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USD 100 /hr
Hire Dr. Mark O.
United Kingdom
USD 100 /hr

Chemical Physicist | Co-inventor Solexa Sequencing | Climate-tech | Nanomaterials | Molecular Imaging | Spectroscopy

Profile Summary
Subject Matter Expertise
Services
Writing Technical Writing
Work Experience

University of Sussex

- Present

Founder/Consultant

Carbon Lock Solutions, Brighton, UK

June 2024 - Present

Scientific collaborator

Deep Science Ventures, London (Remote), UK

August 2024 - October 2024

Associate Professor

University of Sussex, Falmer, UK

October 2008 - December 2021

Royal Society University Research Fellow

University of Sussex

August 2001 - September 2008

Senior Scientist / Group Manager

Solexa Limited (Illumina Inc.), Little Chesterford Research Park, Essex, UK

September 2000 - July 2001

Academic Consultant

Solexa Ltd, University of Cambridge, UK

April 1999 - August 2000

Postdoctoral Reseacher

University of Cambridge, UK

June 1996 - August 2000

Marie Curie Researcher

Commissariat a l'Energie Atomique (CEA Saclay, France)

February 1995 - March 1996

Education

DPhil Chemical Physics

University of Sussex

October 1991 - December 1994

BSc (Hons) Chemical Physics 1st Class

University of Sussex

October 1988 - June 1991

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Thomas J Etheridge, Desiree Villahermosa, Eduard Campillo-Funollet, Alex David Herbert, Anja Irmisch, Adam T Watson, Hung Q Dang, Mark A Osborne, Antony W Oliver, Antony M Carr, et al. (2021). Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo . eLife.
Etheridge, Thomas J. and Villahermosa, Desiree and Irmisch, Anja and Watson, Adam T. and Herbert, Alex and Dang, Hung Q. and Osborne, Mark A. and Oliver, Antony W. and Carr, Antony M. and Murray, Johanne M.(2020). Single-molecule live cell imaging of the Smc5/6 DNA repair complex . bioRxiv. p. 2020.06.19.148106. bioRxiv
Russell, Kieran O. and Osborne, Mark A. and Fisher, Aidan A. E.(2020). Crystallographic phase changes and damage thresholds of CsPbI 3 microwire waveguides through continuous wave photoablation . Materials Advances. 1. (2). p. 161--166. Royal Society of Chemistry (RSC)
Kieran O. Russell, Mark A. Osborne, Aidan A. E. Fisher(2020). Crystallographic phase changes and damage thresholds of CsPbI3 microwire waveguides through continuous wave photoablation . Materials Advances. Royal Society of Chemistry ({RSC})
Kieran O. Russell, Mark A. Osborne, Aidan A. E. Fisher(2020). Crystallographic phase changes and damage thresholds of CsPbI3 microwire waveguides through continuous wave photoablation . Materials Advances. 1. (2). p. 161--166. Royal Society of Chemistry ({RSC})
Fisher, Aidan A. E. and Osborne, Mark A. and Day, Iain J. and {Lucena Alcalde}, Guillermo(2019). Measurement of ligand coverage on cadmium selenide nanocrystals and its influence on dielectric dependent photoluminescence intermittency . Communications Chemistry. 2. (1). p. 63. Nature Publishing Group
Aidan A. E. Fisher, Mark A. Osborne, Iain J. Day, Guillermo Lucena Alcalde (2019). Measurement of ligand coverage on cadmium selenide nanocrystals and its influence on dielectric dependent photoluminescence intermittency . Communications Chemistry.
Aidan A. E. Fisher, Mark A. Osborne(2017). Sizing Up Excitons in Core–Shell Quantum Dots via Shell-Dependent Photoluminescence Blinking . ACS Nano. 11. (8). p. 7829--7840. American Chemical Society ({ACS})
Yasukazu Daigaku, Lorraine S. Symington, Thomas J. Etheridge, Yuka Nakazawa, Mayumi Nakayama, Adam T. Watson, Izumi Miyabe, Tomoo Ogi, Mark A. Osborne, Antony M. Carr(2017). PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast . PLOS Genetics. 13. (5). p. e1006789. Public Library of Science ({PLoS})
Daigaku, Yasukazu and Etheridge, Thomas J. and Nakazawa, Yuka and Nakayama, Mayumi and Watson, Adam T. and Miyabe, Izumi and Ogi, Tomoo and Osborne, Mark A. and Carr, Antony M.(2017). PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast . PLOS Genetics. 13. (5). p. e1006789.
Fisher, Aidan A.E. and Osborne, Mark A.(2017). Sizing Up Excitons in Core-Shell Quantum Dots via Shell-Dependent Photoluminescence Blinking . ACS Nano. 11. (8). p. 7829--7840.
Osborne, M. A. and Fisher, A. A. E.(2016). Charge-tunnelling and self-trapping: common origins for blinking, grey-state emission and photoluminescence enhancement in semiconductor quantum dots . Nanoscale. 8. (17). p. 9272--9283. The Royal Society of Chemistry
Etheridge, Thomas J and Boulineau, R{\'{e}}mi L and Herbert, Alex and Watson, Adam T and Daigaku, Yasukazu and Tucker, Jem and George, Sophie and J{\"{o}}nsson, Peter and Palayret, Matthieu and Lando, David and Laue, Ernest and Osborne, Mark A and Klenerman, David and Lee, Steven F and Carr, Antony M(2014). Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy . Nucleic acids research. 42. (19). p. e146. Oxford University Press
Boulineau, R{\'{e}}mi L. and Osborne, Mark A.(2013). Direct object resolution by image subtraction: A new molecular ruler for nanometric measurements on complexed fluorophores . Chemical Communications. 49. (49). p. 5559--5561. The Royal Society of Chemistry
Nestoras, Konstantinos and Mohammed, Asma Hadi and Schreurs, Ann-Sofie and Fleck, Oliver and Watson, Adam T. and Poitelea, Marius and O'Shea, Charlotte and Chahwan, Charly and Holmberg, Christian and Kragelund, Birthe B. and Nielsen, Olaf and Osborne, Mark and Carr, Antony M. and Liu, Cong(2010). Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms . Genes & Development. 24. (11). p. 1145--1159. Cold Spring Harbor Laboratory Press
Lee, Steven F. and Osborne, Mark A.(2009). Brightening, Blinking, Bluing and Bleaching in the Life of a Quantum Dot: Friend or Foe? . ChemPhysChem. 10. (13). p. 2174--2191. John Wiley {\&} Sons, Ltd
Bentley, David R. and Balasubramanian, Shankar and Swerdlow, Harold P. and Smith, Geoffrey P. and Milton, John and Brown, Clive G. and Hall, Kevin P. and Evers, Dirk J. and Barnes, Colin L. and Bignell, Helen R. and Boutell, Jonathan M. and Bryant, Jason and Carter, Richard J. and {Keira Cheetham}, R. and Cox, Anthony J. and Ellis, Darren J. and Flatbush, Michael R. and Gormley, Niall A. and Humphray, Sean J. and Irving, Leslie J. and Karbelashvili, Mirian S. and Kirk, Scott M. and Li, Heng and Liu, Xiaohai and Maisinger, Klaus S. and Murray, Lisa J. and Obradovic, Bojan and Ost, Tobias and Parkinson, Michael L. and Pratt, Mark R. and Rasolonjatovo, Isabelle M. J. and Reed, Mark T. and Rigatti, Roberto and Rodighiero, Chiara and Ross, Mark T. and Sabot, Andrea and Sankar, Subramanian V. and Scally, Aylwyn and Schroth, Gary P. and Smith, Mark E. and Smith, Vincent P. and Spiridou, Anastassia and Torrance, Peta E. and Tzonev, Svilen S. and Vermaas, Eric H. and Walter, Klaudia and Wu, Xiaolin and Zhang, Lu and Alam, Mohammed D. and Anastasi, Carole and Aniebo, Ify C. and Bailey, David M. D. and Bancarz, Iain R. and Banerjee, Saibal and Barbour, Selena G. and Baybayan, Primo A. and Benoit, Vincent A. and Benson, Kevin F. and Bevis, Claire and Black, Phillip J. and Boodhun, Asha and Brennan, Joe S. and Bridgham, John A. and Brown, Rob C. and Brown, Andrew A. and Buermann, Dale H. and Bundu, Abass A. and Burrows, James C. and Carter, Nigel P. and Castillo, Nestor and {Chiara E. Catenazzi}, Maria and Chang, Simon and {Neil Cooley}, R. and Crake, Natasha R. and Dada, Olubunmi O. and Diakoumakos, Konstantinos D. and Dominguez-Fernandez, Belen and Earnshaw, David J. and Egbujor, Ugonna C. and Elmore, David W. and Etchin, Sergey S. and Ewan, Mark R. and Fedurco, Milan and Fraser, Louise J. and {Fuentes Fajardo}, Karin V. and {Scott Furey}, W. and George, David and Gietzen, Kimberley J. and Goddard, Colin P. and Golda, George S. and Granieri, Philip A. and Green, David E. and Gustafson, David L. and Hansen, Nancy F. and Harnish, Kevin and Haudenschild, Christian D. and Heyer, Narinder I. and Hims, Matthew M. and Ho, Johnny T. and Horgan, Adrian M. and Hoschler, Katya and Hurwitz, Steve and Ivanov, Denis V. and Johnson, Maria Q. and James, Terena and {Huw Jones}, T. A. and Kang, Gyoung-Dong and Kerelska, Tzvetana H. and Kersey, Alan D. and Khrebtukova, Irina and Kindwall, Alex P. and Kingsbury, Zoya and Kokko-Gonzales, Paula I. and Kumar, Anil and Laurent, Marc A. and Lawley, Cynthia T. and Lee, Sarah E. and Lee, Xavier and Liao, Arnold K. and Loch, Jennifer A. and Lok, Mitch and Luo, Shujun and Mammen, Radhika M. and Martin, John W. and McCauley, Patrick G. and McNitt, Paul and Mehta, Parul and Moon, Keith W. and Mullens, Joe W. and Newington, Taksina and Ning, Zemin and {Ling Ng}, Bee and Novo, Sonia M. and O'Neill, Michael J. and Osborne, Mark A. and Osnowski, Andrew and Ostadan, Omead and Paraschos, Lambros L. and Pickering, Lea and Pike, Andrew C. and Pike, Alger C. and {Chris Pinkard}, D. and Pliskin, Daniel P. and Podhasky, Joe and Quijano, Victor J. and Raczy, Come and Rae, Vicki H. and Rawlings, Stephen R. and {Chiva Rodriguez}, Ana and Roe, Phyllida M. and Rogers, John and {Rogert Bacigalupo}, Maria C. and Romanov, Nikolai and Romieu, Anthony and Roth, Rithy K. and Rourke, Natalie J. and Ruediger, Silke T. and Rusman, Eli and Sanches-Kuiper, Raquel M. and Schenker, Martin R. and Seoane, Josefina M. and Shaw, Richard J. and Shiver, Mitch K. and Short, Steven W. and Sizto, Ning L. and Sluis, Johannes P. and Smith, Melanie A. and {Ernest Sohna Sohna}, Jean and Spence, Eric J. and Stevens, Kim and Sutton, Neil and Szajkowski, Lukasz and Tregidgo, Carolyn L. and Turcatti, Gerardo and VandeVondele, Stephanie and Verhovsky, Yuli and Virk, Selene M. and Wakelin, Suzanne and Walcott, Gregory C. and Wang, Jingwen and Worsley, Graham J. and Yan, Juying and Yau, Ling and Zuerlein, Mike and Rogers, Jane and Mullikin, James C. and Hurles, Matthew E. and McCooke, Nick J. and West, John S. and Oaks, Frank L. and Lundberg, Peter L. and Klenerman, David and Durbin, Richard and Smith, Anthony J.(2008). Accurate whole human genome sequencing using reversible terminator chemistry . Nature. 456. (7218). p. 53--59. Nature Publishing Group
Lee, Steven F. and Osborne, Mark A.(2007). Photodynamics of a single quantum dot: Fluorescence activation, enhancement, intermittency, and decay . Journal of the American Chemical Society. 129. (29). p. 8936--8937.
Osborne, Mark A.(2005). Real-Time Dipole Orientational Imaging as a Probe of Ligand−Protein Interactions . The Journal of Physical Chemistry B. 109. (38). p. 18153--18161.
McCaffery, Anthony J. and Osborne, Mark A. and Marsh, Richard J.(2005). Exit routes from the transition state: Angular momentum constraints on the formation of products . Journal of Physical Chemistry A. 109. (23). p. 5005--5015. American Chemical Society
McCaffery, Anthony J. and Osborne, Mark A. and Marsh, Richard J. and Lawrance, Warren D. and Waclawik, Eric R.(2004). The role of angular momentum in collision-induced vibration-rotation relaxation in polyatomics . Journal of Chemical Physics. 121. (1). p. 169--180.
Marsh, Richard J. and McCaffery, Anthony J. and Osborne, Mark A.(2003). Quantitative Calculation of Product Rovibrational Distributions from Atom−Diatom Exchange Reactions . The Journal of Physical Chemistry A. 107. (45). p. 9511--9521.
Osborne, M. A. and Barnes, C. L. and Balasubramanian, S. and Klenerman, D.(2001). Probing DNA Surface Attachment and Local Environment Using Single Molecule Spectroscopy . The Journal of Physical Chemistry B. 105. (15). p. 3120--3126.
Osborne, Mark A. and Furey, W. Scott and Klenerman, David and Balasubramanian, Shankar(2000). Single-Molecule Analysis of DNA Immobilized on Microspheres . Analytical Chemistry. 72. (15). p. 3678--3681.
Horsey, Imogen and Furey, W. Scott and Harrison, Joseph G. and Osborne, Mark A. and Balasubramanian, Shankar(2000). Double fluorescence resonance energy transfer to explore multicomponent binding interactions: A case study of DNA mismatches . Chemical Communications. (12). p. 1043--1044. Royal Society of Chemistry
Osborne, M. A. and Balasubramanian, S. and Furey, W. S. and Klenerman, D.(1998). Optically biased diffusion of single molecules studied by confocal fluorescence microscopy . Journal of Physical Chemistry B. 102. (17). p. 3160--3167. American Chemical Society
Furey, W. Scott and Joyce, Catherine M. and Osborne, Mark A. and Klenerman, David and Peliska, James A. and Balasubramanian, Shankar(1998). Use of Fluorescence Resonance Energy Transfer To Investigate the Conformation of DNA Substrates Bound to the Klenow Fragment \textlesssup\textgreater†\textless/sup\textgreater . Biochemistry. 37. (9). p. 2979--2990.
Osborne, M. A. and Gaveau, M. A. and Gee, C. and Sublemontier, O. and Mestdagh, J. M. and Visticot, J. P.(1997). Dynamics of the deactivation and desorption of Ba atoms from Ar clusters . Journal of Chemical Physics. 106. (4). p. 1449--1462. American Institute of Physics Inc.
Osborne, M. A. and McCaffery, A. J.(1996). Recovery of the Intermolecular Potential from Inelastic Transfer Cross Sections . The Journal of Physical Chemistry. 100. (32). p. 13346--13347.
{C. G{\'{e}}e} and {M. A. Gaveau} and {J. M. Mestdagh} and {M. Osborne} and {O. Sublemontier}, And and Visticot*, J. P.(1996). Cluster Isolated Chemical Reactions: Evidence for the Formation of Ba2O in Oxidation Reactions of Barium Dimers . Journal of Physical Chemistry. 100. p. 13421--13427. American Chemical Society
AlWahabi, Zeyad T. and Besley, Nicholas A. and McCaffery, Anthony J. and Osborne, Mark A. and Rawi, Zaid(1995). Dynamical angular momentum models for rotational transfer in polyatomic molecules . The Journal of Chemical Physics. 102. (20). p. 7945--7952.
Osborne, Mark A. and McCaffery, Anthony J.(1994). A fitting law for rotational transfer rates: An angular momentum model with predictive power . The Journal of Chemical Physics. 101. (7). p. 5604--5614. American Institute of Physics
McCaffery, Anthony J. and Alwahabi, Zeyad T. and Osborne, Mark A. and Williams, Colin J.(1993). Rotational transfer, an angular momentum model . The Journal of Chemical Physics. 98. (6). p. 4586--4602.
CONFERENCE PAPER
Marsh, Richard J. and Osborne, Mark A. and Bain, Angus J.(2003). Control of single-molecule fluorescence dynamics by stimulated emission depletion . Nanocrystals, and Organic and Hybrid Nanomaterials. 5222. p. 78. SPIE