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USD 40 /hr

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☆☆☆☆☆

Hire Dr. Peter S.

United Kingdom

USD 40 /hr

Profile Summary

My lab researches the connection between epigenetics and evolution using comparative genomics and a variety of molecular biology techniques

Subject Matter Expertise

• ★ Genetics
• ☆ Molecular Biology
• ☆ Comparative Genomics
• ☆ Genomics
• ☆ Epigenetics
• ☆ Bioinformatics

Services

• Writing
• Consulting
• Data & AI
• Product Development

Work Experience

Junior Research Fellow

Imperial College London

October 2015 - Present

Principal Investigator

MRC Clinical Sciences Centre

October 2014 - Present

Postdoctoral Researcher

University of Cambridge

December 2011 - September 2014

Education

PhD

MRC Laboratory of Molecular Biology

October 2008 - May 2012

MBiochem (Biochemistry)

University of Oxford

October 2004 - July 2008

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Peter Sarkies, Toni Beltran, Vahid Shahrezaei, Vaishali Katju (2020). Epimutations driven by small RNAs arise frequently but most have limited duration in Caenorhabditis elegans . Nature Ecology & Evolution.

Peter Sarkies, Samuel H. Lewis, Wolf Reik, Laura Ross, Stevie A. Bain, Eleni Pahita, Stephen A. Smith, Richard Cordaux, Eric A. Miska, Boris Lenhard, et al.(2020). {\-}{\-}{\-}{\-}{\-}{\-}Widespread conservation and lineage-specific diversification of genome-wide {DNA} methylation patterns across arthropods . {PLOS} Genetics. 16. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1008864. Public Library of Science ({PLoS})

Peter Sarkies, Ricardo J. Cordeiro Rodrigues, António Miguel de Jesus Domingues, Svenja Hellmann, Sabrina Dietz, Bruno F.M. de Albuquerque, Christian Renz, Helle D. Ulrich, Falk Butter, René F. Ketting(2019). {PETISCO} is a novel protein complex required for 21U {RNA} biogenesis and embryonic viability . Genes {\&} Development. 33. (13-14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 857--870. Cold Spring Harbor Laboratory

(2019). Mechanistic Insights into Cytosine-N3 Methylation by DNA Methyltransferase DNMT3A . Journal of Molecular Biology.

Peter Sarkies(2019). Molecular mechanisms of epigenetic inheritance: Possible evolutionary implications . Seminars in Cell {\&} Developmental Biology. Elsevier {BV}

Peter Sarkies, Tony Belicard, Pree Jareosettasin(2018). The {piRNA} pathway responds to environmental signals to establish intergenerational adaptation to stress . {BMC} Biology. 16. (1). Springer Nature

Rošić S, Amouroux R, Requena CE, Gomes A, Emperle M, Beltran T, Rane JK, Linnett S, Selkirk ME, Schiffer PH, et al.(2018). Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity . Nature genetics.

Osman GA, Fasseas MK, Koneru SL, Essmann CL, Kyrou K, Srinivasan MA, Zhang G, Sarkies P, Félix MA, Barkoulas M(2018). Natural Infection of C. elegans by an Oomycete Reveals a New Pathogen-Specific Immune Response . Current biology : CB.

Lewis SH, Quarles KA, Yang Y, Tanguy M, Frézal L, Smith SA, Sharma PP, Cordaux R, Gilbert C, Giraud I, et al.(2018). Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements . Nature ecology & evolution.

(2017). An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans . mBio.

et al.(2017). miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA . Cell reports.

et al.(2016). The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion . eLife.

et al.(2016). Specific down-regulation of spermatogenesis genes targeted by 22G RNAs in hybrid sterile males associated with an X-Chromosome introgression . Genome research.

et al.(2016). Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways . PLoS pathogens.

Peter Sarkies, Alyson Ashe, Jérémie Le Pen, Mélanie Tanguy, Eric A. Miska, A. Simon(2015). Antiviral {RNA} Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans . J. Virol. 89. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12035--12046. American Society for Microbiology

Peter Sarkies, Alper Akay, Eric A. Miska(2015). E. coli {OxyS} non-coding {RNA} does not trigger {RNAi} in C. elegans . Sci. Rep. 5. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9597. Nature Publishing Group

Peter Sarkies, Alexandra Sapetschnig, Nicolas J. Lehrbach, Eric A. Miska, Nelson C Lau(2015). Tertiary {siRNAs} Mediate Paramutation in C. elegans . {PLoS} Genet. 11. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1005078. Public Library of Science ({PLoS})

Peter Sarkies, Murray E. Selkirk, John T. Jones, Vivian Blok, Thomas Boothby, Bob Goldstein, Ben Hanelt, Alex Ardila-Garcia, Naomi M. Fast, Phillip M. Schiffer, et al.(2015). Ancient and Novel Small {RNA} Pathways Compensate for the Loss of {piRNAs} in Multiple Independent Nematode Lineages . {PLOS} Biology. 13. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1002061. Public Library of Science ({PLoS})

D. Schiavone, G. Guilbaud, P. Murat, C. Papadopoulou, P. Sarkies, M.-N. Prioleau, S. Balasubramanian, J. E. Sale(2014). Determinants of G quadruplex-induced epigenetic instability in {REV}1-deficient cells . The {EMBO} Journal. 33. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2507--2520. {EMBO}

A. Sakaguchi, P. Sarkies, M. Simon, A.-L. Doebley, L. D. Goldstein, A. Hedges, K. Ikegami, S. M. Alvares, L. Yang, J. R. LaRocque, et al.(2014). Caenorhabditis elegans {RSD}-2 and {RSD}-6 promote germ cell immortality by maintaining small interfering {RNA} populations . Proceedings of the National Academy of Sciences. 111. (41). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString E4323--E4331. Proceedings of the National Academy of Sciences

Peter Sarkies, Alexander Frey, Tamar Listovsky, Guillaume Guilbaud, Julian E. Sale(2014). Histone H3.3 Is Required to Maintain Replication Fork Progression after {UV} Damage . Current Biology. 24. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2195--2201. Elsevier {BV}

Peter Sarkies, Eric A. Miska(2014). Small {RNAs} break out: the molecular cell biology of mobile small {RNAs} . Nature Reviews Molecular Cell Biology. 15. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 525--535. Nature Publishing Group

Peter Sarkies, Matt Simon, Kohta Ikegami, Anna-Lisa Doebley, Leonard D. Goldstein, Jacinth Mitchell, Aisa Sakaguchi, Eric A. Miska, Shawn Ahmed(2014). Reduced Insulin/{IGF}-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants . Cell Reports. 7. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 762--773. Elsevier {BV}

Peter Sarkies, Katharina Gapp, Ali Jawaid, Johannes Bohacek, Pawel Pelczar, Julien Prados, Laurent Farinelli, Eric Miska, Isabelle M Mansuy(2014). Implication of sperm {RNAs} in transgenerational inheritance of the effects of early trauma in mice . Nature Neuroscience. 17. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 667--669. Nature Publishing Group

(2014). PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans . Genes & development.

Peter Sarkies, Alyson Ashe, Tony Bélicard, Jérémie Le Pen, Lise Frézal, Nicolas J Lehrbach, Marie-Anne Félix, Eric A Miska(2013). A deletion polymorphism in the Caenorhabditis elegans {RIG}-I homolog disables viral {RNA} dicing and antiviral immunity . {eLife}. 2. {eLife} Sciences Organisation, Ltd.

P. Sarkies, E. A. Miska(2013). Is There Social {RNA}? . Science. 341. (6145). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 467--468. American Association for the Advancement of Science ({AAAS})

P. Sarkies, E. A. Miska(2013). Is There Social {RNA}? . Science. 341. (6145). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 467--468. American Association for the Advancement of Science ({AAAS})

Peter Sarkies, Eric A. Miska(2013). {RNAi} pathways in the recognition of foreign {RNA}: antiviral responses and host{\textendash}parasite interactions in nematodes: Figure 1 . Biochm. Soc. Trans. 41. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 876--880. Portland Press Ltd.

P. Sarkies, A. Ashe, J. Le Pen, M. A. McKie, E. A. Miska(2013). Competition between virus-derived and endogenous small {RNAs} regulates gene expression in Caenorhabditis elegans . Genome Research. 23. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1258--1270. Cold Spring Harbor Laboratory Press

Peter Sarkies, Alyson Ashe, Alexandra Sapetschnig, Eva-Maria Weick, Jacinth Mitchell, Marloes P. Bagijn, Amy C. Cording, Anna-Lisa Doebley, Leonard D. Goldstein, Nicolas J. Lehrbach, et al.(2012). {piRNAs} Can Trigger a Multigenerational Epigenetic Memory in the Germline of C.~elegans . Cell. 150. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 88--99. Elsevier {BV}

Peter Sarkies, Julian E. Sale(2012). Cellular epigenetic stability and cancer . Trends in Genetics. 28. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 118--127. Elsevier {BV}

Peter Sarkies, Julian E. Sale(2011). Propagation of histone marks and epigenetic memory during normal and interrupted {DNA} replication . Cell. Mol. Life Sci. 69. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 697--716. Springer Science $\mathplus$ Business Media

P. Sarkies, P. Murat, L. G. Phillips, K. J. Patel, S. Balasubramanian, J. E. Sale(2011). {FANCJ} coordinates two pathways that maintain epigenetic stability at G-quadruplex {DNA} . Nucleic Acids Research. 40. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1485--1498. Oxford University Press ({OUP})

Peter Sarkies, Charlie Reams, Laura J. Simpson, Julian E. Sale(2010). Epigenetic Instability due to Defective Replication of Structured {DNA} . Molecular Cell. 40. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 703--713. Elsevier {BV}

I. Vakonakis, D. Staunton, I. R. Ellis, P. Sarkies, A. Flanagan, A. M. Schor, S. L. Schor, I. D. Campbell(2009). Motogenic Sites in Human Fibronectin Are Masked by Long Range Interactions . Journal of Biological Chemistry. 284. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15668--15675. American Society for Biochemistry {\&} Molecular Biology ({ASBMB})

Peter Sarkies, Jennifer J. Paynter, Isabelle Andres-Enguix, Stephen J. Tucker(2008). Genetic selection of activatory mutations in {KcsA} . Channels. 2. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 413--418. Informa {UK} Limited

OTHER

Peter Sarkies, Toni Beltran, Elena Pahita, Subhanita Ghosh, Boris Lenhard(2020). Integrator terminates promoter-proximal Pol {II} to generate C. elegans {piRNA} precursors . Cold Spring Harbor Laboratory

Peter Sarkies, Peter J. Taylor, Jana Hagen, Farid N. Faruqu, Khuloud T. Al-Jamal, Bonnie Quigley, Morgan Beeby, Murray E. Selkirk(2020). Trichinella spiralis secretes abundant unencapsulated small {RNAs} with potential effects on host gene expression . Cold Spring Harbor Laboratory

S. Lewis, L. Ross, S.A. Bain, E. Pahita, S.A. Smith, R. Cordaux, E.M. Miska, B. Lenhard, F.M. Jiggins, P. Sarkies(2020). Widespread conservation and lineage-specific diversification of genome-wide {DNA} methylation patterns across arthropods . Cold Spring Harbor Laboratory

Peter Sarkies, Toni Beltran, Vahid Shahrezaei, Vaishali Katju(2019). Epimutations driven by small {RNAs} arise frequently but have limited duration in a metazoan organism . Cold Spring Harbor Laboratory

REPORT

A. Akay, P. Sarkies, E. A. Miska(2014). E. coli {OxyS} non-coding {RNA} does not trigger {RNAi} in C. elegans . Cold Spring Harbor Laboratory Press