Profile Details

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Hire Dr. Sebastian Z.

United States

USD 55 /hr

Molecular biologist, virologist, and grant writer with over a decade of experience.

Profile Summary

Experienced PhD-level scientist with over 10 years in regulated lab environments, including GMP-aligned operations, SOP development, and analytical chemistry. Proven ability to lead cross-functional teams, maintain audit-ready records, and consistently deliver results in compliance-driven settings. Adept in microbiology, wet chemistry, method validation, and preclinical drug development. ___________________________________________________________________________________________ PROFESSIONAL EXPERIENCE Senior Research Scientist III — University of Arizona, Tucson, AZ 2020–2023 • Oversaw multiple research projects with cumulative annual budgets exceeding $xxxxxxxxx. • Reviewed and updated SOPs and lab protocols in alignment with GMP and QA standards. • Directed cross-functional teams to meet technical and regulatory milestones. • Maintained detailed electronic and paper-based records in accordance with documentation best practices. • Conducted routine and specialized wet chemistry assays and supported method development. Senior Research Scientist I — University of Arizona, Tucson, AZ 2018–2020 • Ensured daily data collection and documentation met industry-standard compliance expectations. • Collaborated with internal stakeholders to achieve project deliverables on schedule. • Analyzed assay results and compiled technical summaries for internal reporting and publication. • Conducted bench-level wet chemistry and supported scale-up decisions. Graduate Researcher — University of Arizona, Tucson, AZ 2013–2018 • Led independent research contributing to preclinical drug development and pharmacodynamic studies. • Applied molecular biology and cell-based assay techniques to screen and characterize novel compounds. • Developed SOPs and maintained detailed lab documentation supporting grant compliance. • Performed chromatography, titration, and other wet chemistry techniques. ___________________________________________________________________________________________ EDUCATION Ph.D. in Cellular and Molecular Medicine University of Arizona — May 2016 B.S. in Ecology and Evolutionary Biology University of Arizona — May 2008 ___________________________________________________________________________________________ SKILLS & COMPETENCIES • GMP & GLP Compliance | SOP Development | Wet Chemistry | Microbiology • Electronic Lab Notebook (ELN) Systems | Method Validation | Data Integrity • Project Management | Team Leadership | Quality Documentation | Root Cause Analysis Wet Lab Skills • PCR, qPCR, rtPCR, and molecular cloning • CRISPR/Cas9 and traditional gene editing • Tissue culture (primary and immortal cell lines) • Lentiviral and adenovirus engineering and propagation • RNA interference design and application • Protein extraction and purification (ELISA, Western blot, immunoprecipitation, HPLC) • Flow cytometry and confocal microscopy

Subject Matter Expertise

• ★ Recombinant DNA
• ★ DNA Damage & Repair
• ★ Cell Culture
• ☆ Evolutionary Biology
• ☆ Microbiology
• ☆ Industrial Microbiology
• ☆ Microbiological Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Gene Expression Analysis
• ☆ Mutagenesis
• ☆ DNA/Gene Synthesis
• ☆ Plasmid DNA
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Biomedical Engineering
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ Scanning Probe Microscopy
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Large Scale Cell Culture
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Cytometry
• ☆ Cell Aging

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Creative Writing

Research Market Research, User Research

Consulting Business Strategy Consulting, Operations Consulting

Data & AI Image Processing, Image Analysis, Data Visualization

Work Experience

Senior Research Scientist III

University of Arizona

January 2020 - June 2023

Education

Cellular and Molecular Medicine

University of Arizona

August 2011 - June 2016

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity. Longmire P, Zeltzer S, Zarrella K, Daigle O, Svoboda M, Reitsma JM, Terhune SS, Bobak C, Bosco G, Goodrum F. Nucleic Acids Res. 2026 Jan 14;54(2):gkaf1445. doi: 10.1093/nar/gkaf1445. PMID: 41533576 .

Complex roles for proliferating cell nuclear antigen in restricting human cytomegalovirus replication. Longmire P, Daigle O, Zeltzer S, Lee M, Svoboda M, Padilla-Rodriguez M, Bobak C, Bosco G, Goodrum F. mBio. 2025 May 14;16(5):e0045025. doi: 10.1128/mbio.00450-25. Epub 2025 Mar 25. PMID: 40130902 .

5 Cite Liver X Receptor-Inducible Host E3 Ligase IDOL Targets a Human Cytomegalovirus Reactivation Determinant. Mlera L, Collins-McMillen D, Zeltzer S, Buehler JC, Moy M, Zarrella K, Caviness K, Cicchini L, Tafoya DJ, Goodrum F. J Virol. 2023 Jul 27;97(7):e0075823. doi: 10.1128/jvi.00758-23. Epub 2023 Jun 20. PMID: 37338407 .

Cite Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection. Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F. PLoS Pathog. 2023 Jun 8;19(6):e1011185. doi: 10.1371/journal.ppat.1011185. eCollection 2023 Jun. PMID: 37289831 .

Cite Host translesion polymerases are required for viral genome integrity. Zeltzer S, Longmire P, Svoboda M, Bosco G, Goodrum F. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203203119. doi: 10.1073/pnas.2203203119. Epub 2022 Aug 10. PMID: 35947614 .

Virus Control of Trafficking from Sorting Endosomes. Zeltzer S, Zeltzer CA, Igarashi S, Wilson J, Donaldson JG, Goodrum F. mBio. 2018 Jul 24;9(4):e00683-18. doi: 10.1128/mBio.00683-18. PMID: 30042195 .