Profile Details

Create Project

★★★★★

☆☆☆☆☆

USD 50 /hr

★★★★★

☆☆☆☆☆

Hire Dr. Mayasah A.

Canada

USD 50 /hr

Postdoctoral Research Fellow | Medical Writer & Editor | Researcher experienced in Computer-Aided Drug Design

Profile Summary

I am a multidisciplinary researcher with a diverse skill set in the field of drug design, blending my expertise as a researcher, computational-drug designer, medical writer, and pharmacist. As a medical writer, my goal is to effectively communicate complex scientific information to diverse audiences. With a strong foundation in scientific research and writing, I have experience crafting a wide range of materials, from research/review articles and scientific books to medical and health content. I have published several articles and books in international, peer-reviewed journals. My doctoral project was a real highlight, as I worked on identifying a dual inhibitor of PDE1B and PDE10A using a structure-based approach. My work has focused on exploring complex areas of drug design, including structure-based drug design, enzyme kinetics, and preclinical studies utilizing animal models. The result was a promising antipsychotic agent that demonstrated activity in a rat model of schizophrenia. Further, my passion for computational chemistry and drug design has led me to participate in numerous other projects, working with ligand and structure-based approaches and collaborating with fellow scientists.

Subject Matter Expertise

• ☆ Computational Chemistry
• ☆ Computational Biology
• ☆ Biochemistry
• ☆ Structural Biology
• ☆ Enzyme Activity Assays
• ☆ Recipe Formulation
• ☆ Pharmacy
• ☆ Pharmacy Education
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ In vivo Preclinical Toxicology

Services

• Writing
• Research
• Consulting
• Product Development

Writing Medical Writing, Technical Writing

Research Fact Checking, Scientific and Technical Research

Consulting Scientific and Technical Consulting

Product Development Recipe Development

Work Experience

Medical Editor

Medical Literacy Initiative

December 2023 - Present

Medical Writer-Article Writer

Klarity

March 2023 - Present

Peer-Reviewer Expert

Heliyon-Cell Press

September 2020 - Present

Founder

Choco Cream

June 2016 - Present

Researcher

UCSI University

January 2022 - May 2023

Teaching assistant

UCSI University

December 2018 - January 2022

Education

Ph.D. Pharmaceutical Sciences (Faculty of Pharmaceutical Sciences)

UCSI University

August 2018 - August 2022

MSc. Pharmaceutical chemistry (faculty of pharmaceutical sciences )

UCSI University

2016 - 2018

Advanced Diploma in Pastry and Bakery Arts

Academy of Pastry Arts Malaysia

August 2015 - June 2016

B.Sc. pharmacy (faculty of pharmacy)

Al-Yarmouk University College

- 2015

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Mayasah Al-Nema, Anand Gaurav, Vannajan Sanghiran Lee(2023). Designing of 2,3-dihydrobenzofuran derivatives as inhibitors of PDE1B using pharmacophore screening, ensemble docking and molecular dynamics approach . Computers in Biology and Medicine. 159. p. 106869. Elsevier {BV}

Al-Nema M, Anand Gaurav, Lee MT, Okechukwu P, Nimmanpipug P, Lee VS (2022). Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia . PloS one.

Gaurav, Anand, Agrawal, Neetu, Al-Nema, Mayasah, Gautam, Vertika (2022). Computational Approaches in the Discovery and Development of Therapeutic and Prophylactic Agents for Viral Diseases . Current Topics in Medicinal Chemistry.

Wei, Foong Xi, Gaurav, Anand, Al-Nema, Mayasah (2022). In silico investigation on the probable macromolecular drug targets involved in the anti-schizophrenia activity of Nardostachys jatamansi . Brazilian Journal of Pharmaceutical Sciences.

Mayasah Al-Nema and Anand Gaurav and Vannajan Sanghiran Lee and Baskaran Gunasekaran and Ming Tatt Lee and Patrick Okechukwu and Piyarat Nimmanpipug(2022). Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as a phosphodiesterase 10A inhibitor . RSC Advances. 12. (3). p. 1576--1591. Royal Society of Chemistry ({RSC})

Al-Nema, Mayasah, Gaurav, Anand, Lee, Vannajan Sanghiran, Gunasekaran, Baskaran, Lee, Ming Tatt, Okechukwu, Patrick, Nimmanpipug, Piyarat (2022). Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as a phosphodiesterase 10A inhibitor . RSC Advances.

Fei, Lim Chiew, Gaurav, Anand, Al-Nema, Mayasah (2022). In Silico Investigations on the Probable Macromolecular Drug Targets Involved in the Anti-Schizophrenia Activity of Terminalia bellerica . Letters in Organic Chemistry.

Mayasah Al-Nema and Anand Gaurav and Vannajan Sanghiran Lee and Baskaran Gunasekaran and Ming Tatt Lee and Patrick Okechukwu(2021). Identification of dual inhibitor of phosphodiesterase 1B/10A using structure-based drug design approach . Journal of Molecular Liquids. 342. p. 117485. Elsevier {BV}

Lim Chiew Fei and Anand Gaurav and Mayasah Al-Nema(2021). In Silico Investigations on the Probable Macromolecular Drug Targets Involved in the Anti-Schizophrenia Activity of Terminalia bellerica . Letters in Organic Chemistry. 18. Bentham Science Publishers Ltd.

Al-Nema, Mayasah, Gaurav, Anand, Lee, Vannajan Sanghiran, Gunasekaran, Baskaran, Lee, Ming Tatt, Okechukwu, Patrick (2021). Identification of dual inhibitor of phosphodiesterase 1B/10A using structure-based drug design approach . Journal of Molecular Liquids.

Patrick Okechukwu and Mridula Sharma and Wen Hui Tan and Hor Kuan Chan and Kavita Chirara and Anand Gaurav and Mayasah Al-Nema(2020). In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes . Pharmacia. 67. (4). p. 363--371. Pensoft Publishers

Mayasah Y. Al-Nema and Anand Gaurav(2020). Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia . Current Topics in Medicinal Chemistry. 20. (26). p. 2404--2421. Bentham Science Publishers Ltd.

Mayasah Al-Nema and Anand Gaurav and Vannajan Sanghiran Lee(2020). Docking based screening and molecular dynamics simulations to identify potential selective PDE4B inhibitor . Heliyon. 6. (9). p. e04856. Elsevier {BV}

Goh Yen Joe and Anand Gaurav and Mayasah Al Nema(2020). In Silico Investigation on the Probable Macromolecular Drug Targets Involved in the Anti-Schizophrenia Activity of Ocimum sanctum . Current Trends in Biotechnology and Pharmacy. 14. (5). p. 1--10. {EManuscript} Technologies

Okechukwu, P., Sharma, M., Tan, W.H., Chan, H.K., Chirara, K., Gaurav, A., Al-Nema, M.(2020). In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes . Pharmacia. 67. (4). p. 363-371.

Al-Nema, Mayasah Y., Gaurav, Anand (2020). Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia . Current Topics in Medicinal Chemistry.

Al-Nema, Mayasah, Gaurav, Anand, Lee, Vannajan Sanghiran (2020). Docking based screening and molecular dynamics simulations to identify potential selective PDE4B inhibitor . Heliyon.

Al-Nema, M., Gaurav, A., Lee, V.S.(2020). Docking based screening and molecular dynamics simulations to identify potential selective PDE4B inhibitor . Heliyon. 6. (9).

Al-Nema, M.Y., Gaurav, A.(2020). Phosphodiesterase as a target for cognition enhancement in schizophrenia . Current Topics in Medicinal Chemistry. 20. (26). p. 2404-2421.

Okechukwu, Patrick, Sharma, Mridula, Tan, Wen Hui, Chan, Hor Kuan, Chirara, Kavita, Gaurav, Anand, Al-Nema, Mayasah (2020). In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes . Pharmacia.

Mayasah Al-Nema, Anand Gaurav (2020). Advanced Applications of Gene Therapy in the Treatment of Haematologic Disorders . Frontiers in Clinical Drug Research: Hematology: Volume 4.

(2019). Molecular Modeling-Based Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells . ACS Omega.

(2019). Protein-Protein Interactions of Phosphodiesterases . Current Topics in Medicinal Chemistry.

Al-Nema, M.Y., Gaurav, A.(2019). Protein-protein interactions of phosphodiesterases . Current Topics in Medicinal Chemistry. 19. (7). p. 555-564.

Al-Nema, Mayasah Y., Gaurav, Anand (2019). Protein-Protein Interactions of Phosphodiesterases . Current Topics in Medicinal Chemistry.

Gaurav, Anand, Al-Nema, Mayasah (2019). Polymerases of Coronaviruses: Structure, Function, and Inhibitors . Viral Polymerases: Structures, Functions, and Roles as Antiviral Drug Targets.

Maki, M.A.A., Kumar, P.V., Cheah, S.-C., Siew Wei, Y., Al-Nema, M., Bayazeid, O., Majeed, A.B.B.A.(2019). Molecular Modeling-<inf>B</inf>ased Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells . ACS Omega. 4. (5). p. 8767-8777.

Maki, Marwan Abdelmahmoud Abdelkarim, Kumar, Palanirajan Vijayaraj, Cheah, Shiau-Chuen, Wei, Yeong Siew, Al-Nema, Mayasah, Bayazeid, Omer, Majeed, Abu Bakar Bin Abdul (2019). Molecular Modeling-(B)ased Delivery System Enhances Everolimus-Induced Apoptosis in Caco-2 Cells . ACS Omega.

(2018). Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening . Computational Biology and Chemistry.

(2018). Management and treatment of atopic dermatitis with modern therapies, complementary and alternative medicines: a review . Oriental Pharmacy and Experimental Medicine.

Al-Nema, Mayasah, Gaurav, Anand, Akowuah, Gabriel (2018). Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening . Computational Biology and Chemistry.

Chew, Y.-L., Al-Nema, M., Ong, V.W.-M.(2018). Management and treatment of atopic dermatitis with modern therapies, complementary and alternative medicines: a review . Oriental Pharmacy and Experimental Medicine. 18. (2). p. 67-76.

Chew, Yik-Ling, Al-Nema, Mayasah, Ong, Vivian Wai-Mun (2018). Management and treatment of atopic dermatitis with modern therapies, complementary and alternative medicines: a review . Oriental Pharmacy and Experimental Medicine.

(2018). Identification of Selective Inhibitors of Phosphodiesterase 4B using Pharmacophore-Based Virtual Screening and Molecular Docking Approaches . Frontiers in Pharmacology.

Al-Nema, M., Gaurav, A., Akowuah, G.(2018). Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening . Computational Biology and Chemistry. 77. p. 52-63.

Anand Gaurav, Ming Xing, Mayasah Al‐Nema (2017). Computational Approaches in the Development of Phosphodiesterase Inhibitors . Quantitative Structure-Activity Relationship.

BOOK CHAPTER

Mayasah Al-Nema and Anand Gaurav(2020). Advanced Applications of Gene Therapy in the Treatment of Haematologic Disorders . Frontiers in Clinical Drug Research: Hematology: Volume 4. p. 84--123. {BENTHAM} {SCIENCE} {PUBLISHERS}

Anand Gaurav and Mayasah Al-Nema(2019). Polymerases of Coronaviruses . Viral Polymerases. p. 271--300. Elsevier

Gaurav, A., Al-Nema, M.(2018). Polymerases of coronaviruses: Structure, function, and inhibitors . Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets. p. 271-300.

(2017). Computational Approaches in the Development of Phosphodiesterase Inhibitors . Quantitative Structure-activity Relationship.