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Hire Dr. Mariela N.

Brazil

USD 15 /hr

Profile Summary

I have a post-doctoral position for two years at the Laboratory on Thymus Research, FIOCRUZ, Brazil. My lab is interested in the molecular mechanisms and cellular compartments that regulate the regenerative capacity of human skeletal muscle in normal and pathological situations. My goal is to aplay my expertise in analysis of laboratory experiments and theoretical knowledge like as proliferation, migration and cell differentiation in tissue context and tissue response to injury, repair and regeneration processes. I'm very interested in help to economize time of the Researchers, planning and designing experiments also analyzing them. During my thesis I test the exogenous administration of G-CSF as an inductor of the expression of molecules involved in cardiac remodelation in T. cruzi-infected mice, as an attempt to repair the damage caused by the parasite, also I assay its effectiveness as an enhancer of the treatment with anti-tripanocidal drug. I've been working to understand the immunological and histological aspects that may be contributing to limit cardiac regeneration during Chagas disease. Besides, I've investigated new anti-tripanocidal drugs. During this period, I've learned to employ real time RT-PCR, western blotting and immunohistochemistry approaches to examine the expression level and localization of selected genes/proteins considered to be essential for generation and homing of stem cells for cardiac regeneration, etc.

Subject Matter Expertise

• ★ STEM
• ★ Structural Biology
• ☆ Molecular Imaging
• ☆ Immunoassay
• ☆ PCR
• ☆ Cytochemistry
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Small Molecule Drug Development
• ☆ Research Methodology

Services

• Consulting
• Data & AI
• Product Development

Work Experience

Post-doctoral position

Instituto Oswaldo Cruz

July 2015 - Present

Laboratory Technique

Instituto Oswaldo Cruz

March 2014 - June 2015

Desenvolvimento Tecnológico e Industrial

Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro

September 2013 - February 2014

Researcher

Administración Nacional de Laboratorios e Institutos de Salud Dr Carlos G Malbrán

May 2012 - July 2013

Education

PhD (Dr. Mario Fatala Chaben" / ANLIS "Dr. Carlos G. Malbran")

Universidad de Buenos Aires Facultad de Medicina

April 2007 - December 2012

Bachelor Degree in Biotechnology, Molecular Biology

National University of Quilmes

March 2000 - December 2005

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2017). HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway . Skeletal muscle.

(2016). Trypanosoma cruzi infection induces the expression of CD40 in murine cardiomyocytes favoring CD40 ligation-dependent production of cardiopathogenic IL-6 . Parasitology research.

(2015). Effects of artesunate against Trypanosma cruzi . Experimental parasitology.

(2014). Altered distribution of peripheral blood memory B cells in humans chronically infected with Trypanosoma cruzi . PloS one.

(2014). Caspase-1/ASC inflammasome-mediated activation of IL-1β-ROS-NF-κB pathway for control of Trypanosoma cruzi replication and survival is dispensable in NLRP3-/- macrophages . PloS one.

(2013). Granulocyte colony-stimulating factor partially repairs the damage provoked by Trypanosoma cruzi in murine myocardium . International journal of cardiology.

(2013). Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease . PloS one.

(2010). Trypanosoma cruzi: biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs . Experimental parasitology.