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Hire Nuno S.

Portugal

USD 100 /hr

Principal Investigator with 10+ years of experience in pre-clinical research

Profile Summary

Nuno Silva completed his BSc in Applied Biology (2007) and received is PhD in Tissue Engineering, Regenerative Medicine and Stem Cells from the University of Minho in 2012. His PhD work consisted on the development of novel approaches for Spinal Cord Injury Repair based on biodegradable materials and stem cells. His PhD was carried out in the 3B¿s Research Group and the Life and Health Sciences Research Institute (ICVS), both from the University of Minho, and in the Centre for Cellular and Biomolecular Research of the University of Toronto. In 2012 he started a post-doc at ICVS dedicated to study the best therapeutic combination to treat the injured spinal cord. In 2014 he was able to capture national competitive funding and started his own lab. In 2019 his position was reinforced through a FCT CEEC grant (Assistant Researcher - CEECIND/04794/2017). The concept of his lab is based on an intimate cross talk between pharmacotherapies, stem cells, biomaterials and basic neuroscience. The team is presently constituted by 3 post-doctoral fellows, 1 MD-PhD student, 4 PhD students and 1 MSc student. He is currently an author of 37 papers published in international peer-reviewed journals. Nuno Silva has currently more than 1800 citations and an h-index of 20. Additionally he is author of 7 book chapters and has more than 60 communications in national and international conferences. He supervises/supervised 19 post-graduation students. Parallel to his research activity his has been acting as referee for several international journals and for the European Science Foundation. He was part of the scientific and organizing committees of the Spinal Cord Iberian Symposium (SCiS 2015) and was the meeting chair of the first Minho Spinal Cord Injury Meeting (MiSCI-2019). Finally, during his research career, Nuno Silva was able to capture around 1.000.000¿ of competitive funding, either as salary grants (438k) or in research projects (579k). Currently, he is managing as a Principal Investigator one FCT Project (239k) and, as co-Principal Investigator, the Melo e Castro Award 2017 (60k).

Subject Matter Expertise

• ★ Spinal Cord Injury
• ☆ Biomaterials
• ☆ Animal Behavior/Ethology
• ☆ Stem Cell Research
• ☆ Cell Culture
• ☆ Grant Writing
• ☆ Project Management

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Newswriting

Research Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization

Product Development Formulation

Work Experience

Post-Doc

University of Minho

November 2012 - Present

Phd Student

Universidade do Minho

September 2011 - October 2012

PhD Student

University of Toronto

September 2010 - August 2011

Phd Student

Universidade do Minho

January 2008 - August 2010

Undergrad - Trainee

University of Minho

March 2007 - October 2007

Education

PhD (School of Engineering )

University of Minho

2008 - 2012

PhD (Department of Chemical Engineering and Applied Chemistry)

University of Toronto

September 2010 - August 2011

BSc (Department of Biology)

University of Minho

July 2003 - October 2007

Certifications

• NINDS - Spinal Cord Injury Training Program

  Ohio State University

  May 2013 - Present

Publications

JOURNAL ARTICLE

Rui Lima, Eduardo D. Gomes, Jorge R. Cibrão, Luís A. Rocha, Rita C. Assunção-Silva, Cláudia S. Rodrigues, Andreia Neves-Carvalho, Susana Monteiro, António J. Salgado, Nuno A. Silva (2021). Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord . npj Regenerative Medicine.

Role of Baclofen in Modulating Spasticity and Neuroprotection in Spinal Cord Injury @article { author = {de Sousa, Nídia and Santos, Diogo and Monteiro, Susana and Silva, Nuno and Barreiro-Iglesias, Antón and Salgado, António J}, title = {Role of Baclofen in Modulating Spasticity and Neuroprotection in Spinal Cord Injury}, journal = {Journal of Neurotrauma}, year = {2021}, month = {feb}, url = {http://dx.doi.org/10.1089/neu.2020.7591}, doi = {10.1089/neu.2020.7591} } . Journal of Neurotrauma.

Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord @article { author = {Monteiro, Susana and Pinho, Andreia G. and Macieira, Mara and Serre-Miranda, Cláudia and Cibrão, Jorge R. and Lima, Rui and Soares-Cunha, Carina and et al.}, title = {Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord}, journal = {Journal of Neuroinflammation}, volume = {17}, number = {1}, year = {2020}, month = {sep}, url = {http://dx.doi.org/10.1186/s12974-020-01945-8}, doi = {10.1186/s12974-020-01945-8} } . Journal of Neuroinflammation.

Combination of a Gellan Gum-Based Hydrogel With Cell Therapy for the Treatment of Cervical Spinal Cord Injury @article { author = {Gomes, Eduardo D. and Ghosh, Biswarup and Lima, Rui and Goulão, Miguel and Moreira-Gomes, Tiago and Martins-Macedo, Joana and Urban, Mark W. and et al.}, title = {Combination of a Gellan Gum-Based Hydrogel With Cell Therapy for the Treatment of Cervical Spinal Cord Injury}, journal = {Frontiers in Bioengineering and Biotechnology}, volume = {8}, year = {2020}, month = {aug}, url = {http://dx.doi.org/10.3389/fbioe.2020.00984}, doi = {10.3389/fbioe.2020.00984} } . Frontiers in Bioengineering and Biotechnology.

Rui Lima, Susana Monteiro, Eduardo D. Gomes, Natália L. Vasconcelos, Rita Assunção-Silva, Mónica Morais, António J. Salgado, Nuno A. Silva(2020). Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury . International Journal of Molecular Sciences. 21. (14). p. 5062. {MDPI} {AG}

In vitro Evaluation of ASCs and HUVECs Co-cultures in 3D Biodegradable Hydrogels on Neurite Outgrowth and Vascular Organization @article { author = {Rocha, Luís A. and Gomes, Eduardo D. and Afonso, João L. and Granja, Sara and Baltazar, Fatima and Silva, Nuno A. and Shoichet, Molly S. and et al.}, title = {In vitro Evaluation of ASCs and HUVECs Co-cultures in 3D Biodegradable Hydrogels on Neurite Outgrowth and Vascular Organization}, journal = {Frontiers in Cell and Developmental Biology}, volume = {8}, year = {2020}, month = {jun}, url = {http://dx.doi.org/10.3389/fcell.2020.00489}, doi = {10.3389/fcell.2020.00489} } . Frontiers in Cell and Developmental Biology.

Andreia G. Pinho, Jorge R. Cibrão, Nuno A. Silva, Susana Monteiro, António J. Salgado(2020). Cell Secretome: Basic Insights and Therapeutic Opportunities for CNS Disorders . Pharmaceuticals. 13. (2). p. 31. {MDPI} {AG}

Rocha, L.A., Silva, D., Barata-Antunes, S., Cavaleiro, H., Gomes, E.D., Silva, N.A., Salgado, A.J.(2020). Cell and Tissue Instructive Materials for Central Nervous System Repair . Advanced Functional Materials.

Pre-Clinical Assessment of Mesenchymal Stem Cell-Based Therapies in Spinocerebellar Ataxia Type 3 @article { author = {Neves-Carvalho, Andreia and Mendes-Pinheiro, Bárbara and Correia, Joana Sofia and Pires, Joel and Teixeira, Fábio Gabriel and Silva, Nuno and Lima, Rui and et al.}, title = {Pre-Clinical Assessment of Mesenchymal Stem Cell-Based Therapies in Spinocerebellar Ataxia Type 3}, journal = {SSRN Electronic Journal}, year = {2019}, month = {oct}, url = {http://dx.doi.org/10.2139/ssrn.3475576}, doi = {10.2139/ssrn.3475576} } . SSRN Electronic Journal.

Inês M. Pereira, Ana Marote, António J. Salgado, Nuno A. Silva(2019). Filling the Gap: Neural Stem Cells as A Promising Therapy for Spinal Cord Injury . Pharmaceuticals. 12. (2). p. 65. {MDPI} {AG}

Inês Pereira, Ana Marote, António J. Salgado, Nuno A. Silva (2019). Filling the Gap: Neural Stem Cells as A Promising Therapy for Spinal Cord Injury . Pharmaceuticals.

Costa, M.M., Lima, R., Melo-Fonseca, F., Bartolomeu, F., Alves, N., Miranda, A., Gasik, M., Silva, F.S., Silva, N.A., Miranda, G.(2019). Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties . Materials Science and Engineering C. 98. p. 705-716.

Pereira, I.M., Marote, A., Salgado, A.J., Silva, N.A.(2019). Filling the gap: Neural stem cells as a promising therapy for spinal cord injury . Pharmaceuticals. 12. (2).

Gomes, E., Silva, N., Salgado, A.(2019). Combinatorial therapies for spinal cord injury: Strategies to induce regeneration . Neural Regeneration Research. 14. (1). p. 69-71.

Monteiro, S., Salgado, A.J., Silva, N.A.(2018). Immunomodulation as a neuroprotective strategy after spinal cord injury . Neural Regeneration Research. 13. (3). p. 423-424.

Serra, S.C., Costa, J.C., Assunção-Silva, R.C., Teixeira, F.G., Silva, N.A., Anjo, S.I., Manadas, B., Gimble, J.M., Behie, L.A., Salgado, A.J.(2018). Influence of passage number on the impact of the secretome of adipose tissue stem cells on neural survival, neurodifferentiation and axonal growth . Biochimie. 155. p. 119-128.

Melo-Fonseca, F., Lima, R., Costa, M.M., Bartolomeu, F., Alves, N., Miranda, A., Gasik, M., Silva, F.S., Silva, N.A., Miranda, G.(2018). 45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular response . Materials and Design. 160. p. 95-105.

45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular response @article { author = {Melo-Fonseca, F. and Lima, R. and Costa, M.M. and Bartolomeu, F. and Alves, N. and Miranda, A. and Gasik, M. and Silva, F.S. and Silva, N.A. and Miranda, G.}, title = {45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular response}, journal = {Materials and Design}, volume = {160}, pages = {95--105}, year = {2018}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-85052955202&partnerID=MN8TOARS}, doi = {10.1016/j.matdes.2018.08.056} } . Materials and Design.

Gomes, E.D., Mendes, S.S., Assunção-Silva, R.C., Teixeira, F.G., Pires, A.O., Anjo, S.I., Manadas, B., Leite-Almeida, H., Gimble, J.M., Sousa, N., et al.(2018). Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair . Stem Cells. 36. (5). p. 696-708.

Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection @article { author = {Silva, Nuno}, title = {Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection}, journal = {Pharmaceuticals}, year = {2017}, month = {oct}, url = {http://www.mdpi.com/1424-8247/10/4/83}, doi = {10.3390/ph10040083} } . Pharmaceuticals.

(2017). Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection . Pharmaceuticals.

Lima, R., Monteiro, S., Lopes, J.P., Barradas, P., Vasconcelos, N.L., Gomes, E.D., Assunção-Silva, R.C., Teixeira, F.G., Morais, M., Sousa, N., et al.(2017). Systemic interleukin-4 administration after spinal cord injury modulates inflammation and promotes neuroprotection . Pharmaceuticals. 10. (4).

E. Oliveira, R. C. Assunção-Silva, O. Ziv-Polat, E. D. Gomes, F. G. Teixeira, N. A. Silva, A. Shahar, A. J. Salgado(2017). Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells . Stem Cells International. 2017. p. 1--10. Hindawi Limited

Oliveira, E., Assunção-Silva, R.C., Ziv-Polat, O., Gomes, E.D., Teixeira, F.G., Silva, N.A., Shahar, A., Salgado, A.J.(2017). Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells . Stem Cells International. 2017.

Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells @article { author = {E. Oliveira and R. C. Assunção-Silva and O. Ziv-Polat and E. D. Gomes and F. G. Teixeira and N. A. Silva and A. Shahar and A. J. Salgado}, title = {Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells}, journal = {Stem Cells International}, volume = {2017}, pages = {1--10}, year = {2017}, url = {https://doi.org/10.1155/2017/6319129}, doi = {10.1155/2017/6319129} } . Stem Cells International.

Bioengineered cell culture systems of central nervous system injury and disease @article { author = {Teixeira, F.G. and Vasconcelos, N.L. and Gomes, E.D. and Marques, F. and Sousa, J.C. and Sousa, N. and Silva, N.A. and Assunção-Silva, R. and Lima, R. and Salgado, A.J.}, title = {Bioengineered cell culture systems of central nervous system injury and disease}, journal = {Drug Discovery Today}, year = {2016}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84975780622&partnerID=MN8TOARS}, doi = {10.1016/j.drudis.2016.04.020} } . Drug Discovery Today.

Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury @article { author = {Vasconcelos, N.L. and Gomes, E.D. and Oliveira, E.P. and Silva, C.J. and Lima, R. and Sousa, N. and Salgado, A.J. and Silva, N.A.}, title = {Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury}, journal = {Spine Journal}, volume = {16}, number = {8}, pages = {1015--1024}, year = {2016}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84965002844&partnerID=MN8TOARS}, doi = {10.1016/j.spinee.2016.04.013} } . Spine Journal.

Erratum: Microglia Response and in Vivo Therapeutic Potential of Methylprednisolone-Loaded Dendrimer Nanoparticles in Spinal Cord Injury (Small (2013) 9 (738-749) DOI: 10.1002/smll.201201888) @article { author = {Cerqueira, S.R. and Oliveira, J.M. and Silva, N.A. and Leite-Almeida, H. and Ribeiro-Samy, S. and Almeida, A. and Mano, J.F. and Sousa, N. and Salgado, A.J. and Reis, R.L.}, title = {Erratum: Microglia Response and in Vivo Therapeutic Potential of Methylprednisolone-Loaded Dendrimer Nanoparticles in Spinal Cord Injury (Small (2013) 9 (738-749) DOI: 10.1002/smll.201201888)}, journal = {Small}, volume = {12}, number = {8}, year = {2016}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84959036510&partnerID=MN8TOARS}, doi = {10.1002/smll.201503492} } . Small.

Erratum: Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations (Biochimie (2013) 95:12 (2297-2303) DOI: 10.1016/j.biochi.2013.06.028) @article { author = {Fraga, J.S. and Silva, N.A. and Lourenço, A.S. and Gonçalves, V. and Neves, N.M. and Reis, R.L. and Rodrigues, A.J. and Manadas, B. and Sousa, N. and Salgado, A.J.}, title = {Erratum: Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations (Biochimie (2013) 95:12 (2297-2303) DOI: 10.1016/j.biochi.2013.06.028)}, journal = {Biochimie}, volume = {121}, year = {2016}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84957818600&partnerID=MN8TOARS}, doi = {10.1016/j.biochi.2015.11.025} } . Biochimie.

Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis @article { author = {Pires, A.O. and Mendes-Pinheiro, B. and Teixeira, F.G. and Anjo, S.I. and Ribeiro-Samy, S. and Gomes, E.D. and Serra, S.C. and Silva, N.A. and Manadas, B. and Sousa, N. and Salgado, A.J.}, title = {Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis}, journal = {Stem Cells and Development}, volume = {25}, number = {14}, pages = {1073--1083}, year = {2016}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84978401618&partnerID=MN8TOARS}, doi = {10.1089/scd.2016.0048} } . Stem Cells and Development.

Combination of a peptide-modified gellan gum hydrogel with cell therapy in a lumbar spinal cord injury animal model @article { author = {Gomes, E.D. and Mendes, S.S. and Leite-Almeida, H. and Gimble, J.M. and Tam, R.Y. and Shoichet, M.S. and Sousa, N. and Silva, N.A. and Salgado, A.J.}, title = {Combination of a peptide-modified gellan gum hydrogel with cell therapy in a lumbar spinal cord injury animal model}, journal = {Biomaterials}, volume = {105}, pages = {38--51}, year = {2016}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84982786577&partnerID=MN8TOARS}, doi = {10.1016/j.biomaterials.2016.07.019} } . Biomaterials.

Teixeira, F.G., Vasconcelos, N.L., Gomes, E.D., Marques, F., Sousa, J.C., Sousa, N., Silva, N.A., Assunção-Silva, R., Lima, R., Salgado, A.J.(2016). Bioengineered cell culture systems of central nervous system injury and disease . Drug Discovery Today.

Gomes, E.D., Mendes, S.S., Leite-Almeida, H., Gimble, J.M., Tam, R.Y., Shoichet, M.S., Sousa, N., Silva, N.A., Salgado, A.J.(2016). Combination of a peptide-modified gellan gum hydrogel with cell therapy in a lumbar spinal cord injury animal model . Biomaterials. 105. p. 38-51.

Vasconcelos, N.L., Gomes, E.D., Oliveira, E.P., Silva, C.J., Lima, R., Sousa, N., Salgado, A.J., Silva, N.A.(2016). Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury . Spine Journal. 16. (8). p. 1015-1024.

Cerqueira, S.R., Oliveira, J.M., Silva, N.A., Leite-Almeida, H., Ribeiro-Samy, S., Almeida, A., Mano, J.F., Sousa, N., Salgado, A.J., Reis, R.L.(2016). Erratum: Microglia Response and in Vivo Therapeutic Potential of Methylprednisolone-Loaded Dendrimer Nanoparticles in Spinal Cord Injury (Small (2013) 9 (738-749) DOI: 10.1002/smll.201201888) . Small. 12. (8).

Fraga, J.S., Silva, N.A., Lourenço, A.S., Gonçalves, V., Neves, N.M., Reis, R.L., Rodrigues, A.J., Manadas, B., Sousa, N., Salgado, A.J.(2016). Erratum: Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations (Biochimie (2013) 95:12 (2297-2303) DOI: 10.1016/j.biochi.2013.06.028) . Biochimie. 121.

Pires, A.O., Mendes-Pinheiro, B., Teixeira, F.G., Anjo, S.I., Ribeiro-Samy, S., Gomes, E.D., Serra, S.C., Silva, N.A., Manadas, B., Sousa, N., et al.(2016). Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis . Stem Cells and Development. 25. (14). p. 1073-1083.

Sevivas, N., Serra, S.C., Portugal, R., Teixeira, F.G., Carvalho, M.M., Silva, N., Espregueira-Mendes, J., Sousa, N., Salgado, A.J.(2015). Animal model for chronic massive rotator cuff tear: behavioural and histologic analysis . Knee Surgery, Sports Traumatology, Arthroscopy. 23. (2). p. 608-618.

Canha-Gouveia, A., Rita Costa-Pinto, A., Martins, A.M., Silva, N.A., Faria, S., Sousa, R.A., Salgado, A.J., Sousa, N., Reis, R.L., Neves, N.M.(2015). Hierarchical scaffolds enhance osteogenic differentiation of human Wharton's jelly derived stem cells . Biofabrication. 7. (3).

Assunção-Silva, R.C., Gomes, E.D., Sousa, N., Silva, N.A., Salgado, A.J.(2015). Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration . Stem Cells International. 2015.

Assunção-Silva, R.C., Oliveira, C.C., Ziv-Polat, O., Gomes, E.D., Sahar, A., Sousa, N., Silva, N.A., Salgado, A.J.(2015). Induction of neurite outgrowth in 3D hydrogel-based environments . Biomedical materials (Bristol, England). 10. (5).

Silva, N.A., Sousa, N., Reis, R.L., Salgado, A.J.(2014). From basics to clinical: A comprehensive review on spinal cord injury . Progress in Neurobiology. 114. p. 25-57.

Silva, N.A., Sousa, R.A., Fraga, J.S., Fontes, M., Leite-Almeida, H., Cerqueira, R., Almeida, A., Sousa, N., Reis, R.L., Salgado, A.J.(2013). Benefits of spine stabilization with biodegradable scaffolds in spinal cord injured rats . Tissue Engineering - Part C: Methods. 19. (2). p. 101-108.

Silva, N.A., Gimble, J.M., Sousa, N., Reis, R.L., Salgado, A.J.(2013). Combining adult stem cells and olfactory ensheathing cells: The secretome effect . Stem Cells and Development. 22. (8). p. 1232-1240.

Ribeiro-Samy, S., Silva, N.A., Correlo, V.M., Fraga, J.S., Pinto, L., Teixeira-Castro, A., Leite-Almeida, H., Almeida, A., Gimble, J.M., Sousa, N., et al.(2013). Development and Characterization of a PHB-HV-based 3D Scaffold for a Tissue Engineering and Cell-therapy Combinatorial Approach for Spinal Cord Injury Regeneration . Macromolecular Bioscience.

Cerqueira, S.R., Oliveira, J.M., Silva, N.A., Leite-Almeida, H., Ribeiro-Samy, S., Almeida, A., Mano, J.F., Sousa, N., Salgado, A.J., Reis, R.L.(2013). Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury . Small. 9. (5). p. 738-749.

Silva, N.A., Moreira, J., Ribeiro-Samy, S., Gomes, E.D., Tam, R.Y., Shoichet, M.S., Reis, R.L., Sousa, N., Salgado, A.J.(2013). Modulation of bone marrow mesenchymal stem cell secretome by ECM-like hydrogels . Biochimie.

Silva, N.A., Moreira, J., Ribeiro-Samy, S., Gomes, E.D., Tam, R.Y., Shoichet, M.S., Reis, R.L., Sousa, N., Salgado, A.J.(2013). Modulation of bone marrow mesenchymal stem cell secretome by ECM-like hydrogels . Biochimie. 95. (12). p. 2314-2319.

Fraga, J.S., Silva, N.A., Lourenço, A.S., Gonçalves, V., Neves, N.M., Reis, R.L., Rodrigues, A.J., Manadas, B., Sousa, N., Salgado, A.J.(2013). Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations . Biochimie. 95. (12). p. 2297-2303.

Combining adult stem cells and olfactory ensheathing cells: The secretome effect @article { author = {Silva, N.A. and Gimble, J.M. and Sousa, N. and Reis, R.L. and Salgado, A.J.}, title = {Combining adult stem cells and olfactory ensheathing cells: The secretome effect}, journal = {Stem Cells and Development}, volume = {22}, number = {8}, pages = {1232--1240}, year = {2013}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84876109990&partnerID=MN8TOARS}, doi = {10.1089/scd.2012.0524} } . Stem Cells and Development.

Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury @article { author = {Cerqueira, S.R. and Oliveira, J.M. and Silva, N.A. and Leite-Almeida, H. and Ribeiro-Samy, S. and Almeida, A. and Mano, J.F. and Sousa, N. and Salgado, A.J. and Reis, R.L.}, title = {Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury}, journal = {Small}, volume = {9}, number = {5}, pages = {738--749}, year = {2013}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84874681851&partnerID=MN8TOARS}, doi = {10.1002/smll.201201888} } . Small.

Modulation of bone marrow mesenchymal stem cell secretome by ECM-like hydrogels @article { author = {Silva, N.A. and Moreira, J. and Ribeiro-Samy, S. and Gomes, E.D. and Tam, R.Y. and Shoichet, M.S. and Reis, R.L. and Sousa, N. and Salgado, A.J.}, title = {Modulation of bone marrow mesenchymal stem cell secretome by ECM-like hydrogels}, journal = {Biochimie}, volume = {95}, number = {12}, pages = {2314--2319}, year = {2013}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84887825247&partnerID=MN8TOARS}, doi = {10.1016/j.biochi.2013.08.016} } . Biochimie.

Interactions between Schwann and olfactory ensheathing cells with a starch/polycaprolactone scaffold aimed at spinal cord injury repair @article { author = {Silva, N.A. and Sousa, R.A. and Pires, A.O. and Sousa, N. and Salgado, A.J. and Reis, R.L.}, title = {Interactions between Schwann and olfactory ensheathing cells with a starch/polycaprolactone scaffold aimed at spinal cord injury repair}, journal = {Journal of Biomedical Materials Research - Part A}, volume = {100 A}, number = {2}, pages = {470--476}, year = {2012}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84655175084&partnerID=MN8TOARS}, doi = {10.1002/jbm.a.33289} } . Journal of Biomedical Materials Research - Part A.

Oliveira, A.L., Sousa, E.C., Silva, N.A., Sousa, N., Salgado, A.J., Reis, R.L.(2012). Peripheral mineralization of a 3D biodegradable tubular construct as a way to enhance guidance stabilization in spinal cord injury regeneration . Journal of Materials Science: Materials in Medicine. 23. (11). p. 2821-2830.

Silva, N.A., Cooke, M.J., Tam, R.Y., Sousa, N., Salgado, A.J., Reis, R.L., Shoichet, M.S.(2012). The effects of peptide modified gellan gum and olfactory ensheathing glia cells on neural stem/progenitor cell fate . Biomaterials. 33. (27). p. 6345-6354.

Silva, N.A., Sousa, R.A., Pires, A.O., Sousa, N., Salgado, A.J., Reis, R.L.(2012). Interactions between Schwann and olfactory ensheathing cells with a starch/polycaprolactone scaffold aimed at spinal cord injury repair . Journal of Biomedical Materials Research - Part A. 100 A. (2). p. 470-476.

Ribeiro, C.A., Salgado, A.J., Fraga, J.S., Silva, N.A., Reis, R.L., Sousa, N.(2011). The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures) . Journal of Tissue Engineering and Regenerative Medicine. 5. (8). p. 668-672.

The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures) @article { author = {Ribeiro, C.A. and Salgado, A.J. and Fraga, J.S. and Silva, N.A. and Reis, R.L. and Sousa, N.}, title = {The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures)}, journal = {Journal of Tissue Engineering and Regenerative Medicine}, volume = {5}, number = {8}, pages = {668--672}, year = {2011}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-79960554011&partnerID=MN8TOARS}, doi = {10.1002/term.365} } . Journal of Tissue Engineering and Regenerative Medicine.

Silva, N.A., Salgado, A.J., Sousa, R.A., Oliveira, J.T., Pedro, A.J., Leite-Almeida, H., Cerqueira, R., Almeida, A., Mastronardi, F., Mano, J.F., et al.(2010). Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury repair . Tissue Engineering - Part A. 16. (1). p. 45-54.

DISCLOSURE

Electric stimulator for cell culture, device, methods and uses thereof @misc { author = {Silva, Nuno A.}, title = {Electric stimulator for cell culture, device, methods and uses thereof}, year = {2020}, month = {mar} }.

Compositions for treatment of spinal cord injury, methods and uses thereof @misc { author = {Silva, Nuno A.}, title = {Compositions for treatment of spinal cord injury, methods and uses thereof}, year = {2020}, month = {mar}, keywords = { Neurotrauma; Stem Cells} }.

BOOK CHAPTER

Animal Models of CNS Disorders @inbook { author = {Eduardo Gomes and Sandra Barata-Antunes and Andreia Teixeira-Castro and Rita C. Assunção-Silva and Cláudia R. Marques and Susana Monteiro and Fábio G. Teixeira and Aline M. Fernandes and Silva, Nuno A.}, editor = {António J. Salgado}, title = {Animal Models of CNS Disorders}, edition = {1st}, publisher = {Elsevier}, year = {2020}, url = {https://www.elsevier.com/books/handbook-of-innovations-in-central-nervous-system-regenerative-medicine/salgado/978-0-12-818084-6}, keywords = { Neurotrauma} } . Handbook of Innovations in Central Nervous System Regenerative Medicine 1st Edition.

Neuroprotection in the Injured Spinal Cord @inbook { author = {Rui Lima and Inês, M. Pereira and Silva, Nuno A.}, editor = {António J. Salgado}, title = {Neuroprotection in the Injured Spinal Cord}, edition = {1st}, publisher = {Elsevier}, year = {2020}, url = {https://www.elsevier.com/books/handbook-of-innovations-in-central-nervous-system-regenerative-medicine/salgado/978-0-12-818084-6}, keywords = { Neurotrauma; Neuroprotection} } . Handbook of Innovations in Central Nervous System Regenerative Medicine.

Gomes, E.D., Rocha, L.A., Assunção-Silva, R.C., Lima, R., Silva, N.A., Salgado, A.J.(2019). Cell therapies for spinal cord injury regeneration . Spinal Cord Injury (SCI) Repair Strategies. p. 157-186.

Assunção-Silva, R.C., Gomes, E.D., Silva, N.A., Salgado, A.J.(2018). Nanoengineered biomaterials for spinal cord regeneration . Nanoengineered Biomaterials for Regenerative Medicine. p. 167-185.

Modulation of Stem Cells Behavior Through Bioactive Surfaces @inbook { author = {Gomes, Eduardo D. and Assunção-Silva, Rita C. and Sousa, Nuno and Silva, Nuno A. and Salgado, António J.}, title = {Modulation of Stem Cells Behavior Through Bioactive Surfaces}, pages = {67--86}, publisher = {John Wiley & Sons, Inc.}, year = {2016}, url = {http://dx.doi.org/10.1002/9781119242642.ch4}, doi = {10.1002/9781119242642.ch4} } . Advanced Surfaces for Stem Cell Research.

Hydrogels for spinal cord injury regeneration @inbook { author = {SALGADO, A.J. and SOUSA, N. and SILVA, N.A. and NEVES, N.M. and REIS, R.L.}, title = {Hydrogels for spinal cord injury regeneration}, pages = {570--594}, publisher = {Elsevier}, year = {2008}, url = {http://dx.doi.org/10.1533/9781845694814.4.570}, doi = {10.1533/9781845694814.4.570} } . Natural-Based Polymers for Biomedical Applications.

BOOK

Gomes, E.D., Assunção-Silva, R.C., Sousa, N., Silva, N.A., Salgado, A.J.(2016). Modulation of Stem Cells Behavior through Bioactive Surfaces . Advanced Surfaces for Stem Cell Research. p. 67-86.

Salgado, A.J., Oliveira, J.M., Martins, A., Teixeira, F.G., Silva, N.A., Neves, N.M., Sousa, N., Reis, R.L.(2013). Tissue engineering and regenerative medicine: Past, present, and future . International Review of Neurobiology. 108. p. 1-33.

Salgado, A.J., Sousa, N., Silva, N.A., Neves, N.M., Reis, R.L.(2008). Hydrogels for spinal cord injury regeneration . Natural-Based Polymers for Biomedical Applications. p. 570-594.