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Hire Dr. Kaveh D.

United States

USD 150 /hr

Lead Senior Scientist at Flagship Pioneering | Former Research Faculty at Harvard | RNA Therapeutics | Regenerative Medicine

Profile Summary

Cell and molecular biologist with expertise in RNA-based therapeutics, functional genomics, genome editing, and regenerative medicine. Experienced in leading teams of scientists and innovators in fast-paced environments. Efficient communicator with several high-impact publications and presentations at international meetings. 10+ years of experience in leading and mentoring teams of academic and biotech industry researchers and innovators to conduct research projects related to human health. Stem cell biology - The culture of human embryonic stem cells (hESC), induced pluripotent stem cells (iPSC), and primary human cells. - Genome engineering of iPSCs and embryonic stem cells using TALEN and CRISPR to generate knockout lines for the use in disease modeling. - Scalable differentiation of pluripotent stem cells toward endoderm lineages. - Scalable differentiation of pluripotent stem cells into embryonic lineages and hepatic stellate cells to study hepatic fibrosis. Disease modeling - In vitro (human) and in vivo (mouse) models of hepatic fibrosis. - The culture of primary liver cells. - Using pluripotent stem cells to model human liver fibrosis. RNA biology - RNA and protein-centric biochemical approaches to reveal the RNA-protein interactome. - Optical and biochemical detection and quantification of RNA molecules. - Delivery of RNA molecules into the cells. - Engineering functional synthetic RNA molecules. Genomics, Epigenomics, and Epitranscriptomics -Genome-wide transcription factor binding and chromatin modification (ChIP-sequencing and CUT&RUN). - Epi-transcriptomic mapping of RNA modification. - Computational analysis of next-generation DNA sequencing data (sequence alignment, differential transcriptomic analysis, peak calling) using local computers and clusters.

Subject Matter Expertise

• ★ Molecular Biology
• ★ Genetics
• ★ Gene Editing/CRISPR
• ☆ Transcriptomics
• ☆ Chromatin
• ☆ RNA Sequencing
• ☆ Stem Cell Research
• ☆ Biotechnology & Bioengineering
• ☆ Bioinformatics
• ☆ Phylogenetics
• ☆ Audio Transcription

Services

• Research

Research Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Work Experience

Senior Scientist

Flagship Pioneering

April 2020 - Present

Instructor

Massachusetts General Hospital

April 2019 - Present

Instructor in Medicine (Research Faculty)

Harvard Medical School

April 2019 - April 2020

Postdoctoral Fellow

Massachusetts General Hospital, Harvard Medical School

October 2012 - April 2019

Education

PhD (Biology)

University of North Carolina at Charlotte

2007 - 2012

MSc (Biology)

Razi University

2004 - 2007

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Zhou, Chan and Molinie, Benoit and Daneshvar, Kaveh and Pondick, Joshua V and Wang, Jinkai and Van Wittenberghe, Nicholas and Xing, Yi and Giallourakis, Cosmas C and Mullen, Alan C(2017). Genome-wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell reports. 20. (9). p. 2262--2276. Cell Press

Kaveh Daneshvar, Benoit Molinie, Jinkai Wang, Kok Seong Lim, Roman Hillebrand, Zhi-xiang Lu, Nicholas Van Wittenberghe, Benjamin D Howard, Alan C Mullen, Peter Dedon, et al.(2016). m6A-{LAIC}-seq reveals the census and complexity of the m6A epitranscriptome . Nature Methods. 13. (8). p. 692--698. Springer Nature

Daneshvar, Kaveh and Pondick, Joshua V and Kim, Byeong-moo and Zhou, Chan and York, Samuel R and Macklin, Jillian A and Abualteen, Ameed and Tan, Bo and Sigova, Alla A and Marcho, Chelsea and Tremblay, Kimberly D and Mager, Jesse and Choi, Michael Y and Mullen, Alan C(2016). DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells. Cell Reports. p. 1--13.

Daneshvar, Kaveh(2015). CRISPR-Cas9 in gene therapy: much control on breaking, little control on repairing. PeerJ PrePrints. 3. p. e818v4. PeerJ Inc. San Francisco, USA

Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY, Cell stem cell, 2014, vol. 15, no. 6, pp. 707-719 .

Daneshvar K, Nath S, Khan A, Shover W, Richardson C, Goodliffe JM, Biology open, 2013, vol. 2, no. 1, pp. 1-9 .

Nath S, Daneshvar K, Roy LD, Grover P, Kidiyoor A, Mosley L, Sahraei M, Mukherjee P, Oncogenesis, 2013, vol. 2, pp. e51 .

Daneshvar K, Khan A, Goodliffe JM, PloS one, 2011, vol. 6, no. 8, pp. e23928 .