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USD 120 /hr

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Hire Qingzhou Z.

Canada

USD 120 /hr

Computational Omics Consultant — scRNA-seq Audit, Multi-Omics Integration & Reproducibility

Profile Summary

I work at the intersection of computational omics and experimental reproducibility. My core focus is auditing single-cell and bulk genomics pipelines for statistical circularity — the kind that produces "significant" marker lists that can't replicate. I've traced this failure pattern across multiple lab pipelines. The fix is usually a redesign of the statistical framework: pseudobulk over pseudoreplication, donor-level replication over cell-level inflation, and a validation structure that doesn't just confirm the clustering algorithm's own partition. I take on projects in three areas: (1) scRNA-seq differential expression audit & validation, (2) multi-omics integration (transcriptomics + proteomics + epigenomics), and (3) custom pipeline design with reproducible reporting. Past engagements include pipeline audits for academic labs and R&D groups working in tumor immunology, neurodegeneration, and rare disease. Also available for fixed-price projects ($2,500+ depending on scope).

Subject Matter Expertise

• ☆ Biostatistics
• ☆ Data Analysis
• ☆ Machine Learning
• ☆ Deep Learning
• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Systems Biology

Services

• Consulting
• Data & AI

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Data Visualization, Big Data Analytics, Data Mining, Data Processing, Data Insights

Work Experience

Post Doctoral Fellow

Ottawa Hospital Research Institute

January 2021 - Present

Education

PhD Biochemistry (Chemistry and Biochemistry)

University of Regina

January 2016 - June 2021

MSc Computational Molecular Biology(Bioinformatics) (Faculty of Life Sciences)

University of Manchester

September 2009 - September 2010

BSc Biotechnology (School of Life Sciences)

Nanjing Agricultural University

September 2004 - June 2008

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2019). Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis . iScience.

(2018). Global landscape of cell envelope protein complexes in Escherichia coli . Nature Biotechnology.

(2017). Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione . Oncotarget.

(2017). A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling . Cell Systems.

Q. Zhang, B. Yang, X. Chen, J. Xu, C. Mei, Z. Mao(2014). Renal Gene Expression Database (RGED): a relational database of gene expression profiles in kidney disease . Database. 2014. (0). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString bau092--bau092. Oxford University Press ({OUP})

BOOK CHAPTER

(2019). A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes . Mitochondria in Health and in Sickness.