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Hire Dr. Saurabh S.

India

USD 8 /hr

Network Biology | Data Science | Machine Learning | MD Simulations | PLINK | Virtual Screening | Stats | Meta-analysis

Profile Summary

I have worked with a diverse set of teams over the years, with the most recent being involved in developing lessons for PhD scholars and post-docs. I have experience with systematic review and meta-analysis and computer-aided drug design protocols.

Subject Matter Expertise

• ☆ Computational Biology
• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ PCR
• ☆ Next Generation Sequencing (NGS)
• ☆ Gene Expression Analysis
• ☆ Data Analysis
• ☆ Computer Simulation/Computational Modeling
• ☆ Data Processing
• ☆ Data Exploration
• ☆ Cluster Analysis
• ☆ Data Visualization
• ☆ Big Data Analytics
• ☆ Data Management
• ☆ Data Manipulation
• ☆ Machine Learning
• ☆ Artificial Intelligence
• ☆ Deep Learning
• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Systems Biology
• ☆ Population Genetics
• ☆ Forensic Genetics
• ☆ Exercise & Fitness
• ☆ Physical Fitness
• ☆ Athletic Training & Coaching
• ☆ Personal Training
• ☆ R
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Drug Design
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Pharmacogenomics
• ☆ Pharmacovigilance/Drug Safety Monitoring
• ☆ Neurology
• ☆ Epilepsy & Seizures
• ☆ Alzheimer's Disease
• ☆ Autism Spectrum Disorders

Services

• Writing
• Research
• Data & AI

Writing Medical Writing

Research Meta-Research, Technology Scouting, Scientific and Technical Research

Data & AI Predictive Modeling

Work Experience

Research Associate

Post Graduate Institute of Medical Education and Research

October 2019 - Present

Medical / Science writer

JoVE

July 2022 - January 2023

Data Analyst and Research Associate

PGIMER

October 2019 - April 2022

Education

PhD

PGIMER

January 2013 - May 2019

Masters in Microbiology

Panjab University

July 2007 - May 2009

Certifications

• Introduction to Genomic Technologies

  John Hopkins University

  https://coursera.org/share/c6e664626c0761cbd7a9a7c70e2929b5

  June 2022 - Present

• Work Smarter with Microsoft Excel

  coursera

  https://coursera.org/share/f9615b3b1a6832053fe1dc0de16b5d21

  June 2022 - Present

• MTA: Introduction to Programming Using Python

  Microsoft Corporation

  December 2018 - Present

• Cycling coach

  International Cycling Union

  June 2016 - Present

• CoachTrue anti-doping program

  World anti-doping Agency

  June 2016 - Present

• Introduction to R

  DataCamp

  October 2015 - Present

• The Data Scientist's Toolbox

  John Hopkins University

  June 2014 - Present

• Research Methodology and Biostatistics

  Postgraduate Institute of Medical Education and Research

  April 2013 - Present

Publications

BOOK CHAPTER

Saurabh Sharma (2023). Target identification and validation . Computational Approaches in Drug Discovery, Development and Systems Pharmacology.

Saurabh Sharma, Ajay Prakash, Phulen Sarma, Bikash Medhi(2021). Machine Learning Techniques for Development of Drugs Against Coronavirus Disease 2019 (COVID-19): A Case Study Protocol . Methods in Pharmacology and Toxicology. p. 307--325. Springer {US}

Madhu Khullar, Saurabh Sharm(2012). Pharmacogenetics of Essential Hypertension . Genetics and Pathophysiology of Essential Hypertension. {InTech}

JOURNAL ARTICLE

Saurabh Sharma, ARUSHI CHAUHAN, Pramod Avti, Nishant Shekhar, manisha prajapat, PHULEN SARMA, NAMRATA SANGWAN, Jitender Singh, Anusuya Bhattacharyya, Dr Subodh Kumar, et al.(2022). An insight into the simulation directed understanding of the mechanism in SARS CoV-2 N-CTD, dimer integrity, and RNA-binding: Identifying potential antiviral inhibitors . Journal of Biomolecular Structure and Dynamics. 40. (24). p. 13912--13924. Informa {UK} Limited

Saurabh Sharma, Pramod Avti, Arushi Chauhan, Nishant Shekhar, Manisha Prajapat, Phulen Sarma, Hardeep Kaur, Anusuya Bhattacharyya, Subodh Kumar, Ajay Prakash, et al. (2022). Computational basis of SARS-CoV 2 main protease inhibition: an insight from molecular dynamics simulation based findings . Journal of Biomolecular Structure and Dynamics.

Saurabh Sharma, Pramod Avti, Arushi Chauhan, Nishant Shekhar, manisha prajapat, PHULEN SARMA, HARDEEP KAUR, Anusuya Bhattacharyya, Dr Subodh Kumar, Ajay Prakash, et al.(2022). Computational basis of SARS-CoV 2 main protease inhibition: an insight from molecular dynamics simulation based findings . Journal of Biomolecular Structure and Dynamics. 40. (19). p. 8894--8904. Informa {UK} Limited

Saurabh Sharma, Phulen Sarma, Anusuya Bhattacharyya, Ajay Prakash, Hardeep Kaur, Manisha Prajapat, Mukundam Borah, Subodh Kumar, Seema Bansal, Gurjeet Kaur, et al.(2022). Yogic Neti-Kriya Using Povidone Iodine: Can it have a Preventive Role Against SARS-CoV-2 Infection Gateway? . Indian Journal of Otolaryngology and Head & Neck Surgery. 74. (S2). p. 3186--3192. Springer Science and Business Media {LLC}

Saurabh Sharma, Amit Raj Sharma, Gitika Batra, Lokesh Saini, Abhishek Mishra, Rubal Singla, Ashutosh Singh, Rahul Soloman Singh, Ashish Jain, Seema Bansal, et al.(2022). Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure . CNS & Neurological Disorders - Drug Targets. 21. (5). p. 399--408. Bentham Science Publishers Ltd.

Saurabh Sharma, Prasanna K.R. Allu, Malapaka Kiranmayi, Sromona D. Mukherjee, Venkat R. Chirasani, Richa Garg, Durairajpandian Vishnuprabu, Sudesh Ravi, Lakshmi Subramanian, Bhavani S. Sahu, et al.(2022). Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders . Diabetes. 71. (3). p. 538--553. American Diabetes Association

Saurabh Sharma, Hardeep Kaur, Phulen Sarma, Anusuya Bhattacharyya, Neeraj Chhimpa, Manisha Prajapat, Ajay Prakash, Subodh Kumar, Ashutosh Singh, Rahul Singh, et al.(2021). Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review . European Journal of Pharmacology. 906. p. 174233. Elsevier {BV}

Prajapat M, Handa V, Sarma P, Prakash A, Kaur H, Sharma S, Bhattacharyya A, Dr Subodh Kumar, Sharma AR, Avti P, et al. (2021). Update on geographical variation and distribution of SARS-nCoV-2: A systematic review . Indian journal of pharmacology.

Saurabh Sharma, Harpinder Kaur, Nishant Shekhar, Phulen Sarma, Ajay Prakash, Bikash Medhi(2021). Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes . Pharmacological Reports. 73. (3). p. 736--749. Springer Science and Business Media {LLC}

Saurabh Sharma, Bikash Medhi, Hardeep Kaur, Manpreet Kaur, Anusuya Bhattacharyya, Manisha Prajapat, Prasad Thota, Phulen Sarma, Subodh Kumar, Gurjeet Kaur, et al.(2021). Indian contribution toward biomedical research and development in COVID-19: A systematic review . Indian Journal of Pharmacology. 53. (1). p. 63. Medknow

Saurabh Sharma, Manisha Prajapat, Nishant Shekhar, Phulen Sarma, Pramod Avti, Sanjay Singh, Hardeep Kaur, Anusuya Bhattacharyya, Subodh Kumar, Ajay Prakash, et al.(2020). Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2 . Journal of Molecular Graphics and Modelling. 101. p. 107716. Elsevier {BV}

Saurabh Sharma, Nishant Shekhar, Phulen Sarma, Manisha Prajapat, Pramod Avti, Hardeep Kaur, Anupam Raja, Harvinder Singh, Anusuya Bhattacharya, Subodh Kumar, et al.(2020). <i>In Silico</i> Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations . mSystems. 5. (5). American Society for Microbiology

Bhattacharyya A, Dr Subodh Kumar, Sarma P, Kaur H, Prajapat M, Shekhar N, Bansal S, Pramod Avti, Hazarika M, Sharma S, et al. (2020). Safety and efficacy of lopinavir/ritonavir combination in COVID-19: A systematic review, meta-analysis, and meta-regression analysis . Indian journal of pharmacology.

Saurabh Sharma, Bikash Medhi, Phulen Sarma, Anusuya Bhattacharyya, Hardeep Kaur, Manisha Prajapat, Ajay Prakash, Subodh Kumar, Seema Bansal, Richard Kirubakaran, et al.(2020). Efficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis . Indian Journal of Pharmacology. 52. (6). p. 535. Medknow

Saurabh Sharma, Lakshmi Subramanian, Sakthisree Maghajothi, Mrityunjay Singh, Kousik Kesh, Ananthamohan Kalyani, Madhu Khullar, Suma M. Victor, Snehasikta Swarnakar, Shailendra Asthana, et al.(2019). A Common Tag Nucleotide Variant in <i>MMP7</i> Promoter Increases Risk for Hypertension via Enhanced Interactions With CREB (Cyclic AMP Response Element-Binding Protein) Transcription Factor . Hypertension. 74. (6). p. 1448--1459. Ovid Technologies (Wolters Kluwer Health)

Saurabh Sharma, Lakshmi Subramanian, Abrar A. Khan, Prasanna K.R. Allu, Malapaka Kiranmayi, Bhavani S. Sahu, Madhu Khullar, Ajit S. Mullasari, Nitish R. Mahapatra(2017). A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders . Journal of Biological Chemistry. 292. (34). p. 13970--13985. Elsevier {BV}

Saurabh Sharma, Gurinder Bir Singh, Sanskriti Khanna, Satish K. Raut, Rajni Sharma, Madhu Khullar(2017). <i>DUSP-1</i> gene expression is not regulated by promoter methylation in diabetes-associated cardiac hypertrophy . Therapeutic Advances in Cardiovascular Disease. 11. (5-6). p. 147--154. {SAGE} Publications

Saurabh Sharma, Gurinder Bir Singh, Satish K. Raut, Sanskriti Khanna, Akhilesh Kumar, Rishikesh Prasad, Madhu Khullar(2017). MicroRNA-200c modulates DUSP-1 expression in diabetes-induced cardiac hypertrophy . Molecular and Cellular Biochemistry. 424. (1-2). p. 1--11. Springer Science and Business Media {LLC}

Saurabh Sharma, Malapaka Kiranmayi, Venkat R. Chirasani, Prasanna K.R. Allu, Lakshmi Subramanian, Elizabeth E. Martelli, Bhavani S. Sahu, Durairajpandian Vishnuprabu, Rathnakumar Kumaragurubaran, Dhanasekaran Bodhini, et al.(2016). Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway . Hypertension. 68. (2). p. 334--347. Ovid Technologies (Wolters Kluwer Health)