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Profile Details
Subject Matter Expertise
Services
Work Experience
Professor
NITC
January 2020 - Present
Education
PhD
MAHE
January 2020 - January 2020
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
V. S. Suvanish Kumar, Etheresia Pretorius, G. K. Rajanikant(2018). The Synergistic Combination of Everolimus and Paroxetine Exerts Post-ischemic Neuroprotection In Vitro . Cellular and Molecular Neurobiology. 38. (7). p. 1383--1397. Springer Science and Business Media {LLC}
Aswathi Gopalakrishnan, Sahadev A. Shankarappa, G. K. Rajanikant(2018). Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain . Translational Stroke Research. 10. (1). p. 1--18. Springer Nature
Neelakandan, A.R., Rajanikant, G.K.(2018). Endophenotypes as disease modifiers: Decoding the biology of Alzheimer?s by genome-wide association studies . CNS and Neurological Disorders - Drug Targets. 17. (1). p. 6-8.
Nampoothiri, S.S., Potluri, T., Subramanian, H., Krishnamurthy, R.G.(2017). Rodent Gymnastics: Neurobehavioral Assays in Ischemic Stroke . Molecular Neurobiology. 54. (9). p. 6750-6761.
Gokul, S., Rajanikant, G.K.(2017). Bay 1436032: A novel pan-mutant IDH1 inhibitor extends survival of mice with experimental brain tumors . CNS and Neurological Disorders - Drug Targets. 16. (6). p. 636-637.
Nampoothiri, S.S., Rajanikant, G.K.(2017). Decoding the ubiquitous role of microRNAs in neurogenesis . Molecular Neurobiology. 54. (3). p. 2003-2011.
Fayaz, S.M., Rajanikant, G.K.(2017). Structure-based pharmacophore clustering of multi-conformation proteins: Application to identify novel and diverse CypD inhibitors . Current Proteomics. 14. (3). p. 224-233.
Sinoy, S., Fayaz, S.M., Charles, K.D., Suvanish, V.K., Kapfhammer, J.P., Rajanikant, G.K.(2017). Amikacin Inhibits miR-497 Maturation and Exerts Post-ischemic Neuroprotection . Molecular Neurobiology. 54. (5). p. 3683-3694.
Davis, C.K., Laud, P.J., Bahor, Z., Rajanikant, G.K., Majid, A.(2016). Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke . Journal of Cerebral Blood Flow and Metabolism. 36. (10). p. 1686-1694.
Kumar, V.S.S., Krishnamurthy, R.G.(2016). Research highlights: Adaptive PTEN loss enhances the outgrowth of brain metastatic tumour cell . CNS and Neurological Disorders - Drug Targets. 15. (3). p. 262-264.
Sugunan, S., Nampoothiri, S.S., Garg, T., Krishnamurthy, R.G.(2016). Role of KCa3.1 channels in CNS diseases: A concise review . CNS and Neurological Disorders - Drug Targets. 15. (10). p. 1299-1305.
Eslavath, R.K., Sharma, D., Bin Omar, N.A.M., Chikati, R., Teli, M.K., Rajanikant, G.K., Singh, S.S.(2016). ?-N-oxalyl-L-?, ?- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions . European Journal of Pharmacology. 791. p. 405-411.
Das, J., Krishnamurthy, R.G.(2016). Death associated protein kinase 1: A perp in cerebral ischemia . CNS and Neurological Disorders - Drug Targets. 15. (8). p. 874-877.
Vijayakumar N, T., Sangwan, A., Sharma, B., Majid, A., GK, R.(2016). Cerebral Ischemic Preconditioning: the Road So Far? . Molecular Neurobiology. 53. (4). p. 2579-2593.
Nampoothiri, S.S., Menon, H.V., Das, D., Krishnamurthy, R.G.(2016). Ischemirs: Finding a way through the obstructed cerebral arteries . Current Drug Targets. 17. (7). p. 800-810.
Krishnamurthy, R.G.(2016). Meet our editorial board member . CNS and Neurological Disorders - Drug Targets. 15. (1). p. 1.
Nampoothiri, S.S., Krishnamurthy, R.G.(2016). Research highlights: Targeted inhibition of miR-155 promotes post-stroke neovascularization and functional recovery . CNS and Neurological Disorders - Drug Targets. 15. (4). p. 372-374.
Fayaz, S.M., Suvanish Kumar, V.S., Davis, C.K., Rajanikant, G.K.(2016). Novel RIPK3 inhibitors discovered through a structure-based approach exert post-ischemic neuroprotection . Molecular Diversity. 20. (3). p. 719-728.
S. Shashikumar, H. Pradeep, Salim Chinnu, P.S. Rajini, G.K. Rajanikant(2015). Alpha-linolenic acid suppresses dopaminergic neurodegeneration induced by 6-{OHDA} in C. elegans . Physiology {\&} Behavior. 151. p. 563--569. Elsevier {BV}
Fayaz, S.M., Raj, Y.V., Krishnamurthy, R.G.(2015). CypD: The key to the death door . CNS and Neurological Disorders - Drug Targets. 14. (5). p. 654-663.
Fayaz, S.M., Rajanikant, G.K.(2015). Modelling the molecular mechanism of protein?protein interactions and their inhibition: CypD?p53 case study . Molecular Diversity. 19. (4). p. 931-943.
Fayaz, S.M., Rajanikant, G.K.(2015). Ensembling and filtering: an effective and rapid in silico multitarget drug-design strategy to identify RIPK1 and RIPK3 inhibitors . Journal of Molecular Modeling. 21. (12). p. 1-13.
Shradgan, F.M., Krishnmurthy, R.G.(2014). Research highlights: USP30 regulates the mitophagy-mediated neuroprotection in Parkinson?s disease . CNS and Neurological Disorders - Drug Targets. 13. (10). p. 1633-1634.
Pradeep, H., Rajanikant, G.K.(2014). Computational prediction of a putative binding site on drp1: Implications for antiparkinsonian therapy . Journal of Chemical Information and Modeling. 54. (7). p. 2042-2050.
Fayaz, S.M., Rajanikant, G.K.(2014). Ensemble pharmacophore meets ensemble docking: A novel screening strategy for the identification of RIPK1 inhibitors . Journal of Computer-Aided Molecular Design. 28. (7). p. 779-794.
Rajanikant, G.K., Pretorius, E.(2014). Critical appraisal of ischemic stroke pathophysiology: Road to cerebral resuscitation? Part i . Current Medicinal Chemistry. 21. (18). p. 2023-2024.
Fayaz, S.M., Kumar, V.S.S., Rajanikant, K.G.(2014). Finding needles in a haystack: Application of network analysis and target enrichment studies for the identification of potential Anti-Diabetic phytochemicals . PLoS ONE. 9. (11).
Rajanikant, G.K., Fayaz, S.M.(2014). Ikk? mediates a?-triggered microglial inflammation and neuronal death during alzheimer{'}s disease . CNS and Neurological Disorders - Drug Targets. 13. (8). p. 1305-1307.
Hanumanthappa, P., Rajanikant, G.K.(2014). In silico identification of potential dynamin-related protein 1 antagonists: Implications for diseases involving mitochondrial dysfunction . Combinatorial Chemistry and High Throughput Screening. 17. (1). p. 25-34.
Fayaz, S.M., Kumar, V.S.S., Rajanikant, G.K.(2014). Necroptosis: Who knew there were so many interesting ways to die? . CNS and Neurological Disorders - Drug Targets. 13. (1). p. 42-51.
Hanumanthappa, P., Krishnamurthy, R.G.(2014). A comparative molecular dynamics simulation study to assess the exclusion ability of novel GSK3? inhibitors . Medicinal Chemistry Research. 23. (6). p. 3092-3095.
Kumar, V.S.S., Gopalakrishnan, A., Naziroǧlu, M., Rajanikant, G.K.(2014). Calcium ion - The key player in cerebral ischemia . Current Medicinal Chemistry. 21. (18). p. 2065-2075.
Pradeep, H., Shashikumar, S., Rajini, P.S., Rajanikant, G.K.(2014). Anti-parkinsonian efficacy of target-specific GSK3? inhibitors demonstrated in Caenorhabditis elegans . Medicinal Chemistry Research. 23. (12). p. 5263-5268.
Hanumanthappa, P., Densi, A., Krishnamurthy, R.G., Hanumanthappa, P., Densi, A., Krishnamurthy, R.G.(2014). Glycogen synthase kinase-3? in ischemic neuronal death . Current Neurovascular Research. 11. (3). p. 271-278.
Das, S., Rajanikant, G.K., Das, S., Rajanikant, G.K.(2014). Huntington disease: Can a zebrafish trail leave more than a ripple? . Neuroscience and Biobehavioral Reviews. 45. p. 258-261.
Pradeep, H., Sharma, B., Rajanikant, G.K.(2014). Drp1 in ischemic neuronal death: An unusual suspect . Current Medicinal Chemistry. 21. (19). p. 2183-2189.
Fayaz, S.M., Rajanikant, G.K.(2014). ATF4: The perpetrator in axonal-mediated neurodegeneration in alzheimer?s disease . CNS and Neurological Disorders - Drug Targets. 13. (9). p. 1483-1484.
Chechneva, O.V., Mayrhofer, F., Daugherty, D.J., Krishnamurty, R.G., Bannerman, P., Pleasure, D.E., Deng, W.(2014). A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury . Cell Death and Disease. 5. (10).
Rajanikant, G.K., Pretorius, E.(2014). Critical appraisal of ischemic stroke pathophysiology: Road to cerebral resuscitation? Part II . Current Medicinal Chemistry. 21. (19). p. 2119-2120.
Sugunan, S., Joseph, D.B., Rajanikant, G.K.(2013). Evolving therapeutic targets in ischemic stroke: A concise review . Current Drug Targets. 14. (4). p. 497-506.
Teli, M.K., Krishnamurthy, R.G.(2013). A combination of 3D-QSAR modeling and molecular docking approach for the discovery of potential HIF prolyl hydroxylase inhibitors . Medicinal Chemistry. 9. (3). p. 360-370.
Teli, M.K., Rajanikant, G.K.(2013). Computational repositioning and experimental validation of approved drugs for HIF-prolyl hydroxylase inhibition . Journal of Chemical Information and Modeling. 53. (7). p. 1818-1824.
Sugunan, S., Rajanikant, G.K.(2013). Linking productive autophagy to neuroprotection: Potential implications for anti-ischemic therapy . CNS and Neurological Disorders - Drug Targets. 12. (3). p. 298-299.
Rajanikant, G.K.(2013). Neuroprotection and neuroregeneration in ischemic stroke: Emerging treatment strategies and potential molecular targets . Current Drug Targets. 14. (1). p. 1-2.
Nair, S.B., Fayaz, S.M., Rajanikant, G.K.(2013). A novel multi-target drug screening strategy directed against key proteins of DAPk family . Combinatorial Chemistry and High Throughput Screening. 16. (6). p. 449-457.
Nair, S., Hagberg, H., Krishnamurthy, R., Thornton, C., Mallard, C.(2013). Death associated protein kinases: Molecular structure and brain injury . International Journal of Molecular Sciences. 14. (7). p. 13858-13872.
Teli, M.K., Rajanikant, G.K.(2012). Pharmacophore generation and atom-based 3D-QSAR of novel quinoline-3-carbonitrile derivatives as Tpl2 kinase inhibitors . Journal of Enzyme Inhibition and Medicinal Chemistry. 27. (4). p. 558-570.
Fayaz, S.M.A., Rajanikant, G.K.(2012). A critical appraisal of the functional evolution of P2Y12 antagonists as antiplatelet drugs . Current Pharmaceutical Design. 18. (12). p. 1625-1634.
Nair, S.B., Fayaz, S.M.A., Krishnamurthy, R.G.(2012). In Silico prediction of novel inhibitors of the DNA binding activity of FoxG1 . Medicinal Chemistry. 8. (6). p. 1155-1162.
Nair, S.B., Dileep, A., Rajanikant, G.K.(2012). Nanotechnology based diagnostic and therapeutic strategies for neuroscience with special emphasis on ischemic stroke . Current Medicinal Chemistry. 19. (5). p. 744-756.
Teli, M.K., Rajanikant, G.K.(2012). Identification of novel potential HIF-prolyl hydroxylase inhibitors by in silico screening . Molecular Diversity. 16. (1). p. 193-202.
Hanumanthappa, P., Teli, M.K., Krishnamurthy, R.G.(2012). Generation of pharmacophore and atom based 3D-QSAR model of novel isoquinolin-1-one and quinazolin-4-one-type inhibitors of TNF? . Medicinal Chemistry. 8. (3). p. 436-451.
Nair, S.B., Teli, M.K., Pradeep, H., Rajanikant, G.K.(2012). Computational identification of novel histone deacetylase inhibitors by docking based QSAR . Computers in Biology and Medicine. 42. (6). p. 697-705.
Pradeep, H., Rajanikant, G.K.(2012). Nanochannels: Biological channel analogues . IET Nanobiotechnology. 6. (2). p. 63-70.
Jagetia, G.C., Rajanikant, G.K.(2012). Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated ? radiation . International Wound Journal. 9. (1). p. 76-92.
Bae, O.-N., Rajanikant, K., Min, J., Smith, J., Baek, S.-H., Serfozo, K., Hejabian, S., Lee, K.Y., Kassab, M., Majid, A.(2012). Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning . Journal of Neuroscience. 32. (21). p. 7278-7286.
Pradeep, H., Diya, J.B., Shashikumar, S., Rajanikant, G.K.(2012). Oxidative stress - Assassin behind the ischemic stroke . Folia Neuropathologica. 50. (3). p. 219-230.
Pradeep, H., Rajanikant, G.K.(2012). A rational approach to selective pharmacophore designing: An innovative strategy for specific recognition of Gsk3? . Molecular Diversity. 16. (3). p. 553-562.
Teli, M.K., Hanumanthappa, P., Krishnamurthy, R.G.(2012). Pharmacophore generation and 3D-QSAR of novel 2-(quinazolin-4-ylamino)-[1, 4] benzoquinone derivatives as VEGFR-2 inhibitors . Letters in Drug Design and Discovery. 9. (10). p. 899-914.
Teli, M.K., Mutalik, S., Rajanikant, G.K.(2010). Nanotechnology and nanomedicine: Going small means aiming big . Current Pharmaceutical Design. 16. (16). p. 1882-1892.
Krishnamurthy, R.G., Senut, M.-C., Zemke, D., Min, J., Frenkel, M.B., Greenberg, E.J., Yu, S.-W., Ahn, N., Goudreau, J., Kassab, M., et al.(2009). Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia . Journal of Neuroscience Research. 87. (11). p. 2541-2550.
Min, J., Senut, M.-C., Rajanikant, K., Greenberg, E., Bandagi, R., Zemke, D., Mousa, A., Kassab, M., Farooq, M.U., Gupta, R., et al.(2008). Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia . Journal of Neuroscience Research. 86. (13). p. 2984-2991.
Rajanikant, G.K., Zemke, D., Senut, M.-C., Frenkel, M.B., Chen, A.F., Gupta, R., Majid, A.(2007). Carnosine is neuroprotective against permanent focal cerebral ischemia in mice . Stroke. 38. (11). p. 3023-3031.
Rajanikant, G.K., Zemke, D., Kassab, M., Majid, A.(2007). The therapeutic potential of statins in neurological disorders . Current Medicinal Chemistry. 14. (1). p. 103-112.
Jagetia, G.C., Rajanikant, G.K., Mallikarjun Rao, K.V.N.(2007). Ascorbic acid increases healing of excision wounds of mice whole body exposed to different doses of ?-radiation . Burns. 33. (4). p. 484-494.
Jagetia, G.C., Rajanikant, G.K.(2005). Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody ?-irradiation . Plastic and Reconstructive Surgery. 115. (2). p. 515-528.
Jagetia, G.C., Rajanikant, G.K., Baliga, M.S., Rao, K.V.N.M., Kumar, P.(2004). Augmentation of wound healing by ascorbic acid treatment in mice exposed to ?-radiation . International Journal of Radiation Biology. 80. (5). p. 347-354.
Jagetia, G.C., Rajanikant, G.K.(2004). Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of ?-radiation . Journal of Surgical Research. 120. (1). p. 127-138.
Jagetia, G.C., Rajanikant, G.K., Rao, S.K.(2003). Evaluation of the effect of ascorbic acid treatment on wound healing in mice exposed to different doses of fractionated gamma radiation . Radiation Research. 159. (3). p. 371-380.
Jagetia, G.C., Baliga, M.S., Aruna, R., Rajanikant, G.K., Jain, V.(2003). Effect of abana (a herbal preparation) on the radiation-induced mortality in mice . Journal of Ethnopharmacology. 86. (2-3). p. 159-165.
Chandra Jagetia, G., Rajanikant, G.K., Rao, S.K., Shrinath Baliga, M.(2003). Alteration in the glutathione, glutathione peroxidase, superoxide dismutase and lipid peroxidation by ascorbic acid in the skin of mice exposed to fractionated ? radiation . Clinica Chimica Acta. 332. (1-2). p. 111-121.
Jagetia, G.C., Rajanikant, G.K., Mallikarjun Rao, K.V.N.(2003). Modulation of Radiation-Induced Delay in the Wound Healing by Ascorbic Acid in Mice Exposed to Different Doses of Hemi-Body Gamma Radiation . Wounds. 15. (10). p. 324-338.
BOOK
Nampoothiri, S.S., Jain, S.A., Burrows, D., Bae, O.-N., Majid, A., Rajanikant, G.K.(2018). Chapter 6: The Molecular Neuroprotective Strategies in Cerebral Ischemia: An Insight into Emerging Treatments for Oxidative Stress . RSC Drug Discovery Series. 2018-January. (62). p. 82-104.
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