Want to hire this expert for a project? Request a quote for free.
Profile Details
Create Project
USD 70 /hr
Hire Dr. Konstantin Kostya P.
Switzerland
USD 70 /hr
Medical Writer | Genomic Data Analysis | Aging | Mitochondrial DNA | Statistician & Data Analyst | Expert in R |
Profile Summary
Subject Matter Expertise
Services
Writing
Clinical Trial Documentation,
Medical Writing,
Creative Writing,
Translation
Research
Scientific and Technical Research,
Systematic Literature Review
Consulting
Scientific and Technical Consulting
Data & AI
Predictive Modeling,
Statistical Analysis,
Image Processing,
Image Analysis,
Algorithm Design-Non ML,
Data Visualization,
Big Data Analytics,
Text Mining & Analytics,
Data Mining,
Data Cleaning,
Data Processing,
Data Insights
Work Experience
Senior Scientific Assistant
EPFL - EPF Lausanne
January 2019 - January 2023
Education
Evolution of genes and genomes in the absence of homologous recombination
Lomonosov Moscow State University
January 2001 - January 2005
Certifications
Publications
PREPRINT
Melissa Franco, Jacob Bandell, Konstantin Popadin, Dori Woods, Konstantin Khrapko (2025). Are mitochondrial DNA mutations under purifying selection in somatic tissues? .
Melissa Franco, Konstantin Popadin, Dori Woods, Konstantin Khrapko (2024). Evolutionary mismatch between nuclear and mitochondrial genomes does not promote reversion mutations in mtDNA .
Victor Shamanskiy, Konstantin Popadin (2024). Harnessing Stress: balancing the Burden of Slightly-Deleterious Variants by a Handicap .
Aleksandr Kuzmin, Viktoria Skripskaya, Valeria Lobanova, Polina Brodovaya, Alina Tarasova, Konstantin Popadin, Alina G. Mikhailova, Elena Kozenkova, Nikolai Mugue, Evgenii Vinogradov, et al. (2024). Selection of different parameters to study epistatic effect between heat shock and slightly deleterious mutations in the most fragile stage of embryogenesisCyprinus carpioL .
Bogdan Efimenko, Konstantin Popadin, Konstantin Gunbin (2023). NeMu: A Comprehensive Pipeline for Accurate Reconstruction of Neutral Mutation Spectra from Evolutionary Data .
Melissa Franco, Auden Cote-L’Heureux, Zoë Fleischmann, Zhibin Chen, Mark Khrapko, Benjamin Vyshedskiy, Maxim Braverman, Konstantin Popadin, Sarah Pickett, Dori C. Woods, et al. (2023). A novel, wave-shaped profile of germline selection of pathogenic mtDNA mutations is discovered by bypassing a classical statistical bias .
Auden Cote-L’Heureu, Melissa Franco, Yogesh N. K. Maithania, Konstantin Popadin, Dori Woods, Jonathan Tilly, Konstantin Khrapko (2023). The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysis .
Zoë Fleischmann, Auden Cote-L’Heureux, Melissa Franco, Sergey Oreshkov, Sofia Annis, Mark Khrapko, Dylan Aidlen, Konstantin Popadin, Dori C. Woods, Jonathan L. Tilly, et al. (2022). Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive .
M.A. Tatarkina, V.V. Lobanova, I.I. I.I. Kozenkov, B.E. Efimenko, A. K. Dzhigkaev, K.Y. Popadin, K.V. Gunbin, A.G. Goncharov (2022). Isolation of highly purified genomic material from mitochondria of muscle tissue cells .
Victor Shamanskiy, Alina A. Mikhailova, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry Knorre, Evgenii O. Tretiakov, Natalia Ri, Jonathan B. Overdevest, Samuel W. Lukowski, et al.(2019). Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome . Cold Spring Harbor Laboratory
JOURNAL ARTICLE
A. H. Dzhigkaev, A. M. Tynterova, I. I. Kozenkov, E. V. Khaibulin, E. V. Trofimova, K. Yu. Popadin, K. V. Gunbin, A. G. Goncharov (2024). Clinical, functional and neuropsychological status of joint replacement patients . Genij Ortopedii.
Bogdan Efimenko, Konstantin Popadin, Konstantin Gunbin (2024). NeMu: a comprehensive pipeline for accurate reconstruction of neutral mutation spectra from evolutionary data . Nucleic Acids Research.
Efimenko, B., Popadin, K., Gunbin, K.(2024). NeMu: A comprehensive pipeline for accurate reconstruction of neutral mutation spectra from evolutionary data . Nucleic Acids Research. 52. (W1). p. W108-W115.
Fleischmann, Z., Cote-L'Heureux, A., Franco, M., Oreshkov, S., Annis, S., Khrapko, M., Aidlen, D., Popadin, K., Woods, D.C., Tilly, J.L., et al.(2024). Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive . Mitochondrion. 74.
Tofilo, M., Voronova, N., Nigmatullina, L., Kuznetsova, E., Timonina, V., Efimenko, B., Turgunkhujaev, O., Avdeichik, S., Ansar, M., Popadin, K., et al.(2023). Live Birth of a Healthy Child in a Couple with Identical mtDNA Carrying a Pathogenic c.471_477delTTTAAAAinsG Variant in the MOCS2 Gene . Genes. 14. (3).
Shamanskiy, V., Mikhailova, A.A., Tretiakov, E.O., Ushakova, K., Mikhailova, A.G., Oreshkov, S., Knorre, D.A., Ree, N., Overdevest, J.B., Lukowski, S.W., et al.(2023). Secondary structure of the human mitochondrial genome affects formation of deletions . BMC Biology. 21. (1).
Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Victor Shamansky, Valeria Lobanova, Ivan Kozenkov, Bogdan Efimenko, Andrey A Yurchenko, et al.(2022). A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand . Nucleic Acids Research. 50. (18). p. 10264--10277. Oxford University Press ({OUP})
Konstantin Popadin, Konstantin Gunbin, Leonid Peshkin, Sofia Annis, Zoe Fleischmann, Melissa Franco, Yevgenya Kraytsberg, Natalya Markuzon, Rebecca R. Ackermann, Konstantin Khrapko (2022). Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors . Genes.
Alexander G. Bick, Konstantin Popadin, Christian W. Thorball, Md Mesbah Uddin, Markella V. Zanni, Bing Yu, Matthias Cavassini, Andri Rauch, Philip Tarr, Patrick Schmid, et al.(2022). Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV . Scientific Reports. 12. (1). Springer Science and Business Media {LLC}
Bick, A.G., Popadin, K., Thorball, C.W., Uddin, M.M., Zanni, M.V., Yu, B., Cavassini, M., Rauch, A., Tarr, P., Schmid, P., et al.(2022). Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV . Scientific Reports. 12. (1).
Bick, A.G., Popadin, K., Thorball, C.W., Uddin, M.M., Zanni, M.V., Yu, B., Cavassini, M., Rauch, A., Tarr, P., Schmid, P., et al.(2022). Author Correction: Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV (Scientific Reports, (2022), 12, 1, (577), 10.1038/s41598-021-04308-2) . Scientific Reports. 12. (1).
Franco, M., Pickett, S.J., Fleischmann, Z., Khrapko, M., Cote-L'Heureux, A., Aidlen, D., Stein, D., Markuzon, N., Popadin, K., Braverman, M., et al.(2022). Dynamics of the most common pathogenic mtDNA variant m.3243A > G demonstrate frequency-dependency in blood and positive selection in the germline . Human Molecular Genetics. 31. (23). p. 4075-4086.
Mikhailova, A.G., Mikhailova, A.A., Ushakova, K., Tretiakov, E.O., Iliushchenko, D., Shamansky, V., Lobanova, V., Kozenkov, I., Efimenko, B., Yurchenko, A.A., et al.(2022). A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand . Nucleic Acids Research. 50. (18). p. 10264-10277.
Popadin, K., Gunbin, K., Peshkin, L., Annis, S., Fleischmann, Z., Franco, M., Kraytsberg, Y., Markuzon, N., Ackermann, R.R., Khrapko, K.(2022). Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors . Genes. 13. (5).
Romanov, R.A., Tretiakov, E.O., Kastriti, M.E., Zupancic, M., Häring, M., Korchynska, S., Popadin, K., Benevento, M., Rebernik, P., Lallemend, F., et al.(2020). Molecular design of hypothalamus development . Nature. 582. (7811). p. 246-252.
Delaneau, O., Zazhytska, M., Borel, C., Giannuzzi, G., Rey, G., Howald, C., Kumar, S., Ongen, H., Popadin, K., Marbach, D., et al.(2019). Chromatin three-dimensional interactions mediate genetic effects on gene expression . Science. 364. (6439).
Shamanskiy, V.A., Timonina, V.N., Popadin, K.Y., Gunbin, K.V.(2019). Correction to: ImtRDB: a database and software for mitochondrial imperfect interspersed repeats annotation (BMC Genomics DOI: 10.1186/s12864-019-5536-1) . BMC Genomics. 20. (1).
Skuratovskaia, D., Litvinova, L., Vulf, M., Zatolokin, P., Popadin, K., Mazunin, I.(2019). From normal to obesity and back: The associations between mitochondrial DNA copy number, gender, and body mass index . Cells. 8. (5).
Shamanskiy, V.N., Timonina, V.N., Popadin, K.Y., Gunbin, K.V.(2019). ImtRDB: A database and software for mitochondrial imperfect interspersed repeats annotation . BMC Genomics. 20.
Kuzminkova, A.A., Sokol, A.D., Ushakova, K.E., Popadin, K.Y., Gunbin, K.V.(2019). MtProtEvol: The resource presenting molecular evolution analysis of proteins involved in the function of Vertebrate mitochondria . BMC Evolutionary Biology. 19.
Konstantin Popadin, Stephan Peischl, Marco Garieri, M. Reza Sailani, Audrey Letourneau, Federico Santoni, Samuel W. Lukowski, Georgii A. Bazykin, Sergey Nikolaev, Diogo Meyer, et al.(2018). Slightly deleterious genomic variants and transcriptome perturbations in Down syndrome embryonic selection . Genome Research. 28. (1). p. 1--10. Cold Spring Harbor Laboratory
Popadin, K., Peischl, S., Garieri, M., Reza Sailani, M., Letourneau, A., Santoni, F., Lukowski, S.W., Bazykin, G.A., Nikolaev, S., Meyer, D., et al.(2018). Slightly deleterious genomic variants and transcriptome perturbations in Down syndrome embryonic selection . Genome Research. 28. (1). p. 1-10.
Skuratovskaia, D.A., Sofronova, J.K., Zatolokin, P.A., Popadin, K.Y., Vasilenko, M.A., Litvinova, L.S., Mazunin, I.O.(2018). Additional evidence of the link between mtDNA copy number and the body mass index . Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis. 29. (8). p. 1240-1244.
Gunbin, K., Peshkin, L., Popadin, K., Annis, S., Ackermann, R.R., Khrapko, K.(2017). Data on the time of integration of the human mitochondrial pseudogenes (NUMTs) into the nuclear genome . Data in Brief. 13. p. 536-544.
Gunbin, K., Peshkin, L., Popadin, K., Annis, S., Ackermann, R.R., Khrapko, K.(2017). Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis . Mitochondrion. 34. p. 20-23.
Loviglio, M.N., Arbogast, T., Jønch, A.E., Collins, S.C., Popadin, K., Bonnet, C.S., Giannuzzi, G., Maillard, A.M., Jacquemont, S., Loviglio, M.N., et al.(2017). The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs . American Journal of Human Genetics. 101. (4). p. 564-577.
Gaspar, L., Howald, C., Popadin, K., Maier, B., Mauvoisin, D., Moriggi, E., Gutierrez-Arcelus, M., Falconnet, E., Borel, C., Kunz, D., et al.(2017). The genomic landscape of human cellular circadian variation points to a novel role for the signalosome . eLife. 6.
Seplyarskiy, V.B., Soldatov, R.A., Popadin, K.Y., Antonarakis, S.E., Bazykin, G.A., Nikolaev, S.I.(2016). APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication . Genome Research. 26. (2). p. 174-182.
Safdar, A., Annis, S., Kraytsberg, Y., Laverack, C., Saleem, A., Popadin, K., Woods, D.C., Tilly, J.L., Khrapko, K.(2016). Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis . Current Opinion in Genetics and Development. 38. p. 127-132.
Bonilla, X., Parmentier, L., King, B., Bezrukov, F., Kaya, G., Zoete, V., Seplyarskiy, V.B., Sharpe, H.J., McKee, T., Letourneau, A., et al.(2016). Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma . Nature Genetics. 48. (4). p. 398-406.
Polishchuk, L.V., Popadin, K.Y., Baranova, M.A., Kondrashov, A.S.(2015). A genetic component of extinction risk in mammals . Oikos. 124. (8). p. 983-993.
Borel, C., Ferreira, P.G., Santoni, F., Delaneau, O., Fort, A., Popadin, K.Y., Garieri, M., Falconnet, E., Ribaux, P., Guipponi, M., et al.(2015). Biased allelic expression in human primary fibroblast single cells . American Journal of Human Genetics. 96. (1). p. 70-80.
Sailani, M.R., Santoni, F.A., Letourneau, A., Borel, C., Makrythanasis, P., Hibaoui, Y., Popadin, K., Bonilla, X., Guipponi, M., Gehrig, C., et al.(2015). DNA-methylation patterns in trisomy 21 using cells from monozygotic twins . PLoS ONE. 10. (8).
Konstantin Y. Popadin, Maria Gutierrez-Arcelus, Tuuli Lappalainen, Alfonso Buil, Julia Steinberg, Sergey I. Nikolaev, Samuel W. Lukowski, Georgii A. Bazykin, Vladimir B. Seplyarskiy, Panagiotis Ioannidis, et al.(2014). Gene Age Predicts the Strength of Purifying Selection Acting on Gene Expression Variation in Humans . The American Journal of Human Genetics. 95. (6). p. 660--674. Elsevier {BV}
Konstantin Popadin, Adeel Safdar, Yevgenya Kraytsberg, Konstantin Khrapko(2014). When man got his mt
<scp>DNA</scp>
deletions? . Aging Cell. 13. (4). p. 579--582. Wiley
Popadin, K., Safdar, A., Kraytsberg, Y., Khrapko, K.(2014). When man got his mtDNA deletions? . Aging Cell. 13. (4). p. 579-582.
Letourneau, A., Santoni, F.A., Bonilla, X., Sailani, M.R., Gonzalez, D., Kind, J., Chevalier, C., Thurman, R., Sandstrom, R.S., Hibaoui, Y., et al.(2014). Domains of genome-wide gene expression dysregulation in Down's syndrome . Nature. 508. (7496). p. 345-350.
Popadin, K., Gunbin, K.V., Khrapko, K.(2014). Mitochondrial DNA mutations and cancer: Lessons from the parathyroid . American Journal of Pathology. 184. (11). p. 2852-2854.
Popadin, K.Y., Gutierrez-Arcelus, M., Lappalainen, T., Buil, A., Steinberg, J., Nikolaev, S.I., Lukowski, S.W., Bazykin, G.A., Seplyarskiy, V.B., Ioannidis, P., et al.(2014). Gene age predicts the strength of purifying selection acting on gene expression variation in humans . American Journal of Human Genetics. 95. (6). p. 660-674.
Konstantin Popadin, Maria Gutierrez-Arcelus, Emmanouil T. Dermitzakis, Stylianos E. Antonarakis(2013). Genetic and Epigenetic Regulation of Human lincRNA Gene Expression . The American Journal of Human Genetics. 93. (6). p. 1015--1026. Elsevier {BV}
K. Y. Popadin, S. I. Nikolaev, T. Junier, M. Baranova, S. E. Antonarakis(2013). Purifying Selection in Mammalian Mitochondrial Protein-Coding Genes Is Highly Effective and Congruent with Evolution of Nuclear Genes . Molecular Biology and Evolution. 30. (2). p. 347--355. Oxford University Press ({OUP})
Popadin, K., Gutierrez-Arcelus, M., Dermitzakis, E.T., Antonarakis, S.E.(2013). Genetic and epigenetic regulation of human lincrna gene expression . American Journal of Human Genetics. 93. (6). p. 1015-1026.
Popadin, K.Y., Nikolaev, S.I., Junier, T., Baranova, M., Antonarakis, S.E.(2013). Purifying selection in mammalian mitochondrial protein-coding genes is highly effective and congruent with evolution of nuclear genes . Molecular Biology and Evolution. 30. (2). p. 347-355.
Knorre, D.A., Popadin, K.Y., Sokolov, S.S., Severin, F.F.(2013). Roles of mitochondrial dynamics under stressful and normal conditions in yeast cells . Oxidative Medicine and Cellular Longevity.
Sailani, M.R., Makrythanasis, P., Valsesia, A., Santoni, F.A., Deutsch, S., Popadin, K., Borel, C., Migliavacca, E., Sharp, A.J., Sail, G.D., et al.(2013). The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome . Genome Research. 23. (9). p. 1410-1421.
Xinhong Guo, Konstantin Yu. Popadin, Natalya Markuzon, Yuriy L. Orlov, Yevgenya Kraytsberg, Kim J. Krishnan, Gábor Zsurka, Douglas M. Turnbull, Wolfram S. Kunz, Konstantin Khrapko(2010). Repeats, longevity and the sources of mtDNA deletions: evidence from ‘deletional spectra’ . Trends in Genetics. 26. (8). p. 340--343. Elsevier {BV}
Guo, X., Popadin, K.Y., Markuzon, N., Orlov, Y.L., Kraytsberg, Y., Krishnan, K.J., Zsurka, G., Turnbull, D.M., Kunz, W.S., Khrapko, K.(2010). Repeats, longevity and the sources of mtDNA deletions: Evidence from 'deletional spectra' . Trends in Genetics. 26. (8). p. 340-343.
Shcherbakov, V.P., Sizova, S.T., Shcherbakova, T.S., Granovskiǐ, I.E., Popad'in, K.I.(2008). In vivo study of fidelity of DNA double-strand break repair in bacteriophage T4 . Genetika. 44. (9). p. 1178-1183.
Shcherbakov, V.P., Sizova, S.T., Shcherbakova, T.S., Granovsky, I.E., Popad'In, K.Y.(2008). In vivo study of fidelity of DNA double-strand break repair in bacteriophage T4 . Russian Journal of Genetics. 44. (9). p. 1025-1030.
Konstantin Popadin, Leonard V. Polishchuk, Leila Mamirova, Dmitry Knorre, Konstantin Gunbin(2007). Accumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammals . Proceedings of the National Academy of Sciences. 104. (33). p. 13390--13395. Proceedings of the National Academy of Sciences
Popadin, K., Polishchuk, L.V., Mamirova, L., Knorre, D., Gunbin, K.(2007). Accumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammals . Proceedings of the National Academy of Sciences of the United States of America. 104. (33). p. 13390-13395.
Popadin, K.Y., Mamirova, L.A., Kondrashov, F.A.(2007). A manually curated database of tetrapod mitochondrially encoded tRNA sequences and secondary structures . BMC Bioinformatics. 8.
Nikolaev, S.I., Montoya-Burgos, J.I., Popadin, K., Parand, L., Margulies, E.H., Antonarakis, S.E., Bouffard, G.G., Idol, J.R., Maduro, V.V.B., Blakesley, R.W., et al.(2007). Life-history traits drive the evolutionary rates of mammalian coding and noncoding genomic elements . Proceedings of the National Academy of Sciences of the United States of America. 104. (51). p. 20443-20448.
Mamirova, L., Popadin, K., Gelfand, M.S.(2007). Purifying selection in mitochondria, free-living and obligate intracellular proteobacteria . BMC Evolutionary Biology. 7.
Popadin, K.Yu.(2003). The evolution of sex: Role of deleterious mutations and mobile elements . Zhurnal Obshchei Biologii. 64. (6). p. 476-478.
OTHER
Kuzmin, A., Skripskaya, V., Lobanova, V., Brodovaya, P., Tarasova, A., Popadin, K., Mikhailova, A.G., Kozenkova, E., Mugue, N., Vinogradov, E., et al.(2024). Selection of different parameters to study epistatic effect between heat shock and slightly deleterious mutations in the most fragile stage of embryogenesis Cyprinus carpio L . bioRxiv.
Franco, M., Popadin, K., Woods, D., Khrapko, K.(2024). Evolutionary mismatch between nuclear and mitochondrial genomes does not promote reversion mutations in mtDNA . bioRxiv.
Shamanskiy, V., Popadin, K.(2024). Harnessing Stress: balancing the Burden of Slightly-Deleterious Variants by a Handicap . bioRxiv.
Kuzmin, A., Evgenii, V., Balashov, D., Kozenkova, E., Iliushchenko, D., Mikhailova, A.G., Patlay, N., Ekaterina, Z., Ivan, K., Ivan, P., et al.(2023). Improving genome quality through artificial truncating purifying selection using heat shock: Case of carps . bioRxiv.
Iliushchenko, D., Efimenko, B., Mikhailova, A.G., Shamanskiy, V., Saparbaev, M.K., Mazunin, I., Knorre, D., Kunz, W.S., Kapranov, P., Denisov, S., et al.(2023). Mitochondrial mutation spectrum in Chordates: damage versus replication signatures, causes, and dynamics . bioRxiv.
Efimenko, B., Popadin, K., Gunbin, K.(2023). NeMu: A Comprehensive Pipeline for Accurate Reconstruction of Neutral Mutation Spectra from Evolutionary Data . bioRxiv.
Cote-L'Heureu, A., Franco, M., Maithania, Y.N.K., Popadin, K., Woods, D., Tilly, J., Khrapko, K.(2023). The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysis . bioRxiv.
Cote-L'Heureux, A., Fleischmann, Z., Franco, M., Chen, Z., Khrapko, M., Vyshedskiy, B., Braverman, M., Popadin, K., Pickett, S., Woods, D.C., et al.(2023). A novel, wave-shaped profile of germline selection of pathogenic mtDNA mutations is discovered by bypassing a classical statistical bias . bioRxiv.
Ri, M., Ree, N., Oreshkov, S., Tofilo, M., Zvereva, I., Kirillova, A., Gunbin, K., Yurov, V., Salumets, A., Woods, D.C., et al.(2022). Aneuploidy in human embryos is associated with a maternal age-independent increase in mitochondrial DNA content and an enrichment of ultra-rare mitochondrial DNA variants . bioRxiv.
Timonina, V., Tretiakov, E., Goncharov, A., Gunbin, K., Fellay, J., Popadin, K.(2022). Buffering role of HSP shapes the molecular evolution of mammalian and human genomes at short and long-term scales . bioRxiv.
Voronka, A., Efimenko, B., Oreshkov, S., Franco, M., Fleischmann, Z., Yurov, V., Trufanova, A., Timonina, V., Ree, N., Zalevsky, A., et al.(2022). Direction mutation pressure of SARS-CoV-2 helps to understand the past and predict the future evolution: C>U and G>U biased mutagenesis forces the majority of amino-acid substitutions to be from CG-rich losers to U-rich gainers . bioRxiv.
Tatarkina, M.A., Lobanova, V.V., Kozenkov, I.I.I.I., Efimenko, B.E., Dzhigkaev, A.K., Popadin, K.Y., Gunbin, K.V., Goncharov, A.G.(2022). Isolation of highly purified genomic material from mitochondria of muscle tissue cells . bioRxiv.
Fleischmann, Z., Cote-L'Heureux, A., Franco, M., Oreshkov, S., Annis, S., Khrapko, M., Aidlen, D., Popadin, K., Woods, D.C., Tilly, J.L., et al.(2022). Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive . bioRxiv.
Franco, M., Pickett, S.J., Fleischmann, Z., Khrapko, M., Cote-L’Heureux, A., Aidlen, D., Stein, D., Markuzon, N., Popadin, K., Braverman, M., et al.(2021). Dynamics of the most common pathogenic mtDNA variant m.3243A>G demonstrate frequency-dependency in blood and positive selection in the germline . bioRxiv.
Fleischmann, Z., Annis, S., Franco, M., Oreshkov, S., Popadin, K., Woods, D.C., Tilly, J.L., Khrapko, K.(2021). Nuclear DNA-encoded fragments of mitochondrial DNA (mtDNA) confound analysis of selection of mtDNA mutations in human primordial germ cells . bioRxiv.
Mikhaylova, A.G., Mikhailova, A.A., Ushakova, K., Tretiakov, E.O., Iliushchenko, D., Shamansky, V., Iurchenko, A., Zazhytska, M., Kozenkova, E., Zdobnov, E., et al.(2021). A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on a heavy chain . bioRxiv.
Mikhailova, A.G., Iliushchenko, D., Shamansky, V., Mikhailova, A.A., Ushakova, K., Tretyakov, E., Oreshkov, S., Knorre, D., Polishchuk, L., Lawless, D., et al.(2020). A>G substitutions on a heavy chain of mitochondrial genome marks an increased level of aerobic metabolism in warm versus cold vertebrates . bioRxiv.
Bick, A.G., Popadin, K., Thorball, C.W., Uddin, M.M., Zanni, M., Yu, B., Cavassini, M., Rauch, A., Tarr, P., Schmid, P., et al.(2020). Increased CHIP Prevalence Amongst People Living with HIV . medRxiv.
Shamanskiy, V., Mikhailova, A.A., Ushakova, K., Mikhailova, A.G., Oreshkov, S., Knorre, D., Tretiakov, E.O., Ri, N., Overdevest, J.B., Lukowski, S.W., et al.(2019). Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome . bioRxiv.
Mikhaylova, A.G., Mikhailova, A.A., Ushakova, K., Tretiakov, E., Yurchenko, A., Zazhytska, M., Knorre, D.A., Zdobnov, E., Fleischmann, Z., Annis, S., et al.(2019). Mitochondrial mutational spectrum provides an universal marker of cellular and organismal longevity . bioRxiv.
Delaneau, O., Zazhytska, M., Borel, C., Howald, C., Kumar, S., Ongen, H., Popadin, K., Marbach, D., Ambrosini, G., Bielser, D., et al.(2017). Intra- and inter-chromosomal chromatin interactions mediate genetic effects on regulatory networks . bioRxiv.
Popadin, K., Gunbin, K., Peshkin, L., Annis, S., Fleischmann, Z., Kraytsberg, G., Markuzon, N., Ackermann, R.R., Khrapko, K.(2017). Mitochondrial pseudogenes suggest repeated inter-species hybridization among direct human ancestors . bioRxiv.
Ratings and Comments
_Popadin.jpg "Konstantin Kostya P. - Evolution of genes and genomes in the absence of homologous recombination - Subject Matter Expert from Kolabtree")
Total Projects Awarded:
Comments: