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Hire Dr. Pavel R.

Czech Republic

USD 50 /hr

Physician, experienced anesthesiologist, researcher, PhD in Pharmacology

Profile Summary

I am a physician, trained and licensed anesthesiologist with clinical experience in Germany and Czech Republic. After eight years of clinical work I switched to academia and became a researcher in the field of Pharmacology. My main scientific field of interest is preclinical pharmacokinetics with special focus on lymphatic transport of drugs after oral administration. I am skilled at designing and conducting preclinical pharmacokinetic studies (model animals: rat and pig). I have also participated on several clinical studies. I am skilled at medical writing and publishing (10+ Web of Science indexed articles, grant proposals, overviews etc.).

Subject Matter Expertise

• ☆ Drug Development
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ Bioavailability
• ☆ Anesthesiology

Services

• Writing
• Research
• Consulting

Writing Medical Writing, Translation

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Work Experience

Assisitant Professor

Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague

July 2018 - Present

anesthesiologist

Motol University hospital in Prague

September 2017 - August 2020

anesthesiologist

Klinikum Chemnitz

January 2015 - August 2017

anesthesiologist

Elbe-Elster Klinikum

September 2012 - December 2014

Education

PhD in Pharmacology and Toxicology

Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague

October 2018 - April 2023

Doctor of Medicine

First Faculty of Medicine, Charles University in Prague

October 2005 - May 2022

Certifications

• Certification details not provided.

Publications

PREPRINT

Klára Šíchová, Barbara Mallarino, Lucie Janečková, Petr Palivec, Magdaléna Vágnerová, Čestmír Vejmola, Marek Nikolič, Lucie Olejníková-Ladislavová, Kristýna Mazochová, Pavel Ryšánek, et al. (2024). Hexahydrocannabinol (HHC): pharmacokinetics, systemic toxicity, and acute behavioural effects in Wistar rats .

JOURNAL ARTICLE

Jiří Hofmann, Aleš Bartůněk, Tomáš Hauser, Gregor Sedmak, Josef Beránek, Pavel Ryšánek, Martin Šíma, Ondřej Slanař (2023). Dasatinib anhydrate containing oral formulation improves variability and bioavailability in humans . Leukemia.

et al., Petra Šalamúnová, Tereza Krejčí, Pavel Ryšánek, Ivan Saloň, Jiřina Kroupová, Anna Hubatová-Vacková, Jakub Petřík, Tomáš Grus, Peter Lukáč, Petr Kozlík (2023). Serum and lymph pharmacokinetics of nilotinib delivered by yeast glucan particles per os . International Journal of Pharmaceutics.

Pavel Rysanek, Petr Jelínek, Jaroslava Roušarová, Pavel Ryšánek, Martina Ježková, Tereza Havlůjová, Jiří Pozniak, Petr Kozlík, Tomáš Křížek, Tomáš Kučera, et al.(2022). Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis . Cannabis and Cannabinoid Research. Mary Ann Liebert Inc

Pavel Rysanek, Jan Miroslav Hartinger, Pavel Ryšánek, Ondřej Slanař, Martin Šíma(2022). Pharmacokinetic principles of dose adjustment of mTOR inhibitors in solid organ transplanted patients . Journal of Clinical Pharmacy and Therapeutics. 47. (9). p. 1362--1367. Wiley

Martin Šíma, Daniel Bobek, Petra Cihlářová, Pavel Ryšánek, Jaroslava Roušarová, Jan Beroušek, Martin Kuchař, Tomáš Vymazal, Ondřej Slanař (2022). Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin . Pharmaceutics.

Martin Šíma, Daniel Bobek, Petra Cihlářová, Pavel Rysanek, Jaroslava Roušarová, Jan Beroušek, Martin Kuchar, Tomáš Vymazal, Ondrej Slanar (2022). Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin . Pharmaceutics.

Pavel Rysanek, Erika Hriňová, Eliška Skořepová, Igor Čerňa, Jana Královičová, Petr Kozlík, Tomáš Křížek, Jaroslava Roušarová, Pavel Ryšánek, Martin Šíma, et al.(2022). Explaining dissolution properties of rivaroxaban cocrystals . International Journal of Pharmaceutics. 622. p. 121854. Elsevier {BV}

Jana Královičová, Aleš Bartůněk, Jiří Hofmann, Tomáš Křížek, Petr Kozlík, Jaroslava Roušarová, Pavel Ryšánek, Martin Šíma, Ondřej Slanař(2022). Pharmacokinetic Variability in Pre-Clinical Studies: Sample Study with Abiraterone in Rats and Implications for Short-Term Comparative Pharmacokinetic Study Designs . Pharmaceutics. 14. (3). p. 643. {MDPI} {AG}

Jana Královičová, Aleš Bartůněk, Jiří Hofmann, Tomáš Křížek, Petr Kozlík, Jaroslava Roušarová, Pavel Rysanek, Martin Šíma, Ondrej Slanar (2022). Pharmacokinetic Variability in Pre-Clinical Studies: Sample Study with Abiraterone in Rats and Implications for Short-Term Comparative Pharmacokinetic Study Designs . Pharmaceutics.

Pavel Ryšánek, Tomáš Grus, Peter Lukáč, Petr Kozlík, Tomáš Křížek, Jiří Pozniak, Jaroslava Roušarová, Jana Královičová, Nikolina Kutinová Canová, Tereza Boleslavská, et al.(2021). Validity of cycloheximide chylomicron flow blocking method for the evaluation of lymphatic transport of drugs . British Journal of Pharmacology. 178. (23). p. 4663--4674. Wiley

Martin Šíma, Danica Michaličková, Pavel Ryšánek, Petra Cihlářová, Martin Kuchař, Daniela Lžičařová, Jan Beroušek, Jan Miroslav Hartinger, Tomáš Vymazal, Ondřej Slanař (2021). No Time Dependence of Ciprofloxacin Pharmacokinetics in Critically Ill Adults: Comparison of Individual and Population Analyses . Pharmaceutics.

Martin Šíma, Danica Michaličková, Pavel Rysanek, Petra Cihlářová, Martin Kuchař, Daniela Lžičařová, Jan Beroušek, Jan Miroslav Hartinger, Tomáš Vymazal, Ondřej Slanař (2021). No Time Dependence of Ciprofloxacin Pharmacokinetics in Critically Ill Adults: Comparison of Individual and Population Analyses . Pharmaceutics.

Bioavailability Enhancement and Food Effect Elimination of Abiraterone Acetate by Encapsulation in Surfactant-Enriched Oil Marbles @article{2020, doi = {10.1208/s12248-020-00505-5}, url = {https://doi.org/10.1208%2Fs12248-020-00505-5}, year = 2020, month = {sep}, publisher = {Springer Science and Business Media {LLC}}, volume = {22}, number = {6}, author = {Tereza Boleslavsk{\'{a}} and Ond{\v{r}}ej Rycheck{\'{y}} and Martin Krov and Pavel {\v{Z}}v{\'{a}}tora and Ond{\v{r}}ej Dammer and Josef Ber{\'{a}}nek and Petr Kozl{\'{\i}}k and Tom{\'{a}}{\v{s}} K{\v{r}}{\'{\i}}{\v{z}}ek and Jana Ho{\v{r}}{\'{\i}}nkov{\'{a}} and Pavel Ry{\v{s}}{\'{a}}nek and Jaroslava Rou{\v{s}}arov{\'{a}} and Nikolina Kutinov{\'{a}} Canov{\'{a}} and Martin {\v{S}}{\'{\i}}ma and Ond{\v{r}}ej Slana{\v{r}} and Franti{\v{s}}ek {\v{S}}t{\v{e}}p{\'{a}}nek}, title = {Bioavailability Enhancement and Food Effect Elimination of Abiraterone Acetate by Encapsulation in Surfactant-Enriched Oil Marbles}} . The AAPS Journal.

Pavel Ryšánek, Tomáš Grus, Martin Šíma, Ondřej Slanař(2020). Lymphatic Transport of Drugs after Intestinal Absorption: Impact of Drug Formulation and Physicochemical Properties . Pharmaceutical Research. 37. (9). Springer Science and Business Media {LLC}

Gastric pH in Rats: Key Determinant for Preclinical Evaluation of pH-dependent Oral Drug Absorption @article{2019, doi = {10.14712/23362936.2019.5}, url = {https://doi.org/10.14712%2F23362936.2019.5}, year = 2019, publisher = {Charles University in Prague, Karolinum Press}, volume = {120}, number = {1}, pages = {5--9}, author = {Martin {\v{S}}{\'{\i}}ma and Nikolina Kutinov{\'{a}}-Canov{\'{a}} and Pavel Ry{\v{s}}{\'{a}}nek and Jana Ho{\v{r}}{\'{\i}}nkov{\'{a}} and Denisa Mo{\v{s}}ko{\v{r}}ov{\'{a}} and Ond{\v{r}}ej Slana{\v{r}}}, title = {Gastric {pH} in Rats: Key Determinant for Preclinical Evaluation of {pH}-dependent Oral Drug Absorption}} . Prague Medical Report.