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Hire Dr. Kathryn H.

United States

Profile Summary

My research focuses on the study of human immunology. More specifically, I am interested in understanding how the mucosal immune system is altered during chronic inflammatory diseases, especially as it relates to local activation of B cells and antibody production. I hope that by gaining a better understanding of the mechanisms that lead to chronic inflammation at mucosal sites, we may be able to design improved therapeutic strategies for patients who suffer from diseases such as asthma, allergies and chronic rhinosinusits, or any disease that is mediated by B cells and antibodies. Some of the important skills I have acquired over the course of my career include problem solving and trouble shooting, experimental design and hypothesis testing, and verbal and oral communication skills. I enjoy finding creative solutions to problems in the lab, as well as synthesizing new ideas and hypotheses to address unique research questions from what is known in diverse areas of immunology and biology.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Antibody Engineering
• ☆ Inflammation
• ☆ Asthma
• ☆ Hypothesis

Services

• Writing
• Consulting
• Product Development

Work Experience

Research Assistant Professor

Northwestern University - Chicago

September 2013 - Present

Research Specialist I

Medical University of South Carolina

January 2001 - June 2003

Laboratory Technologist I

Medical College of Wisconsin

December 2000 - December 2000

Education

Postdoctoral (Feinberg School of Medicine)

Northwestern University - Chicago

April 2009 - August 2013

Ph.D. Microbiology and Immunology

University of Virginia

July 2003 - December 2008

B.S. Biochemistry and Molecular Biology

University of Wisconsin Eau Claire

August 1996 - June 2000

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2015). Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease. Journal of Allergy and Clinical Immunology.

(2015). Analysis of Cytokine Production by Peanut-Reactive T Cells Identifies Residual Th2 Effectors in Highly Allergic Children Who Received Peanut Oral Immunotherapy. Clinical and Experimental Allergy.

(2015). A retrospective, cross-sectional study reveals that women with CRSwNP have more severe disease than men. Immunity, Inflammation and Disease.

Poposki, J.A., Peterson, S., Welch, K., Schleimer, R.P., Hulse, K.E., Peters, A.T., Norton, J., Suh, L.A., Carter, R., Harris, K.E., et al.(2015). Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis . Clinical and Experimental Allergy. 45. (2). p. 384-393.

Hulse, K.E., Stevens, W.W., Tan, B.K., Schleimer, R.P.(2015). Pathogenesis of nasal polyposis . Clinical and Experimental Allergy. 45. (2). p. 328-346.

Kashani, S., Carr, T.F., Grammer, L.C., Schleimer, R.P., Hulse, K.E., Kato, A., Kern, R.C., Conley, D.B., Chandra, R.K., Tan, B.K., et al.(2015). Clinical Characteristics of Adults With Chronic Rhinosinusitis and Specific Antibody Deficiency . Journal of Allergy and Clinical Immunology: In Practice. 3. (2). p. 236-242.

Mahdavinia, M., Carter, R.G., Ocampo, C.J., Stevens, W., Kato, A., Tan, B.K., Kern, R.C., Conley, D.B., Chandra, R., Hulse, K.E., et al.(2014). Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity . Journal of Allergy and Clinical Immunology. 133. (6). p. 1759-1763.

Hulse, K.E., Chaung, K., Seshadri, S., Suh, L., Norton, J.E., Carter, R.G., Kern, R.C., Conley, D.B., Chandra, R.K., Tan, B.K., et al.(2014). Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps . Journal of Allergy and Clinical Immunology. 133. (1). p. 275-277.

Kato, A., Hulse, K.E.(2014). Searching for distinct mechanisms in eosinophilic and noneosinophilic airway inflammation . American journal of respiratory and critical care medicine. 190. (6). p. 596-598.

Nagarkar, D.R., Poposki, J.A., Tan, B.K., Comeau, M.R., Peters, A.T., Hulse, K.E., Suh, L.A., Norton, J., Harris, K.E., Grammer, L.C., et al.(2013). Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis . Journal of Allergy and Clinical Immunology. 132. (3).

Takabayashi, T., Kato, A., Peters, A.T., Hulse, K.E., Suh, L.A., Carter, R., Norton, J., Grammer, L.C., Tan, B.K., Chandra, R.K., et al.(2013). Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps . Journal of Allergy and Clinical Immunology. 132. (3).

Jeffe, J.S., Seshadri, S., Hamill, K.J., Huang, J.H., Carter, R., Suh, L., Hulse, K.E., Norton, J., Conley, D.B., Chandra, R.K., et al.(2013). A role for anti-BP180 autoantibodies in chronic rhinosinusitis . Laryngoscope. 123. (9). p. 2104-2111.

Kato, A., Hulse, K.E., Tan, B.K., Schleimer, R.P.(2013). B-lymphocyte lineage cells and the respiratory system . Journal of Allergy and Clinical Immunology. 131. (4). p. 933-957.

Hulse, K.E., Norton, J.E., Suh, L., Zhong, Q., Mahdavinia, M., Simon, P., Kern, R.C., Conley, D.B., Chandra, R.K., Tan, B.K., et al.(2013). Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression . Journal of Allergy and Clinical Immunology. 131. (4).

Takabayashi, T., Kato, A., Peters, A.T., Hulse, K.E., Suh, L.A., Carter, R., Norton, J., Grammer, L.C., Cho, S.H., Tan, B.K., et al.(2013). Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression . American Journal of Respiratory and Critical Care Medicine. 187. (1). p. 49-57.

Agrawal, R., Hulse, K., Woodfolk, J.A.(2013). Targeting antibody receptors as an approach towards immunotherapy . Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen. 97. p. 153-156.

Kumar, R., Williams, L.K., Kato, A., Peterson, E.L., Favoreto Jr., S., Hulse, K., Wang, D., Beckman, K., Thyne, S., LeNoir, M., et al.(2012). Genetic variation in B cell-activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects . Journal of Allergy and Clinical Immunology. 130. (4). p. 996-999.

Reefer, A.J., Hulse, K.E., Lannigan, J.A., Solga, M.D., Wright, P.W., Kelly, L.A., Patrie, J., Chapman, M.D., Woodfolk, J.A.(2010). Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu . Journal of Allergy and Clinical Immunology. 126. (5).

Peters, A.T., Kato, A., Zhang, N., Conley, D.B., Suh, L., Tancowny, B., Carter, D., Carr, T., Radtke, M., Hulse, K.E., et al.(2010). Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps . Journal of Allergy and Clinical Immunology. 125. (2).

Hulse, K.E., Reefer, A.J., Engelhard, V.H., Patrie, J.T., Ziegler, S.F., Chapman, M.D., Woodfolk, J.A.(2010). Targeting allergen to FcγRI reveals a novel TH2 regulatory pathway linked to thymic stromal lymphopoietin receptor . Journal of Allergy and Clinical Immunology. 125. (1-3).

Hulse, K.E., Reefer, A.J., Engelhard, V.H., Satinover, S.M., Patrie, J.T., Chapman, M.D., Woodfolk, J.A.(2008). Targeting Fel d 1 to FcγRI induces a novel variation of the TH2 response in subjects with cat allergy . Journal of Allergy and Clinical Immunology. 121. (3).

Hulse, K.E., Woodfolk, J.A.(2008). Targeting allergen to FcγRI: A strategy to treat allergic disease? . Current Opinion in Allergy and Clinical Immunology. 8. (6). p. 547-552.

Rohrer, B., Pinto, F.R., Hulse, K.E., Lohr, H.R., Zhang, L., Almeida, J.S.(2004). Multidestructive Pathways triggered in photoreceptor cell death of the RD mouse as determined through gene expression profiling . Journal of Biological Chemistry. 279. (40). p. 41903-41910.

(2003). Three color cDNA microarrays: quantitative assessment through the use of fluorescein-labeled probes. Nucleic Acids Research.