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Profile Details
Contact
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USD 30 /hr
Hire Dr. Ragothaman Yennamalli
India
USD 30 /hr

Computational Biologist

Profile Summary
Subject Matter Expertise
Services
Work Experience

Assistant Professor

SASTRA University

December 2019 - Present

Senior Scientist

VivagenDX Labs

July 2019 - Present

Assistant Professor

Jaypee University of Information Technology

September 2015 - June 2019

Postdoctoral Research Associate

Rice University

September 2012 - June 2014

Postdoctoral Research Associate

University of Wisconsin Madison

October 2011 - September 2012

Postdoctoral Research Associate

Iowa State University

July 2009 - September 2011

Research Assistant

Jawaharlal Nehru University

October 2008 - February 2009

Education

Ph.D

Jawaharlal nehru university

July 2003 - July 2008

PhD (Center for Computational Biology and Bioinformatics)

Jawaharlal Nehru University

2003 - 2008

PG Diploma in Bioinformatics (Center for Computational Biology and Bioinformatics)

Jawaharlal Nehru University

2002 - 2003

M.Sc. Microbial Gene Technology (Microbial Technology)

Madurai Kamaraj University

2000 - 2002

B.Sc (Microbiology)

University of Madras

1997 - 2000

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Chatterjee J, Coe RA, Acebron K, Thakur V, Yennamalli RM, Danila F, Lin HC, Balahadia CP, Bagunu E, Padhmapreiya POS, et al.(2021). Identification of a low CO2 responsive mutant from chemical mutagenesis of Setaria viridis shows that reduced carbonic anhydrase severely limits C4 photosynthesis . Journal of experimental botany.
Sanjay Singh, Ragothaman M. Yennamalli, Manish Gupta, Harish Changotra(2020). Identification of nsSNPs of transcription factor E2F1 predisposing individuals to lung cancer and head and neck cancer . Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 821. p. 111704. Elsevier {BV}
Poonam Katoch, Kinam Gupta, Ragothaman M. Yennamalli, Jitendraa Vashistt, Gopal Singh Bisht, Rahul Shrivastava(2020). Random insertion transposon mutagenesis of Mycobacterium fortuitum identified mutant defective in biofilm formation . Biochemical and Biophysical Research Communications. Elsevier {BV}
Pulkit Anupam Srivastava, Eric L. Hegg, Brian G. Fox, Ragothaman M. Yennamalli(2020). PreDSLpmo: A neural network-based prediction tool for functional annotation of lytic polysaccharide monooxygenases . Journal of Biotechnology. 308. p. 148--155. Elsevier {BV}
Deepa Teotia, Mariam Gaid, Shashank S. Saini, Aparna Verma, Ragothaman M. Yennamalli, Satyajeet P. Khare, Kiran Ambatipudi, Javid Iqbal Mir, Till Beuerle, Robert Hänsch, et al.(2019). Cinnamate‐CoA ligase is involved in biosynthesis of benzoate‐derived biphenyl phytoalexin in Malus  ×  domestica ‘Golden Delicious’ cell cultures . The Plant Journal. Wiley
Singaraju GS, Sagar A, Kumar A, Samuel JS, Hazra JP, Sannigrahi MK, Yennamalli RM, Ashish F, Rakshit S(2019). Structural basis of the strong cell-cell junction formed by cadherin-23 . The FEBS journal.
Vijay Singh Gondil, Taru Dube, Jiban J. Panda, Ragothaman M. Yennamalli, Kusum Harjai, Sanjay Chhibber (2019). Comprehensive evaluation of chitosan nanoparticle based phage lysin delivery system; a novel approach to counter S. pneumoniae infections . International Journal of Pharmaceutics.
Singh D, Soni S, Khan S, Sarangi AN, Yennamalli RM, Aggarwal R, Veerapu NS(2019). Genome-wide mutagenesis of hepatitis C virus reveals genome ability to overcome detrimental mutations . Journal of virology.
Chauhan D, Srivastava PA, Ritzl B, Yennamalli RM, Cava F, Priyadarshini R(2019). Amino Acid-Dependent Alterations in Cell Wall and Cell Morphology of Deinococcus indicus DR1 . Frontiers in microbiology.
Poonam, Ragothaman M. Yennamalli, Gopal S. Bisht, Rahul Shrivastava(2019). Ribosomal maturation factor (RimP) is essential for survival of nontuberculous mycobacteria Mycobacterium fortuitum under in vitro acidic stress conditions . 3 Biotech. 9. (4). Springer Science and Business Media {LLC}
Deepika Chauhan, Pulkit A. Srivastava, Vidushi Agnihotri, Ragothaman M. Yennamalli, Richa Priyadarshini(2019). Structure and function prediction of arsenate reductase from Deinococcus indicus DR1 . Journal of Molecular Modeling. 25. (1). Springer Science and Business Media {LLC}
Mansi Arora, Ragothaman M. Yennamalli, Taner Z. Sen(2018). Application of Molecular Simulations Toward Understanding Cellulase Mechanisms . BioEnergy Research. 11. (4). p. 850--867. Springer Nature
Arora R, Bharval P, Sarswati S, Sen TZ, Yennamalli RM(2018). Structural dynamics of lytic polysaccharide monoxygenases reveals a highly flexible substrate binding region . Journal of molecular graphics & modelling.
Kumar A, Mehta V, Raj U, Varadwaj PK, Udayabanu M, Yennamalli RM, Singh TR(2018). Computational and in-vitro validation of natural molecules as potential Acetylcholinesterase inhibitors and neuroprotective agents . Current Alzheimer research.
Nancy Singh, Sunil Datt Sharma, Ragothaman M. Yennamalli(2017). Modified S-transform as a tool to identify secondary structure elements in RNA . Bio-Algorithms and Med-Systems. 0. (0). Walter de Gruyter {GmbH}
Chauhan D, Srivastava PA, Yennamalli RM, Priyadarshini R(2017). Draft Genome Sequence of Deinococcus indicus DR1, a Novel Strain Isolated from a Freshwater Wetland . Genome announcements.
Chauhan, D., Srivastava, P.A., Yennamalli, R.M., Priyadarshini, R.(2017). Draft genome sequence of Deinococcus indicus DR1, a novel strain isolated from a freshwater wetland . Genome Announcements. 5. (31). p. e00754-17.
Jones, D.C., Zheng, W., Huang, S., Du, C., Zhao, X., Yennamalli, R.M., Sen, T.Z., Nettleton, D., Wurtele, E.S., Li, L.(2016). A Clade-specific arabidopsis gene connects primary metabolism and senescence . Frontiers in Plant Science. 7. (JULY2016).
Chauhan, M., Yennamalli, R.M., Garlapati, V.K.(2016). Biochemical characterization and molecular modeling of a unique lipase from Staphylococcus arlettae JPBW-1 . Engineering in Life Sciences. 16. (8). p. 762-768.
Cao, H., Tan, K., Wang, F., Bigelow, L., Yennamalli, R.M., Jedrzejczak, R., Babnigg, G., Bingman, C.A., Joachimiak, A., Kharel, M.K., et al.(2016). Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate . Structural Dynamics. 3. (3).
Huang, T., Chang, C.-Y., Lohman, J.R., Rudolf, J.D., Kim, Y., Chang, C., Yang, D., Ma, M., Yan, X., Crnovcic, I., et al.(2016). Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027 . Journal of Antibiotics. 69. (10). p. 731-740.
Gautam, L.K., Yennamalli, R.M., Rathore, J.S.(2016). Implication on the function of novel Xn-relE toxin structure of xenorhabdus nematophila using homology modeling . Current Bioinformatics. 11. (3).
Chang, C.-Y., Lohman, J.R., Cao, H., Tan, K., Rudolf, J.D., Ma, M., Xu, W., Bingman, C.A., Yennamalli, R.M., Bigelow, L., et al.(2016). Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus . Biochemistry. 55. (36). p. 5142-5154.
Auldridge, M.E., Cao, H., Sen, S., Franz, L.P., Bingman, C.A., Yennamalli, R.M., Phillips, G.N., Mead, D., Steinmetz, E.J.(2015). LucY: A versatile new fluorescent reporter protein . PLoS ONE. 10. (4).
Weerth, R.S., Michalska, K., Bingman, C.A., Yennamalli, R.M., Li, H., Jedrzejczak, R., Wang, F., Babnigg, G., Joachimiak, A., Thomas, M.G., et al.(2015). Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 Å resolution . Proteins: Structure, Function and Bioinformatics. 83. (2). p. 383-388.
Singh, S., Michalska, K., Bigelow, L., Endres, M., Kharel, M.K., Babnigg, G., Yennamalli, R.M., Bingman, C.A., Joachimiak, A., Thorson, J.S., et al.(2015). Structural characterization of cals8, a tdp-α-d-glucose dehydrogenase involved in calicheamicin aminodideoxypentose biosynthesis . Journal of Biological Chemistry. 290. (43). p. 26249-26258.
Ilgu, M., Fulton, D.B., Yennamalli, R.M., Lamm, M.H., Sen, T.Z., Nilsen-Hamilton, M.(2014). An adaptable pentaloop defines a robust neomycin-B RNA aptamer with conditional ligand-bound structures . RNA. 20. (6). p. 815-824.
Book, A.J., Yennamalli, R.M., Takasuka, T.E., Currie, C.R., Phillips, G.N., Fox, B.G.(2014). Evolution of substrate specificity in bacterial AA10 lytic polysaccharide monooxygenases . Biotechnology for Biofuels. 7. (1).
Yennamalli, R., Arangarasan, R., Bryden, A., Gleicher, M., Phillips Jr., G.N.(2014). Using a commodity high-definition television for collaborative structural biology . Journal of Applied Crystallography. 47. (3). p. 1153-1157.
Elshahawi, S.I., Ramelot, T.A., Seetharaman, J., Chen, J., Singh, S., Yang, Y., Pederson, K., Kharel, M.K., Xiao, R., Lew, S., et al.(2014). Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19 . ACS Chemical Biology. 9. (10). p. 2347-2358.
Wang, F., Zhou, M., Singh, S., Yennamalli, R.M., Bingman, C.A., Thorson, J.S., Phillips, G.N.(2013). Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis . Proteins: Structure, Function and Bioinformatics. 81. (7). p. 1277-1282.
Yennamalli, R.M., Rader, A.J., Kenny, A.J., Wolt, J.D., Sen, T.Z.(2013). Endoglucanases: Insights into thermostability for biofuel applications . Biotechnology for Biofuels. 6. (1).
Rader, A.J., Yennamalli, R.M., Harter, A.K., Sen, T.Z.(2012). A rigid network of long-range contacts increases thermostability in a mutant endoglucanase . Journal of Biomolecular Structure and Dynamics. 30. (6). p. 628-637.
Yennamalli, R.M., Rader, A.J., Wolt, J.D., Sen, T.Z.(2011). Thermostability in endoglucanases is fold-specific . BMC Structural Biology. 11.
Khan, S.N., Yennamalli, R., Subbarao, N., Khan, A.U.(2011). Mitoxantrone Induced Impediment of Histone Acetylation and Structural Flexibility of the Protein . Cell Biochemistry and Biophysics. 60. (3). p. 209-218.
Yennamalli, R.M., Wolt, J.D., Sen, T.Z.(2011). Dynamics of endoglucanase catalytic domains: Implications towards thermostability . Journal of Biomolecular Structure and Dynamics. 29. (3). p. 509-526.
Yennamalli, R., Subbarao, N., Kampmann, T., McGeary, R.P., Young, P.R., Kobe, B.(2009). Identification of novel target sites and an inhibitor of the dengue virus E protein . Journal of Computer-Aided Molecular Design. 23. (6). p. 333-341.
Kampmann, T., Yennamalli, R., Campbell, P., Stoermer, M.J., Fairlie, D.P., Kobe, B., Young, P.R.(2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses . Antiviral Research. 84. (3). p. 234-241.
Vashist, J., Vishvanath, Kapoor, R., Kapil, A., Yennamalli, R., Subbarao, N., Rajeswari, M.R.(2009). Interaction of nalidixic acid and ciprofloxacin with wild type and mutated quinolone-resistance-determining region of DNA gyrase a . Indian Journal of Biochemistry and Biophysics. 46. (2). p. 147-153.
Das, S., Yennamalli, R.M., Vishnoi, A., Gupta, P., Bhattacharya, A.(2009). Single-nucleotide variations associated with Mycobacterium tuberculosis KwaZulu-Natal strains . Journal of Biosciences. 34. (3). p. 397-404.
Mueller, D.S., Kampmann, T., Yennamalli, R., Young, P.R., Kobe, B., Mark, A.E.(2008). Histidine protonation and the activation of viral fusion proteins . Biochemical Society Transactions. 36. (1). p. 43-45.
Khan, S.N., Islam, B., Yennamalli, R., Zia, Q., Subbarao, N., Khan, A.U.(2008). Characterization of doxorubicin binding site and drug induced alteration in the functionally important structural state of oxyhemoglobin . Journal of Pharmaceutical and Biomedical Analysis. 48. (4). p. 1096-1104.
Khan, S.N., Islam, B., Yennamalli, R., Sultan, A., Subbarao, N., Khan, A.U.(2008). Interaction of mitoxantrone with human serum albumin: Spectroscopic and molecular modeling studies . European Journal of Pharmaceutical Sciences. 35. (5). p. 371-382.
OTHER
Chauhan, Deepika; Srivastava, Pulkit Anupam; Agnihotri, Vidushi; Yennamalli, Ragothaman M; Priyadarshini, Richa (2019). Arsenate Reductase (ArsC) of Deinococcus indicus DR1 . modelarchive.org.
Singaraju GS, Kumar A, Samuel JS, Sagar A, Hazra JP, Sannigrahi MK, Yennamalli RM, Ashish FNU, Rakshit S(2017). Molecular mechanism of cell-cell adhesion mediated by cadherin-23 .
Yennamalli, Ragothaman;Chauhan, Mamta;Garlapati, Vijay Kumar (2016). Staphylococcus aureus Capsular Polysaccharide D . modelarchive.org.
Gautam, Lalit Kumar;Yennamalli, Ragothaman M;Rathore, Jitendra Singh (2016). Xenorhabdus nematophila RelE antitoxin . modelarchive.org.
Gautam, Lalit Kumar;Yennamalli, Ragothaman M;Rathore, Jitendra Singh (2016). Xenorhabdus nematophila RelE toxin . modelarchive.org.
Book, Adam J.;Yennamalli, Ragothaman M.;Takasuka, Taichi E.;Currie, Cameron R.;Phillips Jr., George N.;Fox, Brian G. (2014). Evolution of substrate specificity in bacterial AA10 lytic polysaccharide monooxygenases . modelarchive.org.
Book, Adam J.;Yennamalli, Ragothaman M.;Takasuka, Taichi E.;Currie, Cameron R.;Phillips Jr., George N.;Fox, Brian G. (2014). Evolution of substrate specificity in bacterial AA10 lytic polysaccharide monooxygenases . modelarchive.org.