Profile Details

Create Project

★★★★★

☆☆☆☆☆

USD 50 /hr

★★★★★

☆☆☆☆☆

Hire Dr. Maria T.

Germany

USD 50 /hr

An accomplished scientist and enthusiastic writer skilled in cell & molecular biology with over 50 highly-cited papers.

Profile Summary

As a doctorate in biochemistry with several years of professional experience in cellular and molecular biology, (patho)physiology, diagnostics and project coordination, I have been working in clinic-related explorative investigations, developing and optimizing cell-based assays for high-throughput screening or diagnostic methods for more than 15 years. My experiences span over a decade of biological and biomedical studies and encompass research-model applications for cancer, metabolic disorders and cardiovascular diseases. I am a passionate Editor & Content Writer, certified by European Medical Writers Association as a "Medial Writer". CEO of OFFICE42 (https://office42.my.canva.site/office42): Scientific Writing, Pharma Journalism, Expert Literature Research.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Apoptosis
• ☆ Molecular Biology
• ☆ Epigenetics
• ☆ PCR
• ☆ Gene Expression Analysis
• ☆ Cell Biology
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Drug Development
• ☆ Preclinical Pharmacology
• ☆ Women's Health
• ☆ Breast Cancer
• ☆ Oncology
• ☆ Gastroenterology & Hepatology
• ☆ Liver Cancer
• ☆ Hematology
• ☆ Leukemia & Lymphoma
• ☆ Inflammation

Services

• Writing
• Research

Writing Medical Writing, Technical Writing, Copywriting, Creative Writing, Newswriting, Audio Transcription, General Proofreading & Editing

Research User Research, Fact Checking, Gray Literature Search, Systematic Literature Review

Work Experience

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology

March 2009 - Present

Research Application Scientist

Fluidigm

January 2016 - March 2019

Natural and Medical Institute

May 2007 - December 2008

Education

PhD (Institute of Cell Biology)

University of Tuebingen

June 2003 - July 2006

Diplom

Lomonosov Moscow State University

September 1994 - June 1999

Certifications

• Foundation Certificate in Medical Writing

  European Medical Writers Association

  January 2022 - Present

• PhD

  University of Tuebingen, Germany

  January 2022 - Present

Publications

JOURNAL ARTICLE

Thomas, Maria, Keller, Roland, Klein, Marcus, Drager, Andreas, Metzger, Ute, Templin, Markus F., Joos, Thomas O., Thasler, Wolfgang E., Zell, Andreas, Zanger, Ulrich M.(2016). Coordinating Role of RXRalpha in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling . PLoS computational biology. 12. (1). p. e1004431.

Thomas, Maria, Klein, Marcus, Hofmann, Ute, Seehofer, Daniel, Damm, Georg, Zanger, Ulrich M.(2015). A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells . Drug Metabolism and Disposition. 43. (2). p. 273-283.

Thomas, Maria, Bayha, Christine, Vetter, Silvia, Hofmann, Ute, Schwarz, Michael, Zanger, Ulrich M., Braeuning, Albert(2015). Activating and Inhibitory Functions of WNT/beta-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells . Molecular Pharmacology. 87. (6). p. 1013-1020.

Thomas, Maria, Braeuning, Albert, Hofmann, Ute, Vetter, Silvia, Zeller, Eva, Petzuch, Barbara, Johanning, Janina, Schroth, Werner, Weiss, Thomas S., Zanger, Ulrich M., et al.(2015). Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists . Drug metabolism and disposition: the biological fate of chemicals. 43. (11). p. 1781-7.

Thomas, Maria, Meyer, Christoph, Liebe, Roman, Breitkopf-Heinlein, Katja, Liu, Yan, Mueller, Alexandra, Rakoczy, Pia, Weng, Honglei, Bachmann, Anastasia, Ebert, Matthias, et al.(2015). Hepatocyte fate upon TGF-beta challenge is determined by the matrix environment . Differentiation. 89. (5). p. 105-116.

Thomas, Maria, Feuer, Ronny, Vlaic, Sebastian, Arlt, Janine, Sawodny, Oliver, Dahmen, Uta, Zanger, Ulrich M.(2015). LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods . Plos One. 10. (9).

Thomas, Maria, Abshagen, Kerstin, Koenig, Matthias, Hoppe, Andreas, Mueller, Isabell, Ebert, Matthias, Weng, Honglei, Holzhuetter, Herrmann-Georg, Zanger, Ulrich M., Bode, Johannes, et al.(2015). Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice . Bmc Systems Biology. 9.

Thomas, Maria, Winter, Stefan, Klumpp, Britta, Turpeinen, Miia, Klein, Kathrin, Schwab, Matthias, Zanger, Ulrich M.(2015). Peroxisome proliferator-activated receptor alpha, PPAR alpha, directly regulates transcription of cytochrome P450 CYP2C8 . Frontiers in Pharmacology. 6.

Thomas, Maria, Bayha, Christine, Klein, Kathrin, Mueller, Simon, Weiss, Thomas S., Schwab, Matthias, Zanger, Ulrich M.(2015). The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPAR alpha-tr, autonomously regulates proliferative and pro-inflammatory genes . Bmc Cancer. 15.

Thomas, Maria, Garmhausen, Marius, Hofmann, Falko, Senderov, Viktor, Kandel, Benjamin A., Habermann, Bianca Hermine(2015). Virtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways . Bmc Genomics. 16.

Thomas, Maria, Ehlting, Christian, Boehmer, Oliver, Hahnel, Maximilian J., Zanger, Ulrich M., Gaestel, Matthias, Knoefel, Wolfram T., Esch, Jan Schulte Am, Haeussinger, Dieter, Bode, Johannes G.(2015). Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2 . Cellular Signalling. 27. (3). p. 555-567.

Thomas, Maria, Kungulovski, Goran, Nunna, Suneetha, Zanger, Ulrich M., Reinhardt, Richard, Jeltsch, Albert(2015). Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained . Epigenetics & Chromatin. 8.

Thomas, Maria, Lutz, Anna, Sanwald, Julia, Feuer, Ronny, Sawodny, Oliver, Ederer, Michael, Borner, Christoph, Humar, Matjaz, Merfort, Irmgard(2014). Interleukin-1 beta Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes . Plos One. 9. (12).

Zanger, U. M., Thomas, M., Kandel, B. A., Klein, K.(2014). REGULATION OF DRUG METABOLISM AND ENDOGENOUS FUNCTIONS BY PPARA VERSUS CAR/PXR. Drug Metabolism Reviews. 45. p. 4.

Zanger, U. M., Thomas, M., Kandel, B. A., Klein, K.(2014). REGULATION OF DRUG METABOLISM AND ENDOGENOUS FUNCTIONS BY PPARA VERSUS CAR/PXR . Drug Metabolism Reviews. 45. p. 4.

Klein, M., Kandel, B. A., Thomas, M., Hofmann, U., Metzger, U., Templin, M., Damm, G., Zanger, U. M.(2014). SIGNALING PATHWAYS OF IL-6-MEDIATED DOWN-REGULATION OF DRUG DETOXIFICATION CAPACITY IN HUMAN HEPATOCYTES. Drug Metabolism Reviews. 45. p. 87.

Klein, M., Kandel, B. A., Thomas, M., Hofmann, U., Metzger, U., Templin, M., Damm, G., Zanger, U. M.(2014). SIGNALING PATHWAYS OF IL-6-MEDIATED DOWN-REGULATION OF DRUG DETOXIFICATION CAPACITY IN HUMAN HEPATOCYTES . Drug Metabolism Reviews. 45. p. 87.

Thomas, Maria, Rieger, Jessica K., Kandel, Benjamin A., Klein, Kathrin, Zanger, Ulrich M.(2014). Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes . Cellular Physiology and Biochemistry. 33. (6). p. 2003-2013.

Thomas, Maria, Genz, Berit, Puetzer, Brigitte M., Siatkowski, Marcin, Fuellen, Georg, Vollmar, Brigitte, Abshagen, Kerstin(2014). Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells . Experimental Cell Research. 328. (2). p. 429-443.

Zanger, U. M., Klein, K., Thomas, M., Rieger, J. K., Tremmel, R., Kandel, B. A., Klein, M., Magdy, T.(2014). Genetics, Epigenetics, and Regulation of Drug-Metabolizing Cytochrome P450 Enzymes . Clinical Pharmacology & Therapeutics. 95. (3). p. 258-261.

Thomas, M. and Burk, O. and Klumpp, B. and Kandel, B. A. and Damm, G. and Weiss, T. S. and Klein, K. and Schwab, M. and Zanger, U. M.(2013). Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator-Activated Receptor Alpha (PPARα) . Mol Pharmacol.

Thomas, M., Burk, O., Klumpp, B., Kandel, B. A., Damm, G., Weiss, T. S., Klein, K., Schwab, M., Zanger, U. M.(2013). Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator-Activated Receptor Alpha (PPAR alpha) . Molecular Pharmacology. 83. (3). p. 709-718.

Zanger, U., Thomas, M., Burk, O., Klumpp, B., Kandel, B. A., Klein, K.(2012). NOVEL LINK BETWEEN LIPID HOMEOSTASIS AND DRUG METABOLISM: PPARA IS A DIRECT TRANSCRIPTIONAL REGULATOR OF CYP3A4. Drug Metabolism Reviews. 44. p. 91.

Zanger, U., Thomas, M., Burk, O., Klumpp, B., Kandel, B. A., Klein, K.(2012). NOVEL LINK BETWEEN LIPID HOMEOSTASIS AND DRUG METABOLISM: PPARA IS A DIRECT TRANSCRIPTIONAL REGULATOR OF CYP3A4 . Drug Metabolism Reviews. 44. p. 91.

Klein, K. and Thomas, M. and Winter, S. and Nussler, A.K. and Niemi, M. and Schwab, M. and Zanger, U.M.(2012). PPARA: A novel genetic determinant of CYP3A4 in vitro and in vivo . Clinical Pharmacology and Therapeutics. 91. (6). p. 1044-1052.

Thomas, Maria, Klein, Kathrin, Winter, Stefan, Nussler, Andreas K., Niemi, Mikko, Schwab, Matthias, Zanger, Ulrich M.(2012). PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo . Clinical Pharmacology & Therapeutics. 91. (6). p. 1044-1052.

Klein, Kathrin and Thomas, Maria and Winter, Stefan and Weiss, Thomas and Schwab, Matthias and Zanger, Ulrich M.(2011). Extensive pathway oriented candidate gene approach allows identification of factors influencing CYP3A4 expression and function. Drug Metabolism Reviews. 43. p. 170.

Thomas, Maria, Klein, Kathrin, Winter, Stefan, Weiss, Thomas, Schwab, Matthias, Zanger, Ulrich M.(2011). Extensive pathway oriented candidate gene approach allows identification of factors influencing CYP3A4 expression and function . Drug Metabolism Reviews. 43. p. 170.

Thomas, Maria, Schroeder, Adrian, Wollnik, Johannes, Wrzodek, Clemens, Draeger, Andreas, Bonin, Michael, Burk, Oliver, Thasler, Wolfgang E., Zanger, Ulrich M., Zell, Andreas(2011). Inferring statin-induced gene regulatory relationships in primary human hepatocytes . Bioinformatics. 27. (18). p. 2473-2477.

Schroeder, Adrian and Wollnik, Johannes and Wrzodek, Clemens and Draeger, Andreas and Bonin, Michael and Burk, Oliver and Thomas, Maria and Thasler, Wolfgang E. and Zanger, Ulrich M. and Zell, Andreas(2011). Inferring statin-induced gene regulatory relationships in primary human hepatocytes . Bioinformatics. 27. (18). p. 2473-2477.

Klein, Marcus and Kandel, Benjamin A. and Klein, Kathrin and Thomas, Maria and Thasler, Wolfgang E. and Schwab, Matthias and Zanger, Ulrich M.(2011). Influence of inflammatory processes on ADME gene expression in human liver and hepatocytes. Drug Metabolism Reviews. 43. p. 117-118.

Thomas, Maria, Klein, Marcus, Kandel, Benjamin A., Klein, Kathrin, Thasler, Wolfgang E., Schwab, Matthias, Zanger, Ulrich M.(2011). Influence of inflammatory processes on ADME gene expression in human liver and hepatocytes . Drug Metabolism Reviews. 43. p. 117-118.

Kandel, Benjamin A. and Rieger, Jessica K. and Thomas, Maria and Hofmann, Nina and Knobeloch, Daniel and Zanger, Ulrich M.(2011). Lentiviral knock down of the nuclear receptors CAR and PXR in human hepatocytes. Drug Metabolism Reviews. 43. p. 118-119.

Thomas, Maria, Kandel, Benjamin A., Rieger, Jessica K., Hofmann, Nina, Knobeloch, Daniel, Zanger, Ulrich M.(2011). Lentiviral knock down of the nuclear receptors CAR and PXR in human hepatocytes . Drug Metabolism Reviews. 43. p. 118-119.

Gessner, A. and Thomas, M. and Castro, P. Garrido and Buechler, L. and Scholz, A. and Bruemmendorf, T. H. and Soria, N. Martinez and Vormoor, J. and Greil, J. and Heidenreich, O.(2010). Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT . Leukemia. 24. (10). p. 1751-1759.

Gessner, A., Thomas, M., Castro, P. Garrido, Buechler, L., Scholz, A., Bruemmendorf, T. H., Soria, N. Martinez, Vormoor, J., Greil, J., Heidenreich, O.(2010). Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT . Leukemia. 24. (10). p. 1751-1759.

Oehmig, Angelika and Klotzbuecher, Andrea and Thomas, Maria and Weise, Frank and Hagner, Ursula and Brundiers, Ralf and Waldherr, Dirk and Lingnau, Andreas and Knappik, Achim and Kubbutat, Michael H. G. and Joos, Thomas O. and Volkmer, Hansjuergen(2008). A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries . Bmc Genomics. 9.

Thomas, Maria, Oehmig, Angelika, Klotzbuecher, Andrea, Weise, Frank, Hagner, Ursula, Brundiers, Ralf, Waldherr, Dirk, Lingnau, Andreas, Knappik, Achim, Kubbutat, Michael H. G., et al.(2008). A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries . Bmc Genomics. 9.

Gessner, Andreas and Thomas, Maria and Castro, Patricia Garrido and Heidenreich, Olaf and Greil, Johann(2008). The T(4;11) Fusion Protein MLL/AF4 Regulates TERT Expression. Blood. 112. (11). p. 1067.

Thomas, Maria, Gessner, Andreas, Castro, Patricia Garrido, Heidenreich, Olaf, Greil, Johann(2008). The T(4;11) Fusion Protein MLL/AF4 Regulates TERT Expression . Blood. 112. (11). p. 1067.

Greil, J. and Thomas, M. and Gessner, A. and Garrido-Castro, P. and Buechler, L. and Heidenreich, O.(2007). Identification and characterisation of MLL-AF4-regulated cellular processes. Haematologica-the Hematology Journal. 92. p. 5.

Greil, J., Thomas, M., Gessner, A., Garrido-Castro, P., Buechler, L., Heidenreich, O.(2007). Identification and characterisation of MLL-AF4-regulated cellular processes . Haematologica-the Hematology Journal. 92. p. 5.

Mathews, Vikram and Thomas, Maria and Srivastava, Vivi M. and George, Biju and Srivastava, Alok and Chandy, Mammen(2007). Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen . Haematologica-the Hematology Journal. 92. (7). p. 994-995.

Thomas, Maria, Mathews, Vikram, Srivastava, Vivi M., George, Biju, Srivastava, Alok, Chandy, Mammen(2007). Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen . Haematologica-the Hematology Journal. 92. (7). p. 994-995.

Gessner, A. and Thomas, M. and Greil, J. and Heidenreich, O.(2006). SiRNA-mediated MLL-AF4 knockdown affects hTERT expression. Klinische Padiatrie. 218. (3). p. 187.

Gessner, A., Thomas, M., Greil, J., Heidenreich, O.(2006). SiRNA-mediated MLL-AF4 knockdown affects hTERT expression . Klinische Padiatrie. 218. (3). p. 187.

Thomas, M. and Greil, J. and Heidenreich, O.(2006). Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials . Acta Pharmacologica Sinica. 27. (3). p. 273-281.

Thomas, M., Greil, J., Heidenreich, O.(2006). Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials . Acta Pharmacologica Sinica. 27. (3). p. 273-281.

Greil, J. and Gessner, A. and Thomas, M. and Heidenreich, O.(2005). Depletion of the leukemic fusion protein MLL-AF4 with short interfering RNAs (siRNAs) affects post-translational modification of aldolase A. Blood. 106. (11). p. 165B.

Greil, J., Gessner, A., Thomas, M., Heidenreich, O.(2005). Depletion of the leukemic fusion protein MLL-AF4 with short interfering RNAs (siRNAs) affects post-translational modification of aldolase A . Blood. 106. (11). p. 165B.

Greil, J. and Thomas, M. and Gessner, A. and Heidenreich, O.(2005). Targeting MLL-AF4 with short interfering RNAs (siRNAs) induces apoptosis related genes APAF-1 and SEPT4 in t(4;11)-positive human leukemic cells. Blood. 106. (11). p. 733A.

Greil, J., Thomas, M., Gessner, A., Heidenreich, O.(2005). Targeting MLL-AF4 with short interfering RNAs (siRNAs) induces apoptosis related genes APAF-1 and SEPT4 in t(4;11)-positive human leukemic cells . Blood. 106. (11). p. 733A.

Thomas, M. and Gessner, A. and Vornlocher, H. P. and Hadwiger, P. and Greil, J. and Heidenreich, O.(2005). Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells . Blood. 106. (10). p. 3559-3566.

Thomas, M., Gessner, A., Vornlocher, H. P., Hadwiger, P., Greil, J., Heidenreich, O.(2005). Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells . Blood. 106. (10). p. 3559-3566.

Greil, J. and Thomas, M. and Huenefeld, C. and Vornlocher, H. P. and Hadwiger, P. and Heidenreich, O.(2004). Suppression of MLL-AF4 by small interfering RNAs inhibits proliferation and induces apoptosis in t(4;11)-positive SEM cells. Blood. 104. (11). p. 191B.

Greil, J., Thomas, M., Huenefeld, C., Vornlocher, H. P., Hadwiger, P., Heidenreich, O.(2004). Suppression of MLL-AF4 by small interfering RNAs inhibits proliferation and induces apoptosis in t(4;11)-positive SEM cells. Blood. 104. (11). p. 191B.

Greil, J., Thomas, M., Huenefeld, C., Vornlocher, H. P., Hadwiger, P., Heidenreich, O.(2004). Suppression of MLL-AF4 by small interfering RNAs inhibits proliferation and induces apoptosis in t(4;11)-positive SEM cells . Blood. 104. (11). p. 191B.

Astapova, M. V. and Lipkin, V. M. and Arkhipova, M. V. and Andreeva, S. G. and Dranitsyna, S. M. and Merkulova, M. I. and Nurieva, R. I. and Navolotskaya, E. V. and Kostanyan, I. A.(1999). L-glutamic acid, a modulator of the physiological state of myeloid blood cells. Bioorganicheskaya Khimiya. 25. (11). p. 816-820.

Astapova, M. V., Lipkin, V. M., Arkhipova, M. V., Andreeva, S. G., Dranitsyna, S. M., Merkulova, M. I., Nurieva, R. I., Navolotskaya, E. V., Kostanyan, I. A.(1999). L-glutamic acid, a modulator of the physiological state of myeloid blood cells . Bioorganicheskaya Khimiya. 25. (11). p. 816-820.

Ozoline, O. N. and Deev, A. A. and Arkhipova, M. V. and Chasov, V. V. and Travers, A.(1999). Proximal transcribed regions of bacterial promoters have a non-random distribution of A/T tracts . Nucleic Acids Research. 27. (24). p. 4768-4774.

Ozoline, O. N., Deev, A. A., Arkhipova, M. V., Chasov, V. V., Travers, A.(1999). Proximal transcribed regions of bacterial promoters have a non-random distribution of A/T tracts . Nucleic Acids Research. 27. (24). p. 4768-4774.

Ozoline, O. N. and Deev, A. A. and Arkhipova, M. V.(1997). Non-canonical sequence elements in the promoter structure. Cluster analysis of promoters recognized by Escherichia coli RNA polymerase . Nucleic Acids Research. 25. (23). p. 4703-4709.

Ozoline, O. N., Deev, A. A., Arkhipova, M. V.(1997). Non-canonical sequence elements in the promoter structure. Cluster analysis of promoters recognized by Escherichia coli RNA polymerase . Nucleic Acids Research. 25. (23). p. 4703-4709.