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Profile Details
Subject Matter Expertise
Services
Work Experience
Postdoctoral researcher in the Department of Gastroenterology and Hepatology
University Hospital Zurich, University of Zurich, Zurich, Switzerland
July 2014 - Present
Postdoctoral associate in the Infectious and Inflammatory Diseases Center
Sanford-Burnham Medical Research Institute, La Jolla, CA, USA
November 2012 - March 2014
Postdoctoral fellow in the Respiratory Diseases Area
Novartis Institutes for Biomedical Research, Horsham, United Kingdom
July 2008 - June 2011
Postdoctoral researcher in the Department of Immunobiology of Nutrition
Technical University of Munich, Freising, Germany
March 2007 - February 2008
Education
Ph.D. in Life Sciences
Technical University of Munich, Freising, Germany
February 2003 - January 2006
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
(2020). Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model . Scientific Reports.
(2020). Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis . Journal of Inflammation.
(2020). Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis . Journal of Inflammation.
(2019). Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease . Journal of Crohn's & colitis.
(2019). The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation . BMC gastroenterology.
Tcymbarevich, I., Tcymbarevich, I., Richards, S.M., Russo, G., Kühn-Georgijevic, J., Cosin-Roger, J., Baebler, K., Lang, S., Bengs, S., Atrott, K., et al.(2019). Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease . Journal of Crohn's and Colitis. 13. (2). p. 245-258.
(2018). Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium . Cellular and molecular gastroenterology and hepatology.
(2018). Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis . Scientific reports.
(2018). BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice . Clinical and experimental immunology.
(2018). Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation . PloS one.
(2018). Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis . Scientific Reports. 8. (1).
(2018). BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice . Clinical and Experimental Immunology. 193. (3). p. 346-360.
(2018). Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation . PLoS ONE. 13. (2).
(2018). Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis . Journal of Crohn's & colitis. 12. (11). p. 1348-1358.
(2018). BCL2 Regulates Differentiation of Intestinal Fibroblasts . Inflammatory Bowel Diseases. 24. (9). p. 1953-1966.
(2017). Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation . Nature communications.
(2017). Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation . Nature Communications. 8. (1).
(2017). Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: The Altitude IBD Study . BMJ Open. 7. (1).
(2017). Titanium dioxide nanoparticles exacerbate DSS-induced colitis: Role of the NLRP3 inflammasome . Gut. 66. (7). p. 1216-1224.
(2016). Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells? . Scientific reports.
(2016). Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome . Gut.
de Vallière, C., Cosin-Roger, J., de Vallière, C., Cosin-Roger, J., Simmen, S., Atrott, K., Melhem, H., Zeitz, J., Madanchi, M., Tcymbarevich, I., et al.(2016). Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68) . Cellular and Molecular Gastroenterology and Hepatology. 2. (6). p. 796-810.
(2016). Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells? . Scientific Reports. 6.
(2015). PQBP1 is a proximal sensor of the cGAS-dependent innate response to HIV-1 . Cell. 161. (6). p. 1293-1305.
(2014). Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase . Cellular and molecular gastroenterology and hepatology.
(2012). Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices . Fibrogenesis & tissue repair.
Ruiz, P.A., Jarai, G.(2012). Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices . Fibrogenesis and Tissue Repair. 5. (1).
(2011). Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts . The Journal of biological chemistry.
(2011). Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts . Journal of Biological Chemistry. 286. (15). p. 12912-12923.
(2011). Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration . American Journal of Physiology - Endocrinology and Metabolism. 300. (2).
(2010). Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration . American journal of physiology. Endocrinology and metabolism.
(2007). Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . The Journal of nutrition.
(2007). Quercetin inhibits TNF-induced NF-κB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Journal of Nutrition. 137. (5). p. 1208-1215.
Shkoda, A., Ruiz, P.A., Daniel, H., Kim, S.C., Rogler, G., Sartor, R.B., Haller, D.(2007). Interleukin-10 Blocked Endoplasmic Reticulum Stress in Intestinal Epithelial Cells: Impact on Chronic Inflammation . Gastroenterology. 132. (1). p. 190-207.
(2006). IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation . Annals of the New York Academy of Sciences.
(2006). Functional diversity of flavonoids in the inhibition of the proinflammatory NF-κB, IRF, and Akt signaling pathways in murine intestinal epithelial cells . Journal of Nutrition. 136. (3). p. 664-671.
(2005). Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germ-free rats . Immunology.
(2005). IL-10 gene-deficient mice lack TGF-β/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis . Journal of Immunology. 174. (5). p. 2990-2999.
(2004). 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity . The Journal of biological chemistry.
(2004). 15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<inf>2</inf>-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity . Journal of Biological Chemistry. 279. (34). p. 36103-36111.
BOOK CHAPTER
(2016). Discoidin domain receptor signaling and pharmacological inhibitors . Discoidin Domain Receptors in Health and Disease. p. 217-238.
BOOK
Ruiz, P.A., Shkoda, A., Kim, S.C., Sartor, R.B., Haller, D.(2006). IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation . Annals of the New York Academy of Sciences. 1072. p. 389-394.