bacomind®: A Standardized Extract of Bacopa Monnieri . Pharmacognosy Magazine.

Amit Agarwal, Sumanta Kumar Goswami, Mohammed Naseeruddin Inamdar, Shekhar M Dethe, Giligar M Gururaj, Rohitash Jamwal, Anirban Bhaskar, Deepak Mundkinajeddu (2016). Erectogenic and Aphrodisiac Property of Moringa oleifera: Involvement of Soluble Epoxide Hydrolase Enzyme . Phytotherapy research : PTR.

G. M. Gururaja, Deepak Mundkinajeddu, Shekhar M. Dethe, Gopala K. Sangli, K. Abhilash, Amit Agarwal (2014). Cholesterol esterase inhibitory activity of bioactives from leaves of Mangifera indica L . Pharmacognosy Research.

Shekhar Dethe, Sumanta K Goswami, Mohammed N Inamdar, Rohitash Jamwal (2014). Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats . The Journal of Sexual Medicine.

Mehla, J., Pahuja, M., Gupta, P., Dethe, S., Agarwal, A., Gupta, Y.K.(2014). Erratum to: Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence . Psychopharmacology.

Agarwal, Amit and DSouza, Prashanth and Johnson, T Sudhakar and Dethe, Shekhar M and Chandrasekaran, CV(2014). Use of in vitro bioassays for assessing botanicals . Current Opinion in Biotechnology. 25. p. 39-44. Elsevier

Kumar Goswami, S and Naseeruddin Inamdar, M and Dethe, S and Agarwal, A(2013). Butea Frondosa, A Rho Kinase 2 and Phosphodiesterase 5 Enzyme Inhibitor, Increases Sexual Function In Young And Aged Rats . Planta Medica. 79. (10). Thieme Publishing Group

Mehla, Jogender and Pahuja, Monika and Gupta, Pooja and Dethe, Shekhar and Agarwal, Amit and Gupta, Yogendra Kumar(2013). Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence . Psychopharmacology. 230. (4). p. 589-605. Springer-Verlag

Goswami, S.K., Inamdar, M.N., Jamwal, R., Dethe, S.(2013). Efficacy of Cinnamomum cassia Blume. in age induced sexual dysfunction of rats . Journal of Young Pharmacists. 5. (4). p. 148-153.

Goswami, Sumanta Kumar and Inamdar, Mohammed Naseeruddin and Pandre, Manoj Kumar and Jamwal, Rohitash and Dethe, Shekhar(2013). Erectogenic and Aphrodisiac Effects of Butea frondosa Koenig ex Roxb. in Rats: Involvement of Enzyme Inhibition . Evidence-Based Complementary and Alternative Medicine. 2013. p. 1-10. Hindawi Publishing Corporation

Asha, Mannanthendil Kumaran and Debraj, Debnath and Prashanth, Dsouza and Edwin, Jothie Richard and Srikanth, H.S. and Muruganantham, Nithyanantham and Dethe, Shekhar Michael and Anirban, Bhaskar and Jaya, Balachandran and Deepak, Mundkinajeddu and et al.(2013). In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action . Journal of Ethnopharmacology. 145. (2). p. 581-586. Elsevier

Mehla, Jogender and Pahuja, Monika and Dethe, Shekhar M. and Agarwal, Amit and Gupta, Yogendra Kumar(2012). Amelioration of intracerebroventricular streptozotocin induced cognitive impairment by Evolvulus alsinoides in rats: In vitro and in vivo evidence . Neurochemistry International. 61. (7). p. 1052-1064. Elsevier

Nadig, PratibhaD and Dethe, ShankarM and Aliyar, MeharbanA and Revankar, RoshniR and Narayanswamy, SriniwasB(2012). Effect of Tinospora cordifolia on experimental diabetic neuropathy . Indian Journal of Pharmacology. 44. (5). p. 580. Medknow Publications

Chandrasekaran, ChinampudurVelusami and Mundkinajeddu, Deepak and Balachandran, Jaya and Hiraganahalli, DeepakBhaskarmurthy and Dethe, Shekhar and Pandre, ManojKumar and Agarwal, Amit(2012). Hepatoprotective and antioxidant activity of standardized herbal extracts . Pharmacognosy Magazine. 8. (30). p. 116. Medknow Publications

Goswami, Sumanta Kumar and Manoj Kumar, Pandre and Jamwal, Rohitash and Dethe, Shekhar and Agarwal, Amit and Mohammed Naseeruddin, Inamdar(2012). Screening for Rho-kinase 2 inhibitory potential of Indian medicinal plants used in management of erectile dysfunction . Journal of Ethnopharmacology. 144. (3). p. 483-489. Elsevier

Indian Journal of Experimental Biology Vol. 48, March 2010, pp. 269-274.