level-one heading

Writers
Data Analysts
Consultants
Product Developers
Researchers
Why Kolabtree
Getting started is quick and easy. No upfront fees
It’s free to request a service and invite bids from experts
Discuss requirements with the expert in detail before accepting statement of work from Kolabtree
Collaborate with the expert directly to get your work done the right way
Fund project when you hire the expert, but approve the deliverables only once work is done
Want to hire this expert for a project? Request a quote for free.
Profile Details
Create Project
★★★★★
☆☆☆☆☆
USD 200 /hr
Hire Dr. Krathish B.
India
USD 200 /hr

Strategic consultant & Pharmacolgist in nutrition and botanical extracts, global experience of over 30 years.

Profile Summary
Subject Matter Expertise
Services
Research User Research, Feasibility Study, Fact Checking, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection
Work Experience

Director

Tejhana Consulting LLP

January 2019 - Present

Chief Executive Officer

Semler Research Center (India)

May 2010 - November 2018

Consultant

Tata Consultancy Services

May 2004 - April 2005

Medical Advisor

AstraZeneca

February 1997 - April 2004

Education

Royal Society of Heath

- Present

PhD (Psychopharmacology)

NIMHANS

- Present

Doctor of Science (Pharmacology)

IUCS Washington

April 1999 - April 2002

Master in Pharmacology & Toxicology (Pharmacology)

Maharaja Sayajirao University of Baroda

April 1995 - February 1997

Certifications
  • Certification details not provided.
Publications
PREPRINT
0.20944/preprints202606.1187.v1 .
Krathish Bopanna, S. Mehkri, K.G. Dinesh, G. Ashok (2025). Phosphatidylserine Matrix Enhances Lutein/Zeaxanthin Exposure Versus Phosphatidylcholine, Liposome, and MCT Oil in Rats: A 24‑Hour Pharmacokinetic Study .
Phosphatidylserine Matrix Enhances Lutein/Zeaxanthin Exposure Versus Phosphatidylcholine, Liposome, and MCT Oil in Rats: A 24‑Hour Pharmacokinetic Study @misc{lens.org/027-452-816-258-045, author = {S. Mehkri and K.G. Dinesh and G. Ashok and Krathish Bopanna}, title = {Phosphatidylserine Matrix Enhances Lutein/Zeaxanthin Exposure Versus Phosphatidylcholine, Liposome, and MCT Oil in Rats: A 24‑Hour Pharmacokinetic Study}, month = {October}, date = {2025-10-23}, doi = {10.20944/preprints202510.1830.v1}, note = "\url{https://www.preprints.org/frontend/manuscript/b1fb49b090a7867e723919f3e8e4d300/download_pub} ; \url{https://doi.org/10.20944/preprints202510.1830.v1}", url = {https://lens.org/027-452-816-258-045} } .
Krathish Bopanna, Mehkri S., Dinesh K. G., Ashok G.(2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats .
Krathish Bopanna, Mehkri S., Dinesh K. G., Ashok G. (2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats .
Krathish Bopanna, Mehkri S., Dinesh K. G., Ashok Godavarthi (2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats .
Krathish Bopanna, Mehkri S., Dinesh K. G., Ashok Godavarthi(2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats .
JOURNAL ARTICLE
Curcumin thymoquinone complex in managing inflamasome markets and creating mitochondrial resilience .
Curcumin–Thymoquinone Complex (CTQ) In Mitochondrial Resilience And Inflammasome Regulation: A Translational Review @article{lens.org/103-063-356-855-441, author = {Krathish Bopanna}, title = {Curcumin–Thymoquinone Complex (CTQ) In Mitochondrial Resilience And Inflammasome Regulation: A Translational Review}, journal = {The European Journal of Cancer}, month = {March}, doi = {10.52338/tejoc.2025.5238}, date = {2026-03-09}, url = {https://lens.org/103-063-356-855-441} } . The European Journal of Cancer.
Krathish Bopanna, S Mehkri, K G Dinesh, G Ashok(2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats . Pharmaceutics.
Krathish Bopanna, S. Mehkri, K. G. Dinesh, G. Ashok (2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats . Pharmaceutics.
Krathish Bopanna, S. Mehkri, K. G. Dinesh, G. Ashok (2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats . Pharmaceutics.
Comparative pharmacokinetics of different coenzyme Q₁₀ formulations in Wistar rats: Superior bioavailability of phospholipid complex and lipid-encapsulated delivery systems @article{lens.org/110-451-740-033-694, author = {S Mehkri and K.G Dinesh and G Ashok and Krathish Bopanna}, title = {Comparative pharmacokinetics of different coenzyme Q₁₀ formulations in Wistar rats: Superior bioavailability of phospholipid complex and lipid-encapsulated delivery systems}, journal = {Zenodo (CERN European Organization for Nuclear Research)}, month = {September}, doi = {10.5281/zenodo.17757237}, date = {2025-09-30}, note = "\url{https://zenodo.org/doi/10.5281/zenodo.17757237}", url = {https://lens.org/110-451-740-033-694} } . Zenodo (CERN European Organization for Nuclear Research).
Comparative pharmacokinetics of different coenzyme Q₁₀ formulations in Wistar rats: Superior bioavailability of phospholipid complex and lipid-encapsulated delivery systems @article{lens.org/052-298-686-365-996, author = {null S. Mehkri and null K.G. Dinesh and null G. Ashok and null Krathish Bopanna}, title = {Comparative pharmacokinetics of different coenzyme Q₁₀ formulations in Wistar rats: Superior bioavailability of phospholipid complex and lipid-encapsulated delivery systems}, journal = {World Journal of Advanced Research and Reviews}, month = {September}, doi = {10.30574/wjarr.2025.27.3.3214}, date = {2025-09-30}, url = {https://lens.org/052-298-686-365-996} } . World Journal of Advanced Research and Reviews.
Comparative pharmacokinetics of different coenzyme Q₁₀ formulations in Wistar rats: Superior bioavailability of phospholipid complex and lipid-encapsulated delivery systems @article{lens.org/183-796-532-710-138, author = {S Mehkri and K.G Dinesh and G Ashok and Krathish Bopanna}, title = {Comparative pharmacokinetics of different coenzyme Q₁₀ formulations in Wistar rats: Superior bioavailability of phospholipid complex and lipid-encapsulated delivery systems}, journal = {Zenodo (CERN European Organization for Nuclear Research)}, month = {September}, doi = {10.5281/zenodo.17757236}, date = {2025-09-30}, note = "\url{https://zenodo.org/doi/10.5281/zenodo.17757236}", url = {https://lens.org/183-796-532-710-138} } . Zenodo (CERN European Organization for Nuclear Research).
Krathish Bopanna, S. Mehkri, KG Dinesh, G. Ashok(2025). Pharmacokinetic Comparison of Lutein and Zeaxanthin in Granule, Beadlet, and Liposomal Powder Formulations Following Single OralAdministration in Male Sprague-Dawley Rats . Current Functional Foods.
ENHANCED AND SYNERGISTIC INHIBITION OF PRO-INFLAMMATORY CYTOKINES (IL-1Β, IL-17A, AND IL-6) BY A CURCUMIN- THYMOQUINONE COMPLEX (CURQNONE®), COMPARED TO CURCUMIN MONOTHERAPY IN LPS-STIMULATED RAW 264.7 MURINE MACROPHAGES @article{https://doi.org/10.5281/zenodo.17130164, doi = {10.5281/ZENODO.17130164}, url = {https://zenodo.org/doi/10.5281/zenodo.17130164}, author = {S. Mehkri, and K. G. Dinesh, and G. Ashok, and Krathish Bopanna*, }, keywords = {CurQnone®, curcumin, thymoquinone, cytokines, IL-6, IL-17A, IL-1β, iNOS, COX-2, macrophage inflammation, combination therapy}, language = {en}, title = {ENHANCED AND SYNERGISTIC INHIBITION OF PRO-INFLAMMATORY CYTOKINES (IL-1Β, IL-17A, AND IL-6) BY A CURCUMIN- THYMOQUINONE COMPLEX (CURQNONE®), COMPARED TO CURCUMIN MONOTHERAPY IN LPS-STIMULATED RAW 264.7 MURINE MACROPHAGES}, publisher = {WJPSR}, year = {2025}, copyright = {Creative Commons Attribution Non Commercial 4.0 International}} . WJPSR.
S. Mehkri, K.G. Dinesh, G. Ashok and Krathish Bopanna. Comparative pharmacokinetics of different coenzyme Q₁₀ formulations in Wistar rats: Superior bioavailability of phospholipid complex and lipid-encapsulated delivery systems. World Journal of Advanced Research and Reviews, 2025, 27(03), 789–801 .
Krathish Bopanna, S Mehkri, K G Dinesh, G Ashok(2025). Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley rats . Indian journal of pharmacology.
Krathish Bopanna, S Mehkri, K. G. Dinesh, G. Ashok (2025). Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley rats . Indian Journal of Pharmacology.
Anti-inflammatory Effects of a Curcumin-Thymoquinone Complex (CurQnone®) and Curcumin Alone in LPS-Stimulated RAW 264.7 Cells: A Comparative Study @article{https://doi.org/10.5281/zenodo.15735101, doi = {10.5281/ZENODO.15735101}, url = {https://zenodo.org/doi/10.5281/zenodo.15735101}, author = {S. Mehkri1, K. G. Dinesh2, Dr. G. Ashok3, Dr. Krathish Bopanna*4, }, keywords = {CurQnone®, curcumin, thymoquinone, inflammation, RAW 264.7, TNF-α, COX-2, iNOS, RT-PCR}, title = {Anti-inflammatory Effects of a Curcumin-Thymoquinone Complex (CurQnone®) and Curcumin Alone in LPS-Stimulated RAW 264.7 Cells: A Comparative Study}, publisher = {International Journal of Pharmaceutical Sciences}, year = {2025}, copyright = {Creative Commons Attribution 4.0 International}} . International Journal of Pharmaceutical Sciences.
(2025). Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley rats . INDIAN JOURNAL OF PHARMACOLOGY.
(2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats . Preprints.
(2025). Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats . PHARMACEUTICS.
Study Design & Method: A total of 93 subjects were randomized in a double-blinded, placebo-controlled, parallel, three-armstudy, which was followed for 180 days. Post-study data were subjected to advanced statistical analysis to assess the efficacyof CaroRite™ versus placebo and lutein and zeaxanthin alone on MPOD and its relationship with CFT. Results: CaroRite™(p=0.0001) and lutein and zeaxanthin (p=0.0009) showed statistically significant improvements in MPOD levels compared tobaseline. In contrast, the placebo arm (p=0.6179) did not show any significant changes in MPOD levels compared to baseline.CaroRite™ increased the MPOD by approximately 50.53%, whereas lutein and zeaxanthin increased the MPOD byapproximately 46.91%. CaroRite™ showed a marginally higher positive correlation between MPOD and CFT than lutein andzeaxanthin, while the placebo did not show any positive correlation.Conclusion: CaroRite™ showed a statistically significant increase in MPOD compared with placebo. Compared to lutein andzeaxanthin, CaroRite™ increased the MPOD by a larger amount, although the difference was not statistically significant.Further studies are needed to explore the relationship between the added carotenoids in scavenging free radicals and theirpossible mechanisms of action in protecting against macular degeneration. (PDF) Natural mixed carotenoid complex (CaroRite™) on macular pigment optical density (MPOD), and central foveal thickness (CFT), a randomised, double-blind, placebo-controlled study. Available from: https://www.researchgate.net/publication/383872498_Natural_mixed_carotenoid_complex_CaroRite_on_macular_pigment_optical_density_MPOD_and_central_foveal_thickness_CFT_a_randomised_double-blind_placebo-controlled_study [accessed Sep 17 2025] .
The throat is an area of the body which undergoes constant strain, experiencing the stress of numerous normal activities, such as shouting, snoring, smoking, or drinking alcohol. Frequent exposure to these stressors alongside chemical and environmental factors (e.g., pollution, temperature, humidity) have a detrimental impact on the integrity of the mucosal barrier and cellular function resulting in throat irritation or dryness, ultimately leading to the development of inflammation if left unchecked. This review considers the important role vitamin C and zinc play in processes integral to throat health and how their supplementation is key in maintaining the primary defences of this passage and preventing more serious symptoms. The consequences of deficiency in these micronutrients lead to myriad conditions relating to impaired control of inflammation, poorer control of ROS and their effects, in addition to the inability to properly build, repair and maintain vital cell structures. Supplementation of these micronutrients at higher doses has yielded health benefits in numerous studies centred around symptom and disease management. Therefore, the implications of long-term low dose supplementation of vitamin C and zinc on throat health, which has been seldom studied, are promising. To achieve effective delivery of such supplementation; lozenges present as an optimal delivery system. Their direct and prolonged contact with the mouth and throat potentially increases bioavailability of the dosage and their flavour profile beneficially increases the salivary response and hence demulcent effect of this fortified lozenge while masking the unpleasant flavour of zinc. As this locally supplied supplemental intervention in lozenge form is unstudied in regard to throat health in a preventative capacity, further studies to demonstrate this value would be useful .
S Mehkri, MB Thirumalesh, MV Krishnaiah, G Ashok, Dr. Krathish Bopanna(2023). The effects of Lutein and Zeaxanthin (Lute-genreg;) supplementation, with and without natural mixed carotenoids on Central Foveal Thickness and its relationship with Macular Pigment Optical Density in healthy adult subjects: a randomized, double-blind, placebo-controlled study . International Journal of Ophthalmology Research.
S Mehkri, MB Thirumalesh, MV Krishnaiah, G Ashok, Dr. Krathish Bopanna (2023). The effects of Lutein and Zeaxanthin (Lute-genreg;) supplementation, with and without natural mixed carotenoids on Central Foveal Thickness and its relationship with Macular Pigment Optical Density in healthy adult subjects: a randomized, double-blind, placebo-controlled study . International Journal of Ophthalmology Research.
S Mehkri, MB Thirumalesh, MV Krishnaiah, G Ashok, Dr. Krathish Bopanna (2023). The effects of Lutein and Zeaxanthin (Lute-genreg;) supplementation, with and without natural mixed carotenoids on Central Foveal Thickness and its relationship with Macular Pigment Optical Density in healthy adult subjects: a randomized, double-blind, placebo-controlled study . International Journal of Ophthalmology Research.
Krathish Bopanna, S Mehkri, M B Thirumalesh, M V Krishnaiah, G Ashok(2022). The effects of lutein and zeaxanthin (Lute-genandreg;) supplementation, with and without natural mixed carotenoids on macular pigment optical density in healthy adult subjects: A randomized, double-blind, placebo-controlled study . International Journal of Ophthalmology Research.
Krathish Bopanna, S Mehkri, M B Thirumalesh, M V Krishnaiah, G Ashok (2022). The effects of lutein and zeaxanthin (Lute-genandreg;) supplementation, with and without natural mixed carotenoids on macular pigment optical density in healthy adult subjects: A randomized, double-blind, placebo-controlled study . International Journal of Ophthalmology Research.
Krathish Bopanna, S Mehkri, M B Thirumalesh, M V Krishnaiah, G Ashok (2022). The effects of lutein and zeaxanthin (Lute-genandreg;) supplementation, with and without natural mixed carotenoids on macular pigment optical density in healthy adult subjects: A randomized, double-blind, placebo-controlled study . International Journal of Ophthalmology Research.
Krathish Bopanna, S Mehkri, M B Thirumalesh, M V Krishnaiah, G Ashok (2022). The effects of lutein and zeaxanthin (Lute-genandreg;) supplementation, with and without natural mixed carotenoids on macular pigment optical density in healthy adult subjects: A randomized, double-blind, placebo-controlled study . International Journal of Ophthalmology Research.
The study showed that carotenoids (Lute-gen®) with or without mixed carotenoids were more significant in comparison to placebo in improving the CFT levels as reported in previous studies [10,13,14] . Increased CFT levels in the retina may have benefits, by reducing the risk of occupational-induced macular degeneration or age-related macular degeneration (AMD) by providing protection against oxidative damage and protecting eyes against rays of blue-light. .
The study results showed a decrease in mRNA gene expression of TNF-α (0.97 & 1.17 folds), iNOS (0.91 & 0.99 folds) and COX-2 (1.05 & 1.17 folds) on exposure to lower and higher dose of the test substance respectively when compared to the cell control. The level of expression was observed to decrease when the cells were treated with higher dose (125 μg/ml) in comparison to lower dose (62.5 μg/ml) of ThymoPure TM (Nigella sativa) oil for 24 hours. In the current in-vitro study ThymoPure TM (Nigella sativa) oil has shown potential anti-inflammatory effects as it reduced the expression of TNF-α, COX-2 and iNOS in an accelerated dose response .
Studies have also revealed that TQ enhances phagocytic activity in mouse macrophages, suggesting a potential to strengthen innate immune responses. These effects make TQ a promising candidate for modulating inflammatory diseases (Mehkri et al., 2021a). TQ decreased the secretion of NO and PGE2 and downregulated inflammatory gene expression in activated macrophages .
his attenuation of airway inflammation was concomitant to the inhibition of COX-2 protein expression and PGD2 production [20] . Al Wafai et al showed that supplementation with TQ and N Sativa in streptozotocin (STZ) stimulated diabetic rats prevented COX-2 enzyme expression in pancreatic tissue [22] . In our previous studies with ThymoPure TM (Nigella sativa) oil on mouse macrophages, the dendritic cell maturation, survival, and cytokine release (TNF-alpha, IL-6, IL-1-b and IL-17) was seen to be counteracted following LPS exposure [23] . .
Evaluation of in Vitro phagocytic property of macrophages in presence of thymopure™ (Nigella Sativa) oil @article{lens.org/180-711-417-759-919, author = {S Mehkri and K Chandrasagar and G Ashok and Krathish Bopanna}, title = {Evaluation of in Vitro phagocytic property of macrophages in presence of thymopure™ (Nigella Sativa) oil}, journal = {International Journal of Biology}, note = "\url{http://www.biologyjournal.in/archives/2021/vol6/issue2/6-2-14}", url = {https://lens.org/180-711-417-759-919} } . International Journal of Biology.
Evaluation of in vitro immuno modulatory activity of thymopure™ Nigella sativa oil in dendritic cells @article{lens.org/078-435-249-727-698, author = {S Mehkri and K Chandrasagar and G Ashok and Krathish Bopanna}, title = {Evaluation of in vitro immuno modulatory activity of thymopure™ Nigella sativa oil in dendritic cells}, journal = {International Journal of Biology}, note = "\url{https://www.biologyjournal.in/archives/2021/vol6/issue2/6-2-22}", url = {https://lens.org/078-435-249-727-698} } . International Journal of Biology.
Krathish Bopanna, S Mehkri, C Ambarish, BJ Madankumar, Preethi Shivayogi(2020). Effect of two doses of Fenugreek flakes (fenuleantm) on appetite, body-weight and blood glucose homeostasis: A randomized, double-blind, multicenter, three-arm, long-term, control study in 100 healthy subjects . International Journal of Medical and Health Research.
Krathish Bopanna(2019). Effect of two doses of Fenugreek Flakes (FenuLean TM ) on appetite, body-weight and blood glucose homeostasis: A randomized, double-blind, multicenter, three-arm, long-term, control study in 100 healthy subjects . nternational Journal of Medical Science and Clinical Research. Unpublished
Consistent with this observation, a lower telomere shortening rate was detected compared to the untreated control ( Figure 5). Our results are similar to those of other studies with antioxidants using the same in vitro model and TAT ® analysis [44,101] and are in agreement with previous works demonstrating the protective effects of antioxidants on telomere length [24,52,70]. In this sense, EY may possibly delay the onset of replicative senescence by protecting the telomeres. .
There is appreciable increase in duration of sleep when subjects were under SleepRite TM 100% (7.9 hrs) administration as compared to SleepRite TM 66% (6.8 hrs) as compared to the Placebo arm (6.1 hrs). It has been found that there is substantial increase in sleep efficiency for subjects on SleepRite TM 100% (by 91%) administration as compared to the SleepRite TM 66% (by 86%) administration when compared to placebo arm (by 80%). However, there were no significant changes noted in the quality of sleep as the sample population was small and the sample size did not adequately justify the above objective. However, trends showed some positive changes were observed amongst people with SleepRite TM in the quality of sleep .
Krathish Bopanna, Shobha N, null Sampath, Preethi Shivayogi, null Jaishankar(2019). Assessment of onset, duration, sleep efficiency and quality of sleep through SleepRiteTM combination product(s) on adult subjects with difficulties in falling asleep . International Journal of Medical and Health Research.
Composition of fresh fenugreek leaves and mature fenugreek seeds is shown in Table 2.5. Chandra et al. (2018) revealed that consumption of fenugreek fiber flakes (5 and 10 g) with a standard breakfast increased satiety satisfaction and fullness. Fenugreek fiber flakes reduced hunger and desire to consume food and prospective food consumption in 10 g significantly compared to 5 g. .
Krathish Bopanna, Jayanti Gupta(2009). Managing Clinical Trials in India . Pharmaceutical Medicine.
Krathish Bopanna, Jayanti Gupta (2009). Managing Clinical Trials in India . Pharmaceutical Medicine.
BOPANNA, K.N.; BALARAMAN, R.*; NADIG, R.S.. ORGANOTROPIC ULTRASTRUCTURAL CHANGES PRODUCED BY MONOSODIUM GLUTAMATE IN RATS ON ATHEROGENIC DIET: EFFECT OF S-ALLYL CYSTEINE SULPHOXIDE. Indian Journal of Pharmacology 31(4):p 266-274, Jul–Aug 1999 .
BOPANNA, K. N.; BALARAMAN, R.*; NADIG, R. S.. ROLE OF S-ALLYL CYSTEINE SULPHOXIDE IN ANTAGONISING DELETERIOUS METABOLIC EFFECTS OF MONOSODIUM GLUTAMATE IN RATS ON ATHEROGENIC DIET. Indian Journal of Pharmacology 30(3):p 152-162, May–Jun 1998 .
https://journals.lww.com/iphr/abstract/1998/30020/antioxidant_status_of_s_allyl_cysteine_sulphoxide.3.aspx .
Administration of NP alone (500 mg/kg) as well as the combination of NP (250mg/kg) with glibenclamide (0.25mg/kg) significantly decreased the concentration of serum lipids, blood glucose and activities of serum enzymes like alkaline phosphatase (alk P), acid phosphatase (acid P), lactate dehydrogenase (LDH), liver glucose 6-phosphatase (G6P) and HMG CoA reductase activity in liver and intestine of alloxan diabetic rabbits. However, all the treatments produced an increased liver hexokinase activity. The changes observed were significantly greater when the treatment was given in combination of NP and glibenclamide than with NP alone .
https://journals.lww.com/iphr/abstract/1997/29020/cell_culture_derived_hemidesmus_indicus_in_the.8.aspx .