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Hire Dr. Pedro Antonio R.

Switzerland

Profile Summary

Ph.D. in Life Sciences with more than 15 years’ experience in Biomedical research in both academia and industry –graduated in Biochemistry and Molecular biology Professional English - Spanish freelance translator specialising in biomedical and scientific-related documents with more than 6 years’ experience –born and educated in Spain My scientific background includes: • Ph.D. in life sciences from the University of Munich • Strong research background in molecular mechanisms underlying innate immune/ autoinflammatory responses • Strong publication record with 24 peer-reviewed original research publications in high impact journals, including Nature Communications, Gut, Gastroenterology, and Cell. • Fluent in English and German, with extensive research experience in the United States, United Kingdom, Germany, and Switzerland –Spanish native speaker. Since July 2014 I have been working at the Department of Gastroenterology and Hepatology of the University Hospital Zurich, where in my position as a postdoctoral researcher/group leader I am managing several projects on molecular mechanisms underlying the development of Inflammatory Bowel Diseases. During my career, I aimed to broaden my experience in diverse biological systems associated with autoimmune/chronic inflammatory diseases. My previous position was with the Sanford-Medical Research Institute, La Jolla, CA, where I led a research team working on the identification of therapeutic targets for the treatment of Systemic Lupus Erythematosus. Prior to that, I worked in the Respiratory Disease Area at Novartis Institutes for BioMedical Research at Horsham, United Kingdom, where I enjoyed the opportunity to acquire a thorough understanding of the drug discovery process in the pharmaceutical industry. Original research articles: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/50864718/?sort=date&direction=descending My translator profile includes: Over 6 years’ experience translating documents for medical and ecological organizations and websites. I hold the Cambridge’s Certificate of Proficiency in English (CPE) and the Diploma in Translation from the Chartered Institute of Linguists (DipTransIoLET). My experience includes: Translating medicine leaflets (QRDs) and RedLine projects for the European Medicines Agency (EMA), medical documentation including clinical description, etiology, pathophysiology, epidemiology, diagnosis, and treatment of rare genetic diseases. My areas of expertise include medicine, pharmaceutics, biology, nutrition, genetics, ecology, marine sciences, molecular biology, cellular biology, chemistry, and biochemistry.

Subject Matter Expertise

• ☆ Molecular Biology
• ☆ Science Education
• ☆ Spanish
• ☆ German
• ☆ Medicine
• ☆ Pulmonology/Respiratory Disease
• ☆ Medical Sciences
• ☆ Research Methodology
• ☆ Medical Writing
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Science Communication
• ☆ Language Translation
• ☆ Grant Writing

Services

• Writing
• Consulting
• Product Development

Work Experience

Postdoctoral researcher in the Department of Gastroenterology and Hepatology

University Hospital Zurich, University of Zurich, Zurich, Switzerland

July 2014 - Present

Postdoctoral associate in the Infectious and Inflammatory Diseases Center

Sanford-Burnham Medical Research Institute, La Jolla, CA, USA

November 2012 - March 2014

Postdoctoral fellow in the Respiratory Diseases Area

Novartis Institutes for Biomedical Research, Horsham, United Kingdom

July 2008 - June 2011

Postdoctoral researcher in the Department of Immunobiology of Nutrition

Technical University of Munich, Freising, Germany

March 2007 - February 2008

Education

Ph.D. in Life Sciences

Technical University of Munich, Freising, Germany

February 2003 - January 2006

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2020). Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model . Scientific Reports.

(2020). Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis . Journal of Inflammation.

(2020). Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis . Journal of Inflammation.

(2019). Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease . Journal of Crohn's & colitis.

(2019). The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation . BMC gastroenterology.

Tcymbarevich, I., Tcymbarevich, I., Richards, S.M., Russo, G., Kühn-Georgijevic, J., Cosin-Roger, J., Baebler, K., Lang, S., Bengs, S., Atrott, K., et al.(2019). Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease . Journal of Crohn's and Colitis. 13. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 245-258.

(2018). Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium . Cellular and molecular gastroenterology and hepatology.

(2018). Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis . Scientific reports.

(2018). BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice . Clinical and experimental immunology.

(2018). Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation . PloS one.

(2018). Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis . Scientific Reports. 8. (1).

(2018). BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice . Clinical and Experimental Immunology. 193. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 346-360.

(2018). Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation . PLoS ONE. 13. (2).

(2018). Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis . Journal of Crohn's & colitis. 12. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1348-1358.

(2018). BCL2 Regulates Differentiation of Intestinal Fibroblasts . Inflammatory Bowel Diseases. 24. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1953-1966.

(2017). Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation . Nature communications.

(2017). Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation . Nature Communications. 8. (1).

(2017). Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: The Altitude IBD Study . BMJ Open. 7. (1).

(2017). Titanium dioxide nanoparticles exacerbate DSS-induced colitis: Role of the NLRP3 inflammasome . Gut. 66. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1216-1224.

(2016). Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells? . Scientific reports.

(2016). Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome . Gut.

de Vallière, C., Cosin-Roger, J., de Vallière, C., Cosin-Roger, J., Simmen, S., Atrott, K., Melhem, H., Zeitz, J., Madanchi, M., Tcymbarevich, I., et al.(2016). Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68) . Cellular and Molecular Gastroenterology and Hepatology. 2. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 796-810.

(2016). Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells? . Scientific Reports. 6.

(2015). PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1 . Cell.

(2015). PQBP1 is a proximal sensor of the cGAS-dependent innate response to HIV-1 . Cell. 161. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1293-1305.

(2014). Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase . Cellular and molecular gastroenterology and hepatology.

(2012). Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices . Fibrogenesis & tissue repair.

Ruiz, P.A., Jarai, G.(2012). Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices . Fibrogenesis and Tissue Repair. 5. (1).

(2011). Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts . The Journal of biological chemistry.

(2011). Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts . Journal of Biological Chemistry. 286. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12912-12923.

(2011). Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration . American Journal of Physiology - Endocrinology and Metabolism. 300. (2).

(2010). Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration . American journal of physiology. Endocrinology and metabolism.

(2007). Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . The Journal of nutrition.

(2007). Interleukin-10 Blocked Endoplasmic Reticulum Stress in Intestinal Epithelial Cells: Impact on Chronic Inflammation .

(2007). Quercetin inhibits TNF-induced NF-κB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells . Journal of Nutrition. 137. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1208-1215.

Shkoda, A., Ruiz, P.A., Daniel, H., Kim, S.C., Rogler, G., Sartor, R.B., Haller, D.(2007). Interleukin-10 Blocked Endoplasmic Reticulum Stress in Intestinal Epithelial Cells: Impact on Chronic Inflammation . Gastroenterology. 132. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 190-207.

(2006). IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation . Annals of the New York Academy of Sciences.

(2006). Functional diversity of flavonoids in the inhibition of the proinflammatory NF-κB, IRF, and Akt signaling pathways in murine intestinal epithelial cells . Journal of Nutrition. 136. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 664-671.

(2005). Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germ-free rats . Immunology.

(2005). IL-10 gene-deficient mice lack TGF-β/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis . Journal of Immunology. 174. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2990-2999.

(2004). 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity . The Journal of biological chemistry.

(2004). 15-Deoxy-Δ^12,14-prostaglandin J<inf>2</inf>-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity . Journal of Biological Chemistry. 279. (34). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 36103-36111.

BOOK CHAPTER

(2016). Discoidin domain receptor signaling and pharmacological inhibitors . Discoidin Domain Receptors in Health and Disease. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 217-238.

BOOK

Ruiz, P.A., Shkoda, A., Kim, S.C., Sartor, R.B., Haller, D.(2006). IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation . Annals of the New York Academy of Sciences. 1072. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 389-394.