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Hire Dr. Margriet V.

Netherlands

USD 100 /hr

Freelance Scientific and Medical Writer, European-registered toxicologist

Profile Summary

I am an experienced scientific and medical writer, as well as a European-registered toxicologist. I have extensive knowledge of various medicinal products, medical devices, pesticides, and advanced materials. With my regulatory background and skills in managing interdisciplinary research projects, I can contribute effectively to a wide range of writing projects in the biomedical and life sciences fields.

Subject Matter Expertise

• ☆ Nanotechnology & Nanomaterials
• ☆ Zoology
• ☆ Mammalian Biology
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Microarrays
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Stem Cell Research
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Surface Receptors
• ☆ 3D Cell Culture
• ☆ Drug Development
• ☆ Biosafety Testing
• ☆ Preclinical ADME/PK/PD
• ☆ Drug-Drug Interactions
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Drug Efficacy Testing
• ☆ Bioavailability
• ☆ Oncology
• ☆ Chemotherapy
• ☆ Medical Toxicology
• ☆ Immunotherapy
• ☆ Medical Sciences
• ☆ Inflammation
• ☆ Consumer Products

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Newswriting, General Proofreading & Editing, Translation

Research Fact Checking, Scientific and Technical Research

Work Experience

Scientific and medical writer

Science Lines

August 2021 - Present

Senior Scientific and Medical Writer and toxicologist

ScienceLines

July 2021 - Present

Rijksinstituut voor Volksgezondheid en Milieu

2004 - August 2021

Senior Researcher

National Institute for Public Health and the Environment (RIVM)

October 2004 - July 2021

Toxicologist

Loders Croklaan Lipid Nutrition

February 2003 - September 2004

Research assistant

Michigan State University

September 2001 - October 2002

Education

PhD in Nanotoxicology

Maastricht University

October 2007 - July 2011

PhD (Toxicogenomics)

Maastricht University

2007 - 2011

MSc Biology (Toxicology)

Wageningen Universiteit en Researchcentrum

1996 - 2001

International Baccalaureate

United World College of the Atlantic

September 1992 - June 1994

Certifications

• Foundation Certificate in Medical Writing

  European Medical Writing Association

  March 2024 - Present

• European Registered Toxicologist

  Eurotox

  January 2006 - Present

Publications

JOURNAL ARTICLE

Groenewold, M., Bleeker, E.A.J., Noorlander, C.W., Sips, A.J.A.M., van der Zee, M., Aitken, R.J., Baker, J.H., Bakker, M.I., Bouman, E.A., Doak, S.H., et al.(2024). Governance of advanced materials: Shaping a safe and sustainable future . NanoImpact. 35.

Ruijter, N., van der Zee, M., Katsumiti, A., Boyles, M., Cassee, F.R., Braakhuis, H.(2024). Improving the dichloro-dihydro-fluorescein (DCFH) assay for the assessment of intracellular reactive oxygen species formation by nanomaterials . NanoImpact. 35.

van der Zee, M., de Vries, C., Masa, M., Morales, M., Rayo, M., Hegger, I.(2023). Regulatory aspects of a nanomaterial for imaging therapeutic cells . Drug Delivery and Translational Research. 13. (11). p. 2693-2703.

Christina Giannakou, Margriet V. D. Z. Park, Irene E. M. Bosselaers, Wim H. de Jong, Jan Willem van der Laan, Henk van Loveren, Rob J. Vandebriel, Robert E. Geertsma (2020). Nonclinical regulatory immunotoxicity testing of nanomedicinal products: Proposed strategy and possible pitfalls . WIREs Nanomedicine and Nanobiotechnology.

Fernández-Bertólez, N., Costa, C., Bessa, M.J., Park, M., Carriere, M., Dussert, F., Teixeira, J.P., Pásaro, E., Laffon, B., Valdiglesias, V.(2019). Assessment of oxidative damage induced by iron oxide nanoparticles on different nervous system cells . Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 845.

Halamoda-Kenzaoui, B., Baconnier, S., Bastogne, T., Bazile, D., Boisseau, P., Borchard, G., Borgos, S.E., Calzolai, L., Cederbrant, K., Di Felice, G., et al.(2019). Bridging communities in the field of nanomedicine . Regulatory Toxicology and Pharmacology. 106. p. 187-196.

Giannakou, C., Aimonen, K., Bloois, L.V., Catalán, J., Geertsma, R.E., Gremmer, E.R., De Jong, W.H., Keizers, P.H.J., Schwillens, P.L.W.J., Vandebriel, R.J., et al.(2019). Sensitive method for endotoxin determination in nanomedicinal product samples . Nanomedicine. 14. (10). p. 1231-1246.

Verschoor, A.J., Harper, S., Delmaar, C.J.E., Park, M.V.D.Z., Sips, A.J.A.M., Vijver, M.G., Peijnenburg, W.J.G.M.(2019). Systematic selection of a dose metric for metal-based nanoparticles . NanoImpact. 13. p. 70-75.

Park, M.V.D.Z., Catalán, J., Ferraz, N., Cabellos, J., Vanhauten, R., Vázquez-Campos, S., Janer, G.(2018). Development of a systematic method to assess similarity between nanomaterials for human hazard evaluation purposes–lessons learnt . Nanotoxicology. 12. (7). p. 652-676.

Fernández-Cruz, M.L., Hernández-Moreno, D., Catalán, J., Cross, R.K., Stockmann-Juvala, H., Cabellos, J., Lopes, V.R., Matzke, M., Ferraz, N., Izquierdo, J.J., et al.(2018). Quality evaluation of human and environmental toxicity studies performed with nanomaterials-the GUIDEnano approach . Environmental Science: Nano. 5. (2). p. 381-397.

et al., Margriet V.D.Z. Park, Eric A.J. Bleeker, Walter Brand, Flemming R. Cassee, Merel van Elk, Ilse Gosens, Wim H. de Jong, Johannes A.J. Meesters, Willie J.G.M. Peijnenburg, Joris T.K. Quik(2017). Considerations for Safe Innovation: The Case of Graphene . ACS Nano. 11. (10). p. 9574--9593. American Chemical Society ({ACS})

(2017). Considerations for Safe Innovation: The Case of Graphene . ACS nano.

Park, M.V.D.Z., Bleeker, E.A.J., Brand, W., Cassee, F.R., Van Elk, M., Gosens, I., De Jong, W.H., Meesters, J.A.J., Peijnenburg, W.J.G.M., Quik, J.T.K., et al.(2017). Considerations for Safe Innovation: The Case of Graphene . ACS Nano. 11. (10). p. 9574-9593.

Brand, W., Noorlander, C.W., Giannakou, C., De Jong, W.H., Kooi, M.W., Park, M.V.D.Z., Vandebriel, R.J., Bosselaers, I.E.M., Scholl, J.H.G., Geertsma, R.E.(2017). Nanomedicinal products: A survey on specific toxicity and side effects . International Journal of Nanomedicine. 12. p. 6107-6129.

Giannakou, C., Park, M.V.D.Z., De Jong, W.H., Van Loveren, H., Vandebriel, R.J., Geertsma, R.E.(2016). A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements . International Journal of Nanomedicine. 11. p. 2935-2952.

Braakhuis, H.M., Cassee, F.R., Fokkens, P.H.B., De La Fonteyne, L.J.J., Oomen, A.G., Krystek, P., De Jong, W.H., Van Loveren, H., Park, M.V.D.Z.(2016). Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study . Nanotoxicology. 10. (1). p. 63-73.

Braakhuis, H.M., Giannakou, C., Peijnenburg, W.J.G.M., Vermeulen, J., van Loveren, H., Park, M.V.D.Z.(2016). Simple in vitro models can predict pulmonary toxicity of silver nanoparticles . Nanotoxicology. 10. (6). p. 770-779.

Hougaard, K.S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., Park, M.V.D.Z., de Jong, W.H., Wolterink, G., Piersma, A.H., et al.(2015). A perspective on the developmental toxicity of inhaled nanoparticles . Reproductive Toxicology. 56. p. 118-140.

Delmaar, C.J.E., Peijnenburg, W.J.G.M., Oomen, A.G., Chen, J., de Jong, W.H., Sips, A.J.A.M., Wang, Z., Park, M.V.D.Z.(2015). A practical approach to determine dose metrics for nanomaterials . Environmental Toxicology and Chemistry. 34. (5). p. 1015-1022.

Noorlander, C.W., Kooi, M.W., Oomen, A.G., Park, M.V.D.Z., Vandebriel, R.J., Geertsma, R.E.(2015). Horizon scan of nanomedicinal products . Nanomedicine. 10. (10). p. 1599-1608.

Braakhuis, H.M., Kloet, S.K., Kezic, S., Kuper, F., Park, M.V.D.Z., Bellmann, S., van der Zande, M., Le Gac, S., Krystek, P., Peters, R.J.B., et al.(2015). Progress and future of in vitro models to study translocation of nanoparticles . Archives of Toxicology. 89. (9). p. 1469-1495.

Braakhuis, H.M., Gosens, I., Krystek, P., Boere, J.A.F., Cassee, F.R., Fokkens, P.H.B., Post, J.A., van Loveren, H., Park, M.V.D.Z.(2014). Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles . Particle and Fibre Toxicology. 11. (1).

Braakhuis, H.M., Park, M.V.D.Z., Gosens, I., De Jong, W.H., Cassee, F.R.(2014). Physicochemical characteristics of nanomaterials that affect pulmonary inflammation . Particle and Fibre Toxicology. 11. (1).

De Jong, W.H., Van Der Ven, L.T.M., Sleijffers, A., Park, M.V.D.Z., Jansen, E.H.J.M., Van Loveren, H., Vandebriel, R.J.(2013). Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats . Biomaterials. 34. (33). p. 8333-8343.

Park, M.V.D.Z., Verharen, H.W., Zwart, E., Hernandez, L.G., Van Benthem, J., Elsaesser, A., Barnes, C., McKerr, G., Howard, C.V., Salvati, A., et al.(2011). Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay . Nanotoxicology. 5. (2). p. 168-181.

Park, M.V.D.Z., Lynch, I., Ramírez-García, S., Dawson, K.A., De La Fonteyne, L., Gremmer, E., Slob, W., Briedé, J.J., Elsaesser, A., Howard, C.V., et al.(2011). In vitro evaluation of cytotoxic and inflammatory properties of silica nanoparticles of different sizes in murine RAW 264.7 macrophages . Journal of Nanoparticle Research. 13. (12). p. 6775-6787.

Park, M.V.D.Z., Neigh, A.M., Vermeulen, J.P., de la Fonteyne, L.J.J., Verharen, H.W., Briedé, J.J., van Loveren, H., de Jong, W.H.(2011). The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles . Biomaterials. 32. (36). p. 9810-9817.

Park, M.V.D.Z., Annema, W., Salvati, A., Lesniak, A., Elsaesser, A., Barnes, C., McKerr, G., Howard, C.V., Lynch, I., Dawson, K.A., et al.(2009). In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles . Toxicology and Applied Pharmacology. 240. (1). p. 108-116.

Park, M.V.D.Z., Lankveld, D.P.K., van Loveren, H., de Jong, W.H.(2009). The status of in vitro toxicity studies in the risk assessment of nanomaterials . Nanomedicine. 4. (6). p. 669-685.

CONFERENCE PAPER

de Wit, L., Hendriks, H., van Engelen, J., Heusinkveld, H., Kienhuis, A., Rorije, E., Woutersen, M., van der Zee, M., Jeurissen, S.(2024). New Approach Methodologies (NAMs) for ad hoc human health risk assessment of food and non-food products - Proceedings of a workshop . Regulatory Toxicology and Pharmacology. 149.

OTHER

van der Zee, M., de Vries, C., Masa, M., Morales, M., Rayo, M., Hegger, I.(2022). Regulatory aspects of a nanomaterial for imaging therapeutic cells . Research Square.

BOOK

Colognato, R., Park, M.V.D.Z., Wick, P., De Jong, W.H.(2012). Interactions with the Human Body . Adverse Effects of Engineered Nanomaterials. p. 3-24.