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Hire Dr. Omar E.

Brazil

USD 20 /hr

Phytochemical analysis and bioguided isolation of active plant components.

Profile Summary

My scientific experience concerns applied organic synthesis, natural product extraction, isolation, identification and characterization by spectroscopic technics such as NMR and MS, the performance of in vitro and in vivo bioassays and the analysis of the cardiovascular activity of bioactive natural products.

Subject Matter Expertise

• ★ Phytochemistry
• ☆ Analytical Chemistry
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Botany
• ☆ Cannabis/CBD
• ☆ Biochemistry

Services

• Writing
• Research
• Data & AI

Writing Technical Writing, Newswriting

Research Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Data & AI Statistical Analysis, Data Visualization

Work Experience

Professor

Venezuelan Institute for Scientific Research

July 2007 - Present

Investigador Asociado

Instituto Venezolano de Investigaciones Científicas

July 2007 - Present

Profesor Instructor

Universidad Central de Venezuela

September 2005 - July 2007

professor of Biochemistry

Universidad Central de Venezuela

October 2005 - June 2007

Professor

Universidad Central de Venezuela

October 1998 - June 2005

Profesor Instructor

Universidad Central de Venezuela

April 1997 - May 2005

Education

Doctor en Quimica (Fcaultad de Ciencias)

Universidad Central de Venezuela

October 1996 - April 2002

PhD in chemistry

UCv

October 1996 - November 2001

Licenciado en Quimica (Facultad de ciencias)

Universidad Central de Venezuela

April 1989 - July 1996

Bachelor in chemistry

UCv

May 1989 - May 1995

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

López, R., Bolaños, P., Guillén, A., Fernández, M.C., Ramos, M., Granados, S., Milán, A.F., Caputo, C., Alvarado-Castillo, C., Estrada, O., et al.(2019). Pomolic acid reduces contractility and modulates excitation-contraction coupling in rat cardiomyocytes . European Journal of Pharmacology. 851. p. 88-98.

López, R., Bolaños, P., Guillén, A., Fernández, M.C., Ramos, M., Granados, S., Milán, A.F., Caputo, C., Alvarado-Castillo, C., Estrada, O., et al.(2018). The antihypertensive effect of pomolic acid is mediated through inhibition of voltage-dependent calcium channels in the heart,El efecto antihipertensivo del ácido pomólico está mediado por la inhibición de canales calcio voltaje dependientes en corazón . Iatreia. 31. (1). p. S-18.

Sánchez, G., Estrada, O., Acha, G., Cardozo, A., Peña, F., Ruiz, M.C., Michelangeli, F., Alvarado-Castillo, C.(2018). The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro . Cellular and Molecular Biology Letters. 23. (1).

Ortega, J.T., Estrada, O., Serrano, M.L., Contreras, W., Orsini, G., Pujol, F.H., Rangel, H.R.(2017). Glycosylated flavonoids from psidium guineense as major inhibitors of HIV-1 Replication in vitro . Natural Product Communications. 12. (7). p. 1049-1052.

Guillén, A., Granados, S., Rivas, K.E., Estrada, O., Echeverri, L.F., Balcázar, N.(2015). Antihyperglycemic activity of eucalyptus tereticornis in insulin-resistant cells and a nutritional model of diabetic mice . Advances in Pharmacological Sciences. 2015.

Estrada, O., González-Guzmán, J.M., Salazar-Bookman, M.M., Cardozo, A., Lucena, E., Alvarado-Castillo, C.P.(2015). Hypotensive and Bradycardic Effects of Quinovic Acid Glycosides from Aspidosperma fendleri in Spontaneously Hypertensive Rats . Natural Product Communications. 10. (2). p. 281-284.

Estrada, O., Contreras, W., Acha, G., Lucena, E., Venturini, W., Cardozo, A., Alvarado-Castillo, C.(2014). Chemical constituents from licania cruegeriana and their cardiovascular and antiplatelet effects . Molecules. 19. (12). p. 21215-21225.

Taylor, P., Arsenak, M., Abad, M.J., Fernández, A., Milano, B., Gonto, R., Ruiz, M.-C., Fraile, S., Taylor, S., Estrada, O., et al.(2013). Screening of venezuelan medicinal plant extracts for cytostatic and cytotoxic activity against tumor cell lines . Phytotherapy Research. 27. (4). p. 530-539.

Estrada, O., Conde, D., Mendez, J., Cardozo, A.(2012). Chemical constituents from Chrysobalanus venezuelanus . Biochemical Systematics and Ecology. 45. p. 66-68.

Estrada, O., Echevarria, L., Llovera, L.(2012). Estudio cinético de la interconversión de astilbina mediante espectroscopia de ¹H-rmn . Avances en Quimica. 7. (3). p. 145-150.

Möller, C., Melaun, C., Castillo, C., Díaz, M.E., Renzelman, C.M., Estrada, O., Kuch, U., Lokey, S., Marí, F.(2012). Functional hypervariability and gene diversity of cardioactive neuropeptides (Journal of Biological Chemistry (2010) 285, (40673-40680)) . Journal of Biological Chemistry. 287. (5).

Alvarado-Castillo, C., Estrada, O., Carvajal, E.(2012). Pomolic acid, triterpenoid isolated from Licania pittieri, as competitive antagonist of ADP-induced aggregation of human platelets . Phytomedicine. 19. (6). p. 484-487.

Estrada, O., González-Guzmán, J.M., Salazar-Bookaman, M., Fernández, A.Z., Cardozo, A., Alvarado-Castillo, C.(2011). Pomolic acid of Licania pittieri elicits endothelium-dependent relaxation in rat aortic rings . Phytomedicine. 18. (6). p. 464-469.

Fazio, A.L., Ballén, D., Cesari, I.M., Abad, M.J., Arsenak, M., Estrada, O., Taylor, P.(2010). Antitumour and anti-inflammatory activities in a hydroethanolic extract of lindackeria paludosa, a South American shrub,Actividades antitumorales e anti-inflamatorias de un extracto hidroetanólico de Lindackeria paludosa, un arbusto sudamericano . Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 9. (2). p. 143-150.

Möller, C., Melaun, C., Castillo, C., Díaz, M.E., Renzelman, C.M., Estrada, O., Kuch, U., Lokey, S., Marí, F.(2010). Functional Hypervariability and Gene Diversity of Cardioactive Neuropeptides . Journal of Biological Chemistry. 285. (52). p. 40673-40680.

Estrada, O., Alvarado-Castillo, C., Fernandez, A.Z., Lopez, M., Romero-Vecchione, E., Vasquez, J., Mendez, J., Conde, D., Cardozo, A.(2009). Pomolic acid isolated from the leaves of Licania pittieri inhibits ADP-and epinephrine-induced platelet aggregation and has hypotensive effect on rats . Current Bioactive Compounds. 5. (3). p. 219-225.

Rosa, F., Cedeño, J., León, L., Estrada, O., Romero-Vecchione, E., Vásquez, J., Antequera, R.(2006). Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameii . Investigación clínica. 47. (2). p. 133-141.

Rosa, F., Cedeño, J., León, L., Estrada, O., Romero-Vecchione, E., Vásquez, J., Antequera, R.(2006). Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameii . Investigacion Clinica. 47. (2).

Estrada, O., Hasegawa, M., Gonzalez-Mujíca, F., Motta, N., Perdomo, E., Solorzano, A., Méndez, J., Méndez, B., Zea, E.G.(2005). Evaluation of flavonoids from Bauhinia megalandra leaves as inhibitors of glucose-6-phosphatase system . Phytotherapy Research. 19. (10). p. 859-863.

Gonzalez-Mujica, F., Motta, N., Estrada, O., Perdomo, E., Méndez, J., Hasegawa, M.(2005). Inhibition of hepatic neoglucogenesis and glucose-6-phosphatase by quercetin 3-O-α-(2″-galloyl)rhamnoside isolated from Bauhinia megalandra leaves . Phytotherapy Research. 19. (7). p. 624-627.

Coello, N., Bernal, C., Bertsch, A., Estrada, O., Moccó, Y., Hasegawa, M.(2003). Feathers as agro industrial waste: Their biotechnological utilization to develop new added value products,Las plumas como residuo agroindustrial: Su utilización biotecnológica para producir insumos de interés industrial . Revista de la Facultad de Ingenieria. 18. (3). p. 119-126.

Jiménez, G., Hasegawa, M., Rodríguez, M., Estrada, O., Méndez, J., Castillo, A., Gonzalez-Mujica, F., Motta, N., Vásquez, J., Romero-Vecchione, E.(2001). Biological screening of plants of the Venezuelan Amazons . Journal of Ethnopharmacology. 77. (1). p. 77-83.

CONFERENCE PAPER

Echevarria, L., Rodriguez, L., Marcano, A., Estrada, O., Salazar, M., Quintero, F.(2005). Evaluation of photosensitizers singlet oxygen production for photodynamic therapy applicactions using time resolved thermal lens . Proceedings of SPIE - The International Society for Optical Engineering. 6009.

Vargas, F., Rivas, C., Estrada, O., Marcano, A.O., Echevarría, L., Díaz, Y., Alexander, I., Rodríguez, L., Padrón, L., Rivera, I.R.(2004). Photophysical and photochemical properties of Bauhinia megalandra (Caesalpinaceae) extracts as new PDT photosensitizer . Proceedings of SPIE - The International Society for Optical Engineering. 5622. (PART 1). p. 11-17.

Echevarría, L., Rodríguez, L., Piscitelli, V., Estrada, O., Marcano, A.O.(2004). Stimulated Raman red-light generation by acetone as a perspective source for photo-dynamic therapy applications . Proceedings of SPIE - The International Society for Optical Engineering. 5622. (PART 1). p. 35-39.