Profile Details

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Hire Dr. Kyle B.

United States

USD 50 /hr

Expert in Structural Biology, Biochemistry, and Analytical R&D

Profile Summary

Ph.D. scientist with deep expertise in both structural biology/biochemistry and pharmaceutical analytical R&D, spanning academic and industry settings. My doctoral research at the University of Pennsylvania led to publications in Science, Nature, and Nature Structural & Molecular Biology, focused on uncovering molecular mechanisms using cryo-EM and biochemical assays. In parallel, I’ve worked in Analytical R&D both before and after my Ph.D., developing and validating chromatographic methods in cGMP environments to support pharmaceutical development. I offer clients a rare combination of high-impact academic insight and practical industry experience in method development, validation, and troubleshooting.

Subject Matter Expertise

• ★ Separation & Purification
• ★ Biochemistry
• ★ Structural Biology
• ☆ Analytical Chemistry
• ☆ Spectroscopy
• ☆ UV Spectroscopy
• ☆ Fluorescence Spectroscopy
• ☆ Circular Dichroism Spectroscopy
• ☆ Molecular Imaging
• ☆ Liquid Chromatography/HPLC
• ☆ Microcalorimetry
• ☆ Gas Chromatography
• ☆ Particle Size Distribution
• ☆ Drug Development
• ☆ Bioanalytical Testing

Services

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, General Proofreading & Editing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Product Development Formulation, Product Validation, Quality Assurance & Control (QA/QC)

Work Experience

Senior Scientist

Merck & Co., Inc.

March 2025 - Present

Graduate Student

University of Pennsylvania

August 2020 - February 2025

Chemist

Hovione LLC

July 2018 - July 2020

Education

PhD (Biochemistry and Molecular Biophysics)

University of Pennsylvania

August 2020 - February 2025

BS (Double Major: Physics & Chemistry)

The College of New Jersey

August 2014 - May 2018

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Erika E. Ravitch, Elana E. Baltrusaitis, Tania A. Perez, Kyle R. Barrie, Adam R. Fenton, Erika L. F. Holzbaur, Roberto Dominguez (2025). Structural-functional characterization of the MIRO1-TRAK1 complex . Nature Communications.

Andrew J. Saks, Kyle R. Barrie, Grzegorz Rebowski, Roberto Dominguez (2025). NPF binding to Arp2 is allosterically linked to the release of ArpC5’s N-terminal tail and conformational changes in Arp2/3 complex . Proceedings of the National Academy of Sciences.

Kyle R. Barrie, Grzegorz Rebowski, Roberto Dominguez (2025). Mechanism of actin filament severing and capping by gelsolin . Nature Structural & Molecular Biology.

Nicholas J. Palmer, Kyle R. Barrie, Roberto Dominguez (2024). Mechanisms of actin filament severing and elongation by formins . Nature.

Barrie KR, Carman PJ, Dominguez R (2023). Conformation of actin subunits at the barbed and pointed ends of F-actin with and without capping proteins . Cytoskeleton (Hoboken, N.J.).

Peter J. Carman, Kyle R. Barrie, Grzegorz Rebowski, Roberto Dominguez (2023). Structures of the free and capped ends of the actin filament . Science.

Peter J. Carman, Kyle R. Barrie, Roberto Dominguez(2021). Novel human cell expression method reveals the role and prevalence of posttranslational modification in nonmuscle tropomyosins . Journal of Biological Chemistry. 297. (4). p. 101154. Elsevier {BV}