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★★★★★
☆☆☆☆☆
USD 100 /hr
Hire Dr. Paul D.
United Kingdom
USD 100 /hr

Life Sciences & Technology Innovator and Academic

Profile Summary
Subject Matter Expertise
Services
Writing Non-Medical Regulatory Writing
Research Feasibility Study
Consulting Business Strategy Consulting, Go-to-Market Strategy Consulting
Work Experience

Co-founder, Scientific Director

Stroma Therapeutics

February 2020 - Present

Honorary Reader (2021-present), Reader (2013- 2021), Senior Research Fellow (2005-2013)

University of Edinburgh

September 2005 - Present

Group Leader

Roslin Institute

September 1998 - July 2005

Post-doctoral Fellow

University of Western Ontario Department of Medicine

September 1995 - July 1998

Post-doctoral fellow

University of Pennsylvania

January 1994 - August 1995

Postdoctoral Fellow

University of Toronto

September 1993 - December 1993

Education

PhD (Zoology)

University of Western Ontario Faculty of Science

January 1989 - August 1993

Master of Science (Zoology)

University of Toronto

September 1986 - May 1989

(Honours) Bachelor of Sciences

University of Toronto

September 1982 - May 1986

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Eirini Koutsouraki, Steve Pells, Paul A. De Sousa(2019). Sufficiency of hypoxia-inducible 2-oxoglutarate dioxygenases to block chemical oxidative stress-induced differentiation of human embryonic stem cells . Stem Cell Research. 34. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 101358. Elsevier {BV}
Koutsouraki, E., Pells, S., De Sousa, P.A.(2019). Sufficiency of hypoxia-inducible 2-oxoglutarate dioxygenases to block chemical oxidative stress-induced differentiation of human embryonic stem cells . Stem Cell Research. 34.
De Sousa, P.A., Ritchie, D., Green, A., Chandran, S., Knight, R., Head, M.W.(2019). Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies . Acta Neuropathologica. 137. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 363-377.
De Sousa PA, Ritchie D, Green A, Chandran S, Knight R, Head MW(2018). Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies . Acta neuropathologica.
Paul A. De Sousa, Rachel Steeg, Beate Kreisel, Timothy E. Allsopp(2017). Hot Start to European Pluripotent Stem Cell Banking . Trends in Biotechnology. 35. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 573--576. Elsevier {BV}
Paul A. De Sousa, Rachel Steeg, Elisabeth Wachter, Kevin Bruce, Jason King, Marieke Hoeve, Shalinee Khadun, George McConnachie, Julie Holder, Andreas Kurtz, et al.(2017). Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience . Stem Cell Research. 20. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105--114. Elsevier {BV}
De Sousa, P.A., Steeg, R., Wachter, E., Bruce, K., King, J., Hoeve, M., Khadun, S., McConnachie, G., Holder, J., Kurtz, A., et al.(2017). Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience . Stem Cell Research. 20. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105-114.
De Sousa, P.A., Steeg, R., Kreisel, B., Allsopp, T.E.(2017). Hot Start to European Pluripotent Stem Cell Banking . Trends in Biotechnology. 35. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 573-576.
P.A. De Sousa, J.M. Downie, B.J. Tye, K. Bruce, P. Dand, S. Dhanjal, P. Serhal, J. Harper, M. Turner, M. Bateman(2016). Development and production of good manufacturing practice grade human embryonic stem cell lines as source material for clinical application . Stem Cell Research. 17. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 379--390. Elsevier {BV}
Davis MR, Arner E, Duffy CR, De Sousa PA, Dahlman I, Arner P, Summers KM(2016). Datasets of genes coexpressed with FBN1 in mouse adipose tissue and during human adipogenesis . Data in brief.
Davis MR, Arner E, Duffy CR, De Sousa PA, Dahlman I, Arner P, Summers KM, Molecular genetics and metabolism, 2016, 2016 .
De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, McDonald K, Bradburn H, Laurie A, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 3, pp. 770-775, 2016 .
P.A. De Sousa, B.J. Tye, K. Bruce, P. Dand, G. Russell, D.M. Collins, A. Greenshields, K. McDonald, H. Bradburn, A. Laurie, et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe018-A (RC-14) . Stem Cell Research. Elsevier {BV}
De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, McDonald K, Bradburn H, Laurie A, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 3, pp. 751-755, 2016 .
De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, McDonald K, Bradburn H, Laurie A, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 3, pp. 790-794, 2016 .
De Sousa PA, Tye B, Bruce K, Dand P, Russell G, Gardner J, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 3, pp. 593-596, 2016 .
(2016). Derivation of the human embryonic stem cell line RCe008-A (RC-4) . Stem Cell Research.
P.A. De Sousa, B.J. Tye, K. Bruce, P. Dand, G. Russell, D.M. Collins, A. Greenshields, K. McDonald, H. Bradburn, A. Laurie, et al. (2016). Derivation of the clinical grade human embryonic stem cell line RCe017-A (RC-13) . Stem Cell Research.
De Sousa PA, Tye BJ, Sneddon S, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, McDonald K, Bradburn H, Gardner J, Downie JM, Courtney A, Brison DR, Stem cell research, 2016, vol. 16, no. 2, pp. 476-480, 2016 .
De Sousa PA, Tye B, Bruce K, Dand P, Russell G, Gardner J, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 2, pp. 452-455, 2016 .
De Sousa PA, Tye B, Bruce K, Dand P, Russell G, Collins DM, Gardner J, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 2, pp. 418-422, 2016 .
De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Bradburn H, Gardner J, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 2, pp. 481-484, 2016 .
De Sousa PA, Tye BJ, Collins DM, Bruce K, Dand P, Russell G, Bradburn H, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 2, pp. 485-488, 2016 .
De Sousa PA, Tye BJ, Bruce K, Dand P, Russell G, Collins DM, Greenshields A, Bradburn H, Downie JM, Bateman M, Courtney A, Stem cell research, 2016, vol. 16, no. 2, pp. 489-492, 2016 .
P.A. De Sousa, B.J. Tye, K. Bruce, P. Dand, G. Russell, D.M. Collins, A. Greenshields, H. Bradburn, J.M. Downie, M. Bateman, et al.(2016). Derivation of the human embryonic stem cell line RCe014-A (RC-10) . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 537--540. Elsevier {BV}
N. A. Willoughby, H. Bock, M. A. Hoeve, S. Pells, C. Williams, G. McPhee, P. Freile, D. Choudhury, P. A. De Sousa(2016). A scalable label-free approach to separate human pluripotent cells from differentiated derivatives . Biomicrofluidics. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 014107. {AIP} Publishing
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Laurie, A., et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe015-A (RC-11) . Stem Cell Research. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 42-48.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Canham, M.A., et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe013-A (RC-9) . Stem Cell Research. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 36-41.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., Bradburn, H., Downie, J.M., Bateman, M., et al.(2016). Derivation of the human embryonic stem cell line RCe014-A (RC-10) . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 537-540.
Willoughby, N.A., Bock, H., Hoeve, M.A., Pells, S., Williams, C., McPhee, G., Freile, P., Choudhury, D., De Sousa, P.A.(2016). A scalable label-free approach to separate human pluripotent cells from differentiated derivatives . Biomicrofluidics. 10. (1).
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Allan, D., et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe021-A (RC-17) . Stem Cell Research. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-5.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., Bradburn, H., Downie, J.M., Bateman, M., et al.(2016). Derivation of the human embryonic stem cell line RCe012-A (RC-8) . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 489-492.
De Sousa, P.A., Tye, B.J., Collins, D.M., Bruce, K., Dand, P., Russell, G., Bradburn, H., Downie, J.M., Bateman, M., Courtney, A.(2016). Derivation of the human embryonic stem cell line RCe011-A (RC-7) . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 485-488.
De Sousa, P.A., Tye, B., Bruce, K., Dand, P., Russell, G., Collins, D.M., Gardner, J., Downie, J.M., Bateman, M., Courtney, A.(2016). Derivation of the human embryonic stem cell line RCe009-A (RC-5) . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 418-422.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Bradburn, H., Gardner, J., Downie, J.M., Bateman, M., et al.(2016). Derivation of the human embryonic stem cell line RCe010-A (RC-6) . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 481-484.
De Sousa, P.A., Tye, B., Bruce, K., Dand, P., Russell, G., Gardner, J., Downie, J.M., Bateman, M., Courtney, A.(2016). Derivation of the human embryonic stem cell line RCe006-A (RC-2) . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 452-455.
De Sousa, P.A., Tye, B.J., Sneddon, S., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., et al.(2016). Derivation of the human embryonic stem cell line RCM1 . Stem Cell Research. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 476-480.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Laurie, A., et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe017-A (RC-13) . Stem Cell Research. 16. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 756-760.
De Sousa, P.A., Tye, B., Bruce, K., Dand, P., Gardner, J., Downie, J.M., Bateman, M., Courtney, A.(2016). Derivation of the human embryonic stem cell line RCe008-A (RC-4) . Stem Cell Research. 16. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 607-610.
De Sousa, P.A., Tye, B., Bruce, K., Dand, P., Russell, G., Gardner, J., Downie, J.M., Bateman, M., Courtney, A.(2016). Derivation of the human embryonic stem cell line RCe007-A (RC-3) . Stem Cell Research. 16. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 593-596.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Laurie, A., et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe020-a (RC-16) . Stem Cell Research. 16. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 790-794.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Laurie, A., et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe019-A (RC-15) . Stem Cell Research. 16. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 751-755.
Davis, M.R., Arner, E., Duffy, C.R.E., De Sousa, P.A., Dahlman, I., Arner, P., Summers, K.M.(2016). Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions . Molecular Genetics and Metabolism. 119. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 174-185.
De Sousa, P.A., Tye, B.J., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Laurie, A., et al.(2016). Derivation of the clinical grade human embryonic stem cell line RCe016-A (RC-12) . Stem Cell Research. 16. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 770-775.
Davis, M.R., Arner, E., Duffy, C.R.E., De Sousa, P.A., Dahlman, I., Arner, P., Summers, K.M.(2016). Datasets of genes coexpressed with FBN1 in mouse adipose tissue and during human adipogenesis . Data in Brief. 8. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 851-857.
De Sousa, P.A., Downie, J.M., Tye, B.J., Bruce, K., Dand, P., Dhanjal, S., Serhal, P., Harper, J., Turner, M., Bateman, M.(2016). Development and production of good manufacturing practice grade human embryonic stem cell lines as source material for clinical application . Stem Cell Research. 17. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 379-390.
Mangani C, Lilienkampf A, Roy M, de Sousa PA, Bradley M, Biomaterials science, 2015, vol. 3, no. 10, pp. 1371-1375 .
Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi YM, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha HY, Han E, Haupt S, Healy L, Hei DJ, Regenerative medicine, 2015, vol. 10, no. 2 Suppl, pp. 1-44, 2015 .
Mangani, C., Lilienkampf, A., Roy, M., De Sousa, P.A., Bradley, M.(2015). Thermoresponsive hydrogel maintains the mouse embryonic stem cell "naïve" pluripotency phenotype . Biomaterials Science. 3. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1371-1375.
Pells S, Koutsouraki E, Morfopoulou S, Valencia-Cadavid S, Tomlinson SR, Kalathur R, Futschik ME, De Sousa PA, PloS one, 2015, vol. 10, no. 7, pp. e0131102 .
Pells, S., Koutsouraki, E., Morfopoulou, S., Valencia-Cadavid, S., Tomlinson, S.R., Kalathur, R., Futschik, M.E., De Sousa, P.A.(2015). Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State . PloS one. 10. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e0131102.
Canham MA, Van Deusen A, Brison DR, De Sousa PA, Downie J, Devito L, Hewitt ZA, Ilic D, Kimber SJ, Moore HD, Murray H, Kunath T, Scientific reports, 2015, vol. 5, pp. 17258 .
Canham, M.A., Van Deusen, A., Brison, D.R., De Sousa, P.A., Downie, J., Devito, L., Hewitt, Z.A., Ilic, D., Kimber, S.J., Moore, H.D., et al.(2015). The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines . Scientific Reports. 5.
Andrews, P.W., Baker, D., Benvinisty, N., Miranda, B., Bruce, K., Brüstle, O., Choi, M., Choi, Y.-M., Crook, J.M., De Sousa, P.A., et al.(2015). Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI) . Regenerative Medicine. 10. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-44.
Tsenkina Y, Ruzov A, Gliddon C, Horsburgh K, De Sousa PA, Brain research, 2014, vol. 1592, pp. 82-100, 2014 .
Duffy CR, Zhang R, How SE, Lilienkampf A, De Sousa PA, Bradley M, Biomaterials, 2014, vol. 35, no. 23, pp. 5998-6005, 2014 .
Hansen A, Mjoseng HK, Zhang R, Kalloudis M, Koutsos V, de Sousa PA, Bradley M, Advanced healthcare materials, 2014, vol. 3, no. 6, pp. 848-853 .
Krejciova Z, De Sousa P, Manson J, Ironside JW, Head MW, The American journal of pathology, 2014, vol. 184, no. 1, pp. 64-70 .
Krejciova, Z., De Sousa, P., Manson, J., Ironside, J.W., Head, M.W.(2014). Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes . American Journal of Pathology. 184. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 64-70.
Yan X, Ehnert S, Culmes M, Bachmann A, Seeliger C, Schyschka L, Wang Z, Rahmanian-Schwarz A, Stöckle U, De Sousa PA, Pelisek J, Nussler AK, PloS one, 2014, vol. 9, no. 6, pp. e90846 .
Yan, X., Ehnert, S., Culmes, M., Bachmann, A., Seeliger, C., Schyschka, L., Wang, Z., Rahmanian-Schwarz, A., Stöckle, U., De Sousa, P.A., et al.(2014). 5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation . PLoS ONE. 9. (3).
Hansen, A., Mjoseng, H.K., Zhang, R., Kalloudis, M., Koutsos, V., de Sousa, P.A., Bradley, M.(2014). High-Density Polymer Microarrays: Identifying Synthetic Polymers that Control Human Embryonic Stem Cell Growth . Advanced Healthcare Materials. 3. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 848-853.
Duffy, C.R.E., Zhang, R., How, S.-E., Lilienkampf, A., Tourniaire, G., Hu, W., West, C.C., De Sousa, P., Bradley, M.(2014). A high-throughput polymer microarray approach for identifying defined substrates for mesenchymal stem cells . Biomaterials Science. 2. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1683-1692.
Duffy, C.R.E., Zhang, R., How, S.-E., Lilienkampf, A., De Sousa, P.A., Bradley, M.(2014). Long term mesenchymal stem cell culture on a defined synthetic substrate with enzyme free passaging . Biomaterials. 35. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5998-6005.
Tsenkina, Y., Ruzov, A., Gliddon, C., Horsburgh, K., De Sousa, P.A.(2014). White matter tract and glial-associated changes in 5-hydroxymethylcytosine following chronic cerebral hypoperfusion . Brain Research. 1592. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 82-100.
Krause KH, van Thriel C, De Sousa PA, Leist M, Hengstler JG, Archives of toxicology, 2013, vol. 87, no. 10, pp. 1877-1881 .
De Sousa PA, Regenerative medicine, 2013, vol. 8, no. 5, pp. 519-521 .
Krause, K.-H., Van Thriel, C., De Sousa, P.A., Leist, M., Hengstler, J.G.(2013). Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing . Archives of Toxicology. 87. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1877-1881.
De Sousa, P.A.(2013). Biologically equivalent substitutive technology: What is needed to manufacture pluripotent stem cells for next-generation platforms for discovery and therapy . Regenerative Medicine. 8. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 519-521.
Armit, Chris, Bauer, Nina G., Besseling, Rut, Bradley, Mark, Duffy, Cairnan R. E., Edenhofer, Frank, Helfen, Martina, Hoeve, Marieke A., Kishen, Ria E. B., Mjoseng, Heidi K., et al.(2013). A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells . Nature Communications. 4.
Zhang, R., Mjoseng, H.K., Hoeve, M.A., Bauer, N.G., Pells, S., Besseling, R., Velugotla, S., Tourniaire, G., Kishen, R.E.B., Tsenkina, Y., et al.(2013). A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells . Nature Communications. 4.
Anstee, D., Courtney, A., Forrester, L., Mountford, J., Murphy, W., Newlands, H., Parsons, S., Pelly, J., Turner, M. L., de Sousa, P.(2013). PROGRESS TOWARDS THE CGMP PRODUCTION OF PLURIPOTENT STEM CELL DERIVED RED BLOOD CELLS. Cytotherapy. 15. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S7.
Bradley, Mark, De Sousa, Paul A., Ermakov, Alexander, Freile, Paz, Ganeva, Veronika V., Millar, Robert, Pawson, Adam, Pells, Steve, Wildenhain, Jan(2012). A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture . Stem Cell Research. 9. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 171-184.
Ermakov, A., Pells, S., Freile, P., Ganeva, V.V., Wildenhain, J., Bradley, M., Pawson, A., Millar, R., De Sousa, P.A.(2012). A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture . Stem Cell Research. 9. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 171-184.
Damm, G., Ehnert, S., Martinez Sanchez, J. J., Nuessler, A., Stoeckle, U., Yan, X., de Sousa, P.(2012). CHEMICAL MODIFICATION EPIGENETICALLY 'RENEWS' OLD HUMAN ADIPOSE DERIVED MESENCHYMAL STEM CELLS AND IMPROVES THEIR DIFFERENTIATION INTO HEPATOCYTES LINEAGE. Journal of Hepatology. 56. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S173.
De Sousa, Paul, Duffy, Cairnan R. E., Mjoseng, Heidi K., Pells, Steve, Pethig, Ronald, Smith, Stewart, Velugotla, Srinivas(2012). Dielectrophoresis based discrimination of human embryonic stem cells from differentiating derivatives . Biomicrofluidics. 6. (4).
Bagnaninchi, Pierre, Corradetti, Bruna, Fahmy, Tarek M., Freile, Paz, Park, Jason, Pells, Steve, de Sousa, Paul A.(2012). Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles . Biomaterials. 33. (28). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6634-6643.
Velugotla, S., Pells, S., Mjoseng, H.K., Duffy, C.R.E., Smith, S., De Sousa, P., Pethig, R.(2012). Dielectrophoresis based discrimination of human embryonic stem cells from differentiating derivatives . Biomicrofluidics. 6. (4).
Corradetti, B., Freile, P., Pells, S., Bagnaninchi, P., Park, J., Fahmy, T.M., de Sousa, P.A.(2012). Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles . Biomaterials. 33. (28). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6634-6643.
McVean, Gilean, Murphy, Lee, Robertson, Victoria, Turner, David M., de Sousa, Paul(2012). SNP SCREENING FOR HLA HAPLOTYPES RELEVANT IN ESTABLISHING A HUMAN PLURIPOTENT STEM CELL DERIVED CELL BANK. Tissue Antigens. 79. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 540-541.
Almeida, Rimple D., De Sousa, Paul A., Johnson, Andrew D., Loose, Matthew, Ruzov, Alexey, Sottile, Virginie(2012). Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals . Epigenetics. 7. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 137-140.
Almeida, R.D., Sottile, V., Loose, M., De Sousa, P.A., Johnson, A.D., Ruzov, A.(2012). Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals . Epigenetics. 7. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 137-140.
Courtney A, de Sousa P, George C, Laurie G, Tait J, Nature biotechnology, 2011, vol. 29, no. 2, pp. 115-116, 2011 .
Adya, Ashok K., Bock, Henry, Canetta, Elisabetta, De Sousa, Paul, Kiss, Robert, Moore, Andrew J., Pells, Steve, Willoughby, Nicholas A.(2011). Elasticity of Human Embryonic Stem Cells as Determined by Atomic Force Microscopy . Journal of Biomechanical Engineering-Transactions of the Asme. 133. (10).
Courtney, A., De Sousa, P., George, C., Laurie, G., Tait, J.(2011). Balancing open source stem cell science with commercialization . Nature Biotechnology. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 115-116.
Adya, Ashok K, Bock, Henry, Canetta, Elisabetta, De Sousa, Paul, Kiss, Robert, Moore, Andrew J, Pells, Steve, Willoughby, Nicholas A(2011). Elasticity of human embryonic stem cells as determined by atomic force microscopy . Journal of biomechanical engineering. 133. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 101009.
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Boland, MP, De Sousa, P, Duby, RT, Herrmann, D, Niemann, H, O'Callaghan, D, Overstrom, EW, Watson, AJ, Wrenzycki, C(2000). Effects of superovulated heifer diet type and quantity on relative mRNA abundances and pyruvate metabolism in recovered embryos . Journal of Reproduction and Fertility. 118. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 69-78.
De Sousa, P. A., Ferrier, P., Harkness, L., King, T. J., Ritchie, W. A., Travers, A., Walker, S., Wilmut, I., Young, L. E.(2000). Evaluation of gestational deficiencies in cloned sheep. Theriogenology. 53. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 214.
De Sousa, P., Fletcher, J., Harkness, L., King, T., Telfer, E. E., Wilmut, I., Zhu, J.(2000). Fetal development from parthenogenetically activated in vitro matured porcine oocytes. Journal of Reproduction and Fertility Abstract Series. (25). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 65.
Watson, A.J., De Sousa, P., Caveney, A., Barcroft, L.C., Natale, D., Urquhart, J., Westhusin, M.E.(2000). Impact of bovine oocyte maturation media on oocyte transcript levels, blastocyst development, cell number, and apoptosis . Biology of Reproduction. 62. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 355-364.
Barcroft, LC, Caveney, A, De Sousa, P, Natale, D, Urquhart, J, Watson, AJ, Westhusin, ME(2000). Impact of bovine oocyte maturation media on oocyte transcript levels, blastocyst development, cell number, and apoptosis . Biology of Reproduction. 62. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 355-364.
De Sousa, P. A., Dobrinsky, J. R., Telfer, E. E., Wilmut, I., Zhu, J.(2000). Improving the efficiency of in vitro-matured pig oocyte activation. Theriogenology. 53. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 445.
Barcroft, LC, Betts, DH, De Sousa, PA, Watson, AJ, Westhusin, ME(1999). Gene expression regulating blastocyst formation . Theriogenology. 51. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 117-133.
Watson, A.J., Westhusin, M.E., De Sousa, P.A., Betts, D.H., Barcroft, L.C.(1999). Gene expression regulating blastocyst formation . Theriogenology. 51. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 117-133.
De Sousa, P.A., Winger, Q., Hill, J.R., Jones, K., Watson, A.J., Westhusin, M.E.(1999). Reprogramming of fibroblast nuclei after transfer into bovine oocytes . Cloning and Stem Cells. 1. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 63-69.
De Sousa, P A, Hill, J R, Jones, K, Watson, A J, Westhusin, M E, Winger, Q(1999). Reprogramming of fibroblast nuclei after transfer into bovine oocytes . Cloning. 1. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 63-9.
De Sousa PA, Westhusin ME, Watson AJ, Molecular reproduction and development, 1998, vol. 49, no. 2, pp. 119-130, 1998.
De Sousa, PA, Watson, AJ, Westhusin, ME(1998). Analysis of variation in relative mRNA abundance for specific gene transcripts in single bovine oocytes and early embryos. Molecular Reproduction and Development. 49. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 119-130.
Bilodeau-Goeseels, S, De Sousa, P, Schultz, GA, Watson, AJ(1998). Oogenetic and zygotic gene expression directing early bovine embryogenesis: A review. Molecular Reproduction and Development. 51. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 112-121.
De Sousa, P.A., Watson, A.J., Schultz, G.A., Bilodeau-Goeseels, S.(1998). Oogenetic and zygotic gene expression directing early bovine embryogenesis: A review. Molecular Reproduction and Development. 51. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 112-121.
De Sousa, P.A., Westhusin, M.E., Watson, A.J.(1998). Analysis of variation in relative mRNA abundance for specific gene transcripts in single bovine oocytes and early embryos. Molecular Reproduction and Development. 49. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 119-130.
Caveney, A, De Sousa, PA, Watson, AJ, Westhusin, ME(1998). Temporal patterns of embryonic gene expression and their dependence on oogenetic factors . Theriogenology. 49. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 115-128.
De Sousa, P.A., Caveney, A., Westhusin, M.E., Watson, A.J.(1998). Temporal patterns of embryonic gene expression and their dependence on oogenetic factors . Theriogenology. 49. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 115-128.
De Sousa, PA, Schultz, RM, Watson, AJ(1998). Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos . Biology of Reproduction. 59. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 969-977.
De Sousa, P.A., Watson, A.J., Schultz, R.M.(1998). Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos . Biology of Reproduction. 59. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 969-977.
De Sousa PA, Juneja SC, Caveney S, Houghton FD, Davies TC, Reaume AG, Rossant J, Kidder GM, Journal of cell science, 1997, vol. 110 ( Pt 15), pp. 1751-1758, 1997 .
Caveney, Anita, De Sousa, Paul A., Watson, Andrew J.(1997). Determination of gene transcript relative abundance in single embryos. Biology of Reproduction. 56. (SUPPL. 1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 129.
De Sousa, P.A., Kidder, G.M.(1997). Effects of brefeldin-A and monensin on organelle distribution and morphology in the preimplantation mouse embryo . Development Genes and Evolution. 206. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 503-514.
Betts, D. H., Boland, M., De Sousa, P. A., O'Callaghan, D., Overstrom, E. W., Watson, A. J.(1997). Localization of Na/K-ATPase alpha-subunits and comparison of alpha-subunit transcript levels in single cultured and in vivo bovine blastocysts . Theriogenology. 47. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 316.
De Sousa, P.A., Juneja, S.C., Caveney, S., Houghton, F.D., Davies, T.C., Reaume, A.G., Rossant, J., Kidder, G.M.(1997). Normal development of preimplantation mouse embryos deficient in gap junctional coupling . Journal of Cell Science. 110. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1751-1758.
Caveney, S, Davies, TC, DeSousa, PA, Houghton, DF, Juneja, SC, Kidder, GM, Reaume, AG, Rossant, J(1997). Normal development of preimplantation mouse embryos deficient in gap junctional coupling. Journal of Cell Science. 110. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1751-1758.
Davis W Jr, De Sousa PA, Schultz RM, Developmental biology, 1996, vol. 174, no. 2, pp. 190-201, 1996 .
Davis Jr., W., De Sousa, P.A., Schultz, R.M.(1996). Transient expression of translation initiation factor eIF-4C during the 2-cell stage of the preimplantation mouse embryo: Identification by mRNA differential display and the role of DNA replication in zygotic gene activation . Developmental Biology. 174. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 190-201.
Barcroft, LC, Bets, DH, DeSousa, PA, Gilfoyle, E, Looye, J, PierreLouis, J, Watson, AJ, Winger, QA(1996). Maternal and embryonic control of bovine pre-attachment development: Expression of oviductal and embryonic genes. Archiv Fur Tierzucht-Archives of Animal Breeding. 39. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 55-69.
Watson, A.J., Barcroft, L.C., Betts, D.H., De Sousa, P.A., Gilfoyle, E., Looye, J., Pierre-Louis, J., Winger, Q.A.(1996). Maternal and embryonic control of bovine pre-attachment development: Expression of oviductal and embryonic genes . Archiv fur Tierzucht. 39. (SUPPL.). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 55-69.
Davis, W, DeSousa, PA, Schultz, RM(1996). Transient expression of translation initiation factor eIF-4C during the 2-cell stage of the preimplantation mouse embryo: Identification by mRNA differential display and the role of DNA replication in zygotic gene activation. Developmental Biology. 174. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 190-201.
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Schultz, R.M., Worrad, D.M., Davis Jr., W., De Sousa, P.A.(1995). Regulation of gene expression in the preimplantation mouse embryo . Theriogenology. 44. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1115-1131.
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Macphee, D.J., Barr, K.J., De Sousa, P.A., Todd, S.D.L., Kidder, G.M.(1994). Regulation of Na<sup>+</sup>, K<sup>+</sup>-ATPase α subunit gene expression during mouse preimplantation development . Developmental Biology. 162. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 259-266.
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De Sousa, P.A., Valdimarsson, G., Nicholson, B.J., Kidder, G.M.(1993). Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos . Development. 117. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1355-1367.
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BOOK CHAPTER
Fraser, L., Bruce, K., Campbell, J.M., De Sousa, P.A.(2018). Quality assessment and production of human cells for clinical use . Methods in Molecular Biology. 1780. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 607-629.
Hoeve, M.A., De Sousa, P.A., Willoughby, N.A.(2016). Challenges of Scale-up of Cell Separation and Purification Techniques . Bioprocessing for Cell Based Therapies. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 127-165.
De Sousa, P.A., McRae, S., Stacey, G.(2012). Stem cells in the development of products for regenerative medicine . Regenerative Medicine, Stem Cells and the Liver. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 77-97.
BOOK
Bruce, K.W., Campbell, J.D.M., De Sousa, P.(2017). Quality Assured Characterization of Stem Cells for Safety in Banking for Clinical Application . Methods in Molecular Biology. 1590. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79-98.