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Hire Dr. Rajalakshmi G.

India

Profile Summary

Ph.D. from Indian Institute of Science, Bangalore 560012, India. Structure and expression of tumor suppressor genes RB1 and p53 in human colorectal cancers and in human brain tumors. Effect of small molecules on the survival of tumor cells in vitro. Effect of small molecules on the genes involved in cell survival/cell death pathway. Effect of growth factors EGF and PDGFs on wound healing. Effect of growth factors and small molecules on diabetic wound healing. Effect of AlCl3 on the gene expression in mouse brain and liver.

Subject Matter Expertise

• ☆ Biology/Life Sciences
• ☆ Biomarkers
• ☆ Genetics
• ☆ Biotechnology & Bioengineering
• ☆ Medicine
• ☆ Medical Sciences

Services

• Research

Research Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Work Experience

Professor & Head of the Department (retired)

Department of Human Genetics, NIMHANS, Bangalore

January 1997 - February 2017

Professor

NIMHANS

January 1997 - February 2017

Education

Ph.D. (Microbiology and Cell Biology Laboratory)

Indian Institute of Science

August 1976 - August 1980

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Keshava, R., Muniyappa, N., Gope, R., Ramaswamaiah, A.S.(2016). Anti-cancer effects of Imperata cylindrica leaf extract on human oral squamous carcinoma cell line SCC-9 in vitro . Asian Pacific Journal of Cancer Prevention. 17. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1891-1898.

Mitra, R., Indira Devi, B., Gope, M.L., Subbakrishna, D.K., Gope, R.(2012). Sodium butyrate modulates pRb phosphorylation and induces cell death in human vestibular schwannomas in vitro . Indian Journal of Experimental Biology. 50. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 19-27.

Mitra, R., Bhagavatula, I.D., Gope, R.(2012). BAY 61-3606, CDKi, and sodium butyrate treatments alter gene expression in human vestibular schwannomas and cause cell death in vitro . ecancermedicalscience. 6. (1).

Mazzucco, L., Borzini, P., Gope, R.(2010). Platelet-derived factors involved in tissue repair-from signal to function . Transfusion Medicine Reviews. 24. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 218-234.

Gope, M.L., Gope, R.(2009). Tyrosine phosphorylation of EGF-R and PDGF-R proteins during acute cutaneous wound healing process in mice . Wound Repair and Regeneration. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 71-79.

Rohini, K., Mathivanan, J., Prabhu, P.D.A.H., Subbakrishna, D.K., Gope, M.L., Chandramouli, B.A., Sampath, S., Anandh, B., Gope, R.(2007). Loss of heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors . Molecular and Cellular Biochemistry. 300. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 101-111.

Gope, M.L., Gope, R.(2007). Topically applied EGF and PDGFs affect positively the co-ordinate expression of EGF and PDGF receptor genes during acute cutaneous wound-healing process . Current Science. 92. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 618-627.

Mathivanan, J., Rohini, K., Gope, M.L., Anandh, B., Gope, R.(2007). Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors . Molecular and Cellular Biochemistry. 302. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 67-77.

Dayalan, A.H.P.P., Jothi, M., Keshava, R., Thomas, R., Gope, M.L., Doddaballapur, S.K., Somanna, S., Prabaraj, S.S., Ashwathnarayanarao, C.B., Gope, R.(2006). Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas . Molecular Carcinogenesis. 45. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 38-46.

Nalini, A., Yamini, B.K., Gayatri, N., Thennarasu, K., Gope, R.(2006). Familial Madras motor neuron disease (FMMND): Study of 15 families from southern India . Journal of the Neurological Sciences. 250. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 140-146.

Thomas, R., Prabhu, P.D.A.H., Mathivanan, J., Rohini, Sivakumar, D., Jayakumar, P.N., Devi, B.I., Satish, S., Sastry, K.V.R., Gope, R.(2005). Altered structure and expression of RB1 gene and increased phosphorylation of pRb in human vestibular schwannomas . Molecular and Cellular Biochemistry. 271. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 113-121.

Gope, M.L., Gope, R.(2003). Effect of sodium butyrate on methylation pattern of retinoblastoma (RB1) gene in human colon tumour cell line HT29 . Current Science. 84. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 430-434.

Gope, R.(2002). The effect of epidermal growth factor & platelet-derived growth factors on wound healing process . Indian Journal of Medical Research. 116. (NOV.). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 201-206.

Gope, R., Gope, M.L., Gope, R., Gope, M.L.(1993). Effect of sodium butyrate on the expression of retinoblastoma (RB1) and P53 gene and phosphorylation of retinoblastoma protein in human colon tumor cell line HT29 . Cellular and Molecular Biology. 39. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 589-597.

Wildrick, D.M., Alfaro, S.R., Gope, R., Boman, B.M.(1992). A study of chromosome 6 allele loss in human colorectal carcinomas . Anticancer Research. 12. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1717-1719.

Gope, R., Gope, M.L.(1992). Abundance and state of phosphorylation of the retinoblastoma susceptibility gene product in human colon cancer . Molecular and Cellular Biochemistry. 110. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 123-133.

Gope, M.L., Chun, M., Gope, R.(1992). Comparative study of the expression Rb and p53 genes in human colorectal cancers, color carcinoma cell lines and synchronized human fibroblast . Molecular and Cellular Biochemistry. 110. (1).

Gope, M.L., Chun, M., Gope, R.(1991). Comparative study of the expression of Rb and p53 genes in human colorectal cancers, colon carcinoma cell lines and synchronized human fibroblasts . Molecular and Cellular Biochemistry. 107. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 55-63.

Gope, R., Gope, M.L., Thorson, A., Christensen, M., Smyrk, T., Chun, M., Alvarez, L., Wildrick, D.M., Boman, B.M.(1991). Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas . Anticancer Research. 11. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2047-2050.

Gope, M.L., Gope, R., Zarucki, T.(1991). Effect of dexamethasone and cycloheximide on the expression of amplified EGF-receptor gene in human A431 carcinoma cell line . Molecular and Cellular Biochemistry. 103. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 149-154.

Gope, R., Christensen, M.A., Thorson, A., Lynch, H.T., Smyrk, T., Hodgson, C., Wildrick, D.M., Gope, M.L., Boman, B.M.(1990). Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa . Journal of the National Cancer Institute. 82. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 310-314.

Dean, D.C., Gope, R., Knoll, B.J., Riser, M.E., O'Malley, B.W.(1984). A similar 5'-flanking region is required for estrogen and progesterone induction of ovalbumin gene expression . Journal of Biological Chemistry. 259. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9967-9970.

BOOK

Mitra, R., Gope, M.L., Gope, R.(2013). Personalized genome, current status, and the future of pharmacogenomics . Omics for Personalized Medicine. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 19-37.