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Hire Karen L.

United States

USD 80 /hr

Biopharmaceutical Consultant | 20+ years pharmaceutical industry

Profile Summary

Accomplished biopharmaceutical consultant with a degree in Biochemistry and Cell Biology, offering over 20 years of proven expertise in the biopharmaceutical industry. Specialized in translational medicine, in vivo and in vitro models, and regenerative medicine, with a particular focus on CNS indications such as MS, Parkinson's, Alzheimer's, and orphan neurodegenerative diseases. Additionally, possess expertise in pain and pruritus treatments. Demonstrated track record of success in developing assay tools for characterizing molecular targets in neuroscience and dermatology for pre-clinical research. Strong scientific and technical writing skills, with a talent for preparing talks, presentations, and publications.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Cell Biology
• ☆ Neuroscience
• ☆ Neurophysiology
• ☆ Developmental Neuroscience
• ☆ Molecular Neuroscience
• ☆ Neurobiology

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing, General Proofreading & Editing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis, Data Visualization

Work Experience

Scientist, preclinical development

Teva Pharmaceuticals USA

November 2015 - February 2023

Scientist II / Senior Scientist

Myelin Repair Foundation

September 2012 - November 2015

Scientist

STATegics, Inc

January 2011 - August 2012

Senior Research Associate

iPierian, Inc

December 2008 - October 2010

Senior Research Asscoiate

Roche Palo Alto, LLC

August 2005 - December 2008

Research Biologist

Merck Research Laboratories

July 1995 - January 2005

Research Assistant - Research Associate

University of California San DIego (UCSD)

June 1994 - August 1995

Laboratory Assistant

University of California San DIego (UCSD)

January 1989 - August 1994

Teaching Assistant

University of California San DIego (UCSD)

May 1992 - May 1992

Education

Premedical Postgraduate studies

Columbia University in the City of New York

September 1994 - June 1996

Biochemistry and Cell Biology

University of California, San Diego

September 1988 - September 1992

Certifications

• Professional Diploma in Project Management

  udemy

  http://ude.my/UC-5548d9e5-efaf-441b-95e6-8f6f7c065ee4

  February 2024 - Present

Publications

JOURNAL ARTICLE

Karen Lariosa-Willingham, Dmitri Leonoudakis, Florian Simon, Kendall Walker, Philippe Guillaume, Liling Warren, Jennifer Stratton (2023). Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments . BMC Research Notes.

Dmitri Leonoudakis, Timo Bragge, Laura Tolppanen, Antti Nurmi, Megan Flanagan, Janelle Gibson, David Wilson, Jennifer Stratton, Kimmo K. Lehtimäki, et al., Karen Lariosa-Willingham (2022). An in vivo accelerated developmental myelination model for testing promyelinating therapeutics . BMC Neuroscience.

Villoslada, p, Gemma Vila, Valeria Colafrancesco, Beatriz Moreno, Begoña Fernandez-Diez, Raquel Vazquez, Inna Pertsovskaya, Irati Zubizarreta, Irene Pulido-Valdeolivas, Joaquin Messeguer, et al. (2019). Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation . Neurotherapeutics.

Karen D. Lariosa-Willingham, Elen S. Rosler, Jay S. Tung, Jason C. Dugas, Tassie L. Collins, Dmitri Leonoudakis (2016). A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells . BMC Research Notes.

Karen D. Lariosa-Willingham, Elen S. Rosler, Jay S. Tung, Jason C. Dugas, Tassie L. Collins, Dmitri Leonoudakis (2016). Development of a central nervous system axonal myelination assay for high throughput screening . BMC Neuroscience.

Elen S. Rosler, Karen D. Lariosa-Willingham, Jay S. Tung, Jason C. Dugas, Tassie L. Collins, Dmitri Leonoudakis (2016). Development of a high throughput drug screening assay to identify compounds that protect oligodendrocyte viability and differentiation under inflammatory conditions . BMC Research Notes.

Karen Lariosa-Willingham, James L. Miller, Timothy J. Church, Dmitri Leonoudakis, Normand L. Frigon, Connie S. Tettenborn, Jeffrey R. Spencer, Juha Punnonen (2015). Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor . Molecular Pharmacology.

Karen Lariosa-Willingham, J. Bradley Zuchero, Meng-meng Fu, Steven A. Sloan, Adiljan Ibrahim, Andrew Olson, Anita Zaremba, Jason C. Dugas, Sophia Wienbar, Andrew V. Caprariello, et al. (2015). CNS Myelin Wrapping Is Driven by Actin Disassembly . Developmental Cell.

Jane M. Rodgers, Andrew P. Robinson, Elen S. Rosler, Karen Lariosa‐Willingham, Rachael E. Persons, Jason C. Dugas, Stephen D. Miller (2015). IL-17A activates ERK1/2 and enhances differentiation of oligodendrocyte progenitor cells . Glia.

Richard L. Kraus, Rodger Pasieczny, Karen Lariosa‐Willingham, Mary S. Turner, Alice Jiang, John W. Trauger (2005). Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical‐scavenging activity . Journal of Neurochemistry.

Karen Lariosa-Willingham, Michael Webb, Chui-Se Tham, Fen-Fen Lin, Naichen Yu, Jeffrey Hale, Suzanne Mandala, Jerold Chun, Tadimeti S Rao (2004). Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice . Journal of Neuroimmunology.

Tadimeti S. Rao, Karen D. Lariosa‐Willingham, Fen‐Fen Lin, Naichen Yu, Chui‐Se Tham, Jerold Chun, Michael Webb (2004). Growth factor pre‐treatment differentially regulates phosphoinositide turnover downstream of lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes . International Journal of Developmental Neuroscience.

Naichen Yu, Karen D. Lariosa‐Willingham, Fen‐Fen Lin, Michael Webb, Tadimeti S. Rao (2004). Characterization of lysophosphatidic acid and sphingosine‐1‐phosphate‐mediated signal transduction in rat cortical oligodendrocytes . Glia.

Naichen Yu, Karen D. Lariosa‐Willingham, Fen‐Fen Lin, Michael Webb, Tadimeti S. Rao (2004). Characterization of lysophosphatidic acid and sphingosine‐1‐phosphate‐mediated signal transduction in rat cortical oligodendrocytes . Glia.

Tadimeti S Rao, Karen D Lariosa-Willingham, Fen-Fen Lin, Emma L Palfreyman, Naichen Yu, Jerold Chun, Michael Webb (2003). Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes . Brain Research.

Tadimeti S. Rao, Karen D. Lariosa-Willingham, Naichen Yu (2003). Glutamate-dependent glutamine, aspartate and serine release from rat cortical glial cell cultures . Brain Research.

Tadimeti S. Rao, Karen D. Lariosa-Willingham, Naichen Yu (2003). Glutamate-dependent glutamine, aspartate and serine release from rat cortical glial cell cultures . Brain Research.

BOOK CHAPTER

An in vivo accelerated developmental myelination model for testing promyelinating therapeutics book chapter . Prime Archives in Neuroscience: 2nd ed.

Karen Lariosa‐Willingham, Dmitri Leonoudakis (2018). Using Acutely Dissociated and Purified Oligodendrocyte Precursor Cells for High‐Throughput Drug Screening to Identify Compounds that Promote Oligodendrocyte Differentiation . Current Protocols in Cell Biology.

Karen Lariosa-Willingham, Dmitri Leonoudakis (2018). A Central Nervous System Axonal Myelination Assay for High-Throughput Screening . Methods in Molecular Biology.