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Profile Details
Subject Matter Expertise
Services
Writing
Clinical Trial Documentation,
Technical Writing,
Copywriting,
Newswriting
Research
Market Research,
User Research,
Meta-Research,
Feasibility Study,
Gap Analysis,
Gray Literature Search,
Systematic Literature Review
Consulting
Scientific and Technical Consulting
Data & AI
Statistical Analysis,
Data Visualization
Product Development
Formulation,
Product Evaluation,
Concept Development,
Prototyping
Work Experience
Contract researcher
Universidade de Lisboa Faculdade de Medicina Veterinária
February 2019 - Present 
Postdoctoral Researcher
Faculdade de Medicina Veterinária
January 2015 - January 2019
Postdoctoral Researcher
Instituto de Medicina Molecular
July 2011 - December 2014
Researcher
Instituto de Medicina Molecular
June 2004 - June 2011
Education
General Management Program
Universidade Católica Portuguesa Católica-Lisbon
January 2015 - December 2015
PhD (MRamirez Lab - Microbiology and Infection Unit)
Universidade de Lisboa Faculdade de Medicina
October 2006 - July 2011
Master (MRamirez Lab- Microbiology and Infection Unit)
Universidade de Lisboa Faculdade de Medicina
January 2004 - June 2006
B.Sc (Chemistry - Biotechnology)
Faculdade de Ciencias e Tecnologia Universidade Nova de Lisboa
September 1998 - December 2003
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Highly specific BBB transmigrating single domain antibodies selected by an in vivo phage display screening @article {
author = {Aguiar, Sandra I and André, A.S. and Martins, D and Dias, J.N.R. and Gano, L. and Galamba, J. and Tavares, L. and et al.},
title = {Highly specific BBB transmigrating single domain antibodies selected by an in vivo phage display screening},
year = {2021},
month = {mar},
keywords = {Blood-brain barrier; single domain antibodies; Brain-targeting; Drug-delivery}
}.
Sandra Aguiar, Magda Ferreira, Ana Bettencourt, Maria Manuela Gaspar(2021). Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors . Drug Delivery and Translational Research. 11. (1). p. 72--85. Springer Science and Business Media {LLC}
Catarina Silva-Costa, Maria J. Brito, Sandra I. Aguiar, Joana P. Lopes, Mário Ramirez, José Melo-Cristino(2019). Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012–2015) . Scientific Reports. 9. (1). Springer Science and Business Media {LLC}
(2019). Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012-2015) . Scientific Reports.
Dias JNR, André AS, Aguiar SI, Ministro J, Oliveira J, Peleteiro MC, Rütgen B, Gano L, Correia JDG, Oliveira SS, et al.(2018). Establishment of a bioluminescent canine B-cell lymphoma xenograft model for monitoring tumor progression and treatment response in preclinical studies . PloS one.
Aguiar, Sandra, Neves, Vera, Aires-da-Silva, Frederico, Morais, Mauricio, Gano, Lurdes, Ribeiro, Elisabete, Pinto, Antonia, Gaspar, Diana, Fernandes, Celia, Correia, Joao D G, et al.(2017). Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood-Brain Barrier through a Receptor-Free Mechanism . ACS chemical biology.
Diamantino-Miranda, Jorge, Aguiar, Sandra Isabel, Carrico, Joao Andre, Melo-Cristino, Jose, Ramirez, Mario(2017). Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012 . Plos One. 12. (2).
Costa, A., Afonso, J., Osório, C., Gomes, A.L., Caiado, F., Valente, J., Aguiar, S.I., Pinto, F., Ramirez, M., Dias, S.(2013). MiR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells . Journal of Hematology and Oncology. 6. (1).
Horácio, A.N., Diamantino-Miranda, J., Aguiar, S.I., Ramirez, M., Melo-Cristino, J.(2013). The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5 . PLoS ONE. 8. (9).
Horacio, Andreia N., Diamantino-Miranda, Jorge, Aguiar, Sandra I., Ramirez, Mario, Melo-Cristino, Jose, Portuguese Grp Study Streptococcal(2013). The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5 . Plos One. 8. (9).
Costa, Ana, Afonso, Joana, Osorio, Catarina, Gomes, Ana L., Caiado, Francisco, Valente, Joana, Aguiar, Sandra I., Pinto, Francisco, Ramirez, Mario, Dias, Sergio(2013). miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells . Journal of Hematology & Oncology. 6.
Horácio, A.N., Diamantino-Miranda, J., Aguiar, S.I., Ramirez, M., Melo-Cristino, J.(2012). Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections . Vaccine. 30. (2). p. 218-224.
Aguiar, S.I., Melo-Cristino, J., Ramirez, M.(2012). Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease . Vaccine. 30. (37). p. 5487-5490.
Horacio, Andreia N., Diamantino-Miranda, Jorge, Aguiar, Sandra I., Ramirez, Mario, Melo-Cristino, Jose, Portuguese Grp Study Streptococcal(2012). Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections . Vaccine. 30. (2). p. 218-224.
Aguiar, Sandra I., Melo-Cristino, Jose, Ramirez, Mario(2012). Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease . Vaccine. 30. (37). p. 5487-5490.
Aguiar, Sandra, Sa-Leao, Raquel, Pinto, Francisco, Nunes, Sonia, Carrico, Joao A., Frazao, Nelson, Goncalves-Sousa, Natacha, Melo-Cristino, Jose, de Lencastre, Herminia, Ramirez, Mario(2011). Analysis of Invasiveness of Pneumococcal Serotypes and Clones Circulating in Portugal before Widespread Use of Conjugate Vaccines Reveals Heterogeneous Behavior of Clones Expressing the Same Serotype . Journal of Clinical Microbiology. 49. (4). p. 1369-1375.
Sá-Leao, R., Pinto, F., Aguiar, S., Nunes, S., Carriço, J.A., Frazao, N., Gonçalves-Sousa, N., Melo-Cristino, J., De Lencastre, H., Ramirez, M.(2011). Analysis of invasiveness of pneumococcal serotypes and clones circulating in portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotype . Journal of Clinical Microbiology. 49. (4). p. 1369-1375.
Aguiar, Sandra I., Pinto, Francisco R., Nunes, Sonia, Serrano, Isa, Melo-Cristino, Jose, Sa-Leao, Raquel, Ramirez, Mario, de Lencastre, Herminia(2010). Denmark(14)-230 Clone as an Increasing Cause of Pneumococcal Infection in Portugal within a Background of Diverse Serotype 19A Lineages . Journal of Clinical Microbiology. 48. (1). p. 101-108.
Aguiar, S.I., Brito, M.J., Gonçalo-Marques, J., Melo-Cristino, J., Ramirez, M.(2010). Serotypes 1, 7F and 19A became the leading causes of pediatric invasive pneumococcal infections in Portugal after 7 years of heptavalent conjugate vaccine use . Vaccine. 28. (32). p. 5167-5173.
Aguiar, S.I., Pinto, F.R., Nunes, S., Serrano, I., Melo-Cristino, J., Sá-Leão, R., Ramirez, M., De Lencastre, H.(2010). Denmark14-230 clone as an increasing cause of pneumococcal infection in Portugal within a background of diverse serotype 19A lineages . Journal of Clinical Microbiology. 48. (1). p. 101-108.
Aguiar, Sandra I., Brito, Maria J., Goncalo-Marques, Jose, Melo-Cristino, Jose, Ramirez, Mario(2010). Serotypes 1, 7F and 19A became the leading causes of pediatric invasive pneumococcal infections in Portugal after 7 years of heptavalent conjugate vaccine use . Vaccine. 28. (32). p. 5167-5173.
Pinto, F.R., Aguiar, S.I., Melo-Cristino, J., Ramirez, M.(2008). Optimal control and analysis of two-color genomotyping experiments using bacterial multistrain arrays . BMC Genomics. 9.
PINTO, FR, AGUIAR, SI, MELO-CRISTINO, J, et al.(2008). Optimal control and analysis of two-color genomotyping experiments using bacterial multistrain arrays . BMC GENOMICS. 9.
Aguiar, S.I., Serrano, I., Pinto, F.R., Melo-Cristino, J., Ramirez, M.(2008). The presence of the pilus locus is a clonal property among pneumococcal invasive isolates . BMC Microbiology. 8.
AGUIAR, SI, SERRANO, I, PINTO, FR, et al.(2008). The presence of the pilus locus is a clonal property among pneumococcal invasive isolates . BMC MICROBIOLOGY. 8.
AGUIAR, SI, SERRANO, I, PINTO, FR, et al.(2008). Changes in Streptococcus pneumoniae serotypes causing invasive disease with non-universal vaccination coverage of the seven-valent conjugate vaccine . CLINICAL MICROBIOLOGY AND INFECTION. 14. (9). p. 835-843.
Aguiar, S.I., Serrano, I., Pinto, F.R., Melo-Cristino, J., Ramirez, M.(2008). Changes in Streptococcus pneumoniae serotypes causing invasive disease with non-universal vaccination coverage of the seven-valent conjugate vaccine . Clinical Microbiology and Infection. 14. (9). p. 835-843.
Figueiredo, T.A., Aguiar, S.I., Melo-Cristino, J., Ramirez, M.(2006). DNA methylase activity as a marker for the presence of a family of phage-like elements conferring efflux-mediated macrolide resistance in streptococci . Antimicrobial Agents and Chemotherapy. 50. (11). p. 3689-3694.
FIGUEIREDO, TA, AGUIAR, SI, MELO-CRISTINO, J, et al.(2006). DNA methylase activity as a marker for the presence of a family of phage-like elements conferring efflux-mediated macrolide resistance in streptococci . ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 50. (11). p. 3689-3694.
AGUIAR, SI, FRIAS, MJ, SANTOS, L, et al.(2006). Emergence of optochin resistance among Streptococcus pneumoniae in Portugal . MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE. 12. (4). p. 239-245.
Aguiar, S.I., Frias, M.J., Santos, L., Melo-Cristino, J., Ramirez, M., Lozano, S., Fonseca, A., Coutinho, A., Alves, A.F., Alburquerque, L., et al.(2006). Emergence of optochin resistance among Streptococcus pneumoniae in Portugal . Microbial Drug Resistance. 12. (4). p. 239-245.
CONFERENCE POSTER
Antibiotic-loaded Liposomes with High Potential Towards S. aureus Infections @misc {
author = {Ferreira, Magda and Ribeiro, I.A.C and Aires-da-Silva, Frederico and Aguiar, Sandra I and Gaspar, Maria Manuela},
title = {Antibiotic-loaded Liposomes with High Potential Towards S. aureus Infections},
year = {2020},
month = {jan}
}. XIII Spanish-Portuguese Conference on Controlled Drug Delivery, Santiago de Compostela, Spain.
Overcoming the BBB: in vivo selection of single domain antibodies for brain targeting and drug delivery @misc {
author = {Aguiar, Sandra I and Silva, Marta and Martins, Diana and André, Ana S. and Neves, Vera and Dias, Joana NR and Carrapiço, Belmira and et al.},
title = {Overcoming the BBB: in vivo selection of single domain antibodies for brain targeting and drug delivery},
year = {2019},
month = {nov}
}. 11th Annual PEGS EUROPE 18-22th November 2019, Lisbon, Portugal.
Antibiotic-lipid Based Nanosystems as a Tool for Staphylococcus aureus Associated Bone Infections @misc {
author = {Ferreira, Magda and Pinto, Sandra and Aires-da-Silva, Frederico and António, Almeida and Aguiar, Sandra I and Bettencourt, Ana and Gaspar, Maria Manuela},
title = {Antibiotic-lipid Based Nanosystems as a Tool for Staphylococcus aureus Associated Bone Infections},
year = {2019},
month = {sep}
}. 38th Annual Meeting of the European Bone and Joint Infection Society, European Bone and Joint Infection Society (EBJIS), Antwerp, Belgium;.
Liposomes as a Tool to Improve Antibacterial Effect of Antibiotics Towards S. aureus Infections @misc {
author = {Ferreira, Magda and Pinto, Sandra and Ana F Bettencourt and Aguiar, Sandra I and Gaspar, Maria Manuela},
title = {Liposomes as a Tool to Improve Antibacterial Effect of Antibiotics Towards S. aureus Infections},
year = {2019},
month = {sep}
}. 6th International Symposium on Phospholipids in Pharmaceutical Research – Phospholipid Research Center, Heidelberg, Germany;.
Antibiotic Liposomal Nanoformulations as a Tool to Inhibit Mature Staphylococcus aureus Biofilms @misc {
author = {Ferreira, Magda and Pinto, Sandra and Ribeiro, I.A. and Aires-da-Silva, Frederico and Almeida, António and Bettencourt, Ana and Aguiar, Sandra I and Gaspar, Maria Manuela},
title = {Antibiotic Liposomal Nanoformulations as a Tool to Inhibit Mature Staphylococcus aureus Biofilms},
year = {2019},
month = {jul}
}. 11th iMed.ULisboa and 3rd i3du Postgraduate Students Meeting, Faculdade de Farmácia da Universidade de Lisboa (FFUL);.
sdAb-immunoliposomes for brain targeting and drug delivery @misc {
author = {Aguiar, Sandra I and Gaspar, M.M. and André, A.S. and Martins, D and Ferreira, M and Carvalheiro, M and Neves, V. and et al.},
title = {sdAb-immunoliposomes for brain targeting and drug delivery},
year = {2018},
month = {dec},
keywords = {single domain antibodies; Immunoliposomes; Antibody drug conjugates; Drug-delivery; Drug-targeting; Blood-brain barrier}
}. Antibody Engineering & Therapeutics, SanDiego, USA.
In vivo phage display selections for development of novel blood-brain barrier crossing single-domain antibodies @misc {
author = {Aguiar, Sandra I and Martins, D and André, A.S. and Neves, V. and Dias, J.N.R. and Carrapiço, B and Gano, L. and et al.},
title = { In vivo phage display selections for development of novel blood-brain barrier crossing single-domain antibodies },
year = {2018},
month = {nov}
}. 11th Annual PEGS EUROPE.
Development and optimization of liposomes encapsulated with potent cytotoxic compounds for immunotherapy @misc {
author = {Rico, I and Dias, J.N.R. and Aguiar, SI and Gaspar, MM and Gil, S. and Aires da Silva, F.},
title = {Development and optimization of liposomes encapsulated with potent cytotoxic compounds for immunotherapy},
year = {2018},
month = {nov},
keywords = {Drug-delivery; Antibody drug conjugates}
}. CIISA Congress 2018.
PERSISTENCE OF PCV7 AND PCV13 SEROTYPES IN PEDIATRIC INVASIVE PNEUMOCOCCAL DISEASE IN PORTUGAL AFTER MORE THAN A DECADE OF VACCINE USE @misc {
author = {Silva-Costa, C. and Horácio, A.N. and Aguiar, S.I. and Lopes, JP and Brito, M J and Ramirez, M. and Melo-Cristino, J.},
title = {PERSISTENCE OF PCV7 AND PCV13 SEROTYPES IN PEDIATRIC INVASIVE PNEUMOCOCCAL DISEASE IN PORTUGAL AFTER MORE THAN A DECADE OF VACCINE USE},
year = {2018},
month = {apr},
keywords = {pneumococcal vaccine; Streptococcus pneumoniae; invasive infection; serotypes}
}. 11th International Symposium on Pneumococci and Pneumococcal Diseases, Melbourne, Australia.
SEROTYPE 3 IS THE LEADING CAUSE OF COMPLICATED PEDIATRIC PNEUMOCOCCAL PNEUMONIA IN PORTUGAL EVEN AMONG PCV13 VACCINATED CHILDREN (2010-2015) @misc {
author = {Silva-Costa, C. and Brito, M J and Pinho, M.D. and Friães, A. and Aguiar, S.I. and Ramirez, M. and Melo-Cristino, J.},
title = {SEROTYPE 3 IS THE LEADING CAUSE OF COMPLICATED PEDIATRIC PNEUMOCOCCAL PNEUMONIA IN PORTUGAL EVEN AMONG PCV13 VACCINATED CHILDREN (2010-2015)},
year = {2018},
month = {apr},
keywords = {Streptococcus pneumoniae; Pneumonia; invasive infection; serotypes}
}. 11th International symposium on pneumococci and pneumococcal diseases, Melbourne, Australia.
Immunoliposomes for brain targeting and drug delivery @misc {
author = {Aguiar, S.I. and Gaspar, M.M. and André, A.S. and Carvalheiro, M and Neves, V. and Coelho, S. and Dias, J.N.R. and et al.},
title = {Immunoliposomes for brain targeting and drug delivery},
year = {2018},
month = {jan},
keywords = {Antibody drug conjugates; Immunoliposomes; Blood-brain barrier; sdAbs; Drug-delivery; Brain-targeting}
}. XII Spanish-Portuguese Conference on Controlled Drug Delivery.
Pediatric invasive pneumococcal disease in Portugal: changing epidemiology (2012-2016) @misc {
author = {Silva-Costa, C. and Horácio, A.N. and Aguiar, S.I. and Lopes, J P and Brito, M.J. and Ramirez, M. and Melo-Cristino, J},
title = {Pediatric invasive pneumococcal disease in Portugal: changing epidemiology (2012-2016)},
year = {2017},
month = {dec},
keywords = {Streptococcus pneumoniae; invasive infection; serotypes; pneumococcal vaccine}
}. MicroBioTec'17 - Porto, Portugal.
Canine model for sepsis: a contribution to the classification and stratification of septic patients @misc {
author = {Prata, S and Aguiar, SI and Gomes, J. and Almeida, V. and Bexiga, R. and Tavares, L. and Aires da Silva, F.},
title = {Canine model for sepsis: a contribution to the classification and stratification of septic patients},
year = {2017},
month = {dec},
keywords = {Sepsis; Canine model}
}. Microbiotec'17.
In vitro and in vivo antitumor properties of histone deacetylase inhibitors in canine diffuse large B-cell lymphoma @misc {
author = {Dias, J.N.R. and Aguiar, S.I. and Pereira, DM and André, Ana S. and Gano, L. and Correia JDG and Carrapiço, B and et al.},
title = {In vitro and in vivo antitumor properties of histone deacetylase inhibitors in canine diffuse large B-cell lymphoma},
year = {2017},
month = {dec},
keywords = {Cancer; Lymphoma; HDACs; In vivo models}
}. Microbiotec 17'.
PCV13 serotypes are still important causes of pediatric invasive pneumococcal disease in Portugal after more than a decade of conjugate vaccine @misc {
author = {Silva-Costa, C. and Horácio, A.N. and Aguiar, S.I. and Lopes JP and Brito, M.J. and Ramirez, M. and Melo-Cristino, J.},
title = {PCV13 serotypes are still important causes of pediatric invasive pneumococcal disease in Portugal after more than a decade of conjugate vaccine},
year = {2017},
month = {nov},
keywords = {Streptococcus pneumoniae; Bacterial infections; invasive infection; serotypes; pneumococcal vaccine}
}. International Congress of Chemotherapy and Infection (ICC 2017). Taipei, Taiwan,.
Serotype distribution among Streptococcus pneumoniae isolates causing complicated pneumonia in children in Portugal (2010-2015) @misc {
author = {Silva-Costa, C. and Aguiar, S.I. and Pinho, M.D. and Friães, A. and Ramirez, M. and Melo-Cristino, J.},
title = {Serotype distribution among Streptococcus pneumoniae isolates causing complicated pneumonia in children in Portugal (2010-2015)},
year = {2017},
month = {apr},
keywords = {Streptococcus pneumoniae; pneumococcal vaccine; serotypes; Pneumonia}
}. 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria.
High prevalence of serotype 3 in pneumococcal isolates causing complicated pneumonia and empyema in Portugal (2010-2015) @misc {
author = {Silva-Costa, C. and Aguiar, S.I. and Pinho, M.D. and Friães, A. and Ramirez, M. and Melo-Cristino, J.},
title = {High prevalence of serotype 3 in pneumococcal isolates causing complicated pneumonia and empyema in Portugal (2010-2015)},
year = {2016},
month = {nov},
keywords = {Streptococcus pneumoniae; serotypes; invasive infection; Pneumonia}
}. International Meeting on Emerging Diseases and Surveillance (IMED 2016). Viena, Austria.
Development of a novel antibody-drug conjugated with potent anti-tumor properties against non-Hodgkin´s lymphomas @misc {
author = {Dias, J.N.R. and Gil, S. and Aguiar, S.I. and Oliveira, S. and Carrapiço, B and Rütgen, B and Peleteiro, MC and et al.},
title = {Development of a novel antibody-drug conjugated with potent anti-tumor properties against non-Hodgkin´s lymphomas},
year = {2015},
month = {dec},
keywords = {Lymphoma; Antibody drug conjugates; Drug-delivery; Drug-targeting}
}. Annual Antibody Engineering and Antibody Therapeutics Meeting, San Diego, EUA.
PCV13 serotypes are still major causes of invasive pneumococcal disease in Portugal despite 10 years of conjugate vaccine use in the private market @misc {
author = {Silva-Costa, C. and Horácio, A.N. and Aguiar, S.I. and Lopes, JP and Brito, M.J. and Ramirez, M. and Melo-Cristino, J.},
title = {PCV13 serotypes are still major causes of invasive pneumococcal disease in Portugal despite 10 years of conjugate vaccine use in the private market},
year = {2015},
month = {nov},
keywords = {pneumococcal vaccine; Streptococcus pneumoniae; invasive infection; serotypes}
}. 9th World Congress of the World Society for Pediatric Infectious Diseases. Rio de Janeiro, Brazil.
Development of Highly Specific and Potent Antibody Drug Conjugated Compounds for Treatment of B-Cell Malignancies @misc {
author = {Dias, J.N.R. and Gil, S. and Aguiar, S.I. and Carrapiço, B and Oliveira, S. and Rütgen, B and Peleteiro, MC and et al.},
title = {Development of Highly Specific and Potent Antibody Drug Conjugated Compounds for Treatment of B-Cell Malignancies},
year = {2015},
month = {nov},
keywords = {Lymphoma; Antibody drug conjugates; Drug-targeting; Drug-delivery}
}. PEGS EUROPE The essential protein engineering summit, Lisbon Portugal.
Development of immunoliposomal therapy for treatment of Pneumococcal meningitis @misc {
author = {Aguiar, S I and Dias, J.N.R. and Neves, V. and Carrapiço, B and Tavares, L. and Castanho, M.A.R.B. and Aires da Silva, F.},
title = {Development of immunoliposomal therapy for treatment of Pneumococcal meningitis},
year = {2015},
month = {sep},
keywords = {Immunoliposomes; Streptococcus pneumoniae; Meningitis; Drug-delivery; Blood-brain barrier; Brain-targeting}
}. 3rd iMM postdoc day.
Conjugate vaccine introduction in Portugal was followed by a decrease of serotypes 6A and 6E but not of serotypes 6B and 6C @misc {
author = {Diamantino-Miranda, J. and Aguiar, S.I. and Carriço, J.A. and Melo-Cristino, J. and Ramirez, M.},
title = {Conjugate vaccine introduction in Portugal was followed by a decrease of serotypes 6A and 6E but not of serotypes 6B and 6C},
year = {2015},
month = {jul},
keywords = {Streptococcus pneumoniae; pneumococcal vaccine; serotypes}
}. 12th European Meeting on the Molecular Biology of the Pneumococcus (EuroPneumo). Oxford, UK.
Complicated pneumococcal pneumonia in Portugal: Enhanced ethiological diagnosis and serotype distribution @misc {
author = {Aguiar, S I and Silva-Costa, C. and Pinho, M.D. and Brito, M J and Ramirez, M. and Melo-Cristino, J.},
title = {Complicated pneumococcal pneumonia in Portugal: Enhanced ethiological diagnosis and serotype distribution},
year = {2015},
month = {jun},
keywords = {Pneumonia; Streptococcus pneumoniae; invasive infection; serotypes}
}. 33rd Annual Meeting of the European Society for Paediatric Infectious Diseases, Leipzig, Germany.
Paediatric invasive pneumococcal disease in Portugal after 10 years of pneumococcal conjugate vaccine use @misc {
author = {Aguiar, S I and Horácio, A.N. and Lopes, JP and Brito, M.J. and Ramirez, M. and Melo-Cristino, J.},
title = {Paediatric invasive pneumococcal disease in Portugal after 10 years of pneumococcal conjugate vaccine use},
year = {2015},
month = {may},
keywords = {pneumococcal vaccine; Streptococcus pneumoniae; invasive infection; serotypes}
}. 33rd Annual Meeting of the European Society for Paediatric Infectious Diseases, Leipzig, Germany,.
Development of Highly Specific and Potent Antibody Drug Conjugated Compounds for Treatment of B-Cell Malignancies @misc {
author = {Dias, J.N.R. and Gil, S. and Aguiar, S I and Oliveira, S and Carrapiço, B and Rütgen, B and Peleteiro, MC and et al.},
title = {Development of Highly Specific and Potent Antibody Drug Conjugated Compounds for Treatment of B-Cell Malignancies},
year = {2015},
keywords = {Cancer; Antibody drug conjugates; HDACs; Lymphoma}
}. PEGS EUROPE The essential protein engineering summit.
Pherotype diversity is not affected by conjugate vaccine induced serotype changes @misc {
author = {Diamantino-Miranda, J. and Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {Pherotype diversity is not affected by conjugate vaccine induced serotype changes},
year = {2014},
month = {jun},
keywords = {Streptococcus pneumoniae; pneumococcal vaccine; serotypes; pherotypes}
}. 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain.
Invasive pneumococcal disease in children and adolescents: incidence of infection and serotype coverage of conjugate vaccines in Portugal @misc {
author = {Aguiar, S I and Brito, M J and Horácio, A.N. and Lopes, JP and Ramirez, M. and Melo-Cristino, J.},
title = {Invasive pneumococcal disease in children and adolescents: incidence of infection and serotype coverage of conjugate vaccines in Portugal},
year = {2014},
month = {may},
keywords = {Streptococcus pneumoniae; invasive infection; pneumococcal vaccine; serotypes}
}. 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain.
Declining incidence and changing serotypes in pediatric invasive infections accompany the introduction of expanded valency pneumococcal conjugate vaccines in Portugal @misc {
author = {Aguiar, S I and Brito, M.J. and Horácio, A.N. and Lopes, JP and Ramirez, M. and Melo-Cristino, J.},
title = {Declining incidence and changing serotypes in pediatric invasive infections accompany the introduction of expanded valency pneumococcal conjugate vaccines in Portugal},
year = {2014},
month = {mar},
keywords = {Streptococcus pneumoniae; serotypes; invasive infection; pneumococcal vaccine}
}. 9th International Symposium on pneumococci and pneumococcal diseases - ISPPD9, Hyderabad, India.
High coverage 13-valent pneumococcal conjugate vaccine in children after ten years of non-universal vaccination with pneumococcal conjugate vaccines in Portugal @misc {
author = {Aguiar, S I and Horácio, A.N. and Lopes, JP and Ramirez, M. and Melo-Cristino, J.},
title = {High coverage 13-valent pneumococcal conjugate vaccine in children after ten years of non-universal vaccination with pneumococcal conjugate vaccines in Portugal},
year = {2013},
month = {nov},
keywords = {Streptococcus pneumoniae; pneumococcal vaccine; serotypes; invasive infection}
}. 8th World Congress on Pediatric Infectious Diseases (WSPID), Cape Town, South Africa.
Invasive pneumococcal infections in Portuguese older children and in adolescents: Epidemiological data and new tools for prevention @misc {
author = {Aguiar, S I and Horacio, AN and Lopes, J P and Ramirez, M. and Melo-Cristino, J.},
title = {Invasive pneumococcal infections in Portuguese older children and in adolescents: Epidemiological data and new tools for prevention},
year = {2013},
month = {nov},
keywords = {Streptococcus pneumoniae; invasive infection; serotypes; Molecular epidemiology}
}. 8th World Congress on Pediatric Infectious Diseases (WSPID), Cape Town, South Africa.
Expansion and decline of paediatric pneumococcal clones in response to 7-valent conjugate vaccine (PCV7) use in Portugal @misc {
author = {Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {Expansion and decline of paediatric pneumococcal clones in response to 7-valent conjugate vaccine (PCV7) use in Portugal},
year = {2013},
month = {apr},
keywords = {Streptococcus pneumoniae; invasive infection; pneumococcal vaccine; serotypes; Molecular epidemiology}
}. 23rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Berlin, Germany.
Use of the 13-Valent Conjugate Vaccine Has the Potential to Eliminate Pilus Carrying Isolates as Causes of Invasive Pneumococcal Disease @misc {
author = {Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {Use of the 13-Valent Conjugate Vaccine Has the Potential to Eliminate Pilus Carrying Isolates as Causes of Invasive Pneumococcal Disease},
year = {2012},
month = {sep},
keywords = {Streptococcus pneumoniae; serotypes; invasive infection; pneumococcal vaccine; Pilus}
}. 52nd ICAAC, San Francisco, USA.
Impact of Two years of Non-Universal Pediatric Use of the 13-Valent Conjugate Vaccine (PCV13) in Portugal @misc {
author = {Aguiar, S I and Horácio, A.N. and Diamantino-Miranda, J. and Brito, M J and Ramirez, M. and Melo-Cristino, J.},
title = {Impact of Two years of Non-Universal Pediatric Use of the 13-Valent Conjugate Vaccine (PCV13) in Portugal},
year = {2012},
month = {sep},
keywords = {Streptococcus pneumoniae; serotypes; invasive infection; pneumococcal vaccine}
}. 52nd ICAAC, San Francisco, USA.
Serotypes causing invasive pneumococcal disease in young adults prior the use of new conjugate vaccines @misc {
author = {Horacio, AN and Diamantino-Miranda, J. and Aguiar, S I and Ramirez, M. and Melo-Cristino, J.},
title = {Serotypes causing invasive pneumococcal disease in young adults prior the use of new conjugate vaccines},
year = {2012},
month = {mar},
keywords = {Streptococcus pneumoniae; serotypes; invasive infection; Molecular epidemiology}
}. 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). London, United Kingdom.
Invasive pneumococcal disease in elderly: serotype distribution and antimicrobial resistance before 13-valent conjugate vaccine introduction in Portugal @misc {
author = {Diamantino-Miranda, J. and Horácio, A.N. and Aguiar, S.I. and Ramirez, M. and Melo-Cristino, J.},
title = {Invasive pneumococcal disease in elderly: serotype distribution and antimicrobial resistance before 13-valent conjugate vaccine introduction in Portugal},
year = {2012},
month = {mar},
keywords = {Streptococcus pneumoniae; invasive infection; serotypes}
}. 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). London, United Kingdom.
Recent changes in the proportion of piliated pneumococci: consequences of vaccine use and future prospects @misc {
author = {Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {Recent changes in the proportion of piliated pneumococci: consequences of vaccine use and future prospects},
year = {2012},
month = {mar},
keywords = {Streptococcus pneumoniae; invasive infection; serotypes; pneumococcal vaccine}
}. 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). London, United Kingdom.
After 7 Years of PCV7 (7-valent Pneumococcal Conjugate Vaccine) PCV13 Still Covers the Majority of Invasive Pneumococcal Disease (IPD) in Portugal @misc {
author = {Horácio, A.N. and Diamantino-Miranda, J. and Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {After 7 Years of PCV7 (7-valent Pneumococcal Conjugate Vaccine) PCV13 Still Covers the Majority of Invasive Pneumococcal Disease (IPD) in Portugal},
year = {2011},
month = {sep},
keywords = {Streptococcus pneumoniae; invasive infection; serotypes}
}. 51st ICAAC, Chicago, USA.
Serotype 19A lineages in pneumococci recovered from carriage and infection in Portugal @misc {
author = {Aguiar, Sandra I and Pinto, F. and Nunes, S. and Sa-Leao, R. and Serrano, I and Melo-Cristino, J and Ramirez, M.},
title = {Serotype 19A lineages in pneumococci recovered from carriage and infection in Portugal},
year = {2010},
month = {mar},
keywords = {Streptococcus pneumoniae; serotypes; invasive infection; Molecular epidemiology; carriage}
}. 7th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) Tel Aviv, Israel.
Characterization of pneumococcal strains of serogroup 6 in Portugal @misc {
author = {Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {Characterization of pneumococcal strains of serogroup 6 in Portugal},
year = {2010},
month = {mar},
keywords = {Streptococcus pneumoniae; serotypes; invasive infection}
}. 7th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) Tel Aviv, Israel.
Pili distribution among invasive Streptococcus pneumoniae in Portugal after the introduction of the 7-valent conjugate vaccine @misc {
author = {Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {Pili distribution among invasive Streptococcus pneumoniae in Portugal after the introduction of the 7-valent conjugate vaccine},
year = {2009},
month = {jun},
keywords = {Streptococcus pneumoniae; Pilus; pneumococcal vaccine; invasive infection}
}. 9th European Meeting on the Molecular Biology of the Pneumococcus (Europneumo), Bern, Switzerland.
Changes in Streptococcus pneumoniae serotypes causing invasive disease with non universal vaccination coverage of the seven-valent conjugate vaccine @misc {
author = {Aguiar, S I and Serrano, I and Pinto, FR and Melo-Cristino, J. and Ramirez, M.},
title = {Changes in Streptococcus pneumoniae serotypes causing invasive disease with non universal vaccination coverage of the seven-valent conjugate vaccine},
year = {2008},
month = {jun},
keywords = {Streptococcus pneumoniae; pneumococcal vaccine; invasive infection}
}. 6th International Symposium on Pneumococci & Pneumococcal Diseases , Reykjavik, Iceland.
Quantitative analysis of congruence of Streptococcus pneumoniae typing methods. Relations between serotype, multi-locus sequence typing and pulse-field gel electrophoresis type assignments @misc {
author = {Carriço, J.A. and Pinto, FR and Zemlicková, H. and Jakubu, V. and Nunes, S. and Frazão, N. and Sa-Leao, R. and et al.},
title = {Quantitative analysis of congruence of Streptococcus pneumoniae typing methods. Relations between serotype, multi-locus sequence typing and pulse-field gel electrophoresis type assignments},
year = {2008},
month = {jun},
keywords = {Streptococcus pneumoniae; Molecular epidemiology}
}. 6th International Symposium on Pneumococci & Pneumococcal Diseases, Reykjavik, Iceland.
S. pneumoniae multistrain genomotyping arrays: optimal choice of control in twocolour experiments @misc {
author = {Pinto, FR and Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {S. pneumoniae multistrain genomotyping arrays: optimal choice of control in twocolour experiments},
year = {2008},
month = {jun},
keywords = {Streptococcus pneumoniae; microarrays}
}. 6th International Symposium on Pneumococci & Pneumococcal Diseases , Reykjavik, Iceland.
Comparison of pneumococci isolate from invasive and non-invasive disease in preschool children @misc {
author = {Aguiar, S I and Melo-Cristino, J. and Ramirez, M.},
title = {Comparison of pneumococci isolate from invasive and non-invasive disease in preschool children},
year = {2008},
month = {apr},
keywords = {Streptococcus pneumoniae; serotypes}
}. 18th European Congress of Clinical Microbiology and Infectious Diseases together with the 25th International Congress of Chemotherapy, Barcelona, Spain.
Pili distribution among Streptococcus pneumoniae associated with invasive disease @misc {
author = {Aguiar, S I and Serrano, I and PINTO, FR and Melo-Cristino, J. and Ramirez, M.},
title = {Pili distribution among Streptococcus pneumoniae associated with invasive disease},
year = {2008},
month = {apr},
keywords = {Streptococcus pneumoniae; Pilus; invasive infection; serotypes}
}. 18th European Congress of Clinical Microbiology and Infectious Diseases together with the 25th International Congress of Chemotherapy, Barcelona, Spain.
Emergence of optochin resistance among Streptococcus pneumoniae in Portugal @misc {
author = {Aguiar, S I and Frias, M.J. and Santos, L. and Melo-Cristino, J.},
title = {Emergence of optochin resistance among Streptococcus pneumoniae in Portugal},
year = {2007},
month = {apr},
keywords = {Streptococcus pneumoniae}
}. 8Th European Meeting on the Molecular Biology of the Pneumococcus, Oeiras, Portugal.
Emergence of optochin resistance among Streptococcus pneumoniae in Portugal @misc {
author = {Aguiar, S I and Frias, M.J. and Santos, L. and Melo-Cristino, J. and Ramirez, M.},
title = {Emergence of optochin resistance among Streptococcus pneumoniae in Portugal},
year = {2007},
month = {mar},
keywords = {Streptococcus pneumoniae}
}. 17th European Congress of Clinical Microbiology and Infectious Diseases together with the 25th International Congress of Chemotherapy, Munich, Germany.
Clonal diversity of invasive Streptococcus pneumoniae from Portuguese children @misc {
author = {Serrano, I and Carriço, J.A. and Aguiar, S.I. and Melo-Cristino, J. and Ramirez, M.},
title = {Clonal diversity of invasive Streptococcus pneumoniae from Portuguese children},
year = {2005},
month = {apr},
keywords = {Streptococcus pneumoniae; Molecular epidemiology}
}. 15th European Congress of Clinical Microbiology and Infectious Disease, Copenhagen, Denmark.
BOOK CHAPTER
DISCLOSURE
Single domain antibodies for brain targeting and drug delivery across the blood-brain barrier @misc {
author = {Aguiar, Sandra},
title = {Single domain antibodies for brain targeting and drug delivery across the blood-brain barrier},
year = {2017},
month = {dec},
keywords = {Antibodies; Blood-brain barrier}
}.
DISSERTATION THESIS
Molecular epidemiology of Streptococcus pneumoniae: Impact of PCV7 in the pneumococcal population responsible for invasive pediatric infections @phdthesis {
author = {Aguiar, Sandra I},
title = {Molecular epidemiology of Streptococcus pneumoniae: Impact of PCV7 in the pneumococcal population responsible for invasive pediatric infections},
year = {2011},
month = {jul},
school = {Universidade de Lisboa Faculdade de Medicina; Instituto de Medicina Molecular},
keywords = {Streptococcus pneumoniae; invasive infection; serotypes; pneumococcal vaccine}
}. Universidade de Lisboa Faculdade de Medicina; Instituto de Medicina Molecular.
Caracterização genotípica e fenotípico de Streptococcus pneumoniae responsável por infecção em crianças em idade pré-escolar @phdthesis {
author = {Aguiar, Sandra I},
title = {Caracterização genotípica e fenotípico de Streptococcus pneumoniae responsável por infecção em crianças em idade pré-escolar},
year = {2006},
month = {jun},
school = {Universidade de Lisboa Faculdade de Medicina},
keywords = {Streptococcus pneumoniae; serotypes}
}. Universidade de Lisboa Faculdade de Medicina.
Ratings and Comments
Total Projects Awarded:
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