Profile Details

Create Project

★★★★★

☆☆☆☆☆

USD 100 /hr

★★★★★

☆☆☆☆☆

Hire Dr. Seetharamsing B.

Singapore

USD 100 /hr

PhD Chemist | Head of ADC Linker-Payload Chemistry | 17+ Years Synthetic Chemistry | PMP-Certified & IP-Aware

Profile Summary

PhD Chemist | 17+ Years in Synthetic Chemistry & ADC Linker-Payload Development | PMP‑Certified | Foundational Patent‑Law Knowledge I offer a rare combination of advanced chemical synthesis, structured project leadership, IP awareness, and hands-on experience—perfect for Kolabtree clients seeking expert guidance in ADC and analog design. 🔬 Deep Scientific Expertise Over 17 years designing and synthesizing biologically active molecules—spanning complex natural products, epigenetic nucleoside derivatives, and cleavable payload–linker systems for ADCs. 🏆 Proven Leadership in ADC Chemistry Held the role of Head of Linker‑Payload Chemistry at Singzyme for 3 years, steering strategic development and execution of conjugation platforms—including ADCs and radio‑conjugates. 📈 PMP-Certified Project Manager Experienced in structured project execution: defining milestones, mitigating risks, optimizing resources, and ensuring on-time, on-budget delivery. ⚖️ Patent‑Law Awareness Diploma in patent law providing foundational IP insight—able to flag patent-sensitive opportunities and collaborate effectively with legal teams. 🤝 Proven Translation to Application A track record of 25+ publications, multiple patents, and leadership of multidisciplinary R&D teams (at SMART, NTU, Singzyme), driving projects toward preclinical and clinical readiness. 💡 Client‑Focused Collaboration Transparent communicator and reliable partner—offering clear updates, strong respect for confidentiality and IP, and flexible engagement suited to your project needs. Let’s collaborate on: ADC linker/payload design & optimization Nucleotide or peptide analog synthesis Structured, PMP-driven project execution IP‑sensitive R&D with early patent considerations

Subject Matter Expertise

• ☆ Organic Chemistry
• ☆ Drug Development

Services

• Consulting

Consulting Healthcare Consulting

Work Experience

Head Chemical Development

Singzyme Pvt Ltd

January 2023 - Present

Senior Research Fellow

Nanyang Technological University

February 2022 - Present

Research Scientist

Singapore-MIT Alliance for Research and Technology

October 2016 - January 2022

Education

Research Scholar

CSIR: National Chemical Laboratory

August 2011 - September 2016

Certifications

• Project Managment Professional (PMP)

  PMI

  https://my.pmi.org/certification?_gl=1*qhkw1n*_gcl_aw*R0NMLjE3NTI1NTcxMzUuQ2p3S0NBancxZExEQmhCb0Vpd0FRTlJpUVdsYVh1RjREVWNhQ2F5aE94ZFI1ZlNkSkNwVFZHQXRNaGZyaHpSQmYtek9sN2RFZzhkeFdSb0NWTXNRQXZEX0J3RQ..*_gcl_au*MTg5MDQzMzIzOC4xNzUyNTU3MTE0LjM5Mjg0Njg5LjE3NTI1NTcxMjIuMTc1MjU1NzEyMw..

  August 2020 - Present

Publications

JOURNAL ARTICLE

Seetharamsing Balamkundu, Chuan-Fa Liu (2023). Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates . Biomedicines.

Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans Nucleic Acids Res . 2023 Nov 10;51(20):10829-10845 . Nucleic Acids Research.

Seetharamsing Balamkundu, Chuan-Fa Liu (2023). Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates . Biomedicines.

Liang Cui, Seetharamsing Balamkundu, Chuan-Fa Liu, Hong Ye, Jacob Hourihan, Astrid Rausch, Christopher Hauß, Emelie Nilsson, Matthias Hoetzinger, Karin Holmfeldt, et al. (2023). Four additional natural 7-deazaguanine derivatives in phages and how to make them . Nucleic Acids Research.

Yiyin Xia, Fupeng Li, Xiaohong Zhang, Seetharamsing Balamkundu, Fan Tang, Side Hu, Julien Lescar, James P Tam, Chuan Fa Liu (2023). A Cascade Enzymatic Reaction Scheme for Irreversible Transpeptidative Protein Ligation . Journal of the American Chemical Society.

DingPeng Zhang, Zhen Wang, Side Hu, Seetharamsing Balamkundu, Janet To, Xiaohong Zhang, Julien Lescar, James P Tam, Chuan Fa Liu (2021). pH-Controlled Protein Orthogonal Ligation Using Asparaginyl Peptide Ligases . Journal of the American Chemical Society.

Wenhe Zhong, Kalyan Kumar Pasunooti, Seetharamsing Balamkundu, Yee Hwa Wong, Qianhui Nah, Vinod Gadi, Shanmugavel Gnanakalai, Yok Hian Chionh, Megan E. McBee, Pooja Gopal, et al. (2019). Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-<i>N</i>¹)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism . Journal of Medicinal Chemistry.

B. Seetharamsingh, Routholla Ganesh, D. Srinivasa Reddy (2017). Determination of the Absolute Configuration of Gliomasolide D through Total Syntheses of the C-17 Epimers . Journal of Natural Products.

B. Seetharamsingh, Pankaj V. Khairnar, D. Srinivasa Reddy (2016). First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674 . The Journal of Organic Chemistry.

B. Seetharamsingh, P. R. Rajamohanan, D. Srinivasa Reddy (2015). Total Synthesis and Structural Revision of Mycalol, an Anticancer Natural Product from the Marine Source . Organic Letters.

Kishor L. Handore, B. Seetharamsingh, D. Srinivasa Reddy (2013). Ready Access to Functionally Embellished <i>cis</i>-Hydrindanes and <i>cis</i>-Decalins: Protecting Group-Free Total Syntheses of (±)-Nootkatone and (±)-Noreremophilane . The Journal of Organic Chemistry.

PREPRINT

Seetharamsing Balamkundu, Chuan Fa Liu (2023). Lysosomal Cleavable Peptide Linkers in Antibody-Drug Conjugates .