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Hire Dr. Sangita C.

Profile Summary

A scientist with exceptional track record of research program development and management, strong scientific problem solving skills, result oriented collaborative people skills and mentoring experience. I have extensive experience to leverage in the combined areas of cell biology, single cell molecular biology, molecular biology, biochemistry and bioinformatics. Currently focusing on cardiac regeneration to develop future heart failure treatment options, which is supported by a competitive research grant in the Harvard Medical School System. A regular contributor to success of others through scientific review of research in high impact journals. At present my research focused on identification of novel regulators of cardiomyocyte proliferation as regenerative therapies for heart failure. I have worked on Understanding molecular mechanisms of cardiomyocytes proliferation and differentiation. As a Postdoctoral research fellow at Oak Ridge National Lab and University of Tennessee I had studied the involves delineating the role of serine/threonine kinase in signal transduction using bioinformatics.As a postdoctoral research at cardiovascular division, Harvard Medical School, BIDMC, Boston, MA, Feb 2007- Jan 2011 I worked on understanding the mechanisms of caspase independent apoptosis in heart failure. During my PhD research project at department of Pharmacology, EMAU Greifswald, Germany): Feb 2003 – Jan2007 I Identification of cardiac autoantigen in dilated cardiomyopathy (DCM). To find biomarkers in DCM patients, I had established a detail method to study antigen antibody interaction by Biacore.

Subject Matter Expertise

• ☆ Biology/Life Sciences
• ☆ Microbiology
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Apoptosis
• ☆ Biomarkers
• ☆ Genetics
• ☆ Proteomics
• ☆ Kinases
• ☆ Cell Signaling Pathways
• ☆ Basic Immunology
• ☆ Signal Processing
• ☆ Data Analysis
• ☆ Protein/Enzyme Engineering
• ☆ Antibody Engineering
• ☆ Cell Aging
• ☆ Cardiovascular Disease
• ☆ Vascular Medicine

Services

• Writing
• Consulting
• Product Development

Work Experience

Staff Scientist

Children's Hospital Boston

July 2016 - Present

Instructor of Pediatrics

Children's Hospital Boston

September 2012 - June 2016

Postdoctoral research assistant

Boston children's Hospital

October 2012 - December 2013

Postdoctoral research assistant

Oakridge National Lab and university of Tenessee

February 2011 - September 2012

Postdoctoral Research Scientist

Oak Ridge National Laboratory

February 2011 - August 2012

Post Doctoral Research Fellow

Beth Israel Deaconess Medical Center

February 2007 - January 2011

Post Doctoral Research Fellow

Beth Israel Deaconess Medical Center

January 2007 - January 2011

Education

PhD (Pharmacology)

EMAU

January 2003 - June 2007

Doctor of Philosophy (Ph.D.) - Cell/Cellular and Molecular Biology Grade Magna cum laude

Ernst-Moritz-Arndt-Universität Greifswald, Germany

January 2003 - January 2007

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2018). Thoracic aortic aneurysm in patients with loss of function Filamin A mutations: Clinical characterization, genetics, and recommendations . American journal of medical genetics. Part A.

(2017). Identification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and devoid of Hypercalcemia. Scientific Reports.

Brian D. Polizzotti1,2,*, Balakrishnan Ganapathy1,3,*, Stuart Walsh1,2,*,†, Sangita Choudhury1,2,*, Niyatie Ammanamanchi1,3, David G. Bennett4,‡, Cristobal G. dos Remedios5, Bernhard J. Haubner6, Josef M. Penninger6 and Bernhard K\"uhn1,2,3,7,8,9, \\S(2015). Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. science and translational medicine.

Choudhury S, Schnell M, B\"uhler T, Reinke Y, Landsberger M(2014). Antibodies against potassium channel interacting protein 2 induce necrosis in isolated rat cardiomyocytes. J Cell Biochem. 115. (4). p. 678--89.

Sangita Choudhury, Soochan Bae, Qingen Ke, Ji Yoo Lee, Sylvia S. Singh, Ren\'e St-Arnaud, Federica del Monte, Peter M. Kang(2014). Abnormal Calcium Handling and Exaggerated Cardiac Dysfunction in Mice with Defective Vitamin D Signaling. Plos one.

Bersell K, Choudhury S, Mollova M, Polizzotti BD, K\"uhn B.(2013). Moderate and high amounts of tamoxifen in $α$MHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Dis Model Mech. 6. (6). p. 1459--69.

Choudhury, Sangita and Bae, Soochan and Ke, Qingen and Lee, Ji Yoo and Kim, Jacob and Kang, Peter M(2011). Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion. Basic research in cardiology. 106. (3). p. 397--407. Springer-Verlag

Bae, Soochan and Yalamarti, Bhargavi and Ke, Qingen and Choudhury, Sangita and Yu, Hyeon and Karumanchi, S Ananth and Kroeger, Paul and Thadhani, Ravi and Kang, Peter M(2011). Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats. Cardiovascular research. 91. (4). p. 632--639. Oxford University Press

Bae, Soochan and Siu, Parco M and Choudhury, Sangita and Ke, Qingen and Choi, Jun H and Koh, Young Y and Kang, Peter M(2010). Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA. American Journal of Physiology-Heart and Circulatory Physiology. 299. (5). p. H1374--H1381. Am Physiological Soc

Choudhury, Sangita and Bae, Soochan and Kumar, Sheetal R and Ke, Qingen and Yalamarti, Bhargavi and Choi, Jun H and Kirshenbaum, Lorrie A and Kang, Peter M(2010). Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats. Cardiovascular research. 85. (1). p. 28--37. Oxford University Press

Landsberger, Martin and Staudt, Alexander and Choudhury, Sangita and Trimpert, Christiane and Herda, Lars R and Klingel, Karin and Kandolf, Reinhard and Schultheiss, Heinz-Peter and Kroemer, Heyo K and V\"olker, Uwe and others(2008). Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. American heart journal. 156. (1). p. 92--99. Elsevier