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Hire Dr. Sebastien B.

France

USD 300 /hr

Neurobiologist expert in obesity and metabolism

Profile Summary

I received a Ph.D. in neuroscience from the university of Lille (France) in 2001. I am currently a Research Director at the French National Institute of Health (Inserm) in Lille, France. I have a broad background in the field of metabolic programming and the neurobiology of obesity. I published more than 90 articles, reviews, and book chapters in the field of developmental programming. My research has directly led to several breakthroughs in the understanding of the complex hormonal signals and neurodevelopmental substrates responsible for appetite regulation. Is served on numerous journal editorial boards (including Journal of Neuroendocrinology, Endocrinology, Molecular Metabolism, Metabolism, JCI Insight), organizing committees and grant review panels (including the NIH) and have been invited to lecture internationally.

Subject Matter Expertise

• ★ Obesity
• ☆ Pediatric Endocrinology
• ☆ Metabolism & Metabolic Disease

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Copywriting, Newswriting

Research Market Research, Feasibility Study, Fact Checking, Gap Analysis, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis

Product Development Product Evaluation

Work Experience

Research Director

Inserm

- Present

Research Director

French National Institute of Health

January 2005 - Present

Education

Ph.D.

University of Lille Nord de France

September 1998 - March 2001

PhD

University of Lille

November 1996 - March 2001

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Bochukova EG, Lawler K, Croizier S, Keogh JM, Patel N, Strohbehn G, Lo KK, Humphrey J, Hokken-Koelega A, Damen L, et al.(2018). A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome . Cell reports.

Mendrick DL, Diehl AM, Topor LS, Dietert RR, Will Y, La Merrill MA, Bouret S, Varma V, Hastings KL, Schug TT, et al.(2018). Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic . Toxicological sciences : an official journal of the Society of Toxicology.

Lutz TA, Coester B, Whiting L, Dunn-Meynell AA, Boyle CN, Bouret SG, Levin BE, Le Foll C(2018). Amylin Selectively Signals onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus . Diabetes.

Abegg K, Hermann A, Boyle CN, Bouret SG, Lutz TA, Riediger T(2017). Involvement of Amylin and Leptin in the Development of Projections from the Area Postrema to the Nucleus of the Solitary Tract . Frontiers in endocrinology.

Johnson MD, Bouret SG, Dunn-Meynell AA, Boyle CN, Lutz TA, Levin BE(2016). Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat . American journal of physiology. Regulatory, integrative and comparative physiology.

Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, Bouret SG(2016). Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits . Human molecular genetics.

Zigman JM, Bouret SG, Andrews ZB(2016). Correction to 'Obesity Impairs the Action of the Neuroendocrine Ghrelin System': [Trends in Endocrinology and Metabolism, 27 (2016) 54-63] . Trends in endocrinology and metabolism: TEM.

Croizier S, Prevot V, Bouret SG(2016). Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life . Cell reports.

Zigman JM, Bouret SG, Andrews ZB(2016). Obesity Impairs the Action of the Neuroendocrine Ghrelin System . Trends in endocrinology and metabolism: TEM.

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al.(2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) . Autophagy.

Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, Bouret SG(2015). Neonatal ghrelin programs development of hypothalamic feeding circuits . The Journal of clinical investigation.

Bouret S, Levin BE, Ozanne SE(2015). Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity . Physiological reviews.

Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, Bouret SG(2015). Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin . Molecular metabolism.

Kayser BD, Goran MI, Bouret SG(2015). Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL/6J mice . PloS one.

Leptin-dependent neuronal NO signaling in the preoptic hypothalamusfacilitates reproduction. @article{PMCID:PMC4118081, title = {Leptin-dependent neuronal NO signaling in the preoptic hypothalamusfacilitates reproduction.}, author = {Bellefontaine N and Chachlaki K and Parkash J and Vanacker C and Colledge W and d’Anglemont de Tassigny X and Garthwaite J and Bouret SG and Prevot V}, journal = {The Journal of clinical investigation}, month = {08}, year = {2014} } . The Journal of clinical investigation.

Bellefontaine N, Chachlaki K, Parkash J, Vanacker C, Colledge W, d'Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V(2014). Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction . The Journal of clinical investigation.

Picard A, Rouch C, Kassis N, Moullé VS, Croizier S, Denis RG, Castel J, Coant N, Davis K, Clegg DJ, et al.(2014). Hippocampal lipoprotein lipase regulates energy balance in rodents . Molecular metabolism.

Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, et al.(2014). Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A . PLoS biology.

Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, et al.(2014). Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain . Cell metabolism.

Langlet F, Mullier A, Bouret SG, Prevot V, Dehouck B(2013). Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain . The Journal of comparative neurology.

Goran MI, Dumke K, Bouret SG, Kayser B, Walker RW, Blumberg B(2013). The obesogenic effect of high fructose exposure during early development . Nature reviews. Endocrinology.

Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, et al.(2013). Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting . Cell metabolism.

Bouret SG(2013). Organizational actions of metabolic hormones . Frontiers in neuroendocrinology.

Coupe B, Bouret SG(2013). Development of the hypothalamic melanocortin system . Frontiers in endocrinology.

Bouret SG(2012). Nutritional programming of hypothalamic development: critical periods and windows of opportunity . International journal of obesity supplements.

Bouret SG(2012). RIPping off GABA release in hypothalamic circuits causes obesity . Cell metabolism.

Laloux C, Mairesse J, Van Camp G, Giovine A, Branchi I, Bouret S, Morley-Fletcher S, Bergonzelli G, Malagodi M, Gradini R, et al.(2012). Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress . Psychoneuroendocrinology.

Caron E, Ciofi P, Prevot V, Bouret SG(2012). Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Ishii Y, Bouret SG(2012). Embryonic birthdate of hypothalamic leptin-activated neurons in mice . Endocrinology.

Coupé B, Bouret SG(2012). Weighing on autophagy: a novel mechanism for the CNS regulation of energy balance . Cell cycle (Georgetown, Tex.).

Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG(2012). Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation . Cell metabolism.

Bouret SG, Bates SH, Chen S, Myers MG, Simerly RB(2012). Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Steculorum SM, Bouret SG(2011). Developmental effects of ghrelin . Peptides.

Steculorum SM, Bouret SG(2011). Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring . Endocrinology.

Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ(2011). Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice . Journal of molecular neuroscience : MN.

Patterson CM, Bouret SG, Park S, Irani BG, Dunn-Meynell AA, Levin BE(2010). Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese . Endocrinology.

Bouret SG(2010). Neurodevelopmental actions of leptin . Brain research.

Mullier A, Bouret SG, Prevot V, Dehouck B(2010). Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain . The Journal of comparative neurology.

Bouret SG(2010). Role of early hormonal and nutritional experiences in shaping feeding behavior and hypothalamic development . The Journal of nutrition.

Caron E, Sachot C, Prevot V, Bouret SG(2010). Distribution of leptin-sensitive cells in the postnatal and adult mouse brain . The Journal of comparative neurology.

Bouret SG(2010). Development of hypothalamic neural networks controlling appetite . Forum of nutrition.

Bouret SG(2010). Leptin, nutrition, and the programming of hypothalamic feeding circuits . Nestle Nutrition workshop series. Paediatric programme.

Bouret SG(2009). Early life origins of obesity: role of hypothalamic programming . Journal of pediatric gastroenterology and nutrition.

Patterson CM, Bouret SG, Dunn-Meynell AA, Levin BE(2009). Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling . American journal of physiology. Regulatory, integrative and comparative physiology.

Bouret SG(2008). Crossing the border: developmental regulation of leptin transport to the brain . Endocrinology.

Bouret SG, Gorski JN, Patterson CM, Chen S, Levin BE, Simerly RB(2008). Hypothalamic neural projections are permanently disrupted in diet-induced obese rats . Cell metabolism.

Bouret SG, Simerly RB(2007). Development of leptin-sensitive circuits . Journal of neuroendocrinology.

Prevot V, Dehouck B, Poulain P, Beauvillain JC, Buée-Scherrer V, Bouret S(2007). Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction . Psychoneuroendocrinology.

Bouret SG, Simerly RB(2006). Developmental programming of hypothalamic feeding circuits . Clinical genetics.

Gohlke BC, Huber A, Bartmann P, Fimmers R, Hecher K, Bouret SG, Roth CL(2006). Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins . Journal of pediatric endocrinology & metabolism : JPEM.

Bouret SG, Simerly RB(2004). Minireview: Leptin and development of hypothalamic feeding circuits . Endocrinology.

Bouret S, De Seranno S, Beauvillain JC, Prevot V(2004). Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus . Endocrinology.

Bouret SG, Draper SJ, Simerly RB(2004). Trophic action of leptin on hypothalamic neurons that regulate feeding . Science (New York, N.Y.).

Bouret SG, Draper SJ, Simerly RB(2004). Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice . The Journal of neuroscience : the official journal of the Society for Neuroscience.

Bouret S, Prevot V, Takumi T, Beauvillain JC, Mitchell V(2002). Regulation by gonadal steroids of the mRNA encoding for a type I receptor for TGF-beta in the female rat hypothalamus . Neuroendocrinology.

Bouret S, Croix D, Mariot M, Loyens A, Prevot V, Jegou S, Vaudry H, Beauvillain JC, Mitchell V(2002). Galanin modulates the activity of proopiomelanocortin neurons in the isolated mediobasal hypothalamus of the male rat . Neuroscience.

Bouret S, Chuoi-Mariot MT, Prevot V, Croix D, Takumi T, Jegou S, Vaudry H, Beauvillain JC, Mitchell V(2001). Evidence that TGF beta may directly modulate POMC mRNA expression in the female rat arcuate nucleus . Endocrinology.

Mitchell V, Feyereisen K, Bouret S, Leroy D, Beauvillain JC(2001). Microwave strategy for improving the simultaneous detection of estrogen receptor and galanin receptor mRNA in the rat hypothalamus . The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Mitchell V, Bouret S, Beauvillain JC, Schilling A, Perret M, Kordon C, Epelbaum J(2001). Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary . The Journal of comparative neurology.

Prevot V, Bouret S, Stefano GB, Beauvillain J(2000). Median eminence nitric oxide signaling . Brain research. Brain research reviews.

Goumon Y, Bouret S, Casares F, Zhu W, Beauvillain JC, Stefano GB(2000). Lipopolysaccharide increases endogenous morphine levels in rat brain . Neuroscience letters.

Bouret S, Prevot V, Croix D, Viltart O, Stefano GB, Mitchell V, Beauvillain JC(2000). Mu opioid receptor mRNA expression in neuronal nitric oxide synthase-immunopositive preoptic area neurons . Brain research. Molecular brain research.

Prevot V, Bouret S, Croix D, Takumi T, Jennes L, Mitchell V, Beauvillain JC(2000). Evidence that members of the TGFbeta superfamily play a role in regulation of the GnRH neuroendocrine axis: expression of a type I serine-threonine kinase receptor for TGRbeta and activin in GnRH neurones and hypothalamic areas of the female rat . Journal of neuroendocrinology.

Bouret S, Prevot V, Croix D, Howard A, Habert-Ortoli E, Jegou S, Vaudry H, Beauvillain JC, Mitchell V(2000). Expression of GalR1 and GalR2 galanin receptor messenger ribonucleic acid in proopiomelanocortin neurons of the rat arcuate nucleus: effect of testosterone . Endocrinology.

Prevot V, Bouret S, Croix D, Alonso G, Jennes L, Mitchell V, Routtenberg A, Beauvillain JC(2000). Growth-associated protein-43 messenger ribonucleic acid expression in gonadotropin-releasing hormone neurons during the rat estrous cycle . Endocrinology.

Mitchell V, Bouret S, Prévot V, Jennes L, Beauvillain JC(1999). Evidence for expression of galanin receptor Gal-R1 mRNA in certain gonadotropin releasing hormone neurones of the rostral preoptic area . Journal of neuroendocrinology.

Mitchell V, Bouret S, Howard AD, Beauvillain JC(1999). Expression of the galanin receptor subtype Gal-R2 mRNA in the rat hypothalamus . Journal of chemical neuroanatomy.

Bouret S, Prevot V, Croix D, Jégou S, Vaudry H, Stefano GB, Beauvillain JC, Mitchell V(1999). Mu-opioid receptor mRNA expression in proopiomelanocortin neurons of the rat arcuate nucleus . Brain research. Molecular brain research.

Prevot V, Croix D, Bouret S, Dutoit S, Tramu G, Stefano GB, Beauvillain JC(1999). Definitive evidence for the existence of morphological plasticity in the external zone of the median eminence during the rat estrous cycle: implication of neuro-glio-endothelial interactions in gonadotropin-releasing hormone release . Neuroscience.

Faure-Virelizier C, Croix D, Bouret S, Prévot V, Reig S, Beauvillain JC, Mitchell V(1998). Effects of estrous cyclicity on the expression of the galanin receptor Gal-R1 in the rat preoptic area: a comparison with the male . Endocrinology.