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USD 65 /hr

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Hire Dr. Meetali S.

India

USD 65 /hr

PhD Computational Biologist | Drug–Drug Interaction & Preclinical Drug Safety

Profile Summary

I am a Phd in Computational Biology and Toxicology with over 8 years of research experience in computational toxicology, bioinformatics, and in silico risk assessment, spanning academic research institutes and industry. I hold a PhD from AcSIR (CSIR-IITR, Lucknow), along with M.Tech and B.Tech in Bioinformatics, and I am currently working as a Scientist (Level 2) in an industry role. My core expertise lies in mechanistic, data-driven analysis of chemical and drug safety, including drug–drug interaction (DDI) evaluation, QSAR modeling, predictive toxicology, pathway and network analysis, and phenotype-specific risk assessment. I have extensive experience applying computational biology approaches to real-world safety and regulatory problems, particularly involving specialty chemicals, PFAS, dietary compounds, and therapeutic drugs. In my current role, I am involved in the design, development, and validation of Python-based computational workflows for DDI assessment, integrating molecular targets, gene–drug relationships, and clinical evidence to identify victim–perpetrator dynamics and interaction risks. My work emphasizes logical problem formulation, reproducibility, structured validation, and clear scientific interpretation, making outputs suitable for internal review, regulatory discussion, and decision-making. During my tenure at CSIR-Indian Institute of Toxicology Research (IITR), I worked as a Senior Project Associate, Senior Research Fellow, and Junior Research Fellow, contributing to multiple nationally funded research projects. I was actively involved in the development of toxicity databases (ToxDP2 and ToxFCDB) and in silico evaluation of endocrine disruption, carcinogenicity, hepatotoxicity, mutagenicity, and developmental toxicity. I have also supervised junior researchers and postgraduate students, providing mentorship in computational problem-solving and research design. I have authored 15+ peer-reviewed research articles and 4 book chapters, with publications in reputed journals and edited volumes, and have presented my work at national and international scientific forums. My research excellence has been recognized through awards such as the DST-INSPIRE Fellowship, Eat Right Research Award (FSSAI), and Best Poster Presentation awards. Technically, I am proficient in Python and R, molecular docking and dynamics (GROMACS, Schrödinger Maestro, Discovery Studio), QSAR and toxicoinformatics platforms (DEREK Nexus, VEGA QSAR, SARAH Nexus, CASE Ultra), and bioinformatics databases and visualization tools. I am comfortable working on short-term consulting assignments, collaborative research projects, manuscript preparation, data analysis, and method validation. I am particularly interested in collaborative, interdisciplinary projects where computational analysis supports drug discovery, safety assessment, regulatory science, or translational research, and I value clear communication, scientific rigor, and timely delivery of high-quality results. I am available for remote consulting, research collaboration and expert advisory work.

Subject Matter Expertise

• ★ Bioinformatics
• ★ Python
• ★ Drug-Drug Interactions
• ☆ Molecular Modeling
• ☆ Molecular Docking
• ☆ Chemoinformatics
• ☆ Computational Biology
• ☆ Data Analysis
• ☆ Predictive Modeling & Analytics
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Drug Development
• ☆ In vivo Preclinical Toxicology
• ☆ Health Risk Assessments

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing

Research Meta-Research, Gap Analysis, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Healthcare Consulting, Scientific and Technical Consulting, Regulatory Consulting

Data & AI Predictive Modeling, Algorithm Design-Non ML, Data Processing

Product Development Product Evaluation, Product Validation, Product Compliance , Concept Development

Work Experience

Scientist Level 2

Cellworks Research (India)

August 2024 - Present

Senior Project Associate

Indian Institute of Toxicology Research

November 2022 - Present

Senior Research Fellow

Indian Institute of Toxicology Research

December 2020 - June 2022

Junior Research Fellow

CSIR-Indian Institute of Toxicology Research

June 2017 - December 2020

Education

PhD (Biological sciences)

Academy of Scientific and Innovative Research

January 2017 - January 2022

M.tech Bioinformatics (Department of Bioengineering )

Integral University

July 2013 - May 2015

B.Tech (Department of Biotechnology)

Amity University

August 2009 - December 2012

Certifications

• Fundamentals of Next generation Sequencing and Data Analysis

  The Institute of Biotechnological Research

  https://tibrresearch.com/

  July 2024 - July 2024

Publications

JOURNAL ARTICLE

Meetali Sinha, Deepak Kumar Sachan, Joy Chakraborty, Anamta Ali, Anshika Gupta, Tanya Jamal, Ramakrishnan Parthasarathi (2026). ToxFCDB: Toxicity Database for Forever Chemicals . Journal of Chemical Information and Modeling.

Meetali Sinha, Deepak Kumar Sachan, Joy Chakraborty, Anamta Ali, Anshika Gupta, Tanya Jamal, Ramakrishnan Parthasarathi (2026). ToxFCDB: Toxicity Database for Forever Chemicals . Journal of Chemical Information and Modeling.

Gaurav Prajapati, Sunil Kumar Patel, Durgesh Mourya, Meetali Sinha, Mohd Danish Kamar, Ratan Singh Ray, Ashish Dwivedi (2025). Photosensitization and phototoxicity mechanism of diclofenac sodium (NSAID) under ambient UVR exposure . Journal of Photochemistry and Photobiology B: Biology.

Tulika Srivastava, Divya Tyagi, Siraj Fatima, Malur Thirumalesh Vishnu Sathyan, Ritu Raj, Aniket Sharma, Minal Chaturvedi, Meetali Sinha, Sonia Kumari Shishodia, Dinesh Kumar, et al. (2024). A natural small molecule‐mediated inhibition of alpha‐synuclein aggregation leads to neuroprotection in Caenorhabditis elegans . Journal of Neurochemistry.

ToxDP2 Database: Toxicity prediction of dietary polyphenols @article{2022, doi = {10.1016/j.foodchem.2021.131350}, url = {https://doi.org/10.1016%2Fj.foodchem.2021.131350}, year = 2022, month = {feb}, publisher = {Elsevier {BV}}, volume = {370}, pages = {131350}, author = {Meetali Sinha and Deepak Kumar Sachan and Roshni Bhattacharya and Prakrity Singh and Ramakrishnan Parthasarathi}, title = {{ToxDP}2 Database: Toxicity prediction of dietary polyphenols}} . Food Chemistry.

Prakrity Singh, Shweta Singh Chauhan, Shraddha Pandit, Meetali Sinha, Shristee Gupta, Anshika Gupta, Ramakrishnan Parthasarathi (2022). The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins . Journal of Traditional and Complementary Medicine.

Sinha, M., Sachan, D.K., Bhattacharya, R., Singh, P., Parthasarathi, R.(2022). ToxDP2 Database: Toxicity prediction of dietary polyphenols . Food Chemistry. 370.

Shweta Goyal, Saurabh Tiwari, Brashket Seth, Ankit Tandon, Jai Shankar, Meetali Sinha, Sangh Jyoti Singh, Smriti Priya, Rajnish Kumar Chaturvedi (2021). Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus . NeuroToxicology.

(2021). Analogue discovery of safer alternatives to HCQ and CQ drugs for SAR-CoV-2 by computational design . Computers in biology and medicine.

(2021). Integrated QSAR and Adverse Outcome Pathway Analysis of Chemicals Released on 3D Printing Using Acrylonitrile Butadiene Styrene . Chemical research in toxicology.

Pandit, S., Singh, P., Sinha, M., Parthasarathi, R.(2021). Integrated QSAR and Adverse Outcome Pathway Analysis of Chemicals Released on 3D Printing Using Acrylonitrile Butadiene Styrene . Chemical Research in Toxicology. 34. (2). p. 355-364.

Sinha, M., Gupta, A., Gupta, S., Singh, P., Pandit, S., Chauhan, S.S., Parthasarathi, R.(2021). Analogue discovery of safer alternatives to HCQ and CQ drugs for SAR-CoV-2 by computational design . Computers in Biology and Medicine. 130.

Goyal, S., Tiwari, S., Seth, B., Tandon, A., Shankar, J., Sinha, M., Singh, S.J., Priya, S., Chaturvedi, R.K.(2021). Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus . NeuroToxicology. 85. p. 18-32.

Singh, P., Chauhan, S.S., Pandit, S., Sinha, M., Gupta, S., Gupta, A., Parthasarathi, R.(2021). The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins . Journal of Traditional and Complementary Medicine.

(2020). Study of Caspase 8 Inhibition for the Management of Alzheimer’s Disease: A Molecular Docking and Dynamics Simulation . Molecules.

Syed Sayeed Ahmad, Meetali Sinha, Khurshid Ahmad, Mohammad Khalid, Inho Choi (2020). Study of Caspase 8 Inhibition for the Management of Alzheimer’s Disease: A Molecular Docking and Dynamics Simulation . Molecules.

Ahmad, S.S., Sinha, M., Ahmad, K., Khalid, M., Choi, I.(2020). Study of caspase 8 inhibition for the management of Alzheimer’s disease: A molecular docking and dynamics simulation . Molecules. 25. (9).

(2019). Genotoxicity QSAR (Geno-QSAR) models for the safety prioritization of specialty chemicals . JOURNAL OF THE INDIAN CHEMICAL SOCIETY.

(2014). IN SILICO DIAGNOSIS OF TUBERCULOSIS IN MULTIPLE SPECIES USING SINGLE NUCLEOTIDE POLYMORPHISM AS BIOLOGICAL MARKER . International Journal of Advanced Technology in Engineering and Science.

Insilico identification of novel compound against Urinary Tract Infection . Int. Res. J. Biological Sci., Volume 5.

PHARMACOGENOMICS: A STEP AHEAD IN MODERN DAY DRUG DISCOVERY . International Journal of Advances in Engineering & Scientific Research.

BOOK CHAPTER

Meetali Sinha, Tanya Jamal, Alok Dhawan, R. Parthasarathi (2026). In Silico Approaches in Predictive Genetic Toxicology . Methods in Molecular Biology.

(2019). In Silico Approaches in Predictive Genetic Toxicology . Methods in Molecular Biology.

Sinha, M., Dhawan, A., Parthasarathi, R.(2019). In Silico Approaches in Predictive Genetic Toxicology . Methods in Molecular Biology. 2031. p. 351-373.