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USD 400 /hr

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☆☆☆☆☆

Hire Keith R.

United States

USD 400 /hr

Mass Spectrometrist with over 15 years of experience with LC/MS instrumentation, wet lab practices and MS data analysis.

Profile Summary

I have vast experience with both DIA and DDA LC/MS data collection and analysis. I have also used and compared top of the line mass spectrometers from multiple vendors and am experienced with a variety of different data analysis software.

Subject Matter Expertise

• ☆ Analytical Chemistry
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Data Analysis
• ☆ Data Collection
• ☆ R

Services

• Consulting

Consulting Business Strategy Consulting, Operations Consulting, Scientific and Technical Consulting, Financial Consulting

Work Experience

Broad Institute

- Present

Research Scientist II

Broad Institute

September 2019 - Present

Manager

Cold Spring Harbor Laboratory

August 2011 - September 2019

Research Associate

Broad Institute

February 2009 - August 2010

Education

Masters of Science

Northeastern University

September 2008 - May 2010

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Keith Rivera, Adrian Sutta, Nelia Nina Leemans, Michael Ploug, Anne Rosbjerg, Christian del Agua Villa, Laura Pérez‐Alós, Leon Cyranka, Adam S. Vincek, Tomás de Garay, et al. (2024). CL‐11 circulates in serum as functionally distinct isoforms . The FASEB Journal.

Jennifer G. Abelin, Erik J. Bergstrom, Keith D. Rivera, Hannah B. Taylor, Susan Klaeger, Charles Xu, Eva K. Verzani, C. Jackson White, Hilina B. Woldemichael, Maya Virshup, et al. (2023). Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues . Nature Communications.

Larissa J. Osterbaan, Victoria Hoyle, Michelle Curtis, Stacy DeBlasio, Keith D. Rivera, Michelle Heck, Marc Fuchs (2021). Identification of protein interactions of grapevine fanleaf virus RNA-dependent RNA polymerase during infection of Nicotiana benthamiana by affinity purification and tandem mass spectrometry . Journal of General Virology.

Derek K. Cheng, Tobiloba E. Oni, Jennifer S. Thalappillil, Youngkyu Park, Hsiu-Chi Ting, Brinda Alagesan, Nadia V. Prasad, Kenneth Addison, Keith D. Rivera, Darryl J. Pappin, et al.(2021). Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer . Proceedings of the National Academy of Sciences. 118. (21). Proceedings of the National Academy of Sciences

Keith D. Rivera, Meagan E. Olive, Erik J. Bergstrom, Alissa J. Nelson, Kimberly A. Lee, Shankha Satpathy, Steven A. Carr, Namrata D. Udeshi (2021). Automating UbiFast for High-throughput and Multiplexed Ubiquitin Enrichment . Molecular & Cellular Proteomics.

(2020). Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth . Scientific reports.

(2020). Tryp-N: A Thermostable Protease for the Production of N-terminal Argininyl and Lysinyl Peptides . Journal of proteome research.

Avinash D. Londhe, Alexandre Bergeron, Stephanie M. Curley, Fuming Zhang, Keith D. Rivera, Akaash Kannan, Gérald Coulis, Syed H. M. Rizvi, Seung Jun Kim, Darryl J. Pappin, et al.(2020). Regulation of PTP1B activation through disruption of redox-complex formation . Nature Chemical Biology. 16. (2). p. 122--125. Springer Science and Business Media {LLC}

(2019). The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice . Science (New York, N.Y.).

(2018). Muller's Ratchet and Ribosome Degeneration in the Obligate Intracellular Parasites Microsporidia . International journal of molecular sciences.

(2018). Proteome modifications on tomato under extreme high light induced-stress . Proteome science.

(2018). DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease . Genes & development.

(2018). Error-prone protein synthesis in parasites with the smallest eukaryotic genome . Proceedings of the National Academy of Sciences of the United States of America.

(2018). Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration . iScience.

Lee, Y.-C., Bååth, J.A., Bastle, R.M., Bhattacharjee, S., Cantoria, M.J., Dornan, M., Gamero-Estevez, E., Ford, L., Halova, L., Kernan, J., et al.(2018). Impact of Detergents on Membrane Protein Complex Isolation . Journal of Proteome Research. 17. (1). p. 348-358.

Pattison, S.H., Gibson, D.S., Johnston, E., Peacock, S., Rivera, K., Tunney, M.M., Pappin, D.J., Elborn, J.S.(2017). Proteomic profile of cystic fibrosis sputum cells in adults chronically infected with Pseudomonas aeruginosa . European Respiratory Journal. 50. (1).

Chavez, J.D., Eng, J.K., Schweppe, D.K., Cilia, M., Rivera, K., Zhong, X., Wu, X., Allen, T., Khurgel, M., Kumar, A., et al.(2016). A general method for targeted quantitative cross-linking mass spectrometry . PLoS ONE. 11. (12).

Herrera, V.L.M., Steffen, M., Moran, A.M., Tan, G.A., Pasion, K.A., Rivera, K., Pappin, D.J., Ruiz-Opazo, N.(2016). Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein . BMC Molecular Biology. 17. (1).

Ho, J.M., Reynolds, N.M., Rivera, K., Connolly, M., Guo, L.-T., Ling, J., Pappin, D.J., Church, G.M., Söll, D.(2016). Efficient Reassignment of a Frequent Serine Codon in Wild-Type Escherichia coli . ACS Synthetic Biology. 5. (2). p. 163-171.

Chio, I.I.C., Jafarnejad, S.M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Wilson, J., Sangar, V., Hao, Y., Öhlund, D., et al.(2016). NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer . Cell. 166. (4). p. 963-976.

Roe, J.-S., Mercan, F., Rivera, K., Pappin, D.J., Vakoc, C.R.(2015). BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia . Molecular Cell. 58. (6). p. 1028-1039.

Boj, S.F., Hwang, C.-I., Baker, L.A., Chio, I.I.C., Engle, D.D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M.S., et al.(2015). Organoid models of human and mouse ductal pancreatic cancer . Cell. 160. (1-2). p. 324-338.

Yun, J., Mullarky, E., Lu, C., Bosch, K.N., Kavalier, A., Rivera, K., Roper, J., Chio, I.I.C., Giannopoulou, E.G., Rago, C., et al.(2015). Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH . Science. 350. (6266). p. 1391-1396.

Yang, M., Haase, A., Huang, F.-K., Coulis, G., Rivera, K., Dickinson, B., Chang, C., Pappin, D., Neubert, T., Hannon, G., et al.(2014). Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence . Molecular Cell. 55. (5). p. 782-790.

Ruse, C.I., Peacock, S., Ghiban, C., Rivera, K., Pappin, D.J., Leopold, P.(2013). A tool to evaluate correspondence between extraction ion chromatographic peaks and peptide-spectrum matches in shotgun proteomics experiments . Proteomics. 13. (16). p. 2386-2397.

Broadbelt, K.G., Rivera, K.D., Paterson, D.S., Duncan, J.R., Trachtenberg, F.L., Paulo, J.A., Stapels, M.D., Borenstein, N.S., Belliveau, R.A., Haas, E.A., et al.(2012). Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: A proteomics analysis in the sudden infant death syndrome . Molecular and Cellular Proteomics. 11. (1).

Kuhn, E., Whiteaker, J.R., Mani, D.R., Jackson, A.M., Zhao, L., Pope, M.E., Smith, D., Rivera, K.D., Anderson, N.L., Skates, S.J., et al.(2012). Interlaboratory evaluation of automated, multiplexed peptide immunoaffinity enrichment coupled to multiple reaction monitoring mass spectrometry for quantifying proteins in plasma . Molecular and Cellular Proteomics. 11. (6).

Broadbelt, K.G., Paterson, D.S., Rivera, K.D., L. Trachtenberg, F., Kinney, H.C.(2010). Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medulla . Autonomic Neuroscience: Basic and Clinical. 154. (1-2). p. 30-41.

Paterson, D.S., Rivera, K.D., Broadbelt, K.G., Trachtenberg, F.L., Belliveau, R.A., Holm, I.A., Haas, E.A., Stanley, C., Krous, H.F., Kinney, H.C., et al.(2010). Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego dataset . Pediatric Research. 68. (5). p. 409-413.

OTHER

Keith Rivera, Yu-Chen Lee, Song-Chang Lin, Guoyu Yu, Ming Zhu, Jian H Song, Darryl Pappin, Christopher J. Logothetis, Theocharis Panaretakis, Guocan Wang, et al.(2021). Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition . Cold Spring Harbor Laboratory

PREPRINT

Jennifer G. Abelin, Erik J. Bergstrom, Hannah B. Taylor, Keith D. Rivera, Susan Klaeger, Charles Xu, C. Jackson White, Meagan E. Olive, Myranda Maynard, M. Harry Kane, et al. (2021). MONTE enables serial immunopeptidome, ubiquitylome, proteome, phosphoproteome, acetylome analyses of sample-limited tissues .

Keith D. Rivera, Meagan E. Olive, Erik J. Bergstrom, Alissa J. Nelson, Kimberly A. Lee, Shankha Satpathy, Steven A. Carr, Namrata D. Udeshi (2021). Automating UbiFast for High-throughput and Multiplexed Ubiquitin Enrichment .