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Hire Dr. Paromita M.

United Kingdom

Profile Summary

Paromita Majumder earned her PhD in 2007 studying the role of purinergic receptors P2X2 and P2X4 during neuronal differentiation of P19 embryonal carcinoma cells. Her interests in the purinergic field led her to join in 2007 the Faculty of Live Sciences, Department of Neuroscience at the University of Manchester to work on the characterization of purinergic receptor P2X7 function and ATP release by Pannexin-I (hemichannel) knock-out mice. To evolve the knowledge in ATP signalling and gap junction channels, she joined the Venetian Institute of Molecular Medicine in Padua, Italy (Feb 2009 ̶ Dec 2010) and worked on ATP release by connexin 26 and 30 hemichannels and calcium signalling mediated by gap junction channels in supporting cells in the organ of Corti on prelingual deafness using techniques such as live imaging and IP3 flash photolysis. This research led her to enrol Ear Institute (2011-2016), Brain Sciences faculty, University College London to deepen her knowledge in acquired deafness by understanding the role of calcium signalling and reactive oxygen generation by mitochondria and NOX during aminoglycoside toxicity, noise-induced hearing loss and aged hearing loss in the organ of Corti. During her time at the Ear Institute, she was awarded a two-year post-doctoral fellowship from The Brazilian National Council for Scientific and Technological Development (2014) and the Pauline Ashley Independent junior investigator award from Action on Hearing Loss (2014) to study the role of NADPH oxidase in ototoxicity. Her interests in stem cell differentiation led her to join in UCL-Institute of Ophthalmology (2017-2018), to understand ciliopathy in blindness in the model of Induced Pluripotent Stem Cells (IPS) where she implements experiments in calcium imaging and redox.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Stem Cell Research
• ☆ Visual Neuroscience
• ☆ Cell Aging
• ☆ Deafness & Hearing Impairment

Services

• Writing
• Research
• Consulting
• Product Development

Work Experience

research associate

UCL

June 2017 - October 2018

Research Assistant

DNA Electronics

April 2017 - June 2017

research fellow

UCL

May 2011 - October 2016

Post-doctoral researcher

Venetian Institute of Molecular Medicine

February 2009 - December 2010

research associate

University of Manchester

November 2007 - October 2008

Education

PhD (Bioquimica)

Universidade de Sao Paulo Campus da Capital

February 2002 - March 2007

MSc in Bioquimica e Biologia Molecular (Bioquimica)

Universidade Federal de Sao Paulo Escola Paulista de Medicina

August 1999 - January 2002

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2019). Multiphoton NAD(P)H FLIM reveals metabolic changes in individual cell types of the intact cochlea upon sensorineural hearing loss . Scientific Reports.

DNA and RNA Aptamers: From Tools for Basic Research Towards Therapeutic Applications. Combinatorial Chemistry & High Throughput Screening.

Delivery Systems of Nucleic Acids Drugs For In Vivo Use. Drug Target Insight.

Neuronal Differentiation of P19 Embryonal Carcinoma Cells Modulates Kinin B2 Receptor Gene Expression and Function. Journal of Biological Chemistry.

P19 Embryonal Carcinoma Cells as In Vitro Model for Studying Purinergic Receptor Expression and Modulation of NMDA-Glutamate and Acetylcholine Receptors during Neuronal Differentiation. Neuroscience.

Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high frequency hearing acquisition. PNAS.

The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock in mice. Human Molecular Genetics.

Identification of Human Chromosome 22 Transcribed Sequences with ORF Expressed Sequence Tags. PNAS.

The contribution of 700,000 ORF Sequence Tags to the Definition of the Human Transcriptome. PNAS.

New insights of purinergic receptor signalling in neuronal differentiation, neuroprotection and brain disorders. Purinergic Signalling.

Cellular glutathione content in the organ of Corti and its role during ototoxicity.

Inhibition Mechanism of the Recombinant Rat P2X2 Receptor in Glial Cells by Suramin and TNP-ATP. Biochemistry.

Immobilized P2X2 Purinergic Receptor Stationary Phase for Chromatographic Determination of Pharmacological Properties and Drugs Screening. Journal of Pharmaceutical and Biomedical Analysis.

Targeting DNA Associated Processes for Cancer Therapy by the Use of SELEX and Anti-gene Approaches – When Selection Meets Rational Design. Medicinal Chemistry Reviews on Line.

Embryonal Carcinoma and Stem Cells: From Basic Research of Neuronal Differentiation towards Clinical Applications. Cell Proliferation.

Aptamers: from bench side research towards patented molecules with therapeutic applications. Expert Opinion on Therapeutic Patents.

Characterization of phenoxybenzamine in mammalian hair cell protection. Frontiers in Cellular Neurosciences.

ATP-mediated cell-cell signalling in the organ of Corti: the role of connexin channels. Purinergic Signalling.

CONFERENCE PAPER

ASSESSING CALCIUM RESPONSES IN HUMAN ESC-DERIVED RETINAL ORGANOIDS.