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Hire Dr. Oliver B.

United Kingdom

USD 50 /hr

Immunologist with expertise in high parameter flow cytometry

Profile Summary

Immunologist and cytometrist with expertise in ultra high parameter panel design, fluorophore and antibody testing, data analysis and visualization (tSNE, UMAP, FlowSOM, etc.), machine learning, experimental design and mouse models of disease. After receiving my PhD at the University of Cambridge, I did my postdoctoral training at Boston Children's Hospital where I became a member of the Harvard Medical School faculty. I now work as a staff scientist at the Babraham Institute in Cambridge, England. I have expertise in immune regulation and dysregulation, including autoimmunity, allergies, disease and homeostasis. I've specialized in understanding immune responses in the tissues, recently including neuroimmunology. I have deep technical expertise in the design and development of flow cytometry assays, and can design ultra-high parameter flow panels if desired. I can offer data analysis and visualization (tSNE, FlowSOM, UMAP, etc.) as well as machine learning-based approaches for understanding connections in the data. I have experience testing antibodies and novel fluorophores for use in complex flow cytometry assays. I can provide optimized approaches for intracellular, intranuclear, phospho and other challenging flow cytometry assays.

Subject Matter Expertise

• ★ Cytometry
• ☆ Immunoassay
• ☆ Software Engineering
• ☆ Data Analysis
• ☆ Data Visualization
• ☆ Machine Learning
• ☆ Bioinformatics
• ☆ Organ
• ☆ Immunotherapy

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing

Research Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Data Visualization, Data Processing

Product Development Formulation

Work Experience

Senior Post-doctoral Scientist

Babraham Institute

January 2019 - Present

Senior Post-doctoral Scientist

VIB KU Leuven Center for Brain & Disease Research

April 2017 - December 2018

Instructor

Harvard Medical School

October 2010 - April 2017

Research Fellow

Children's Hospital Boston

October 2010 - April 2017

Education

Ph.D. (Pathology)

UNIVERSITY OF CAMBRIDGE

October 2006 - March 2010

B.A. (Biology)

Williams College

September 2002 - June 2006

Certifications

• PILAB

  UK home office

  April 2019 - Present

Publications

JOURNAL ARTICLE

Carlos P. Roca, Oliver T. Burton, Václav Gergelits, Teresa Prezzemolo, Carly E. Whyte, Richard Halpert, Łukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, et al.(2021). AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data . Nature Communications. 12. (1). Springer Science and Business Media {LLC}

et al., Oliver Burton, Steffie Junius, Adamantios V. Mavrogiannis, Pierre Lemaitre, Margaux Gerbaux, Frederik Staels, Vanshika Malviya, Václav Gergelits, Kailash Singh, Raul Yhossef Tito Tadeo(2021). Unstable regulatory T cells, enriched for naïve and Nrp1 neg cells, are purged after fate challenge . Science Immunology. 6. (61). American Association for the Advancement of Science ({AAAS})

Oliver Burton, Renzo Mancuso, Johanna Van Den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, et al.(2019). Stem-cell-derived human microglia transplanted in mouse brain to study human disease . Nature Neuroscience. 22. (12). p. 2111--2116. Springer Science and Business Media {LLC}

Oliver Burton, Maya Imbrechts, Anneleen Avau, Jessica Vandenhaute, Bert Malengier-Devlies, Karen Put, Tania Mitera, Nele Berghmans, Steffie Junius, Adrian Liston, et al.(2018). Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis . The Journal of Immunology. 201. (9). p. 2654--2663. The American Association of Immunologists

van Nieuwenhuijze A, Burton O, Lemaitre P, Denton AE, Cascalho A, Goodchild RE, Malengier-Devlies B, Cauwe B, Linterman MA, Humblet-Baron S, et al.(2018). Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations . Frontiers in Immunology.

Brajic A, Franckaert D, Burton O, Bornschein S, Calvanese AL, Demeyer S, Cools J, Dooley J, Schlenner S, Liston A(2018). The Long Non-coding RNA Flatr Anticipates Foxp3 Expression in Regulatory T Cells . Frontiers in Immunology.

Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, et al.(2018). Phenotype molding of stromal cells in the lung tumor microenvironment . Nature medicine.

Burton OT, Epp A, Fanny ME, Miller SJ, Stranks AJ, Teague JE, Clark RA, van de Rijn M, Oettgen HC(2018). Tissue-Specific Expression of the Low-Affinity IgG Receptor, FcγRIIb, on Human Mast Cells . Frontiers in immunology.

O. T. Burton, J. Medina Tamayo, A. J. Stranks, S. Miller, K. J. Koleoglou, E. O. Weinberg, H. C. Oettgen(2018). IgE promotes type 2 innate lymphoid cells in murine food allergy . Clinical & Experimental Allergy. Wiley-Blackwell

Agüera-González S, Burton OT, Vázquez-Chávez E, Cuche C, Herit F, Bouchet J, Lasserre R, Del Río-Iñiguez I, Di Bartolo V, Alcover A(2017). Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization . Cell reports.

Burton OT, Tamayo JM, Stranks AJ, Koleoglou KJ, Oettgen HC(2017). Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance . The Journal of allergy and clinical immunology.

Burton OT, Stranks AJ, Tamayo JM, Koleoglou KJ, Schwartz LB, Oettgen HC(2016). A humanized mouse model of anaphylactic peanut allergy . The Journal of allergy and clinical immunology.

Noval Rivas M, Burton OT, Oettgen HC, Chatila T(2016). IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function . The Journal of allergy and clinical immunology.

Hans C Oettgen, Oliver T Burton(2015). IgE receptor signaling in food allergy pathogenesis . Current Opinion in Immunology. 36. p. 109--114. Elsevier {BV}

Noval Rivas M, Burton OT, Wise P, Charbonnier LM, Georgiev P, Oettgen HC, Rachid R, Chatila TA, Immunity, 2015, vol. 42, no. 3, pp. 512-523 .

Mooster JL, Le Bras S, Massaad MJ, Jabara H, Yoon J, Galand C, Heesters BA, Burton OT, Mattoo H, Manis J, Geha RS, The Journal of experimental medicine, 2015, vol. 212, no. 2, pp. 185-202 .

Burton OT, Logsdon SL, Zhou JS, Medina-Tamayo J, Abdel-Gadir A, Noval Rivas M, Koleoglou KJ, Chatila TA, Schneider LC, Rachid R, Umetsu DT, Oettgen HC, The Journal of allergy and clinical immunology, 2014, vol. 134, no. 6, pp. 1310-1317.e6 .

Burton OT, Noval Rivas M, Zhou JS, Logsdon SL, Darling AR, Koleoglou KJ, Roers A, Houshyar H, Crackower MA, Chatila TA, Oettgen HC, Immunity, 2014, vol. 41, no. 1, pp. 141-151 .

Darling AR, Freyschmidt EJ, Burton OT, Koleoglou KJ, Oyoshi MK, Oettgen HC, Clinical immunology (Orlando, Fla.), 2014, vol. 150, no. 2, pp. 153-160 .

Zhou JS, Sandomenico A, Severino V, Burton OT, Darling A, Oettgen HC, Ruvo M, Molecular bioSystems, 2013, vol. 9, no. 11, pp. 2853-2859 .

Burton OT, Darling AR, Zhou JS, Noval-Rivas M, Jones TG, Gurish MF, Chatila TA, Oettgen HC, Mucosal immunology, 2013, vol. 6, no. 4, pp. 740-750 .

Bartnikas LM, Gurish MF, Burton OT, Leisten S, Janssen E, Oettgen HC, Beaupré J, Lewis CN, Austen KF, Schulte S, Hornick JL, Geha RS, Oyoshi MK, The Journal of allergy and clinical immunology, 2013, vol. 131, no. 2, pp. 451-60.e1-6 .

Noval Rivas M, Burton OT, Wise P, Zhang YQ, Hobson SA, Garcia Lloret M, Chehoud C, Kuczynski J, DeSantis T, Warrington J, Hyde ER, Petrosino JF, Gerber GK, Bry L, Oettgen HC, Mazmanian SK, Chatila TA, The Journal of allergy and clinical immunology, 2013, vol. 131, no. 1, pp. 201-212 .

Zaccone P, Burton OT, Gibbs SE, Miller N, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Cooke A, European journal of immunology, 2011, vol. 41, no. 9, pp. 2709-2718 .

Burton OT, Oettgen HC, Immunological reviews, 2011, vol. 242, no. 1, pp. 128-143 .

Burton OT, Zaccone P, Phillips JM, De La Peña H, Fehérvári Z, Azuma M, Gibbs S, Stockinger B, Cooke A, Journal of immunology (Baltimore, Md. : 1950), 2010, vol. 185, no. 5, pp. 2754-2762 .

Burton OT, Gibbs S, Miller N, Jones FM, Wen L, Dunne DW, Cooke A, Zaccone P, European journal of immunology, 2010, vol. 40, no. 8, pp. 2221-2229 .

Zaccone P, Burton OT, Gibbs S, Miller N, Jones FM, Dunne DW, Cooke A, Journal of biomedicine & biotechnology, 2010, vol. 2010, pp. 795210 .

Slater SC, Goldman BS, Goodner B, Setubal JC, Farrand SK, Nester EW, Burr TJ, Banta L, Dickerman AW, Paulsen I, Otten L, Suen G, Welch R, Almeida NF, Arnold F, Burton OT, Du Z, Ewing A, Godsy E, Heisel S, Houmiel KL, Jhaveri J, Lu J, Miller NM, Norton S, Chen Q, Phoolcharoen W, Ohlin V, Ondrusek D, Pride N, Stricklin SL, Sun J, Wheeler C, Wilson L, Zhu H, Wood DW, Journal of bacteriology, 2009, vol. 191, no. 8, pp. 2501-2511 .

Zaccone P, Burton O, Miller N, Jones FM, Dunne DW, Cooke A, European journal of immunology, 2009, vol. 39, no. 4, pp. 1098-1107 .

Zaccone P, Burton OT, Cooke A, Trends in parasitology, 2008, vol. 24, no. 1, pp. 35-42 .

Burton OT, Zaccone P, Trends in immunology, 2007, vol. 28, no. 10, pp. 419-422 .

Atmakuri K, Cascales E, Burton OT, Banta LM, Christie PJ, The EMBO journal, 2007, vol. 26, no. 10, pp. 2540-2551 .

Zottoli SJ, Burton OT, Chambers JA, Eseh R, Gutiérrez LM, Kron MM, The Biological bulletin, 2003, vol. 205, no. 2, pp. 211-212 .

OTHER

Hans C. Oettgen, Oliver T. Burton(2015). IgE and Mast Cells . Advances in Immunology. p. 203--256. Elsevier {BV}