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Hire Dr. Luca Z.

Austria

USD 50 /hr

Neuroscientis with Medical Biotechnology background & Scientific Writer with 10+ years of experience

Profile Summary

Since the beginning of my scientific carrer I had the chance of experiencing different research topics and working methods. I initially dedicated many years to behavioural studies, with a particular focus on addiction disorders, anxiety, depression and epilepsy. More recently, my focus moved towards the understanding of intracellular signaling cascades of receptors such as NMDA, opioid receptors as well as ion channels, this gave me the opportunity to travel and experience how research is conducted oversea, a life changing adventure. Beside the regular work routine I could acquire experience in writing scientific manuscripts and training many PhD students as well as technicians.

Subject Matter Expertise

• ★ Neurology
• ★ Epilepsy & Seizures
• ☆ Nanotechnology
• ☆ Animal Behavior/Ethology
• ☆ Molecular Biology
• ☆ Substance Abuse
• ☆ Stress Management
• ☆ Depression
• ☆ Psychopharmacology
• ☆ Research Methodology

Services

• Writing
• Research
• Data & AI
• Product Development

Writing Technical Writing

Research Systematic Literature Review, Secondary Data Collection

Data & AI Statistical Analysis, Data Visualization

Product Development Formulation

Work Experience

PostDoc

Charité

January 2019 - Present

PostDoc

Charité Universitätsmedizin Berlin Campus Benjamin Franklin

January 2019 - Present

PostDoc

Medizinische Universität Innsbruck

January 2018 - December 2018

Postdoc

Northwestern University - Chicago

April 2016 - November 2017

PhD student

Medizinische Universität Innsbruck

February 2011 - February 2016

Education

SPIN (Neuroscience) PhD program

Medizinische Universität Innsbruck

February 2011 - July 2015

Master in Medical Biotechnologies

Universita degli Studi di Roma Tor Vergata

November 2008 - October 2010

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2019). Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy . EMBO Molecular Medicine.

Agostinho, A.S., Mietzsch, M., Zangrandi, L., Kmiec, I., Mutti, A., Kraus, L., Fidzinski, P., Schneider, U.C., Holtkamp, M., Heilbronn, R., et al.(2019). Dynorphin-based “release on demand” gene therapy for drug-resistant temporal lobe epilepsy . EMBO Molecular Medicine.

Luca Zangrandi, Jeffrey J. Liu, Kirti Sharma, Chongguang Chen, Sean J. Humphrey, Yi-Ting Chiu, Mariana Spetea, Lee-Yuan Liu-Chen, Christoph Schwarzer, Matthias Mann(2018). In vivo brain {GPCR} signaling elucidated by phosphoproteomics . Science. 360. (6395). p. eaao4927. American Association for the Advancement of Science ({AAAS})

Liu, J.J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S.J., Chiu, Y.-T., Spetea, M., Liu-Chen, L.-Y., Schwarzer, C., Mann, M.(2018). In vivo brain GPCR signaling elucidated by phosphoproteomics . Science. 360. (6395).

Burtscher, J., Bean, C., Zangrandi, L., Kmiec, I., Agostinho, A., Scorrano, L., Gnaiger, E., Schwarzer, C.(2018). Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis . Frontiers in Molecular Neuroscience. 11.

Zangrandi L, Burtscher J, MacKay JP, Colmers WF, Schwarzer C(2016). The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion . British journal of pharmacology.

Thongrong S, Hausott B, Marvaldi L, Agostinho AS, Zangrandi L, Burtscher J, Fogli B, Schwarzer C, Klimaschewski L(2016). Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage . Hippocampus.

Weth-Malsch D, Langeslag M, Beroukas D, Zangrandi L, Kastenberger I, Quarta S, Malsch P, Kalpachidou T, Schwarzer C, Proia RL, et al.(2016). Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo . Frontiers in cellular neuroscience.

Thongrong, S., Hausott, B., Marvaldi, L., Agostinho, A.S., Zangrandi, L., Burtscher, J., Fogli, B., Schwarzer, C., Klimaschewski, L.(2016). Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage . Hippocampus. 26. (5). p. 658-667.

Zangrandi, L., Burtscher, J., Mackay, J.P., Colmers, W.F., Schwarzer, C.(2016). The G-protein biased partial κ opioid receptor agonist 6′-GNTI blocks hippocampal paroxysmal discharges without inducing aversion . British Journal of Pharmacology. 173. (11). p. 1756-1767.

Weth-Malsch, D., Langeslag, M., Beroukas, D., Zangrandi, L., Kastenberger, I., Quarta, S., Malsch, P., Kalpachidou, T., Schwarzer, C., Proia, R.L., et al.(2016). Ablation of sphingosine 1-phosphate receptor subtype 3 impairs hippocampal neuron excitability in vitro and spatial working memory in vivo . Frontiers in Cellular Neuroscience. 10. (NOV2016).

Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E(2015). Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry . Mitochondrion.

Burtscher, J., Zangrandi, L., Schwarzer, C., Gnaiger, E.(2015). Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry . Mitochondrion. 25. p. 104-112.

Busceti CL, Bucci D, Molinaro G, Di Pietro P, Zangrandi L, Gradini R, Moratalla R, Battaglia G, Bruno V, Nicoletti F, et al.(2012). Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons . PloS one.

Busceti, C.L., Bucci, D., Molinaro, G., Di Pietro, P., Zangrandi, L., Gradini, R., Moratalla, R., Battaglia, G., Bruno, V., Nicoletti, F., et al.(2012). Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons . PLoS ONE. 7. (9).

Zangrandi L, Schwarzer C(2012). Activation of kappa opioid receptors reduces seizure activity in a dose-dependent way . BMC pharmacology & toxicology.

Zangrandi L, Schwarzer C(2011). Activation of kappa opioid receptors reduces EEG seizure activity in a mouse model of temporal lobe epilepsy . BMC pharmacology.

Chiamulera C, Tedesco V, Zangrandi L, Giuliano C, Fumagalli G(2010). Propranolol transiently inhibits reinstatement of nicotine-seeking behaviour in rats . Journal of psychopharmacology (Oxford, England).