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Profile Details
Subject Matter Expertise
Services
Work Experience
Senior Lecturer
Halmstad University
October 2022 - Present 
Docent (Affiliated)
Karolinska Institutet
December 2011 - Present
Professor
Southern Medical University
October 2016 - October 2021
Senior Research Coordinator (10%)
Karolinska Institutet
April 2017 - March 2019
Senior Researcher
Karolinska Institute
December 2011 - November 2016
Assistant Professor
Karolinska Institutet
July 2008 - November 2011
Researcher
Lunds Universitet
June 1998 - June 2008
Centre For Cellular and Molecular Biology
January 1996 - May 1998
Education
M. Sc. (Department of Medical Biochemistry)
University of Madras
- Present
Ph.D (Department of Immunology)
Madurai Kamaraj University
- Present
Dr. Med. Sci. (Department of Experimental Medicine)
Lunds Universitet
- Present
B.Sc. (Department of Chemistry)
University of Madras
August 1983 - April 1986
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
(2022). HAPLN1 Affects Cell Viability and Promotes the Pro-Inflammatory Phenotype of Fibroblast-Like Synoviocytes . Frontiers in immunology.
Huimei Wu and Longhui Zeng and Jiaxin Ou and Tingting Wang and Yong Chen and Kutty Selva Nandakumar(2022). Estrogen Acts Through Estrogen Receptor-β to Promote Mannan-Induced Psoriasis-Like Skin Inflammation . Frontiers in Immunology. 13. Frontiers Media {SA}
Peibin Liang and Yanpeng Li and Rui Xu and Kutty Selva Nandakumar and Roma Stawikowska and Gregg B. Fields and Rikard Holmdahl(2022). Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst . Molecular Biomedicine. 3. (1). Springer Science and Business Media {LLC}
Kutty Selva Nandakumar, Rongbin Pan, Yanjuan Chen, Yong Chen (2022). Gancao Nurish-Yin Decoction medicated serum inhibits growth and migration of ovarian cancer cells: Network pharmacology-based analysis and biological validation . Pharmacological Research - Modern Chinese Medicine.
Tingting Wang and Lixia Mo and Jiaxin Ou and Qinghua Fang and Huimei Wu and Yuzhe Wu and Kutty Selva Nandakumar(2022). Proteus mirabilis Vesicles Induce Mitochondrial Apoptosis by Regulating miR96-5p/Abca1 to Inhibit Osteoclastogenesis and Bone Loss . Frontiers in Immunology. 13. Frontiers Media {SA}
Kutty Selva Nandakumar, Naru Zhang, Kangchen Li, Zezhong Liu, Shibo Jiang(2022). A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines . Viruses. 14. (2). p. 387. {MDPI} {AG}
Rongbin Pan and Yanjuan Chen and Kutty Selva Nandakumar and Yong Chen(2022). Gancao Nurish-Yin Decoction medicated serum inhibits growth and migration of ovarian cancer cells: network pharmacology-based analysis and biological validation . Pharmacological Research - Modern Chinese Medicine. p. 100062. Elsevier {BV}
NARU ZHANG, Kangchen Li, Zezhong Liu, Jiang Shibo, Kutty Selva Nandakumar (2022). A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines . Viruses.
Kutty Selva Nandakumar (2022). Small molecule SMU-CX24 targeting Toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy . Acta Pharmaceutica Sinica B.
(2021). Effect of Gancao Nurish-Yin decoction (GNY) on improving psoriasis-like skin lesions and regulating inflammation in mice. Journal of Tianjin University Traditional Chinese Medicine.
(2021). Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases . Nature Communications.
Kutty Selva Nandakumar, Gonzalo Fernandez Lahore, Michael Förster, Martina Johannesson, Pierre Sabatier, Erik Lönnblom, Mike Aoun, Yibo He, Roman A. Zubarev, Rikard Holmdahl (2021). Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases . Nature Communications.
Kutty Selva Nandakumar, Xi Li, Sakthi Ponandai‐Srinivasan, Susanne Fabre, Ning Xu Landén, Alain Mavon, Ia Khmaladze(2021). Targeting microRNA for improved skin health . Health Science Reports. 4. (4). Wiley
(2021). Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines . Journal of Inflammation Research.
Kutty Selva Nandakumar, Kehui Zhou, Chaoqun Li, Wen Shi, Xiaodan Hu, Shibo Jiang, Naru Zhang (2021). Current Progress in the Development of Zika Virus Vaccines . Vaccines.
Kutty Selva Nandakumar, Kehui Zhou, Chaoqun Li, Wen Shi, Xiaodan Hu, Jiang Shibo, NARU ZHANG (2021). Current Progress in the Development of Zika Virus Vaccines . Vaccines.
Kutty Selva Nandakumar, Yanjun Zheng, Kui Cheng(2021). Optimization of CAR-T Cell-Based Therapies Using Small-Molecule-Based Safety Switches . Journal of Medicinal Chemistry. 64. (14). p. 9577--9591. American Chemical Society ({ACS})
(2021). Optimization of CAR-T Cell-Based Therapies Using Small-Molecule-Based Safety Switches . Journal of medicinal chemistry.
Kutty Selva Nandakumar, Silvia Hayer, Margriet J Vervoordeldonk, Maria C Denis, Marietta Armaka, Markus Hoffmann, Johan Bäcklund, Birgit Niederreiter, Christina Geka, Anita Fischer, et al.(2021). ‘SMASH’ recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models . Annals of the Rheumatic Diseases. 80. (6). p. 714--726. {BMJ}
Kutty Selva Nandakumar, Zhipeng Chen, Lina Zhang, Junjie Yang, Lu Zheng, Fanjie Hu, Siqin Duan, Shuwen Liu, Hang Yin, Kui Cheng(2021). Design, Synthesis, and Structure–Activity Relationship of N-Aryl-N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy . Journal of Medicinal Chemistry. 64. (11). p. 7371--7389. American Chemical Society ({ACS})
(2021). Imidazole Scaffold based Compounds in the Development of Therapeutic Drugs . Current topics in medicinal chemistry.
Qinghua Fang and Tingyue Li and Peiya Chen and Yuzhe Wu and Tingting Wang and Lixia Mo and Jiaxin Ou and Kutty Selva Nandakumar(2021). Comparative Analysis on Abnormal Methylome of Differentially Expressed Genes and Disease Pathways in the Immune Cells of RA and SLE . Frontiers in Immunology. 12. Frontiers Media {SA}
Kutty Selva Nandakumar, Qiao Zhang, Taizhen Liang, Shuwen Liu(2021). Emerging and state of the art hemagglutinin-targeted influenza virus inhibitors . Expert Opinion on Pharmacotherapy. p. 1--14. Informa {UK} Limited
Kutty Selva Nandakumar, Yanting Xu, Huijing Tan, Kaifei Liu, Cailing Wen, Caixia Pang, Haiqian Liu, Rui Xu, Qixing Li, Chonghua He, et al. (2021). Targeted inhibition of ATP5B gene prevents bone erosion in collagen-induced arthritis by inhibiting osteoclastogenesis . Pharmacological Research.
Kutty Selva Nandakumar, Kangmei Wen, Xiaochuan Fang, Junli Yang, Yongfang Yao, Mohamed Labib Salem, Kui Cheng (2021). Recent Research on Flavonoids and their Biomedical Applications . Current Medicinal Chemistry.
(2021). Targeted inhibition of ATP5B gene prevents bone erosion in collagen-induced arthritis by inhibiting osteoclastogenesis . Pharmacological Research.
Kutty Selva Nandakumar, Ze’an Zhao, Yu Jiang, Lu Li, Yanyu Chen, Yongmei Li, Qunsheng Lan, Ting Wu, Cuiting Lin, Ying Cao, et al.(2020). Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1 . ACS Omega. 5. (51). p. 33421--33432. American Chemical Society ({ACS})
(2020). Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1 . ACS omega.
(2020). Emerging and state of the art hemagglutinin-targeted influenza virus inhibitors . Expert Opinion on Pharmacotherapy.
(2020). Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis . Arthritis Research & Therapy.
(2020). Genetic dissection of a major haplotype associated with arthritis reveal FcγR2b and FcγR3 to act additively . European journal of immunology.
(2020). Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases . Proceedings of the National Academy of Sciences.
(2020). Design and pharmaceutical applications of proteolysis-targeting chimeric molecules . Biochemical Pharmacology.
(2020). Potential treatment methods targeting 2019-nCoV infection . European Journal of Medicinal Chemistry.
(2020). A marine fungus‐derived nitrobenzoyl sesquiterpenoid suppresses RANKL‐induced osteoclastogenesis and attenuates inflammatory bone destruction . British Journal of Pharmacology.
(2020). Metformin, AMPK activator inhibits activation of fibroblast-like synoviocytes but promotes hyaluronan and proteoglycan link protein 1 secretion . Molecular Therapy - Methods & Clinical Development.
Kutty Selva Nandakumar, Qinghua Fang, Chun Zhou (2020). Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis . Mediators of Inflammation.
(2020). Phytoestrogens protect joints in collagen induced arthritis by increasing IgG glycosylation and reducing osteoclast activation . International immunopharmacology.
(2020). Immunotherapy for treating methamphetamine, heroin and cocaine use disorders . Drug Discovery Today.
Wan YH, Wu WY, Guo SX, He SJ, Tang XD, Wu XY, Nandakumar KS, Zou M, Li L, Chen XG, et al.(2019). [1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation . Acta pharmacologica Sinica.
Kutty Selva Nandakumar, Qinghua Fang, Jiaxin Ou (2019). Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis . Mediators of Inflammation.
Kutty Selva Nandakumar, Qinghua Fang, Peiya Chen, Ningchao Du(2019). Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia . Clinical Breast Cancer. 19. (5). p. e624--e636. Elsevier {BV}
Kutty Selva Nandakumar, Kaifei Liu, Ying Liu, Yanting Xu, Huijing Tan, Chonghua He, Wenzhen Dang, Jiahe Lin, Chun Zhou(2019). Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesis . Phytomedicine. 63. p. 153006. Elsevier {BV}
He S, Wu W, Wan Y, Nandakumar KS, Cai X, Tang X, Liu S, Yao X(2019). GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein . Frontiers in Pharmacology.
Kutty Selva Nandakumar, Wen-Zhen Dang, Hui Li, Bing Jiang, Kai-Fei Liu, Li-Xin Liu, Xiao-Chen Yu, Hui-Jing Tan, Chun Zhou(2019). Therapeutic effects of artesunate on lupus-prone MRL/lpr mice are dependent on T follicular helper cell differentiation and activation of JAK2–STAT3 signaling pathway . Phytomedicine. 62. p. 152965. Elsevier {BV}
Kutty Selva Nandakumar, Alex Bersellini Farinotti, Gustaf Wigerblad, Diana Nascimento, Duygu B. Bas, Carlos Morado Urbina, Katalin Sandor, Bingze Xu, Sally Abdelmoaty, Matthew A. Hunt, et al.(2019). Cartilage-binding antibodies induce pain through immune complex–mediated activation of neurons . Journal of Experimental Medicine. 216. (8). p. 1904--1924. Rockefeller University Press
Xiaoshan T, Junjie Y, Wenqing W, Yunong Z, Jiaping L, Shanshan L, Kutty Selva N, Kui C(2019). Immunotherapy for treating methamphetamine, heroin and cocaine use disorders . Drug discovery today.
(2019). SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC . Autophagy.
(2019). Autophagy induced by STING, an unnoticed and primordial function of cGAS . Cellular & molecular immunology.
Liu K, Liu Y, Xu Y, Nandakumar KS, Shen X, Lin J, Li C, He C, Zhou C(2019). Regulatory role of Golgi brefeldin A resistance factor-1 in amyloid precursor protein trafficking, cleavage and Aβ formation . Journal of cellular biochemistry.
Liang B, Ge C, Lönnblom E, Lin X, Feng H, Xiao L, Bai J, Ayoglu B, Nilsson P, Nandakumar KS, et al.(2019). The autoantibody response to cyclic citrullinated collagen type II peptides in rheumatoid arthritis . Rheumatology (Oxford, England).
(2019). OUP accepted manuscript . Database.
Kutty Selva Nandakumar, Marieke F Fransen, Hreinn Benonisson, Wendy W Van Maren, Heng Sheng Sow, Cor Breukel, MM Linssen, Jill WC Claassens, Conny Brouwers, Jos Van Der Kaa, et al. (2018). A Restricted Role for FcγR in the Regulation of Adaptive Immunity . Apollo - University of Cambridge Repository.
Nandakumar KS, Collin M, Happonen KE, Lundström SL, Croxford AM, Xu B, Zubarev RA, Rowley MJ, Blom AM, Kjellman C, et al.(2018). Streptococcal Endo-β-N-Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation In Vivo . Frontiers in immunology.
Yao X, Guo S, Wu W, Wang J, Wu S, He S, Wan Y, Nandakumar KS, Chen X, Sun N, et al.(2018). Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection . Journal of pharmacological sciences.
Tong D, Lönnblom E, Yau ACY, Nandakumar KS, Liang B, Ge C, Viljanen J, Li L, Bãlan M, Klareskog L, et al.(2018). A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis . Frontiers in immunology.
Zhang N, Nandakumar KS(2018). Recent advances in the development of vaccines for chronic inflammatory autoimmune diseases . Vaccine.
Fransen MF, Benonisson H, van Maren WW, Sow HS, Breukel C, Linssen MM, Claassens JWC, Brouwers C, van der Kaa J, Camps M, et al.(2018). A Restricted Role for FcγR in the Regulation of Adaptive Immunity . Journal of immunology (Baltimore, Md. : 1950).
Fransen MF, Benonisson H, van Maren WW, Sow HS, Breukel C, Linssen MM, Claassens JWC, Brouwers C, van der Kaa J, Camps M, et al.(2018). A Restricted Role for FcγR in the Regulation of Adaptive Immunity . Journal of immunology (Baltimore, Md. : 1950).
Fransen MF, Benonisson H, van Maren WW, Sow HS, Breukel C, Linssen MM, Claassens JWC, Brouwers C, van der Kaa J, Camps M, et al.(2018). A Restricted Role for FcγR in the Regulation of Adaptive Immunity . Journal of immunology (Baltimore, Md. : 1950).
Shakya AK, Nandakumar KS(2018). Antigen-Specific Tolerization and Targeted Delivery as Therapeutic Strategies for Autoimmune Diseases . Trends in biotechnology.
Hagert C, Sareila O, Kelkka T, Nandakumar KS, Collin M, Xu B, Guérard S, Bäcklund J, Jalkanen S, Holmdahl R(2018). Chronic active arthritis driven by macrophages without involvement of T cells . Arthritis & rheumatology (Hoboken, N.J.).
Vaartjes D, Nandakumar KS, Holmdahl R, Raposo B(2018). Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T cell-associated autoimmunity . Immunology.
(2018). Tatanan A from the Acorus calamus l. root inhibited dengue virus proliferation and infections . Phytomedicine.
Kutty Selva Nandakumar, Akhilesh Kumar Shakya(2018). An update on smart biocatalysts for industrial and biomedical applications . Journal of The Royal Society Interface. 15. (139). p. 20180062. The Royal Society
(2018). Targeting IgG in Arthritis: Disease Pathways and Therapeutic Avenues . International Journal of Molecular Sciences.
Yao X, Ling Y, Guo S, He S, Wang J, Zhang Q, Wu W, Zou M, Zhang T, Nandakumar KS, et al.(2017). Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5 . European journal of pharmacology.
Zhu G, Xu Y, Cen X, Nandakumar KS, Liu S, Cheng K(2017). Targeting pattern-recognition receptors to discover new small molecule immune modulators . European journal of medicinal chemistry.
Kutty Selva Nandakumar, Albert Dahdah, Katrin Habir, Amit Saxena, Bingze Xu, Rikard Holmdahl, Stephen Malin(2017). Germinal center B cells are essential for collagen-induced arthritis . Arthritis & Rheumatology. Wiley-Blackwell
René Pfeifle, Tobias Rothe, Natacha Ipseiz, Hans U Scherer, Stephan Culemann, Ulrike Harre, Jochen A Ackermann, Martina Seefried, Arnd Kleyer, Stefan Uderhardt, et al.(2016). Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease . Nature Immunology. 18. (1). p. 104--113. Springer Nature
Kutty Selva Nandakumar, Ia Khmaladze, Amit Saxena, Rikard Holmdahl(2015). B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production . Eur. J. Immunol. p. n/a--n/a. Wiley-Blackwell
Kutty Selva Nandakumar, Ia Khmaladze, Rikard Holmdahl(2015). Reactive Oxygen Species in Psoriasis and Psoriasis Arthritis: Relevance to Human Disease . International Archives of Allergy and Immunology. 166. (2). p. 135--149. S. Karger {AG}
Ingrid Lindh, Omri Snir, Erik Lönnblom, Hüseyin Uysal, Ida Andersson, Kutty Nandakumar, Michel Vierboom, Bert 't Hart, Vivianne Malmström, Rikard Holmdahl(2014). Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice . Arthritis Research & Therapy. 16. (4). p. R143. Springer Science $\mathplus$ Business Media
Kutty Selva Nandakumar, Akhilesh Kumar Shakya, Ashok Kumar(2014). Chemical cross-linking abrogates adjuvant potential of natural polymers . RSC Adv. 4. (27). p. 13817. Royal Society of Chemistry ($\lbrace$RSC$\rbrace$)
Kessel, Christoph and Nandakumar, Kutty S. and Peters, Francis B. and Gauba, Varun and Schultz, Peter G. and Holmdahl, Rikard(2013). A single functional group substitution in C5a breaks B and T cell tolerance and protects from experimental arthritis . Arthritis & Rheumatism. p. n/a-n/a. Wiley Blackwell (John Wiley & Sons)
Shakya, Akhilesh Kumar(2013). Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases . Journal of the Royal Society Interface. 10. (79).
Shakya, Akhilesh Kumar and Holmdahl, Rikard and Nandakumar, Kutty Selva and Kumar, Ashok(2013). Characterization of chemically defined poly-N-isopropylacrylamide based copolymeric adjuvants . Vaccine. 31. (35). p. 3519-3527. Elsevier
Geng, Hui and Nandakumar, Kutty Selva and Xiong, Li and Jie, Rui and Dong, Jiahui and Holmdahl, Rikard(2013). Incomplete B Cell Tolerance to Cartilage Oligomeric Matrix Protein in Mice . Arthritis & Rheumatism. 65. (9). p. 2301-2309. Wiley Blackwell (John Wiley & Sons)
Shakya, Akhilesh Kumar and Holmdahl, Rikard and Nandakumar, Kutty Selva and Kumar, Ashok(2013). Polymeric cryogels are biocompatible, and their biodegradation is independent of oxidative radicals . Journal of Biomedical Materials Research Part A. p. n/a-n/a. Wiley Blackwell (John Wiley & Sons)
Geng, Hui(2012). Cartilage oligomeric matrix protein specific antibodies are pathogenic . Arthritis Research & Therapy. 14. (4).
Bas, Duygu B.(2012). Collagen Antibody-Induced Arthritis Evokes Persistent Pain With Spinal Glial Involvement and Transient Prostaglandin Dependency . Arthritis and Rheumatism. 64. (12). p. 3886-3896.
Kelkka, Tiina(2012). Enhancement of Antibody-Induced Arthritis via Toll-Like Receptor 2 Stimulation Is Regulated by Granulocyte Reactive Oxygen Species . American Journal of Pathology. 181. (1). p. 141-150.
Forster, Michael(2012). Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice . Arthritis and Rheumatism. 64. (11). p. 3594-3603.
Forster, Michael(2012). GENETIC CONTROL OF ANTIBODY PRODUCTION DURING COLLAGEN INDUCED ARTHRITIS DEVELOPMENT IN HETEROGENEOUS STOCK MICE . Annals of the Rheumatic Diseases. 71.
Yakimchuk, Konstantin(2012). Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis . Autoimmunity. 45. (7). p. 510-515.
Klaczkowska, Dorota(2012). IDENTIFICATION OF ARTHRITIS PROMOTING NON-OBESE DIABETIC GENES IN THE CIA9 LOCUS USING DIFFERENT GENETIC STRATEGIES . Annals of the Rheumatic Diseases. 71. p. A60.
Cao, D.(2012). Pathogenic autoreactive B cells are not negatively selected toward matrix protein collagen II (vol 187, pg 4451, 2011) . Journal of Immunology. 189. (6). p. 3263.
Kutty Selva Nandakumar, Åsa Jansson, Bingze Xu, Niclas Rydell, Parvien Ahooghalandari, Lars Hellman, Anna M. Blom, Rikard Holmdahl(2011). Correction: A Recombinant Vaccine Effectively Induces C5a-Specific Neutralizing Antibodies and Prevents Arthritis . PLoS ONE. 6. (1). Public Library of Science ($\lbrace$PLoS$\rbrace$)
Nandakumar, Kutty Selva(2011). A dominant suppressive MHC class II haplotype interacting with autosomal genes controls autoantibody production and chronicity of arthritis . Annals of the Rheumatic Diseases. 70. (9). p. 1664-1670.
Shakya, Akhilesh Kumar(2011). Adjuvant properties of a biocompatible thermo-responsive polymer of N-isopropylacrylamide in autoimmunity and arthritis . Journal of the Royal Society Interface. 8. (65). p. 1748-1759.
Lindvall, Therese(2011). An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes . Journal of Neuroimmunology. 235. (1-2). p. 40-47.
Sandor, K(2011). COLLAGEN ANTIBODY-INDUCED ARTHRITIS (CAIA) EVOKES TRANSIENT INFLAMMATION BUT PERSISTENT ALLODYNIA . Annals of the Rheumatic Diseases. 70. p. A90.
Croxford, Allyson M.(2011). Chemical changes demonstrated in cartilage by synchrotron infrared microspectroscopy in an antibody-induced murine model of rheumatoid arthritis . Journal of Biomedical Optics. 16. (6).
Shakya, Akhilesh Kumar(2011). Collagen Type II and a Thermo-Responsive Polymer of N-Isopropylacrylamide Induce Arthritis Independent of Toll-Like Receptors A Strong Influence by Major Histocompatibility Complex Class II and Ncf1 Genes . American Journal of Pathology. 179. (5). p. 2490-2500.
Dobritzsch, Doreen(2011). Crystal structure of an arthritogenic anticollagen immune complex . Arthritis and Rheumatism. 63. (12). p. 3740-3748.
Backlund, Alexandra(2011). Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development . Arthritis Research & Therapy. 13. (2).
Jochems, C(2011). Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis . Clinical and Experimental Immunology. 165. (1). p. 121-129.
Klaczkowska, D(2011). Heterogeneous Stock Mice are Susceptible to Encephalomyelitis and Antibody-initiated Arthritis but not to Collagen- and G6PI-induced Arthritis . Scandinavian Journal of Immunology. 73. (1). p. 46-52.
Ahlqvist, Emma(2011). High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice . Human Molecular Genetics. 20. (15). p. 3031-3041.
Woodruff, Trent M.(2011). Inhibiting the C5-C5a receptor axis . Molecular Immunology. 48. (14). p. 1631-1642.
Cao, Duojia(2011). Pathogenic Autoreactive B Cells Are Not Negatively Selected toward Matrix Protein Collagen II . Journal of Immunology. 187. (9). p. 4451-4458.
Nandakumar, KS(2010). A Recombinant Vaccine Effectively Induces C5a-Specific Neutralizing Antibodies and Prevents Arthritis . Plos One. 5. (10).
Uysal, H(2010). Antibodies to citrullinated proteins: molecular interactions and arthritogenicity. Immunological Reviews. 233. p. 9-33.
Nandakumar, KS(2010). Pathogenic antibody recognition of cartilage . Cell and Tissue Research. 339. (1). p. 213-220.
Hultqvist, M(2010). Rabeximod reduces arthritis severity in mice by decreasing activation of inflammatory cells . Annals of the Rheumatic Diseases. 69. (8). p. 1527-1532.
Croxford, AM(2010). Specific Antibody Protection of the Extracellular Cartilage Matrix Against Collagen Antibody-Induced Damage . Arthritis and Rheumatism. 62. (11). p. 3374-3384.
Blom, AM(2009). C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice . Annals of the Rheumatic Diseases. 68. (1). p. 136-142.
Kielland, A(2009). In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012 . Free Radical Biology and Medicine. 47. (6). p. 760-766.
Johansson, ACM(2009). Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy . Experimental Hematology. 37. (8). p. 969-978.
Uysal, H(2009). Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis . Journal of Experimental Medicine. 206. (2). p. 449-462.
Hultqvist, M(2009). The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders . Annals of the Rheumatic Diseases. 68. (1). p. 130-135.
Kutty Selva Nandakumar, Merrill J. Rowley, Rikard Holmdahl(2008). The role of collagen antibodies in mediating arthritis . Mod Rheumatol. 18. (5). p. 429--441. Informa Healthcare
Nandakumar, KS(2008). Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation . Arthritis and Rheumatism. 58. (1). p. 184-196.
Geng, H(2008). Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis . Arthritis Research & Therapy. 10. (6).
Zang, Song(2008). Development of Collagen II (CII)-induced Arthritis Was Associated with High AID and IL-17 Expression in BXD2 Mice. Faseb Journal. 22.
Uysal, H(2008). The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: Structure to function analysis . Molecular Immunology. 45. (8). p. 2196-2204.
Kolodziej, D(2008). The influence of Cia9 and Cia2 locus on arthritis. Scandinavian Journal of Immunology. 68. (2). p. 195-196.
Rowley, MJ(2008). The role of collagen antibodies in mediating arthritis . Modern Rheumatology. 18. (5). p. 429-441.
Rowley, MJ(2008). The role of collagen antibodies in mediating arthritis . Modern Rheumatology. 18. (5). p. 429-441.
Rowley, MJ(2008). The role of collagen antibodies in mediating arthritis . Modern Rheumatology. 18. (5). p. 429-441.
Nandakumar, KS(2008). Therapeutic cleavage of IgG: new avenues for treating inflammation . Trends in Immunology. 29. (4). p. 173-178.
Nilsang, Suthasinee and Nehru, Vishal and Plieva, Fatima M. and Nandakumar, Kutty Selva and Rakshit, Sudip Kumar and Holmdahl, Rikard and Mattiasson, Bo and Kumar, Ashok(2008). Three-dimensional culture for monoclonal antibody production by hybridoma cells immobilized in macroporous gel particles . Biotechnology Progress. 24. (5). p. 1122-1131. Wiley Blackwell (John Wiley & Sons)
Ahlqvist, E(2007). A new strategy for mapping of loci controlling collagen-induced arthritis using heterogeneous stock mice. Scandinavian Journal of Immunology. 65. (6). p. 590.
Zang, S(2007). Development of collagen II-Induced arthritis was associated with pathogenic autoantibodies in BXD2 mice that exhibited increased AID, SHM and CSR. Arthritis and Rheumatism. 56. (12). p. 4272.
Nandakumar, KS(2007). Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis . European Journal of Immunology. 37. (10). p. 2973-2982.
Jonsson, IM(2007). Ethanol prevents development of destructive arthritis . Proceedings of the National Academy of Sciences of the United States of America. 104. (1). p. 258-263.
Gelderman, KA(2007). Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species . Journal of Clinical Investigation. 117. (10). p. 3020-3028.
Nilsang, S(2007). Monoclonal antibody production using a new supermacroporous cryogel bioreactor . Biotechnology Progress. 23. (4). p. 932-939.
Hansson, M(2007). Targeting of soluble tumor necrosis factor receptor to secretory lysosomes in murine hematopoietic cells in vivo. European Journal of Clinical Investigation. 37. p. 29.
Kolodziej, D(2007). The influence of CIA9 and CIA2 locus on arthritis. Inflammation Research. 56. p. S423.
Lindqvist AK, Johannesson M, Johansson AC, Nandakumar KS, Blom AM, Holmdahl R(2006). Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive effect by two major loci . Journal of immunology (Baltimore, Md. : 1950).
Lange, F(2006). Action of methotrexate in various models of RA and MS is dependent on T-cell activation. Journal of Immunology. 176. p. S147.
Nandakumar, KS(2006). Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis . Arthritis Research & Therapy. 8. (6).
Nandakumar, KS(2006). Arthritis induced with cartilage-specific antibodies is IL-4-dependent . European Journal of Immunology. 36. (6). p. 1608-1618.
Lindqvist, AKB(2006). Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive, effect by two major loci. Journal of Immunology. 177. (6). p. 3952-3959.
Kumar, Ashok and Bansal, Vibha and Nandakumar, Kutty Selva and Galaev, Igor Yu. and Roychoudhury, Pradip K. and Holmdahl, Rikard and Mattiasson, Bo(2006). Integrated bioprocess for the production and isolation of urokinase from animal cell culture using supermacroporous cryogel matrices . Biotechnology and Bioengineering. 93. (4). p. 636-646. Wiley Blackwell (John Wiley & Sons)
Sehnert, B(2006). Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium . Arthritis Research & Therapy. 8. (4).
Carlsen, S(2006). Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity . Arthritis Research & Therapy. 8. (4).
Kumar, A(2005). Affinity binding of cells to cryogel adsorbents with immobilized specific ligands: effect of ligand coupling and matrix architecture . Journal of Molecular Recognition. 18. (1). p. 84-93.
Amirahmadi, SF(2005). Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells . Arthritis and Rheumatism. 52. (6). p. 1897-1906.
Bajtner, E(2005). Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen . Arthritis Research & Therapy. 7. (5). p. R1148-R1157.
Crombie, DE(2005). Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro . Arthritis Research & Therapy. 7. (5). p. R927-R937.
Nandakumar, KS(2005). Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis . Journal of Immunological Methods. 304. (1-2). p. 126-136.
Johannesson, M(2005). Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice . Genes and Immunity. 6. (3). p. 175-185.
Lange, F(2005). Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis . Annals of the Rheumatic Diseases. 64. (4). p. 599-605.
Treschow, AP(2005). Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-beta-deficient mice . Arthritis and Rheumatism. 52. (12). p. 3739-3748.
Sehnert, B(2004). Antileukoproteinase - Modulation of neutrophil function and therapeutic effects on anti-type II collagen antibody-induced arthritis . Arthritis and Rheumatism. 50. (7). p. 2347-2359.
Burkhardt, HL(2004). Antileukoproteinase: Modulation of neutrophil function and therapeutic effects. Annals of the Rheumatic Diseases. 63. p. 153-154.
Nandakumar, KS(2004). Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells . Arthritis Research & Therapy. 6. (6). p. R544-R550.
Hietala, MA(2004). Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis . European Journal of Immunology. 34. (4). p. 1208-1216.
Xu, YK(2004). Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry . Molecular Immunology. 41. (4). p. 411-419.
Nandakumar KS, Svensson L, Holmdahl R(2003). Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes . The American journal of pathology.
Burkhardt H, Sehnert B, Cavcic A, Boehm B, Nandakumar K, Holmdahl R(2003). Antileukoproteinase: modulation of neutrophil function and therapeutic effects in anticollagen II antibody-induced arthritis . Arthritis research & therapy.
Nandakumar, KS(2003). Collagen type II-specific monoclonal antibody-induced arthritis in mice - Description of the disease and the influence of age, sex, and genes. American Journal of Pathology. 163. (5). p. 1827-1837.
Hietala, MA(2003). Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis. Molecular Immunology. 40. (2-4). p. 190.
Nandakumar, KS(2003). Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory Fc gamma RIIB . European Journal of Immunology. 33. (8). p. 2269-2277.
Hietala, MA(2003). Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis . Molecular Immunology. 40. (2-4). p. 190.
Svensson L, Nandakumar KS, Johansson A, Jansson L, Holmdahl R(2002). IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis . European journal of immunology.
Lindqvist, Anna-Karin B and Bockermann, Robert and Johansson, Ã
sa C.M and Nandakumar, Kutty S and Johannesson, Martina and Holmdahl, Rikard(2002). Mouse models for rheumatoid arthritis . Trends in Genetics. 18. (6). p. S7-S13. Elsevier
Burkhardt, H(2002). Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse . Arthritis and Rheumatism. 46. (9). p. 2339-2348.
Svensson, Lars and Nandakumar, KuttyâSelva and Johansson, Ã
sa and Jansson, Liselotte and Holmdahl, Rikard(2002). IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis . European Journal of Immunology. 32. (10). p. 2944-2953. Wiley Blackwell (John Wiley & Sons)
Johansson AC, Hansson AS, Nandakumar KS, Bäcklund J, Holmdahl R(2001). IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies . Journal of immunology (Baltimore, Md. : 1950).
Corthay, Alexandre and Nandakumar, Kutty Selva and Holmdahl, Rikard(2001). Evaluation of the Percentage of Peripheral T Cells with Two Different T Cell Receptor α-Chains and of their Potential Role in Autoimmunity . Journal of Autoimmunity. 16. (4). p. 423-429. Elsevier - Academic Press
Johansson, ACM(2001). IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies. Journal of Immunology. 167. (6). p. 3505-3512.
Nandakumar KS, Muthukkaruppan VR(1999). Influence of immunopotentiators on the antiporin immunoglobulin G subclass: distribution and protective immunity against murine salmonellosis . Scandinavian journal of immunology.
Nandakumar KS, Lakshmi Rao K, Pardhasaradhi BV, Khar A(1999). Upregulation of antitumor immunity by IL-12 gene-transfected AK-5 tumor cells in vivo . Cytokines, cellular & molecular therapy.
Nandakumar KS, Varalakshmi C, Khar A(1998). Role of cytokines in the maintenance of the memory immune response induced by a rat histiocytoma in syngeneic hosts . Cytokines, cellular & molecular therapy.
Nandakumar KS, Kumari AL, Khar A(1997). Early expression of interleukin-12, p40 subunit and IFN-gamma inhibits regression of AK-5 tumor . Cytokines, cellular & molecular therapy.
Nandakumar KS, Palanivel V, Muthukkaruppan V(1993). Diagnosis of typhoid fever: detection of Salmonella typhi porins-specific antibodies by inhibition ELISA . Clinical and experimental immunology.
Muthukkaruppan VR, Nandakumar KS, Palanivel V(1992). Monoclonal antibodies against Salmonella porins: generation and characterization . Immunology letters.
PREPRINT
Gonzalo Fernandez Lahore, Michael Förster, Martina Johannesson, Pierre Sabatier, Erik Lönnblom, Mike Aoun, Yibo He, Kutty Nandakumar, Roman Zubarev, Rikard Holmdahl (2021). Polymorphic estrogen receptor binding site causes CD2-dependent sex bias in the susceptibility to autoimmune diseases .
Yong C, Huimei W, Changhong X, Nandakumar KS(2020). Gancao Nurish-Yin Decoction Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions and Inflammation in Mice .
Du N, Li Y, Xu M, Wu C, Chen X, Yang F, He Q, Liao M, Qiu J, Wang C, et al.(2020). Collagen-induced inflammations .
Chen Y, Fujuan Q, Beijia Y, Fangfang Z, Yanan B, Ensheng C, Xiaofeng Z, Yi Y, Yanyan C, Zhu S, et al.(2020). Adenosine monophosphate-activated protein kinase activator inhibits activation of fibroblast-like synoviocytes but promotes hyaluronan and proteoglycan link protein 1 secretion .
BOOK CHAPTER
(2019). Macrophages in the activation and resolution of inflammation. Autoimmune diseases:Risk Factors, Pathogenesis and Treatments.
(2019). Nano-size based drug delivery systems for autoimmune diseases. Autoimmune diseases:Risk Factors, Pathogenesis and Treatments.
(2019). Psoriasis: Genetic predisposition, pathogenesis, treatment and the role of microbiome. Autoimmune diseases:Risk Factors, Pathogenesis and Treatments.
(2019). N-glycans modulate IgG effector functions and antibody dependent inflammation. Autoimmune diseases:Risk Factors, Pathogenesis and Treatments.
(2019). Pathogenic and protective autoantibodies in arthritis and diabetes. Autoimmune diseases:Risk Factors, Pathogenesis and Treatments.
(2019). Nanobiocatalysts for Industrial Applications . Characterization and Biology of Nanomaterials for Drug Delivery.
Kutty Selva Nandakumar (2014). New generation vaccines: Need for safe and improved adjuvants. Vaccines & vaccine technologies.
OTHER
Kutty Selva Nandakumar, Akhilesh Kumar Shakya(2017). Biomaterials for Induction and Treatment of Autoimmunity . Advances in Biomaterials for Biomedical Applications. p. 167--184. Springer Singapore
Kutty Selva Nandakumar, Akhilesh Kumar Shakya(2015). Applications of Nanomaterials for Activation and Suppression of Immune Responses . Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering. p. 205--220. {IGI} Global
Kutty Selva Nandakumar, Akhilesh Kumar Shakya(2015). Applications of Nanomaterials for Activation and Suppression of Immune Responses . Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering. p. 205--220. {IGI} Global
Kutty Selva Nandakumar, Akhilesh Kumar Shakya(2015). Applications of Nanomaterials for Activation and Suppression of Immune Responses . Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering. p. 205--220. {IGI} Global
Shakya, Akhilesh Kumar and Nandakumar, Kutty Selva(2013). Stimuli-Responsive Polymers as Adjuvants and Carriers for Antigen Delivery . 123-139Wiley Blackwell (John Wiley & Sons)
Nandakumar, Kutty Selva(2012). Antibody-Mediated Arthritis and New Therapeutic Avenues . 407-426Wiley Blackwell (John Wiley & Sons)
Sandor, Katalin and Nandakumar, Kutty Selva and Holmdahl, Rikard and Svensson, Camilla I.(2012). Collagen Antibody-Induced Arthritis: A Disease-Relevant Model for Studies of Persistent Joint Pain . 437-455Springer-Verlag
Kutty Selva Nandakumar, Akhilesh Kumar Shakya (2011). Synthetic Polymer as an Adjuvant in Collagen-Induced Arthritis . Current Protocols in Mouse Biology.
Kutty Selva Nandakumar, Akhilesh Kumar Shakya Applications of Nanomaterials for Activation and Suppression of Immune Responses . Materials Science and Engineering. p. 859--875. {IGI} Global
DISSERTATION THESIS
Kutty Selva, Nandakumar (2006). Analysis of effector pathways in arthritis .
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