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USD 100 /hr

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Hire Dr. Ke S.

Canada

USD 100 /hr

Principal Scientist | Scientific Editor & Consultant | Organic Chemistry, Carbohydrates, Lipidomics & Metabolomics

Profile Summary

I am a PhD-trained chemist and Principal Scientist with more than 20 years of experience in research, scientific writing, and publication support. My background spans organic synthesis, carbohydrate chemistry, peptide chemistry, formulation, analytical chemistry (LC–MS, MS/MS, HPLC, NMR), lipidomics, and metabolomics method development. I have contributed to multidisciplinary research involving biomarker discovery, synthesis of bioactive molecules, and isotope-labelled reference standards. I have authored and co-authored 20+ peer-reviewed publications, including a Very Important Paper in Angewandte Chemie and contributions to the Roskamp–Feng Reaction. I have also completed 100+ peer reviews for journals published under ACS, Wiley, RSC, Elsevier, and Thieme. Alongside research, I provide scientific editing, proofreading, figure caption and alt-text writing, indexing, clarity review, and journal submission formatting. I ensure accuracy while preserving scientific intent. Based in Canada and available for remote global projects and collaboration.

Subject Matter Expertise

• ☆ Chemical Reagent Development
• ☆ Catalysis
• ☆ Biocatalysis
• ☆ Natural Product Chemistry
• ☆ Analytical Chemistry
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Optical Rotation
• ☆ Cosmochemistry
• ☆ Radiochemistry
• ☆ Flow Chemistry
• ☆ Green Chemistry
• ☆ Organometallic Chemistry
• ☆ Photochemistry
• ☆ Organic Chemistry
• ☆ Retrosynthesis
• ☆ Peptide Synthesis

Services

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing

Research Meta-Research, Feasibility Study, Technology Scouting, Scientific and Technical Research, Systematic Literature Review

Consulting Business Strategy Consulting, Go-to-Market Strategy Consulting, Healthcare Consulting, Operations Consulting, Scientific and Technical Consulting, Financial Consulting, Regulatory Consulting, Manufacturing Consulting

Product Development Recipe Development, Stability/Shelf Life Testing, Product Evaluation, Material Sourcing, Product Validation, Manufacturing, Quality Assurance & Control (QA/QC), Product Compliance , Concept Development, Product Launch Support, Packaging Design, Reverse Engineering

Work Experience

Principal Scientist

University of Alberta

July 2021 - Present

Principal Scientist

The Metabolomics Innovation Centre (TMIC)-Genome Alberta

February 2018 - Present

Principal Scientist

Nova Medical Testing Inc.

February 2018 - Present

Research Associate

University of Alberta

November 2011 - January 2018

Education

PhD (Chemistry)

Sichuan University

September 2006 - July 2011

PhD (Chemistry)

Sichuan University

September 2006 - June 2011

B.S. (Chemistry)

Sichuan University

September 2002 - July 2006

Certifications

• Project Management

  NAIT

  January 2019 - Present

Publications

JOURNAL ARTICLE

Ke Shen, Todd L. Lowary (2022). Synthesis of the Mycobacterium tuberculosis Canetti Lipooligosaccharide II Nonasaccharide . Organic Letters.

Shen, Ke, Lowary, Todd L. (2022). Synthesis of the <i>Mycobacterium tuberculosis</i> Canetti Lipooligosaccharide II Nonasaccharide . Organic Letters.

Ke Shen, Bing Bai, Yu‐Hsuan Liu, Todd L. Lowary (2021). Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii . Angewandte Chemie.

Ke Shen, Bing Bai, Yu‐Hsuan Liu, Todd L. Lowary(2021). Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii . Angewandte Chemie International Edition. Wiley

Shen, Ke, Bai, Bing, Liu, Yu-Hsuan, Lowary, Todd L. (2021). Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen <i>Mycobacterium kansasii</i> . Angewandte Chemie International Edition.

Ke Shen, Li Zhang, Hashem A. Taha, Todd L. Lowary (2018). Stereocontrolled Synthesis of α-Xylofuranosides Using a Conformationally Restricted Donor . The Journal of Organic Chemistry.

Ke Shen, Alok Choudhary, Deendayal Patel, William Honnen, Zhong Lai, Raja Sekhar Prattipati, Ruixiang Blake Zheng, Ying-Chao Hsueh, Maria Laura Gennaro, Alfred Lardizabal, et al. (2018). Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of<i>Mycobacterium tuberculosis</i>, and Complexity of Antibody Specificities toward This Antigen . The Journal of Immunology.

Shen, Ke, Zhang, Li, Taha, Hashem A., Lowary, Todd L. (2018). Stereocontrolled Synthesis of α-Xylofuranosides Using a Conformationally Restricted Donor . The Journal of Organic Chemistry.

Shen, Ke, Sigal, George B., Pinter, Abraham, Lowary, Todd L., Kawasaki, Masanori, Li, Andra, Mathew, Anu, Tsionsky, Michael, Zheng, Ruixiang Blake, Plisova, Tatiana, et al. (2018). A Novel Sensitive Immunoassay Targeting the 5-Methylthio-D-Xylofuranose-Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis . Journal of Clinical Microbiology.

Ke Shen, George B. Sigal, Abraham Pinter, Todd L. Lowary, Masanori Kawasaki, Andra Li, Anu Mathew, Michael Tsionsky, Ruixiang Blake Zheng, Tatiana Plisova, et al.(2018). A Novel Sensitive Immunoassay Targeting the 5-Methylthio- <scp>d</scp> -Xylofuranose–Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis . Journal of Clinical Microbiology. 56. (12). American Society for Microbiology

Shen, Ke, Choudhary, Alok, Patel, Deendayal, Honnen, William, Lai, Zhong, Prattipati, Raja Sekhar, Zheng, Ruixiang Blake, Hsueh, Ying-Chao, Gennaro, Maria Laura, Lardizabal, Alfred, et al. (2018). Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of <i>Mycobacterium tuberculosis</i>, and Complexity of Antibody Specificities toward This Antigen . The Journal of Immunology.

Ke Shen, Ruixiang Blake Zheng, Sabine A. F. J&#233;gouzo, Maju Joe, Yu Bai, Huu-Anh Tran, J&#246;rn Saupe, Li Xia, Md. Faiaz Ahmed, Yu-Hsuan Liu, et al.(2017). Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans . ACS Chemical Biology. 12. (12). p. 2990--3002. American Chemical Society ({ACS})

Shen, Ke, Zheng, Ruixiang Blake, Jegouzo, Sabine A. F., Joe, Maju, Bai, Yu, Tran, Huu-Anh, Saupe, Jorn, Xia, Li, Ahmed, Md. Faiaz, Liu, Yu-Hsuan, et al. (2017). Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans . ACS Chemical Biology.

Shen, Ke, Poopari, Mohammad Reza, Dezhahang, Zahra, Wang, Lei, Lowary, Todd L., Xu, Yunjie (2015). Absolute Configuration and Conformation of Two Frater-Seebach Alkylation Reaction Products by Film VCD and ECD Spectroscopic Analyses . The Journal of Organic Chemistry.

Ke Shen, Mohammad Reza Poopari, Zahra Dezhahang, Lei Wang, Todd L. Lowary, Yunjie Xu(2014). Absolute Configuration and Conformation of Two Fráter–Seebach Alkylation Reaction Products by Film VCD and ECD Spectroscopic Analyses . The Journal of Organic Chemistry. 80. (1). p. 428--437. American Chemical Society ({ACS})

Ke Shen, Xiaohua Liu, Lili Lin, Xiaoming Feng(2012). Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action . Chem. Sci. 3. (2). p. 327--334. Royal Society of Chemistry ({RSC})

Shen, Ke, Liu, Xiaohua, Lin, Lili, Feng, Xiaoming (2012). Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action . Chemical Science.

Ke Shen, Xiaohua Liu, Gang Wang, Lili Lin, Xiaoming Feng(2011). Facile and Efficient Enantioselective Hydroxyamination Reaction: Synthesis of 3-Hydroxyamino-2-Oxindoles Using Nitrosoarenes . Angewandte Chemie International Edition. 50. (20). p. 4684--4688. Wiley

Shen, Ke, Liu, Xiaohua, Wang, Gang, Lin, Lili, Feng, Xiaoming (2011). Facile and Efficient Enantioselective Hydroxyamination Reaction: Synthesis of 3-Hydroxyamino-2-Oxindoles Using Nitrosoarenes . Angewandte Chemie International Edition.

Ke Shen, Wei Li, Jun Wang, Xiaolei Hu, Wentao Wang, Yangyang Chu, Lili Lin, Xiaohua Liu, Xiaoming Feng(2010). Catalytic Asymmetric Roskamp Reaction of α-Alkyl-α-diazoesters with Aromatic Aldehydes: Highly Enantioselective Synthesis of α-Alkyl-β-keto Esters . Journal of the American Chemical Society. 132. (25). p. 8532--8533. American Chemical Society ({ACS})

Ke Shen, Zhigang Yang, Zhen Wang, Sha Bai, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng(2010). Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex . Chemistry - A European Journal. 16. (22). p. 6632--6637. Wiley

Ke Shen, Xiaohua Liu, Ke Zheng, Wei Li, Xiaolei Hu, Lili Lin, Xiaoming Feng (2010). Catalytic Asymmetric Synthesis of 3-(α-Hydroxy-β-carbonyl) Oxindoles by a Sc^III-Catalyzed Direct Aldol-Type Reaction . Chemistry - A European Journal.

Shen, Ke, Yang, Zhigang, Wang, Zhen, Bai, Sha, Chen, Donghui, Liu, Xiaohua, Lin, Lili, Feng, Xiaoming (2010). Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex . Chemistry - A European Journal.

Shen, Ke, Liu, Xiaohua, Zheng, Ke, Li, Wei, Hu, Xiaolei, Lin, Lili, Feng, Xiaoming (2010). Catalytic Asymmetric Synthesis of 3-(α-Hydroxy-β-carbonyl) Oxindoles by a Sc<SUP>III</SUP>-Catalyzed Direct Aldol-Type Reaction . Chemistry - A European Journal.

Shen, Ke, Liu, Xiaohua, Wang, Wentao, Wang, Gang, Cao, Weidi, Li, Wei, Hu, Xiaolei, Lin, Lili, Feng, Xiaoming (2010). Highly enantioselective synthesis of 1,3-bis(hydroxymethyl)-2-oxindoles from unprotected oxindoles and formalin using a chiral Nd<SUP>III</SUP> complex . Chemical Science.

Ke Shen, Xiaohua Liu, Wentao Wang, Gang Wang, Weidi Cao, Wei Li, Xiaolei Hu, Lili Lin, Xiaoming Feng(2010). Highly enantioselective synthesis of 1,3-bis(hydroxymethyl)-2-oxindoles from unprotected oxindoles and formalin using a chiral NdIII complex . Chemical Science. 1. (5). p. 590. Royal Society of Chemistry ({RSC})

Shen, Ke, Cai, Yunfei, Wang, Wentao, Wang, Jun, Hu, Xiaolei, Lin, Lili, Liu, Xiaohua, Feng, Xiaoming (2010). Highly enantioselective α-chlorination of cyclic β-ketoesters catalyzed by <i>N</i>,<i>N</i>′-Dioxide using NCS as the chlorine source . Chemical Communications.

Ke Shen, Yunfei Cai, Wentao Wang, Jun Wang, Xiaolei Hu, Lili Lin, Xiaohua Liu, Xiaoming Feng(2010). Highly enantioselective α-chlorination of cyclic β-ketoesters catalyzed by N,N′-Dioxide using NCS as the chlorine source . Chemical Communications. 46. (8). p. 1250. Royal Society of Chemistry ({RSC})

Shen, Ke, Li, Wei, Wang, Jun, Hu, Xiaolei, Wang, Wentao, Chu, Yangyang, Lin, Lili, Liu, Xiaohua, Feng, Xiaoming (2010). Catalytic Asymmetric Roskamp Reaction of α-Alkyl-α-diazoesters with Aromatic Aldehydes: Highly Enantioselective Synthesis of α-Alkyl-β-keto Esters . Journal of the American Chemical Society.

Ke Shen, Jun Wang, Wentao Wang, Wei Li, Xiaolei Hu, Cheng Tan, Xiaohua Liu, Xiaoming Feng(2009). Asymmetric Cyanation of Aldehydes, Ketones, Aldimines, and Ketimines Catalyzed by a Versatile Catalyst Generated from Cinchona Alkaloid, Achiral Substituted 2,2′-Biphenol and Tetraisopropyl Titanate . Chemistry - A European Journal. 15. (43). p. 11642--11659. Wiley

Ke Shen, Xiaohua Liu, Yunfei Cai, Lili Lin, Xiaoming Feng(2009). Facile and Efficient Enantioselective Strecker Reaction of Ketimines by Chiral Sodium Phosphate . Chemistry - A European Journal. 15. (24). p. 6008--6014. Wiley

Ke Shen, Xiaoming Feng, Wentao Wang, Xiaolei Hu, Jun Wang, Xiaohua Liu(2009). Highly Enantioselective Synthesisof α-Diazo-β-hydroxy Esters Using a BifunctionalTitanium Complex . Synlett. 2009. (10). p. 1655--1658. Georg Thieme Verlag {KG}

Shen, Ke, Liu, Xiaohua, Cai, Yunfei, Lin, Lili, Feng, Xiaoming (2009). Facile and Efficient Enantioselective Strecker Reaction of Ketimines by Chiral Sodium Phosphate . Chemistry - A European Journal.

Shen, Ke, Wang, Wentao, Hu, Xiaolei, Wang, Jun, Liu, Xiaohua, Feng, Xiaoming (2009). Highly Enantioselective Synthesis of α-Diazo-β-hydroxy Esters Using a Bifunctional Titanium Complex . Synlett.

Shen, Ke, Wang, Jun, Wang, Wentao, Li, Wei, Hu, Xiaolei, Tan, Cheng, Liu, Xiaohua, Feng, Xiaoming (2009). Asymmetric Cyanation of Aldehydes, Ketones, Aldimines, and Ketimines Catalyzed by a Versatile Catalyst Generated from Cinchona Alkaloid, Achiral Substituted 2,2′-Biphenol and Tetraisopropyl Titanate . Chemistry - A European Journal.

Ke Shen, Xiaohua Liu, Qinghan Li, Xiaoming Feng(2008). Highly enantioselective cyanosilylation of ketones catalyzed by a bifunctional Ti(IV) complex . Tetrahedron. 64. (1). p. 147--153. Elsevier {BV}

Shen, Ke, Liu, Xiaohua, Li, Qinghan, Feng, Xiaoming (2008). Highly enantio selective cyanosilylation of ketones catalyzed by a bifunctional Ti(IV) complex . Tetrahedron.

Ke Shen, Qinghan Li, Xiaohua Liu, Jun Wang, Xiaoming Feng(2006). Asymmetric cyanosilylation of ketones catalyzed by novel chiral N,N′-dioxide titanium complexes . Tetrahedron Letters. 47. (24). p. 4011--4014. Elsevier {BV}

Shen, Ke, Li, Qinghan, Liu, Xiaohua, Wang, Jun, Feng, Xiaoming (2006). Asymmetric cyanosilylation of ketones catalyzed by novel chiral <i>N</i>,<i>N</i>′-dioxide titanium complexes . Tetrahedron Letters.