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Hire Dr. Pieter B.

United States

Profile Summary

I am a postdoctoral research scientist at Columbia University where I design and develop chemical probes and drug candidates for stem cell research. My specialty is synthetic organic chemistry with a strong focus on methodology development and homogenous catalysis. This specialty in synthetic chemistry is complemented by my familiarity with flow chemistry, and computational drug design techniques.

Subject Matter Expertise

• ☆ Chemistry
• ☆ Analytical Chemistry
• ☆ Flow Chemistry
• ☆ Organic Chemistry
• ☆ Medicinal Chemistry

Services

• Consulting
• Product Development

Work Experience

Senior Scientist II

Schrodinger LLC New York Office

April 2018 - Present

Associate Research Scientist

Columbia University

September 2016 - February 2018

Postdoctoral Research Scientist

Columbia University

September 2014 - August 2016

Postdoctoral Research Scientist

Boston University

March 2012 - August 2014

Education

PhD Chemistry (Chemistry)

Rijksuniversiteit Groningen

September 2007 - March 2012

MSc Chemistry (Chemistry)

Rijksuniversiteit Groningen

September 2004 - June 2007

BSc Chemistry (Chemistry)

Rijksuniversiteit Groningen

September 2001 - June 2004

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Bos, P.H., Lowry, E.R., Costa, J., Thams, S., Garcia-Diaz, A., Zask, A., Wichterle, H., Stockwell, B.R.(2019). Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents . Cell Chemical Biology. 26. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1703-1715.e37.

Feng, H., Zhang, Y., Bos, P.H., Chambers, J.M., Dupont, M.M., Stockwell, B.R.(2019). K-Ras^G12D Has a Potential Allosteric Small Molecule Binding Site . Biochemistry. 58. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2542-2554.

Shimada, K., Reznik, E., Stokes, M.E., Krishnamoorthy, L., Bos, P.H., Song, Y., Quartararo, C.E., Pagano, N.C., Carpizo, D.R., deCarvalho, A.C., et al.(2018). Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells . Cell Chemical Biology. 25. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 585-594.e7.

Gaschler, M.M., Andia, A.A., Liu, H., Csuka, J.M., Hurlocker, B., Vaiana, C.A., Heindel, D.W., Zuckerman, D.S., Bos, P.H., Reznik, E., et al.(2018). FINO<inf>2</inf> initiates ferroptosis through GPX4 inactivation and iron oxidation . Nature Chemical Biology. 14. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 507-515.

Hornillos V, Guduguntla S, Fañanás-Mastral M, Pérez M, Bos PH, Rudolph A, Harutyunyan SR, Feringa BL, Nature protocols, 2017, vol. 12, no. 3, pp. 493-505, 2017 .

(2017). Cu-catalyzed enantioselective allylic alkylation with organolithium reagents . Nature Protocols.

Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, Yang WS, Tong L, Olive KP, Ferrando A, Stockwell BR, Cell, 2017, vol. 168, no. 5, pp. 878-889.e29, 2017 .

Stork, G., Yamashita, A., Hanson, R.M., Phan, L., Phillips, E., Dub&#233;, D., Bos, P.H., Clark, A.J., Gough, M., Greenlee, M.L., et al.(2017). Synthetic study toward total synthesis of (±)-germine: Synthesis of (±)-4-methylenegermine . Organic Letters. 19. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5150-5153.

Welsch, M.E., Kaplan, A., Chambers, J.M., Stokes, M.E., Bos, P.H., Zask, A., Zhang, Y., Sanchez-Martin, M., Badgley, M.A., Huang, C.S., et al.(2017). Multivalent Small-Molecule Pan-RAS Inhibitors . Cell. 168. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 878-889.e29.

Hornillos, V., Guduguntla, S., Fa&#241;an&#225;s-Mastral, M., P&#233;rez, M., Bos, P.H., Rudolph, A., Harutyunyan, S.R., Feringa, B.L.(2017). Cu-catalyzed enantioselective allylic alkylation with organolithium reagents . Nature Protocols. 12. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 493-505.

Pizzolato, S.F., Giannerini, M., Bos, P.H., Fa&#241;an&#225;s-Mastral, M., Feringa, B.L.(2015). Catalyst-controlled reverse selectivity in C-C bond formation: NHC-Cu-catalyzed α-selective allylic alkylation with organolithium reagents . Chemical Communications. 51. (38). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8142-8145.

Bos, P.H., Antalek, M.T., Porco, J.A., Stephenson, C.R.J.(2013). Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity . Journal of the American Chemical Society. 135. (47). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 17978-17982.

Fa&#241;an&#225;s-Mastral, M., P&#233;rez, M., Bos, P.H., Rudolph, A., Harutyunyan, S.R., Feringa, B.L.(2012). Enantioselective synthesis of tertiary and quaternary stereogenic centers: Copper/phosphoramidite-catalyzed allylic alkylation with organolithium reagents . Angewandte Chemie - International Edition. 51. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1922-1925.

Bos, P.H., Rudolph, A., P&#233;rez, M., Fa&#241;an&#225;s-Mastral, M., Harutyunyan, S.R., Feringa, B.L.(2012). Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with organolithium reagents . Chemical Communications. 48. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1748-1750.

P&#233;rez, M., Fa&#241;an&#225;s-Mastral, M., Hornillos, V., Rudolph, A., Bos, P.H., Harutyunyan, S.R., Feringa, B.L.(2012). Asymmetric allylic alkylation of acyclic allylic ethers with organolithium reagents . Chemistry - A European Journal. 18. (38). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 11880-11883.

P&#233;rez, M., Fa&#241;an&#225;s-Mastral, M., Bos, P.H., Rudolph, A., Harutyunyan, S.R., Feringa, B.L.(2011). Catalytic asymmetric carbong-carbon bond formation via allylic alkylations with organolithium compounds . Nature Chemistry. 3. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 377-381.

Rudolph, A., Bos, P.H., Meetsma, A., Minnaard, A.J., Feringa, B.L.(2011). Catalytic asymmetric conjugate addition/oxidative dearomatization towards multifunctional spirocyclic compounds . Angewandte Chemie - International Edition. 50. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5834-5838.

Bos, P.H., Bos, P.H., Maci&#225;, B., &#193;ngeles Fern&#225;ndez-Ib&#225;&#241;ez, M., Minnaard, A.J., Feringa, B.L.(2010). Catalytic asymmetric conjugate addition of dialkylzinc reagents to α,β-unsaturated sulfones . Organic and Biomolecular Chemistry. 8. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 47-49.

Bos, P.H., Minnaard, A.J., Feringa, B.L.(2008). Catalytic asymmetric conjugate addition of Grignard reagents to α,β-unsaturated sulfones . Organic Letters. 10. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4219-4222.

Naito, J., Kuwahara, S., Watanabe, M., Decatur, J., Bos, P.H., Van Summeren, R.P., Ter Horst, B., Feringa, B.L., Minnaard, A.J., Harada, N.(2008). Stereoselective synthesis of 2,3,7-trimethylcyclooctanone and related compounds and determination of their relative and absolute contigurations by the MαNP acid method . Chirality. 20. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1053-1065.