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Hire Dr. Marcela A.

Brazil

USD 80 /hr

PhD in genetics/development of new vaccines - science writer, research focused in the control of infectious disease

Profile Summary

"Experienced Postdoc skilled in genetics, cell biology, vaccinology, microbiology, immunology and virology. Graduated in Biological Sciences with Masters in Genetics of microorganisms obtained at Federal University of Minas Gerais (UFMG-Brazil), in collaboration with Tuberculosis Research Center (University of São Paulo-USP, Brazil). Doctor of Philosophy (PhD) degree in Microbial genetics obtained at Université Paris Sud-11 (France) in co-tutele with UFMG, with an exchange period at Wageningen University, Host-microbe Interactions group (Netherlands). During her PhD she was part of the Cross-Talk Marie Curie European program. Spent three years as a postdoctoral researcher at Laboratory of cellular and molecular genetics (2013-2017, UFMG, Brazil), one year as a postdoc at National Institute of Agronomic Research (INRA), Jouy en Josas, France (2017), and as a postdoctoral fellow at Adolfo Lutz Institute (2020-2021, São Paulo, Brazil). Currently, develops research at the Laboratory of Experimental Immunoparasitology from the Institute of Biomedical Sciences (USP, São Paulo, Brazil). Her research is mostly dedicated to development of vaccines, use of probiotic bacterial strains as treatment for intestinal inflammation, diagnosis and control of viral infectious diseases, as COVID-19, at a biosafety level 3 laboratory (BSL-3)."

Subject Matter Expertise

• ★ Vaccine Development
• ☆ Microbiology
• ☆ Virology
• ☆ Molecular Biology
• ☆ Infectious Disease
• ☆ COVID-19

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Technical Writing, Copywriting, Newswriting

Research Market Research, User Research, Meta-Research, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Digital Strategy Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis

Product Development Formulation, Product Evaluation, Product Validation, Concept Development, Prototyping

Work Experience

Post-doc (COVID19 vaccine development, Immunology)

Institute of Biomedical Sciences

June 2021 - Present

Post-Doc

Instituto Adolfo Lutz

June 2020 - May 2021

Post-doc (Probiotics/intestinal inflammatory disease)

L’Institut national de la recherche agronomique

February 2017 - March 2018

Education

PhD

Université Paris Sud (Paris XI)

February 2009 - October 2013

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Mutational profile confers increased stability of SARS-CoV-2 spike protein in Brazilian isolates @article{2021, doi = {10.1080/07391102.2021.1982775}, url = {https://doi.org/10.1080%2F07391102.2021.1982775}, year = 2021, month = {oct}, publisher = {Informa {UK} Limited}, pages = {1--6}, author = {Felipe Rocha da Silva Santos and Marcela Santiago Pacheco de Azevedo and Monica Bielavsky and Hernan Hermes Monteiro da Costa and Daniela Gomes Ribeiro and Gleidson Guedes do Nascimento and Gabrielle Menezes Paz Marcondes and Beatriz Portugal de Castro and Daniel Ferreira de Lima Neto and Carlos Roberto Prudencio}, title = {Mutational profile confers increased stability of {SARS}-{CoV}-2 spike protein in Brazilian isolates}} . Journal of Biomolecular Structure and Dynamics.

(2019). Oral delivery of pancreatitis‐associated protein by Lactococcus lactis displays protective effects in dinitro‐benzenesulfonic‐acid‐induced colitis model and is able to modulate the composition of the microbiota . Environmental Microbiology.

(2019). SUN-PO140: During Low-Grade Intestinal Inflammation, Ingestion of Streptococcus Thermophilus CNRZ160 Limited the Lean Body Mass Loss in Older Adults . Clinical Nutrition.

(2017). Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis . Microbial Cell Factories.

(2017). Lactococcus lactiscarrying a DNA vaccine coding for theESAT-6antigen increases IL-17 cytokine secretion and boosts the BCG vaccine immune response . Journal of Applied Microbiology.

(2017). Use of Wild Type or Recombinant Lactic Acid Bacteria as an Alternative Treatment for Gastrointestinal Inflammatory Diseases: A Focus on Inflammatory Bowel Diseases and Mucositis . Frontiers in Microbiology.

(2016). Corynebacterium pseudotuberculosis may be under anagenesis and biovar Equi forms biovar Ovis: a phylogenic inference from sequence and structural analysis . BMC Microbiology.

(2015). Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer . Vaccine.

(2015). Milk Fermented with a 15-Lipoxygenase-1-Producing Lactococcus Lactis Alleviates Symptoms of colitis in a Murine Model . Current Pharmaceutical Biotechnology.

(2015). GABA and GABA receptors in the gastrointestinal tract: from motility to inflammation . Pharmacological Research.

(2015). Prospective uses of recombinant Lactococcus lactis expressing both listeriolysin O and mutated internalin A from Listeria monocytogenes as a tool for DNA vaccination . Genetics and Molecular Research.

(2014). RecombinantLactococcus lactisfails to secrete bovine chymosine . Bioengineered.

(2014). Immune Response Elicited by DNA Vaccination Using Lactococcus lactis Is Modified by the Production of Surface Exposed Pathogenic Protein . PLoS ONE.

(2014). Local and Systemic Immune Mechanisms Underlying the Anti-Colitis Effects of the Dairy Bacterium Lactobacillus delbrueckii . PLoS ONE.

(2014). Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis . Gut Pathogens.

(2014). DNA Vaccines Approach: From Concepts to Applications . World Journal of Vaccines.

(2013). Immunotherapy of allergic diseases using probiotics or recombinant probiotics . Journal of Applied Microbiology.

(2012). In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A . BMC Microbiology.

(2012). Cytoplasmic and extracellular expression of pharmaceutical-grade mycobacterial 65-kDa heat shock protein in Lactococcus lactis . Genetics and Molecular Research.

(2011). Lactococcus lactis as a live vector: Heterologous protein production and DNA delivery systems . Protein Expression and Purification.

(2007). Phenotypic and genetic analysis of Enterobacter spp. from a Brazilian oligotrophic freshwater lake . Canadian Journal of Microbiology.

OTHER

Marcela Santiago Pacheco De Azevedo, Daniela Gomes Ribeiro, Felipe Rocha Da Silva Santos, Siomar De Castro Soares, Vasco Ariston De Carvalho Azevedo, Monica Bielavsky, Felipe Gomes Naveca, José Angelo Lauletta Lindoso, Alberto Fernandes De Oliveria Junior, Luíz Carlos Júnior Alcântara, et al.(2021). Application of high-throughput serological tests for controlling zoonotic viral infection in Amazon rainforest and as a strategy to prevent future pandemics (Preprint) . {JMIR} Publications Inc.

Anderson Miyoshi, Luis G. Bermdez-Humarn, Marcela Santiago Pacheco de Azevedo, Philippe Langella, Vasco Azevedo Lactic Acid Bacteria as Live Vectors: Heterologous Protein Production and Delivery Systems . Biotechnology of Lactic Acid Bacteria. p. 161--176. Wiley-Blackwell

BOOK CHAPTER

(2016). Novel Biotechnological and Therapeutic Applications for Wild Type and Genetically Engineered Lactic Acid Bacteria. Fermented Foods of Latin America.

(2015). Human GI Tract Microbiota in Health and Disease: A Focus on Inflammatory Bowel Diseases. Innovative Immunology.

(2013). Use of bacteria in DNA vaccine delivery. Use of bacteria in DNA vaccine delivery.

(2012). Bactérias láticas como vacinas vivas de mucosa. Probióticos e Prebióticos:Atualização e Prospecção.

(2009). Lactic Acid Bacteria as live vectors: Heterologous protein production and delivery systems. Biotechnology of Lactic Acid Bacteria: Novel Applications.

JOURNAL ISSUE

(2016). Oral administration of Lactococcus lactis expressing recombinant 15-lipoxygenase-1 (15 LOX-1) modulates chemically induced colitis in mice. Medical Research Archives.

SUPERVISED STUDENT PUBLICATION

(2015). Future Clinical Applications of the Potential use of Lactic Acid Bacteria as Vehicles to Deliver DNA Vaccines . Austin J Vaccines & Immunother.