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Hire Dr. Pieter B.

United States

Profile Summary

I am a postdoctoral research scientist at Columbia University where I design and develop chemical probes and drug candidates for stem cell research. My specialty is synthetic organic chemistry with a strong focus on methodology development and homogenous catalysis. This specialty in synthetic chemistry is complemented by my familiarity with flow chemistry, and computational drug design techniques.

Subject Matter Expertise

• ☆ Chemistry
• ☆ Analytical Chemistry
• ☆ Flow Chemistry
• ☆ Organic Chemistry
• ☆ Medicinal Chemistry

Services

• Consulting
• Product Development

Work Experience

Senior Scientist II

Schrodinger LLC New York Office

April 2018 - Present

Associate Research Scientist

Columbia University

September 2016 - February 2018

Postdoctoral Research Scientist

Columbia University

September 2014 - August 2016

Postdoctoral Research Scientist

Boston University

March 2012 - August 2014

Education

PhD Chemistry (Chemistry)

Rijksuniversiteit Groningen

September 2007 - March 2012

MSc Chemistry (Chemistry)

Rijksuniversiteit Groningen

September 2004 - June 2007

BSc Chemistry (Chemistry)

Rijksuniversiteit Groningen

September 2001 - June 2004

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Bos, P.H., Lowry, E.R., Costa, J., Thams, S., Garcia-Diaz, A., Zask, A., Wichterle, H., Stockwell, B.R.(2019). Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents . Cell Chemical Biology. 26. (12). p. 1703-1715.e37.

Feng, H., Zhang, Y., Bos, P.H., Chambers, J.M., Dupont, M.M., Stockwell, B.R.(2019). K-Ras^G12D Has a Potential Allosteric Small Molecule Binding Site . Biochemistry. 58. (21). p. 2542-2554.

Shimada, K., Reznik, E., Stokes, M.E., Krishnamoorthy, L., Bos, P.H., Song, Y., Quartararo, C.E., Pagano, N.C., Carpizo, D.R., deCarvalho, A.C., et al.(2018). Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells . Cell Chemical Biology. 25. (5). p. 585-594.e7.

Gaschler, M.M., Andia, A.A., Liu, H., Csuka, J.M., Hurlocker, B., Vaiana, C.A., Heindel, D.W., Zuckerman, D.S., Bos, P.H., Reznik, E., et al.(2018). FINO<inf>2</inf> initiates ferroptosis through GPX4 inactivation and iron oxidation . Nature Chemical Biology. 14. (5). p. 507-515.

Hornillos V, Guduguntla S, Fañanás-Mastral M, Pérez M, Bos PH, Rudolph A, Harutyunyan SR, Feringa BL, Nature protocols, 2017, vol. 12, no. 3, pp. 493-505, 2017 .

(2017). Cu-catalyzed enantioselective allylic alkylation with organolithium reagents . Nature Protocols.

Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, Yang WS, Tong L, Olive KP, Ferrando A, Stockwell BR, Cell, 2017, vol. 168, no. 5, pp. 878-889.e29, 2017 .

Stork, G., Yamashita, A., Hanson, R.M., Phan, L., Phillips, E., Dub&#233;, D., Bos, P.H., Clark, A.J., Gough, M., Greenlee, M.L., et al.(2017). Synthetic study toward total synthesis of (±)-germine: Synthesis of (±)-4-methylenegermine . Organic Letters. 19. (19). p. 5150-5153.

Welsch, M.E., Kaplan, A., Chambers, J.M., Stokes, M.E., Bos, P.H., Zask, A., Zhang, Y., Sanchez-Martin, M., Badgley, M.A., Huang, C.S., et al.(2017). Multivalent Small-Molecule Pan-RAS Inhibitors . Cell. 168. (5). p. 878-889.e29.

Hornillos, V., Guduguntla, S., Fa&#241;an&#225;s-Mastral, M., P&#233;rez, M., Bos, P.H., Rudolph, A., Harutyunyan, S.R., Feringa, B.L.(2017). Cu-catalyzed enantioselective allylic alkylation with organolithium reagents . Nature Protocols. 12. (3). p. 493-505.

Pizzolato, S.F., Giannerini, M., Bos, P.H., Fa&#241;an&#225;s-Mastral, M., Feringa, B.L.(2015). Catalyst-controlled reverse selectivity in C-C bond formation: NHC-Cu-catalyzed α-selective allylic alkylation with organolithium reagents . Chemical Communications. 51. (38). p. 8142-8145.

Bos, P.H., Antalek, M.T., Porco, J.A., Stephenson, C.R.J.(2013). Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity . Journal of the American Chemical Society. 135. (47). p. 17978-17982.

Fa&#241;an&#225;s-Mastral, M., P&#233;rez, M., Bos, P.H., Rudolph, A., Harutyunyan, S.R., Feringa, B.L.(2012). Enantioselective synthesis of tertiary and quaternary stereogenic centers: Copper/phosphoramidite-catalyzed allylic alkylation with organolithium reagents . Angewandte Chemie - International Edition. 51. (8). p. 1922-1925.

Bos, P.H., Rudolph, A., P&#233;rez, M., Fa&#241;an&#225;s-Mastral, M., Harutyunyan, S.R., Feringa, B.L.(2012). Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with organolithium reagents . Chemical Communications. 48. (12). p. 1748-1750.

P&#233;rez, M., Fa&#241;an&#225;s-Mastral, M., Hornillos, V., Rudolph, A., Bos, P.H., Harutyunyan, S.R., Feringa, B.L.(2012). Asymmetric allylic alkylation of acyclic allylic ethers with organolithium reagents . Chemistry - A European Journal. 18. (38). p. 11880-11883.

P&#233;rez, M., Fa&#241;an&#225;s-Mastral, M., Bos, P.H., Rudolph, A., Harutyunyan, S.R., Feringa, B.L.(2011). Catalytic asymmetric carbong-carbon bond formation via allylic alkylations with organolithium compounds . Nature Chemistry. 3. (5). p. 377-381.

Rudolph, A., Bos, P.H., Meetsma, A., Minnaard, A.J., Feringa, B.L.(2011). Catalytic asymmetric conjugate addition/oxidative dearomatization towards multifunctional spirocyclic compounds . Angewandte Chemie - International Edition. 50. (26). p. 5834-5838.

Bos, P.H., Bos, P.H., Maci&#225;, B., &#193;ngeles Fern&#225;ndez-Ib&#225;&#241;ez, M., Minnaard, A.J., Feringa, B.L.(2010). Catalytic asymmetric conjugate addition of dialkylzinc reagents to α,β-unsaturated sulfones . Organic and Biomolecular Chemistry. 8. (1). p. 47-49.

Bos, P.H., Minnaard, A.J., Feringa, B.L.(2008). Catalytic asymmetric conjugate addition of Grignard reagents to α,β-unsaturated sulfones . Organic Letters. 10. (19). p. 4219-4222.

Naito, J., Kuwahara, S., Watanabe, M., Decatur, J., Bos, P.H., Van Summeren, R.P., Ter Horst, B., Feringa, B.L., Minnaard, A.J., Harada, N.(2008). Stereoselective synthesis of 2,3,7-trimethylcyclooctanone and related compounds and determination of their relative and absolute contigurations by the MαNP acid method . Chirality. 20. (9). p. 1053-1065.