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Hire Dr. Manjunath G.

United States

USD 50 /hr

Research Scientist

Profile Summary

I am a biochemist and molecular geneticist by training. My technical areas of expertise include protein biochemistry, structural biology, genetics and next generation sequencing. I am also familiar with animal cell culture and c. elegans. My subject matter expertise includes DNA damage response in both prokaryotes and eukaryotes, cellular and organismal aging, cancer biology and epigenetic regulation of gene expression. During my doctoral and postdoctoral training, I investigated structure function relations in recombinases such as RecA as well as the role of scaffold proteins in regulating DNA damage response. I identified physical interaction of single strand binding protein (SSB) with a bacterial recombinase (RecA) and a helicase (UvrD). The results of the experiments conducted so far suggest that SSB regulates biochemical activities of these proteins and has potential implications for regulation of DNA damage response. My current research interests include understanding the role of epigenetic factors, role of heat shock and associated stress in regulating organismal lifespan. I am also involved in development of a new class of compounds to combat antibiotic resistance in pathogenic bacteria.

Subject Matter Expertise

• ☆ Animal Genetics
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Proteomics
• ☆ Epigenetics
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Protein/Enzyme Engineering
• ☆ Antibiotic Development

Services

• Writing
• Research
• Consulting
• Product Development

Work Experience

Research Associate

New York University Langone Medical Center

February 2017 - Present

Indian Institute of Science Education and Research Mohali

December 2015 - November 2016

Scientist-C

Indian Institute of Science Education Research Pune

May 2012 - August 2015

Post Doctoral Fellow

Indian Institute of Science Education Research Pune

April 2010 - April 2012

Education

Ph.D (Department of Biochemistry)

Indian Institute of Science

August 2002 - December 2009

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Tejal Agarwal, G. P. Manjunath, Farhat Habib, Apratim Chatterji(2019). Bacterial chromosome organization. I. Crucial role of release of topological constraints and molecular crowders . The Journal of Chemical Physics. 150. (14). p. 144908. {AIP} Publishing

Tejal Agarwal, G. P. Manjunath, Farhat Habib, Apratim Chatterji(2019). Bacterial chromosome organization. {II}. Few special cross-links, cell confinement, and molecular crowders play the pivotal roles . The Journal of Chemical Physics. 150. (14). p. 144909. {AIP} Publishing

(2016). Molecular mechanism underlying ATP-induced conformational changes in nucleoprotein filament of Mycobacterium smegmatis RecA. Biochemistry.

(2010). Crystallization and preliminary X-ray studies of the C-terminal domain of Mycobacterium tuberculosis LexA. Acta Crystallographica Section F Structural Biology and Crystallization Communications.

(2008). Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes. Acta Crystallogr Sect F Struct Biol Cryst Commun.

(2007). Snapshots of RecA protein involving movement of the C-domain and different conformations of the DNA-binding loops: crystallographic and comparative analysis of 11 structures of Mycobacterium smegmatis RecA. J Mol Biol.

(2006). Crystallographic identification of an ordered C-terminal domain and a second nucleotide-binding site in RecA: new insights into allostery. Nucleic Acids Res.

(2005). Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association. Acta Crystallogr D Biol Crystallogr.