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Hire Dr. Sharon O.

Ireland

Profile Summary

I recently submitted my PhD thesis titled "Structure-based Drug Design for NADPH oxidases". This project involved mutational analysis to elucidate key similarities/differences between the various members of the NADPH oxidase family, with a view to providing more indepth information to those wishing to develop specific NADPH oxidase inhibitors (NADPH oxidases are an enzyme family that convert molecular oxygen into reactive oxygen species. They are found across the majority of cells and tissues in the body and have been implicated in a vast array of diseases such as CVD, diabetes, fibrosis and cancer). Prior to my PhD, I worked in Singapore as a research associate at Duke-NUS graduate medical school where I studied the role of tryptophan hydroxylase-2 (TPH2) in the development and progression of mood disorders. Following the completion of my Master's degree, studying the effect of Vitamin D on metastatic breast cancers (University of Notre Dame, USA), I spent 3 years working in the biotech industry, as both a research scientist and technical specialist in the IVD sector. My experience spans a number of different scientific disciplines, giving me a wide understanding of various pathophysiological processes, and allowing me to make associations (both scientific and professional) across disciplines.

Subject Matter Expertise

• ☆ Immunoassay
• ☆ Molecular Biology
• ☆ Mutagenesis
• ☆ Neuropsychology
• ☆ Biotechnology & Bioengineering
• ☆ Protein/Enzyme Engineering

Services

• Writing

Work Experience

Research Assistant - Research Associate

Duke-NUS Graduate Medical School, Singapore

October 2007 - October 2012

Technical Specialist

Abbott Ireland Diagnostics Division, Longford, Ireland

September 2005 - July 2007

R&D Scientist

Trinity Biotech Plc., Bray, Co. Wicklow, Ireland

May 2004 - September 2005

Education

PhD (pending)

University College Dublin

January 2013 - Present

MSc

University Of Notre Dame, IN, USA

August 2001 - August 2004

BSc (Hons)

University College Dublin, Ireland

September 1997 - May 2001

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

O'Neill, S., Brault, J., Stasia, M. J., Knaus, U. G.(2015). Genetic disorders coupled to ROS deficiency . Redox Biol. 6. p. 135-56.

Jacobsen, J. P., Plenge, P., Sachs, B. D., Pehrson, A. L., Cajina, M., Du, Y., Roberts, W., Rudder, M. L., Dalvi, P., Robinson, T. J., et al.(2014). The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse . Psychopharmacology (Berl). 231. (23). p. 4527-40.

Ng, C. H., Guan, M. S., Koh, C., Ouyang, X., Yu, F., Tan, E. K., O'Neill, S. P., Zhang, X., Chung, J., Lim, K. L.(2012). AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease . J Neurosci. 32. (41). p. 14311-7.

Flanagan, L., Packman, K., Juba, B., O'Neill, S., Tenniswood, M., Welsh, J.(2003). Efficacy of Vitamin D compounds to modulate estrogen receptor negative breast cancer growth and invasion. J Steroid Biochem Mol Biol. 84. (2-3). p. 181-92.