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Hire Dr. Marina T.

Greece

USD 50 /hr

Formulation and Process Development Expert - Pharmaceuticals - Management level

Profile Summary

Innovative and results-driven pharmaceutical scientist with extensive experience in formulation and process development and a PhD on Pharmaceuticals from Utrecht University. As a key member of the company's R&D team, I specialize in designing, optimizing, and scaling advanced drug delivery systems—from concept through commercial readiness. With a strong academic foundation (PhD and 4 years of postdoctoral experience( and a proven track record at a leading Greek pharmaceutical company, I bring deep technical knowledge paired with practical execution skills. 🔬 Core Competencies • Innovative Formulation Design – expertise in controlled-release and novel dosage forms • Process Optimization & Scale‑up – ensuring reproducible manufacturing quality at commercial scale • Cross-functional Collaboration – partnering closely with analytical, quality assurance, and manufacturing teams • Regulatory Liaison – supporting product registration through robust documentation and process knowledge • Continuous Improvement – utilizing data-driven methodologies to optimize formulations and processes

Subject Matter Expertise

• ☆ Drug Development
• ☆ Drug Formulation
• ☆ Drug Substance Characterization
• ☆ Drug Stability Testing
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ Pharmaceutical Regulatory Affairs
• ☆ Pharmaceutical Manufacturing
• ☆ Extractable & Leachable Testing
• ☆ Pharmaceutical Process Development
• ☆ Pharmaceutical Management
• ☆ Drug Delivery Technologies
• ☆ Liposomes
• ☆ Pharmaceutical Technology
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Feasibility Studies
• ☆ Regulatory Writing
• ☆ CMC Documentation
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Spec Sheets
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Language Translation

Services

• Writing

Writing Technical Writing

Work Experience

Formulation and Process Development Expert R&D Innovative Formulations

Pharmathen S.A.

January 2025 - Present

Senior R&D Formulation Scientist

Rafarm S.A.

February 2016 - December 2021

Education

PhD in Pharmaceutics

University of Utrecht

October 2007 - November 2011

Chemistry degree

University of Athens

September 2001 - September 2006

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Rojas, J. M., Gavilán, H., Del Dedo, V., Lorente-Sorolla, E., Sanz-Ortega, L., da Silva, G. B., Costo, R., Perez-Yagüe, S., Talelli, M., Marciello, M., et al.(2017). Time-course assessment of the aggregation and metabolization of magnetic nanoparticles . Acta Biomater. 58. p. 181-195.

Rojas, J.M., Gavilán, H., del Dedo, V., Lorente-Sorolla, E., Sanz-Ortega, L., da Silva, G.B., Costo, R., Perez-Yagüe, S., Talelli, M., Marciello, M., et al.(2017). Time-course assessment of the aggregation and metabolization of magnetic nanoparticles . Acta Biomaterialia. 58. p. 181-195.

Roncador, A., Oppici, E., Talelli, M., Pariente, A. N., Donini, M., Dusi, S., Voltattorni, C. B., Vicent, M. J., Cellini, B.(2017). Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I . Nanomedicine. 13. (3). p. 897-907.

Roncador, A., Oppici, E., Talelli, M., Pariente, A.N., Donini, M., Dusi, S., Voltattorni, C.B., Vicent, M.J., Cellini, B.(2017). Use of polymer conjugates for the intraperoxisomal delivery of engineered human alanine:glyoxylate aminotransferase as a protein therapy for primary hyperoxaluria type I . Nanomedicine: Nanotechnology, Biology, and Medicine. 13. (3). p. 897-907.

Talelli, Marina, Guisasola, Eduardo, Baeza, Alejandro, Arcos, Daniel, Vallet-Regi, Maria(2016). Design of thermoresponsive polymeric gates with opposite controlled release behaviors . RSC Advances. 6. (48). p. 42510-42516.

Guisasola, E., Baeza, A., Talelli, M., Arcos, D., Vallet-Regí, M.(2016). Design of thermoresponsive polymeric gates with opposite controlled release behaviors . RSC Advances. 6. (48). p. 42510-42516.

Marina, Talelli, Antonio Aires and Marzia, Marciello(2016). Protein-Modified Magnetic Nanoparticles for Biomedical Applications . Current Organic Chemistry. 20. (11). p. 1252-1261.

Talelli, M., Aires, A., Marciello, M.(2016). Protein-modified magnetic nanoparticles for biomedical applications . Current Organic Chemistry. 20. (11). p. 1252-1261.

Zahraei, M., Marciello, M., Lazaro-Carrillo, A., Villanueva, A., Herranz, F., Talelli, M., Costo, R., Monshi, A., Shahbazi-Gahrouei, D., Amirnasr, M., et al.(2016). Versatile theranostics agents designed by coating ferrite nanoparticles with biocompatible polymers . Nanotechnology. 27. (25). p. 255702.

Zahraei, M., Marciello, M., Lazaro-Carrillo, A., Villanueva, A., Herranz, F., Talelli, M., Costo, R., Monshi, A., Shahbazi-Gahrouei, D., Amirnasr, M., et al.(2016). Versatile theranostics agents designed by coating ferrite nanoparticles with biocompatible polymers . Nanotechnology. 27. (25).

Talelli, M., Barz, M., Rijcken, C. J., Kiessling, F., Hennink, W. E., Lammers, T.(2015). Core-Crosslinked Polymeric Micelles: Principles, Preparation, Biomedical Applications and Clinical Translation . Nano Today. 10. (1). p. 93-117.

Talelli, M., Barz, M., Rijcken, C.J.F., Kiessling, F., Hennink, W.E., Lammers, T.(2015). Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation . Nano Today. 10. (1). p. 93-117.

Guisasola, E., Baeza, A., Talelli, M., Arcos, D., Moros, M., de la Fuente, J. M., Vallet-Regí, M.(2015). Magnetic-Responsive Release Controlled by Hot Spot Effect . Langmuir. 31. (46). p. 12777-82.

Guisasola, E., Baeza, A., Talelli, M., Arcos, D., Moros, M., De La Fuente, J.M., Vallet-Regí, M.(2015). Magnetic-Responsive Release Controlled by Hot Spot Effect . Langmuir. 31. (46). p. 12777-12782.

Ruiz-Hernández, E., Hess, M., Melen, G.J., Theek, B., Talelli, M., Shi, Y., Ozbakir, B., Teunissen, E.A., Ramírez, M., Moeckel, D., et al.(2014). PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses . Polymer Chemistry. 5. (5). p. 1674-1681.

Ruiz-Hernández, E., Hess, M., Melen, G. J., Theek, B., Talelli, M., Shi, Y., Ozbakir, B., Teunissen, E. A., Ramírez, M., Moeckel, D., et al.(2014). PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses . Polym Chem. (5). p. 1674-1681.

Talelli, M., Vicent, M. J.(2014). Reduction sensitive Poly(l-glutamic acid) (PGA)-protein conjugates designed for polymer masked-unmasked protein therapy . Biomacromolecules. 15. (11). p. 4168-77.

Talelli, M., Vicent, M.J.(2014). Reduction sensitive poly(l-glutamic acid) (PGA)-protein conjugates designed for polymer masked-unmasked protein therapy . Biomacromolecules. 15. (11). p. 4168-4177.

Deckers, R., Paradissis, A., Oerlemans, C., Talelli, M., Storm, G., Hennink, W. E., Nijsen, J. F.(2013). New insights into the HIFU-triggered release from polymeric micelles . Langmuir. 29. (30). p. 9483-90.

Deckers, R., Paradissis, A., Oerlemans, C., Talelli, M., Storm, G., Hennink, W.E., Nijsen, J.F.W.(2013). New insights into the HIFU-triggered release from polymeric micelles . Langmuir. 29. (30). p. 9483-9490.

Talelli, M., Oliveira, S., Rijcken, C. J., Pieters, E. H., Etrych, T., Ulbrich, K., van Nostrum, R. C., Storm, G., Hennink, W. E., Lammers, T.(2013). Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy . Biomaterials. 34. (4). p. 1255-60.

Talelli, M., Oliveira, S., Rijcken, C.J.F., Pieters, E.H.E., Etrych, T., Ulbrich, K., van Nostrum, R.C.F., Storm, G., Hennink, W.E., Lammers, T.(2013). Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy . Biomaterials. 34. (4). p. 1255-1260.

Talelli, Marina, Rijcken, Cristianne J. F., Hennink, Wim E., Lammers, Twan(2012). Polymeric micelles for cancer therapy: 3 C's to enhance efficacy . Current Opinion in Solid State & Materials Science. 16. (6). p. 302-309.

Talelli, M., Rijcken, C.J.F., Hennink, W.E., Lammers, T.(2012). Polymeric micelles for cancer therapy: 3 C's to enhance efficacy . Current Opinion in Solid State and Materials Science. 16. (6). p. 302-309.

Khonkarn, R., Mankhetkorn, S., Talelli, M., Hennink, W. E., Okonogi, S.(2012). Cytostatic effect of xanthone-loaded mPEG-b-p(HPMAm-Lac2) micelles towards doxorubicin sensitive and resistant cancer cells . Colloids Surf B Biointerfaces. 94. p. 266-73.

Khonkarn, R., Mankhetkorn, S., Talelli, M., Hennink, W.E., Okonogi, S.(2012). Cytostatic effect of xanthone-loaded mPEG-b-p(HPMAm-Lac 2) micelles towards doxorubicin sensitive and resistant cancer cells . Colloids and Surfaces B: Biointerfaces. 94. p. 266-273.

Talelli, M., Rijcken, C. J., Oliveira, S., van der Meel, R., van Bergen En Henegouwen, P. M., Lammers, T., van Nostrum, C. F., Storm, G., Hennink, W. E.(2011). Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting . J Control Release. 151. (2). p. 183-92.

Talelli, M., Rijcken, C.J.F., Oliveira, S., Van Der Meel, R., Van Bergen En Henegouwen, P.M.P., Lammers, T., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2011). Nanobody - Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting . Journal of Controlled Release. 151. (2). p. 183-192.

Talelli, M., Rijcken, C. J., Oliveira, S., van der Meel, R., van Bergen en Henegouwen, P. M., Lammers, T., van Nostrum, C. F., Storm, G., Hennink, W. E.(2011). Reprint of "Nanobody--shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting" . J Control Release. 153. (1). p. 93-102.

Talelli, M., Rijcken, C.J.F., Oliveira, S., Van Der Meel, R., Van Bergen En Henegouwen, P.M.P., Lammers, T., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2011). Reprint of "nanobody - Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting" . Journal of Controlled Release. 153. (1). p. 93-102.

Talelli, M., Morita, K., Rijcken, C. J., Aben, R. W., Lammers, T., Scheeren, H. W., van Nostrum, C. F., Storm, G., Hennink, W. E.(2011). Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry . Bioconjug Chem. 22. (12). p. 2519-30.

Talelli, M., Morita, K., Rijcken, C.J.F., Aben, R.W.M., Lammers, T., Scheeren, H.W., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2011). Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry . Bioconjugate Chemistry. 22. (12). p. 2519-2530.

Talelli, M., Hennink, W. E.(2011). Thermosensitive polymeric micelles for targeted drug delivery . Nanomedicine (Lond). 6. (7). p. 1245-55.

Talelli, M., Hennink, W.E.(2011). Thermosensitive polymeric micelles for targeted drug delivery . Nanomedicine. 6. (7). p. 1245-1255.

Talelli, M., Iman, M., Varkouhi, A. K., Rijcken, C. J., Schiffelers, R. M., Etrych, T., Ulbrich, K., van Nostrum, C. F., Lammers, T., Storm, G., et al.(2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . Biomaterials. 31. (30). p. 7797-804.

Talelli, M., Iman, M., Varkouhi, A.K., Rijcken, C.J.F., Schiffelers, R.M., Etrych, T., Ulbrich, K., van Nostrum, C.F., Lammers, T., Storm, G., et al.(2010). Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . Biomaterials. 31. (30). p. 7797-7804.

Rijcken, C.J.F., Talelli, M., Van Nostrum, C.F., Storm, G., Hennink, W.E.(2010). Crosslinked micelles with transiently linked drugs - A versatile drug delivery system . European Journal of Nanomedicine. 3. (1). p. 19-24.

Talelli, M., Rijcken, C. J., van Nostrum, C. F., Storm, G., Hennink, W. E.(2010). Micelles based on HPMA copolymers . Adv Drug Deliv Rev. 62. (2). p. 231-9.

Talelli, M., Rijcken, C.J.F., van Nostrum, C.F., Storm, G., Hennink, W.E.(2010). Micelles based on HPMA copolymers . Advanced Drug Delivery Reviews. 62. (2). p. 231-239.

Talelli, M., Iman, M., Rijcken, C. J., van Nostrum, C. F., Hennink, W. E.(2010). Targeted core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . J Control Release. 148. (1). p. e121-2.

Talelli, M., Iman, M., Rijcken, C.J., van Nostrum, C.F., Hennink, W.E.(2010). Targeted core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin . Journal of controlled release : official journal of the Controlled Release Society. 148. (1).

van Hasselt, P.M., Janssens, G.E.P.J., Slot, T.K., van der Ham, M., Minderhoud, T.C., Talelli, M., Akkermans, L.M., Rijcken, C.J.F., van Nostrum, C.F.(2009). The influence of bile acids on the oral bioavailability of vitamin K encapsulated in polymeric micelles . Journal of Controlled Release. 133. (2). p. 161-168.

Talelli, M., Rijcken, C. J., Lammers, T., Seevinck, P. R., Storm, G., van Nostrum, C. F., Hennink, W. E.(2009). Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery . Langmuir. 25. (4). p. 2060-7.

Talelli, M., Rijcken, C.J.F., Lammers, T., Seevinck, P.R., Storm, G., Van Nostrum, C.F., Hennink, W.E.(2009). Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: Toward a targeted nanomedicine suitable for image-guided drug delivery . Langmuir. 25. (4). p. 2060-2067.

van Hasselt, P. M., Janssens, G. E., Slot, T. K., van der Ham, M., Minderhoud, T. C., Talelli, M., Akkermans, L. M., Rijcken, C. J., van Nostrum, C. F.(2009). The influence of bile acids on the oral bioavailability of vitamin K encapsulated in polymeric micelles . J Control Release. 133. (2). p. 161-8.

Talelli, M., Pispas, S.(2008). Complexes of cationic block copolymer micelles with DNA: histone/DNA complex mimetics . Macromol Biosci. 8. (10). p. 960-7.

Talelli, M., Pispas, S.(2008). Complexes of cationic block copolymer micelles with DNA: Histone/DNA complex mimetics . Macromolecular Bioscience. 8. (10). p. 960-967.

Karatzas, A., Talelli, M., Vasilakopoulos, T., Pitsikalis, M., Hadjichristidis, N.(2006). Micellization of omega-functionalized diblock copolymers in selective solvent. Study on the effect of hydrogen bonds . Macromolecules. 39. (24). p. 8456-8466.

Karatzas, A., Talelli, M., Vasilakopoulos, T., Pitsikalis, M., Hadjichristidis, N.(2006). Micellization of ω-functionalized diblock copolymers in selective solvent. Study on the effect of hydrogen bonds . Macromolecules. 39. (24). p. 8456-8466.

BOOK

Talelli, M., Duro-Castaño, A., Rodríguez-Escalona, G., Vicent, M.J.(2014). Smart polymer nanocarriers for drug delivery . Smart Polymers and their Applications. p. 327-358.

OTHER

Therapeutic Nanomedicine: Cross linked micelles with transiently linked drugs – a versatile drug delivery system @misc{RID:0821171005886-63, title = {Therapeutic Nanomedicine: Cross linked micelles with transiently linked drugs – a versatile drug delivery system}, author = {Rijcken Cristianne, J. F. and Talelli, Marina and van Nostrum Cornelus, F. and Storm, Gert and Hennink Wim, E.}, volume = {3}, number = {1}, pages = {19}, month = {2010}, isbn = {1662596}, year = {2010} } . European Journal of Nanomedicine.