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Profile Details
Subject Matter Expertise
Services
Work Experience
Clinical Variant Scientist
Counsyl Inc
August 2016 - Present 
Post Doctoral Researcher
Memorial Sloan-Kettering Cancer Center
August 2010 - May 2013
Doctoral Research Fellow
Memorial Sloan-Kettering Cancer Center
May 2005 - July 2010
Teaching Assistant
University of North Carolina at Greensboro
August 2002 - June 2004
Instructor
MCKV Institute of Engineering
August 2001 - June 2002
Education
PhD, Applied Biomedical Sciences (Chemical Biology)
Joan and Sanford I Weill Medical College of Cornell University
July 2004 - July 2010
MS (Chemistry and Biochemistry)
University of North Carolina at Greensboro
August 2002 - June 2004
Post Graduate Diploma in Computer Applications (RCC)
Jadavpur University
August 1999 - August 2000
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
(2017). Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss–Driven Tumorigenesis . Molecular cancer therapeutics.
(2012). Biochemical evidence towards the existence of an oncogenic Hsp90 complex. Cancer Research.
(2011). Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chemical Biology.
(2011). Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorg. Med. Chem.
(2010). Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators. Assay Drug Dev. Technol.
(2009). Heat shock protein inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A.
(2007). Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A.
(2007). Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature Chemical Biology.
(2007). Effects of herbal products and their constituents on human cytochrome P450(2E1) activity. Food Chem. Toxicol.
(2007). High-throughput screening fluorescence polarization assay for tumor-specific hsp90. Biomol. Screen.
(2006). Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorg. Med. Chem. Lett.
(2006). Emerging Hsp90 inhibitors: from discovery to clinic. Anticancer Agents Med. Chem.
CONFERENCE POSTER
(2009). Probing cancer-specific activating signaling pathways through a tumor-specific Hsp90 inhibitor. American Association of Cancer Research (AACR), Annual Meeting.
(2008). Cell-based assay for rapid identification of Hsp70 Modulators. World Pharmaceutical Congress.
(2007). High-throughput screening fluorescence polarization assay for tumor-specific Hsp90. American Association of Cancer Research (AACR), Annual Meeting.
(2006). 419 POSTER Defining Hsp90 as inhibitor of apoptosis in small cell lung cancer . European Journal of Cancer Supplements.
(2006). Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. American Association of Cancer Research (AACR), Annual Meeting.
(2004). Inhibition of Human Cytochrome P4502e1 by Herbal Extracts and Their Major Isolated Constituents. Southeast Regional Meeting, American Chemical Society (ACS).
(2003). Effects of Echinacea on human metabolizing systems. American Chemical Society (ACS).
CONFERENCE PAPER
(2007). Targeting basal-like breast cancer via purine-scaffold Hsp90 inhibitors. American Association of Cancer Research (AACR), Annual Meeting.
DISSERTATION THESIS
(2006). Interactions of Echinacea and Spilanthes with Human Metabolizing Systems . University of North Carolina at Greensboro.
Ratings and Comments
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