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Hire Piero P.

Italy

Profile Summary

Currently I am concerned with development of tools for cancer diagnosis and therapy, based on the discovery of novel cancer markers and therapeutic targets. The identification, validation and biological characterization of novel cancer markers that are candidate to be novel therapeutic targets, are performed with a reverse-proteomic approach. Moreover the generation of marker-specific monoclonal antibodies and the characterization of their diagnostic/therapeutic properties are actively pursued. The study performed so far led to the identification of 89 novel tumour-associated proteins over-expressed in the prevalent human cancers. Furthermore, among these last, there is a subset of candidate markers with potential diagnostic and therapeutic activity. Monoclonal antibodies against the lead candidates are under evaluation for their possible clinical applications. Investigator at Sclavo, Chiron and Novartis Vaccines Research Laboratories (Siena, Italy). During this period I have been involved in several research projects for the development of vaccines against diseases caused by various pathogenic microorganisms, including Bordetella pertussis, Helicobacter pylori, SARS and HCV. One of these activities led to the marketing of innovative recombinant vaccine against whooping cough (pertussis). I have also been involved in cellular and molecular immunology studies aimed to elucidate general mechanisms of immune cell activation and effector functions. This led to publications concerning bystander activation and helper functions of lymphocytes by cytokine combinations. Furthermore I had a key role in studies focused on the identification and characterization of CD81 as a cellular receptor for HCV (for this study I generated and screened several expression libraries in bacteria/phage and mammalian cells). I conceived and performed studies aimed to assess the relevance of exosomes-mediated cellular trafficking of both CD81 and HCV envelope glycoproteins in cultured cells in vitro and its involvement in HCV infection mechanisms. In addition I developed HCV pseudoparticles from several HCV genotypes and set-up neutralization assays suitable for the analysis of the immune response in clinical trials. Visiting scientist at University of Birmingham (Birmingham, UK) Immunology and Immunotherapy Institute Development of tools for in vitro investigation about the entry of the Hepatitis C Virus (HCV) in human cells. To this aim HCV pseudoparticles mimicking the virus were produced by incorporation of the full-length hepatitis C virus glycoproteins onto lentiviral core particles and subsequently used to test the neutralizing activity of immune sera and monoclonal antibody. Visiting scientist Chiron Vaccine (Emeryville, CA, USA) Identification of cell determinants important for Hepatitis C virus entry in human cell lines. I conceived and performed critical experiments for the demonstration that the large extracellular loop of CD81 binds Hepatitis C Virus and neutralization of HCV binding by immune serum. Visiting scientist at Basel University, (Basel, Switzerland) Immunology Department Involved in studies aimed to assess the relevance of γ/δ T cells in multiple sclerosis (MS) starting from the analysis of the T cell receptor - γ/δ- repertoire and the antigen reactivity of γ/δ clones isolated from cerebrospinal fluid. Young scientist at Sclavo Research Centre, (Siena, Italy) Laboratory of Immunopharmacology Involved in studies aimed to characterize and develop a nontoxic mutant of pertussis toxin (PT) obtained by genetic manipulation with the final purpose to obtain new vaccine against whooping cough.

Subject Matter Expertise

• ☆ Molecular Engineering
• ☆ Microbiology
• ☆ Virology
• ☆ Molecular Biology
• ☆ Monoclonal Antibody Production
• ☆ Adjuvant & Antigen Research
• ☆ Antibody Engineering
• ☆ Vaccine Development
• ☆ Hepatitis
• ☆ Severe Acute Respiratory Syndrome (SARS)
• ☆ Immunotherapy
• ☆ Sclerosis & Demyelinating Diseases

Services

• Writing
• Consulting
• Product Development

Work Experience

Senior scientist

Externautics

October 2008 - Present

Adjunct Professor of Molecular Biology

University of Siena (Siena, Italy)

September 2007 - October 2009

Principal scientist

Novartis Vaccines

April 2006 - September 2008

Research scientist

Chiron

April 1992 - April 2006

Young scientist

Sclavo Research Centre, (Siena, Italy)

November 1987 - April 1992

Education

Education details not provided.

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2018). Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer . Journal of Controlled Release.

(2018). Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer . Journal of Controlled Release.

Grifantini, R., Taranta, M., Gherardini, L., Naldi, I., Parri, M., Grandi, A., Giannetti, A., Tombelli, S., Lucarini, G., Ricotti, L., et al.(2018). Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer . Journal of Controlled Release. 280. p. 76-86.

Oncotarget. 2017; 8:95256-95269 .

Cano-Rodriguez, D., Campagnoli, S., Grandi, A., Parri, M., De Camilli, E., Cano-Rodriguez, D., Campagnoli, S., Grandi, A., Parri, M., De Camilli, E., et al.(2017). TCTN2: A novel tumor marker with oncogenic properties . Oncotarget. 8. (56). p. 95256-95269.

Cano-Rodriguez, D., Campagnoli, S., Grandi, A., Parri, M., De Camilli, E., Song, C., Jin, B., Lacombe, A., Pierleoni, A., Bombaci, M., et al.(2017). TCTN2: A novel tumor marker with oncogenic properties . Oncotarget. 8. (56). p. 95256-95269.

Pileri, Piero, Grandi, Alberto, Santi, Alice, Campagnoli, Susanna, Parri, Matteo, De Camilli, Elisa, Song, Chaojun, Jin, Boquan, Lacombe, Aurelien, Castori-Eppenberger, Serenella, et al.(2016). ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer . Oncotarget.

Grandi, A., Santi, A., Campagnoli, S., Parri, M., De Camilli, E., Song, C., Jin, B., Lacombe, A., Castori-Eppenberger, S., Sarmientos, P., et al.(2016). ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer . Oncotarget. 7. (39). p. 63596-63610.

Pileri, Piero, Campagnoli, Susanna, Grandi, Alberto, Parri, Matteo, De Camilli, Elisa, Song, Chaojun, Ganfini, Luisa, Lacombe, Aurelien, Naldi, Ilaria, Sarmientos, Paolo, et al.(2016). FAT1: a potential target for monoclonal antibody therapy in colon cancer . British journal of cancer. 115. (1). p. 40-51.

Pileri, P., Campagnoli, S., Grandi, A., Parri, M., De Camilli, E., Song, C., Ganfini, L., Lacombe, A., Naldi, I., Sarmientos, P., et al.(2016). FAT1: A potential target for monoclonal antibody therapy in colon cancer . British Journal of Cancer. 115. (1). p. 40-51.

Pileri, Piero, Fan, Li, Campagnoli, Susanna, Wu, Hong, Grandi, Alberto, Parri, Matteo, De Camilli, Elisa, Grandi, Guido, Viale, Giuseppe, Grifantini, Renata, et al.(2015). Negatively charged AuNP modified with monoclonal antibody against novel tumor antigen FAT1 for tumor targeting . Journal of experimental & clinical cancer research : CR. 34. p. 103.

Fan, L., Campagnoli, S., Wu, H., Grandi, A., Parri, M., De Camilli, E., Grandi, G., Viale, G., Pileri, P., Grifantini, R., et al.(2015). Negatively charged AuNP modified with monoclonal antibody against novel tumor antigen FAT1 for tumor targeting . Journal of Experimental and Clinical Cancer Research. 34. (1).

Pileri, Piero, Parri, Matteo, Pietrovito, Laura, Grandi, Alberto, Campagnoli, Susanna, De Camilli, Elisa, Bianchini, Francesca, Marchiò, Serena, Bussolino, Federico, Jin, Boquan, et al.(2014). Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer . Angiogenesis. 17. (4). p. 881-896.

Parri, M., Pietrovito, L., Grandi, A., Campagnoli, S., De Camilli, E., Bianchini, F., Marchiò, S., Bussolino, F., Jin, B., Sarmientos, P., et al.(2014). Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer . Angiogenesis. 17. (4). p. 881-896.

Pileri, Piero, Grifantini, Renata, Pagani, Massimiliano, Pierleoni, Andrea, Grandi, Alberto, Parri, Matteo, Campagnoli, Susanna, Cattaneo, Davide, Canidio, Elena, Pontillo, Angela, et al.(2011). A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins . Journal of Proteomics. 75. (2). p. 532-547.

Grifantini, R., Pagani, M., Pierleoni, A., Grandi, A., Parri, M., Campagnoli, S., Pileri, P., Cattaneo, D., Canidio, E., Pontillo, A., et al.(2011). A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins . Journal of Proteomics. 75. (2). p. 532-547.

Pileri, Piero, Frey, Sharon E., Houghton, Michael, Coates, Stephen, Abrignani, Sergio, Chien, David, Rosa, Domenico, Ray, Ranjit, Di Bisceglie, Adrian M., Rinella, Paola, et al.(2010). Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults . Vaccine. 28. (38). p. 6367-6373.

Frey, S.E., Houghton, M., Coates, S., Abrignani, S., Chien, D., Rosa, D., Pileri, P., Ray, R., Di Bisceglie, A.M., Rinella, P., et al.(2010). Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults . Vaccine. 28. (38). p. 6367-6373.

Masciopinto, F., Giovani, C., Campagnoli, S., Galli-Stampino, L., Colombatto, P., Brunetto, M., Yen, T.S.B., Houghton, M., Pileri, P., Abrignani, S.(2004). Association of hepatitis C virus envelope proteins with exosomes . European Journal of Immunology. 34. (10). p. 2834-2842.

Pileri, Piero, Song, Hyun Chul, Seo, Mi-Young, Stadler, Konrad, Yoo, Byoung J., Choo, Qui-Lim, Coates, Stephen R., Uematsu, Yasushi, Harada, Takashi, Greer, Catherine E., et al.(2004). Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein . Journal of virology. 78. (19). p. 10328-35.

Song, H.C., Seo, M.-Y., Stadler, K., Yoo, B.J., Choo, Q.-L., Coates, S.R., Uematsu, Y., Harada, T., Greer, C.E., Polo, J.M., et al.(2004). Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein . Journal of Virology. 78. (19). p. 10328-10335.

Pileri, Piero, Masciopinto, Francesca, Giovani, Cinzia, Campagnoli, Susanna, Galli-Stampino, Luisa, Colombatto, Piero, Brunetto, Maurizia, Yen, T. S. Benedict, Houghton, Michael, Abrignani, Sergio(2004). Association of hepatitis C virus envelope proteins with exosomes . European journal of immunology. 34. (10). p. 2834-42.

Masciopinto, F., Campagnoli, S., Abrignani, S., Uematsu, Y., Pileri, P.(2001). The small extracellular loop of CD81 is necessary for optimal surface expression of the large loop, a putative HCV receptor . Virus research. 80. (1-2). p. 1-10.

Masciopinto, F., Campagnoli, S., Abrignani, S., Uematsu, Y., Pileri, P.(2001). The small extracellular loop of CD81 is necessary for optimal surface expression of the large loop, a putative HCV receptor . Virus Research. 80. (1-2). p. 1-10.

Hadlock, K. G., Lanford, R. E., Perkins, S., Rowe, J., Yang, Q., Levy, S., Pileri, P., Abrignani, S., Foung, S. K.(2000). Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes . Journal of virology. 74. (22). p. 10407-16.

Hadlock, K.G., Lanford, R.E., Perkins, S., Rowe, J., Yang, Q., Levy, S., Pileri, P., Abrignani, S., Foung, S.K.H.(2000). Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes . Journal of Virology. 74. (22). p. 10407-10416.

Pileri, P., Uematsu, Y., Campagnoli, S., Galli, G., Falugi, F., Petracca, R., Weiner, A.J., Houghton, M., Rosa, D., Grandi, G., et al.(1998). Binding of hepatitis C virus to CD81 . Science. 282. (5390). p. 938-941.

Pileri, P., Uematsu, Y., Campagnoli, S., Galli, G., Falugi, F., Petracca, R., Weiner, A. J., Houghton, M., Rosa, D., Grandi, G., et al.(1998). Binding of hepatitis C virus to CD81 . Science (New York, N.Y.). 282. (5390). p. 938-41.

Rosa, D., Campagnoli, S., Moretto, C., Guenzi, E., Cousens, L., Chin, M., Dong, C., Weiner, A. J., Lau, J. Y., Choo, Q. L., et al.(1996). A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells . Proceedings of the National Academy of Sciences of the United States of America. 93. (5). p. 1759-63.

Rosa, D., Campagnoli, S., Moretto, C., Guenzi, E., Cousens, L., Chin, M., Dong, C., Weiner, A.J., Lau, J.Y.N., Choo, Q.-L., et al.(1996). A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: Cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells . Proceedings of the National Academy of Sciences of the United States of America. 93. (5). p. 1759-1763.

Nick, S., Pileri, P., Tongiani, S., Uematsu, Y., Kappos, L., De Libero, G.(1995). T cell receptor γδ repertoire is skewed in cerebrospinal fluid of multiple sclerosis patients: molecular and functional analyses of antigen‐reactive γδ clones . European Journal of Immunology. 25. (2). p. 355-363.

Di Tommaso, A., Xiang, Z., Bugnoli, M., Pileri, P., Figura, N., Bayeli, P. F., Rappuoli, R., Abrignani, S., De Magistris, M. T.(1995). Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies . Infection and immunity. 63. (3). p. 1102-6.

Nick, S., Pileri, P., Tongiani, S., Uematsu, Y., Kappos, L., De Libero, G.(1995). T cell receptor gamma delta repertoire is skewed in cerebrospinal fluid of multiple sclerosis patients: molecular and functional analyses of antigen-reactive gamma delta clones . European journal of immunology. 25. (2). p. 355-63.

Di Tommaso, A., Xiang, Z., Bugnoli, M., Pileri, P., Figura, N., Bayeli, P.F., Rappuoli, R., Abrignani, S., De Magistris, M.T.(1995). Helicobacter pylori-specific CD4⁺ T-cell clones from peripheral blood and gastric biopsies . Infection and Immunity. 63. (3). p. 1102-1106.

Unutmaz, D., Pileri, P., Abrignani, S.(1994). Antigen-independent activation of naive and memory resting T cells by a cytokine combination . Journal of Experimental Medicine. 180. (3). p. 1159-1164.

Unutmaz, D., Pileri, P., Abrignani, S.(1994). Antigen-independent activation of naive and memory resting T cells by a cytokine combination . Journal of Experimental Medicine. 180. (3). p. 1159-1164.

Minutello, M. A., Pileri, P., Unutmaz, D., Censini, S., Kuo, G., Houghton, M., Brunetto, M. R., Bonino, F., Abrignani, S.(1993). Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C . The Journal of experimental medicine. 178. (1). p. 17-25.

Minutello, M.A., Pileri, P., Unutmaz, D., Censini, S., Kuo, G., Houghton, M., Brunetto, M.R., Bonino, F., Abrignani, S.(1993). Compartmentalization of T lymphocytes to the site of disease: Intrahepatic CD4⁺ T cells specific for the protein NS4 of Hepatitis C virus in patients with chronic Hepatitis C . Journal of Experimental Medicine. 178. (1). p. 17-25.

Rappuoli, R., Pizza, M., Bugnoli, M., Manetti, R., Olivieri, R., Vanni, R., Pileri, P., Marsili, I., Nencioni, L.(1991). A new recombinant acellular pertussis vaccine,SVILUPPO DI UN NUOVO VACCINO RICOMBINANTE CONTRO LA PERTOSSE . Giornale di Malattie Infettive e Parassitarie. 43. (8). p. 748-753.

Verdini, A. S., Silvestri, S., Becherucci, C., Longobardi, M. G., Parente, L., Peppoloni, S., Perretti, M., Pileri, P., Pinori, M., Viscomi, G. C.(1991). Immunostimulation by a partially modified retro-inverso-tuftsin analogue containing Thr1 psi[NHCO](R,S)Lys2 modification . Journal of medicinal chemistry. 34. (12). p. 3372-9.

Verdini, A.S., Pinori, M., Silvestri, S., Becherucci, C., Longobardi, M.G., Parente, L., Peppoloni, S., Perretti, M., Pileri, P., Viscomi, G.C., et al.(1991). Immunostimulation by a Partially Modified retro -in verso -Tuftsin Analogue Containing Thr¹ψ[NHCO](R,S)Lys² Modification . Journal of Medicinal Chemistry. 34. (12). p. 3372-3379.

Podda, A., Nencioni, L., Teresa De Magistris, M., Tommaso, A.D., Bossù, P., Nuti, S., Pileri, P., Peppoloni, S., Bugnoli, M., Ruggiero, P., et al.(1990). Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT9K/129G . Journal of Experimental Medicine. 172. (3). p. 861-868.

Podda, A., Nencioni, L., De Magistris, M. T., Di Tommaso, A., Bossù, P., Nuti, S., Pileri, P., Peppoloni, S., Bugnoli, M., Ruggiero, P.(1990). Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G . The Journal of experimental medicine. 172. (3). p. 861-868.

Nencioni, L., Pizza, M., Bugnoli, M., De Magistris, T., Di Tommaso, A., Giovannoni, F., Manetti, R., Marsili, I., Matteucci, G., Nucci, D., et al.(1990). Characterization of genetically inactivated pertussis toxin mutants: candidates for a new vaccine against whooping cough . Infection and Immunity. 58. (5). p. 1308-1315.

PATENT

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2017). Breast Tumor Markers And Methods Of Use Thereof . US 2017/0227543 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2016). Colon And Rectal Tumor Markers And Methods Of Use Thereof . EP 2494351 B1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2016). Lung Tumor Markers And Methods Of Use Thereof . EP 2493916 B1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2016). Ovary Tumor Markers And Methods Of Use Thereof . EP 2494361 B1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2016). Prostate Tumor Markers And Methods Of Use Thereof . EP 2494362 B1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Boquan Jin(2016). Tumor Marker, Monoclonal Antibodies And Methods Of Use Thereof . US 2016/0131656 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Boquan Jin(2016). Tumor Marker, Monoclonal Antibodies And Methods Of Use Thereof . EP 3008086 A2

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2015). Tumor Markers And Methods Of Use Thereof . US 9182404 B2

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2015). Prostate Tumor Markers And Methods Of Use Thereof . US 2015/0093396 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2014). Prostate Tumor Markers And Methods Of Use Thereof . US 8921058 B2

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Boquan Jin(2014). Tumor Marker, Monoclonal Antibodies And Methods Of Use Thereof . WO 2014/198919 A2

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Parri Matteo, Grandi Alberto, Pierleoni Andrea(2013). Tumor Marker And Methods Of Use Thereof . US 2013/0137106 A1

Pileri Piero, Abrignani Sergio(2013). Μεθοδος Για Την Παρασκευη Καθαρισμενου Hcv Rna Με Διαχωρισμο Εξωσωματων . CY 1107521 T1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Parri Matteo, Grandi Alberto, Pierleoni Andrea(2013). Tumor Marker And Methods Of Use Thereof . EP 2564199 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2013). Colon And Rectal Tumor Markers And Methods Of Use Thereof . US 2013/0022983 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2013). Breast Tumor Markers And Methods Of Use Thereof . US 2013/0017546 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2013). Ovary Tumor Markers And Methods Of Use Thereof . US 2013/0004955 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2012). Lung Tumor Markers And Methods Of Use Thereof . US 2012/0322075 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2012). Prostate Tumor Markers And Methods Of Use Thereof . US 2012/0322074 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2012). Breast Tumor Markers And Methods Of Use Thereof . EP 2493917 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2012). Lung Tumor Markers And Methods Of Use Thereof . EP 2493916 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2012). Ovary Tumor Markers And Methods Of Use Thereof . EP 2494361 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2012). Colon And Rectal Tumor Markers And Methods Of Use Thereof . EP 2494351 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2012). Prostate Tumor Markers And Methods Of Use Thereof . EP 2494362 A2

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2012). Tumor Markers And Methods Of Use Thereof . US 2012/0052071 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2012). Tumor Markers And Methods Of Use Thereof . US 2012/0045439 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Parri Matteo, Grandi Alberto, Pierleoni Andrea(2011). Tumor Marker And Methods Of Use Thereof . WO 2011/135068 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Parri Matteo, Grandi Alberto, Pierleoni Andrea(2011). Tumor Marker And Methods Of Use Thereof . EP 2383578 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2011). Tumor Markers And Methods Of Use Thereof . EP 2382239 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2011). Tumor Markers And Methods Of Use Thereof . EP 2382473 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2011). Ovary Tumor Markers And Methods Of Use Thereof . WO 2011/051280 A8

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2011). Prostate Tumor Markers And Methods Of Use Thereof . WO 2011/051271 A2

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2011). Ovary Tumor Markers And Methods Of Use Thereof . WO 2011/051280 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2011). Breast Tumor Markers And Methods Of Use Thereof . WO 2011/051277 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2011). Lung Tumor Markers And Methods Of Use Thereof . WO 2011/051278 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Grandi Alberto, Parri Matteo, Pierleoni Andrea, Nogarotto Renzo(2011). Colon And Rectal Tumor Markers And Methods Of Use Thereof . WO 2011/051276 A1

Pileri Piero, Abrignani Sergio(2011). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . CA 2392075 C

Pileri Piero, Abrignani Sergio(2010). Preparation Of Purified Exosomes Comprising Hcv Rna . US 7807438 B2

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2010). Tumor Markers And Methods Of Use Thereof . WO 2010/086163 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2010). Tumor Markers And Methods Of Use Thereof . WO 2010/086162 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2010). Tumor Markers And Methods Of Use Thereof . EP 2213686 A1

Pileri Piero, Grifantini Renata, Campagnoli Susanna, Pierleoni Andrea, Nogarotto Renzo(2010). Tumor Markers And Methods Of Use Thereof . EP 2214019 A1

Pileri Piero, Abrignani Sergio(2008). Procedimiento Para La Preparacion De Arn De Vhc Purificado Por Separacion De Exosomas . ES 2292489 T3

Pileri Piero, Abrignani Sergio(2007). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . US 2007/0254351 A1

Pileri Piero, Abrignani Sergio(2007). Verfahren Zur Herstellung Von Gereinigtem Hcv Rna Durch Isolierung Von Exosomen . DE 60036403 D1

Pileri Piero, Abrignani Sergio(2007). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . EP 1230347 B1

Pileri Piero, Abrignani Sergio(2007). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . US 7198923 B1

Pileri Piero, Abrignani Sergio(2002). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . EP 1230347 A1

Pileri Piero, Abrignani Sergio(2001). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . AU 2001/017218 A

Pileri Piero, Abrignani Sergio(2001). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . CA 2392075 A1

Pileri Piero, Abrignani Sergio(2001). Method For The Preparation Of Purified Hcv Rna By Exosome Separation . WO 2001/036601 A1

Pileri Piero, Nencioni Luciano, Peppoloni Samuele, Silvestri Sergio(1996). Composition For Vaccines . CA 1338318 C

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Pileri Piero, Nencioni Luciano, Peppoloni Samuele, Silvestri Sergio(1994). Tuftsin-analoge Und Impfstoffe, Die Diese Analoge Als Adjuvantien Enthalten . DE 68917907 D1

Pileri Piero, Nencioni Luciano, Peppoloni Samuele, Silvestri Sergio(1994). Tuftsin Analogues And Vaccines Containing These As Adjuvants . EP 0392095 B1

Pileri Piero, Nencioni Luciano, Peppoloni Samuele, Silvestri Sergio(1991). Composizione Per Vaccini . IT 1230712 B

Pileri Piero, Nencioni Luciano, Peppoloni Samuele, Silvestri Sergio(1990). Tuftsin Analogues And Vaccines Containing These As Adjuvants . EP 0392095 A2

Pileri Piero, Nencioni Luciano, Peppoloni Samuele, Silvestri Sergio(1990). Composition For Vaccines . US 4957736 A

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Grifantini Renata and Pileri Piero and Campagnoli Susanna and Grandi Alberto and Parri Matteo and Boquan Jin Tumor Marker, Monoclonal Antibodies And Methods Of Use Thereof . US 2016/0131656 A1

Nencioni Luciano and Pileri Piero and Peppoloni Samuele and Silvestri Sergio Composition For Vaccines . US 4957736 A