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Profile Summary

Postdoctoral Research - Studied the biological effects induced by microbes radiation in small animal models and the efficacy of a novel UVC radiation source for anti-microbial applications, including prevention of surgical site infections and viral transmission. PhD Project - The research was a NASA funded study focused on the role of type and dose of space radiation in the induction of biological effects in mammalian cells and their impact on human health risks. Bcc Physics Project - Studied murine cell survival after low fluencies of accelerated lithium ions.

Subject Matter Expertise

• ★ STEM
• ★ Biology/Life Sciences
• ★ Molecular Biology
• ☆ Microbiology
• ☆ Physics
• ☆ Science Education

Services

• Writing
• Consulting
• Product Development

Work Experience

Associate Research Scientist

Columbia University

- Present

Postdoctoral Research Scientist

Columbia University

August 2011 - September 2015

Education

PhD (Radiation Oncology)

Rutgers University Newark

- July 2011

BSc (physics)

Università degli Studi di Napoli Federico II

- July 2003

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2017). Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells . Int J Radiat Biol.

(2017). Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light . Radiat Res.

Manuela Buonanno, Milda Stanislauskas, Brian Ponnaiya, Alan W. Bigelow, Gerhard Randers-Pehrson, Yanping Xu, Igor Shuryak, Lubomir Smilenov, David M. Owens, David J. Brenner, et al.(2016). 207-nm {UV} Light{\textemdash}A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. {II}: In-Vivo Safety Studies . {PLOS} {ONE}. 11. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e0138418. Public Library of Science ({PLoS})

Buonanno, M., Stanislauskas, M., Ponnaiya, B., Bigelow, A.W., Randers-Pehrson, G., Xu, Y., Shuryak, I., Smilenov, L., Owens, D.M., Brenner, D.J.(2016). 207-nm UV light - A promising tool for safe low-cost reduction of surgical site infections. II: In-vivo safety studies . PLoS ONE. 11. (6).

M. Buonanno, G. Randers-Pehrson, L. B. Smilenov, N. J. Kleiman, E. Young, B. Ponnayia, D. J. Brenner(2015). A Mouse Ear Model for Bystander Studies Induced by Microbeam Irradiation . Radiation Research. 184. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 219--225. Radiation Research Society

G. Garty, M. U. Ehsan, M. Buonanno, Z. Yang, J. V. Sweedler, D. J. Brenner(2015). Microbeam-coupled capillary electrophoresis . Radiat Prot Dosimetry. 166. (1-4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 188--191. Oxford University Press ({OUP})

M. Buonanno, S. M. De Toledo, R. W. Howell, E. I. Azzam(2015). Low-dose energetic protons induce adaptive and bystander effects that protect human cells against {DNA} damage caused by a subsequent exposure to energetic iron ions . Journal of Radiation Research. 56. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 502--508. Oxford University Press ({OUP})

Garty, G., Ehsan, M.U., Buonanno, M., Yang, Z., Sweedler, J.V., Brenner, D.J.(2015). Microbeam-coupled capillary electrophoresis . Radiation Protection Dosimetry. 166. (1-4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 188-191.

Buonanno, M., Randers-Pehrson, G., Smilenov, L.B., Kleiman, N.J., Young, E., Ponnayia, B., Brenner, D.J.(2015). A mouse ear model for bystander studies induced by microbeam irradiation . Radiation Research. 184. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 219-225.

Manuela Buonanno, Min Li, Géraldine Gonon, Narongchai Autsavapromporn, Sonia M. de Toledo, Debkumar Pain, Edouard I. Azzam(2014). Health Risks of Space Exploration: Targeted and Nontargeted Oxidative Injury by High-Charge and High-Energy Particles . Antioxidants {\&} Redox Signaling. 20. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1501--1523. Mary Ann Liebert Inc

D J Brenner, M Vazquez, M Buonanno, S A Amundson, A W Bigelow, G Garty, A D Harken, T K Hei, S A Marino, B Ponnaiya, et al.(2014). Integrated interdisciplinary training in the radiological sciences . The British Journal of Radiology. 87. (1034). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 20130779. British Institute of Radiology

Brenner, D.J., Vazquez, M., Buonanno, M., Amundson, S.A., Bigelow, A.W., Garty, G., Harken, A.D., Hei, T.K., Marino, S.A., Ponnaiya, B., et al.(2014). Integrated interdisciplinary training in the radiological sciences . British Journal of Radiology. 87. (1034).

Li, M., Gonon, G., Buonanno, M., Autsavapromporn, N., De Toledo, S.M., Pain, D., Azzam, E.I.(2014). Health risks of space exploration: Targeted and nontargeted oxidative injury by high-charge and high-energy particles . Antioxidants and Redox Signaling. 20. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1501-1523.

Buonanno, M., De Toledo, S.M., Howell, R.W., Azzam, E.I.(2014). Low-dose energetic protons induce adaptive and bystander effects that protect human cells against DNA damage caused by a subsequent exposure to energetic iron ions . Journal of Radiation Research. 56. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 502-508.

Manuela Buonanno, Gerhard Randers-Pehrson, Alan W. Bigelow, Sheetal Trivedi, Franklin D. Lowy, Henry M. Spotnitz, Scott M. Hammer, David J. Brenner, Michael Hamblin(2013). 207-nm {UV} Light - A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. I: In Vitro Studies . {PLoS} {ONE}. 8. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e76968. Public Library of Science ({PLoS})

M. Buonanno, G. Garty, M. Grad, M. Gendrel, O. Hobert, D. J. Brenner(2013). Microbeam irradiation of C. elegans nematode in microfluidic channels . Radiat Environ Biophys. 52. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 531--537. Springer Science $\mathplus$ Business Media

Manuela Buonanno, Brian Ponnaiya, Sally A. Amundson, Shanaz A. Ghandhi, Lubomir B. Smilenov, Charles R. Geard, David J. Brenner(2013). Single-cell responses to ionizing radiation . Radiat Environ Biophys. 52. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 523--530. Springer Science $\mathplus$ Business Media

Buonanno, M., Randers-Pehrson, G., Bigelow, A.W., Trivedi, S., Lowy, F.D., Spotnitz, H.M., Hammer, S.M., Brenner, D.J.(2013). 207-nm UV Light - A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. I: In Vitro Studies . PLoS ONE. 8. (10).

Ponnaiya, B., Amundson, S.A., Ghandhi, S.A., Smilenov, L.B., Geard, C.R., Buonanno, M., Brenner, D.J.(2013). Single-cell responses to ionizing radiation . Radiation and Environmental Biophysics. 52. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 523-530.

Buonanno, M., Garty, G., Grad, M., Gendrel, M., Hobert, O., Brenner, D.J.(2013). Microbeam irradiation of C. elegans nematode in microfluidic channels . Radiation and Environmental Biophysics. 52. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 531-537.

Manuela Buonanno, Vered Anzenberg Shaffer, Marjan Boerma, Sylvain Costes, Tracy Criswell, Geraldine Gonon, Badri N. Pandey, Massimo Pinto, Sara Rockwell(2012). Broadcasting in the Airways: The Fifth Anniversary of the Radiation Research Podcast1 . Radiation Research. 178. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 99--100. Radiation Research Society

Shaffer, V.A., Boerma, M., Buonanno, M., Costes, S., Criswell, T., Gonon, G., Pandey, B.N., Pinto, M., Rockwell, S.(2012). Broadcasting in the airways: The fifth anniversary of the radiation research podcast . Radiation Research. 178. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 99-100.

Manuela Buonanno, Sonia M. de Toledo, Edouard I. Azzam, Janine Santos(2011). Increased Frequency of Spontaneous Neoplastic Transformation in Progeny of Bystander Cells from Cultures Exposed to Densely Ionizing Radiation . {PLoS} {ONE}. 6. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e21540. Public Library of Science ({PLoS})

Manuela Buonanno, Sonia M de Toledo, Debkumar Pain, Edouard I Azzam(2011). Long-Term Consequences of Radiation-Induced Bystander Effects Depend on Radiation Quality and Dose and Correlate with Oxidative Stress . Radiation Research. 175. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 405--415. Radiation Research Society

Manuela Buonanno, Sonia M. de Toledo, Min Li, Nesrin Asaad, Yong Qin, Geraldine Gonon, Grace Shim, Mariann Galdass, Yaa Boateng, Jie Zhang, et al.(2011). {THE} {IMPACT} {OF} {ADAPTIVE} {AND} {NON}-{TARGETED} {EFFECTS} {IN} {THE} {BIOLOGICAL} {RESPONSES} {TO} {LOW} {DOSE}/{LOW} {FLUENCE} {IONIZING} {RADIATION}: {THE} {MODULATING} {EFFECT} {OF} {LINEAR} {ENERGY} {TRANSFER} . Health Physics. 100. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 290--292. Ovid Technologies (Wolters Kluwer Health)

Buonanno, M., de Toledo, S.M., Azzam, E.I.(2011). Increased frequency of spontaneous neoplastic transformation in progeny of bystander cells from cultures exposed to densely ionizing radiation . PLoS ONE. 6. (6).

de Toledo, S.M., Buonanno, M., Li, M., Asaad, N., Qin, Y., Gonon, G., Shim, G., Galdass, M., Boateng, Y., Zhang, J., et al.(2011). The impact of adaptive and non-targeted effects in the biological responses to low dose/low fluence ionizing radiation: the modulating effect of linear energy transfer . Health physics. 100. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 290-292.

Buonanno, M., De Toledo, S.M., Pain, D., Azzam, E.I.(2011). Long-Term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress . Radiation Research. 175. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 405-415.

Autsavapromporn, N., de Toledo, S.M., Buonanno, M., Jay-Gerin, J.-P., Harris, A.L., Azzam, E.I.(2011). Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells . Journal of Radiation Research. 52. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 408-414.

Manuela BUONANNO, Narongchai AUTSAVAPROMPORN, Sonia M. DE TOLEDO, Jean-Paul JAY-GERIN, Andrew L. HARRIS, Edouard I. AZZAM(2011). Intercellular Communication Amplifies Stressful Effects in High-Charge, High-Energy ({HZE}) Particle-Irradiated Human Cells . {JRR}. 52. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 408--414. Japan Radiation Research Society

OTHER

Manuela Buonanno, Jie Zhang, Geraldine Gonon, Min Li, Mariann Galdass, Grace Shim, Sonia M. De Toledo, Edouard I. Azzam(2011). Bystander Effects and Adaptive Responses Modulate In Vitro and In Vivo Biological Responses to Low Dose Ionizing Radiation . 71--86Springer Science $\mathplus$ Business Media