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Hire Dr. Julio Cesar C.

United States

USD 250 /hr

Biologist with 15 years of experience on immunology, genetics and antibody development

Profile Summary

My research focuses on the understanding of HIV biology, especially on the latent reservoir and the development of passive immunotherapy using broadly neutralizing antibodies (bNAbs). I’m also interested in the development of tools and methodologies that help the analysis of HIV genetics and virulence. In the past few months, I started to work on the COVID-19 problem, especially on the development of neutralizing antibodies against Sars-Cov-2.

Subject Matter Expertise

• ☆ Severe Acute Respiratory Syndrome (SARS)

Services

• Research
• Data & AI

Research Market Research, Feasibility Study, Systematic Literature Review, Secondary Data Collection

Work Experience

Pos Doctoral Fellow

Rockefeller University

February 2014 - Present

Education

Ph.D. (Genetics)

Universidade de São Paulo

August 2009 - December 2013

Master (Immunology)

Universidade de São Paulo

February 2006 - May 2008

Bachelor (Biology)

Universidade Federal de Alfenas

March 2002 - December 2005

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Fabian Schmidt, Yiska Weisblum, Frauke Muecksch, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Julio C.C. Lorenzi, Pilar Mendoza, Magdalena Rutkowska, Eva Bednarski, Christian Gaebler, et al. (2020). Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses . Journal of Experimental Medicine.

Davide F. Robbiani, Christian Gaebler, Frauke Muecksch, Julio C. C. Lorenzi, Zijun Wang, Alice Cho, Marianna Agudelo, Christopher O. Barnes, Anna Gazumyan, Shlomo Finkin, et al.(2020). Convergent antibody responses to {SARS}-{CoV}-2 in convalescent individuals . Nature. Springer Science and Business Media {LLC}

Yehuda Z. Cohen, Julio C.C. Lorenzi, Lisa Krassnig, John P. Barton, Leah Burke, Joy Pai, Ching-Lan Lu, Pilar Mendoza, Thiago Y. Oliveira, Christopher Sleckman, et al.(2018). Relationship between latent and rebound viruses in a clinical trial of anti{\textendash}{HIV}-1 antibody 3BNC117 . The Journal of Experimental Medicine. 215. (9). p. 2311--2324. Rockefeller University Press

Cohn LB, da Silva IT, Valieris R, Huang AS, Lorenzi JCC, Cohen YZ, Pai JA, Butler AL, Caskey M, Jankovic M, et al.(2018). Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation . Nature medicine.

Cohen, Yehuda Z., Lorenzi, Julio C. C., Seaman, Michael S., Nogueira, Lilian, Schoofs, Till, Krassnig, Lisa, Butler, Allison, Millard, Katrina, Fitzsimons, Tomas, Daniell, Xiaoju, et al.(2018). Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells . Journal of Virology. 92. (5).

Horwitz, Joshua A., Bar-On, Yotam, Lu, Ching-Lan, Fera, Daniela, Lockhart, Ainsley A. K., Lorenzi, Julio C. C., Nogueira, Lilian, Golijanin, Jovana, Scheid, Johannes F., Seaman, Michael S., et al.(2017). Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo . Cell. 170. (4). p. 637-+.

Ruhrmann, S., Ewing, E., Piket, E., Kular, L., Cetrulo Lorenzi, J.C., Fernandes, S.J., Morikawa, H., Aeinehband, S., Sayols-Baixeras, S., Aslibekyan, S., et al.(2017). Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes . Multiple Sclerosis Journal.

Lorenzi, Julio C. C., Cohen, Yehuda Z., Cohn, Lillian B., Kreider, Edward F., Barton, John P., Learn, Gerald H., Oliveira, Thiago, Lavine, Christy L., Horwitz, Joshua A., Settler, Allison, et al.(2017). Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA (vol 113, pg E7908, 2016) . Proceedings of the National Academy of Sciences of the United States of America. 114. (4). p. E648-E649.

Freund, Natalia T., Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A., Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A., Sok, Devin, Cai, Hui, et al.(2017). Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller . Science Translational Medicine. 9. (373).

Marchini, J. F. M., Pinto, M. R., Novaes, G. C., Badran, A. V., Pavao, R. B., Figueiredo, G. L., Lago, I. M., Lima-Filho, M. O., Lemos, D. C., Tonani, M., et al.(2017). Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients . Brazilian Journal of Medical and Biological Research. 50. (1).

Cetrulo Lorenzi, Julio Cesar, Malardo, Thiago, Gardinassi, Luiz Gustavo, Moreira, Bernardo Pereira, Padilha, Everton, Soares, Luana Silva, Gembre, Ana Flavia, Fontoura, Isabela Cardoso, de Almeida, Luciana Previato, Ferreira de Miranda Santos, Isabel Kinney, et al.(2016). MicroRNA expression signatures in lungs of mice infected with Mycobacterium tuberculosis . Tuberculosis. 101. p. 151-159.

Schoofs, Till, Klein, Florian, Braunschweig, Malte, Kreider, Edward F., Feldmann, Anna, Nogueira, Lilian, Oliveira, Thiago, Lorenzi, Julio C. C., Parrish, Erica H., Learn, Gerald H., et al.(2016). HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1 . Science. 352. (6288). p. 997-1001.

Cetrulo Lorenzi, Julio Cesar, Kaneto, Carla M., Lima, Patricia S. P., Zanette, Dalila Luciola, Kikuchi Oliveira, Thiago Yukio, Pereira, Francisco de Assis, dos Santos, Jane Lima, Prata, Karen L., Pina Neto, Joao M., de Paula, Francisco J. A., et al.(2016). Osteoblastic differentiation of bone marrow mesenchymal stromal cells in Bruck Syndrome . Bmc Medical Genetics. 17.

Cetrulo Lorenzi, Julio Cesar, Muys, Bruna Rodrigues, Zanette, Dalila Luciola, Lima e Bueno, Rafaela de Barros, de Araujo, Luza Ferreira, Dinarte-Santos, Anemari Ramos, Alves, Cleidson Padua, Ramao, Anelisa, de Molfetta, Greice Andreotti, Vidal, Daniel Onofre, et al.(2016). Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line . Plos One. 11. (3).

Scheid, Johannes F., Horwitz, Joshua A., Bar-On, Yotam, Kreider, Edward F., Lu, Ching-Lan, Lorenzi, Julio C. C., Feldmann, Anna, Braunschweig, Malte, Nogueira, Lilian, Oliveira, Thiago, et al.(2016). HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption . Nature. 535. (7613). p. 556-+.

Zanette, D.L., Lorenzi, J.C.C., Panepucci, R.A., Palma, P.V.B., Dos Santos, D.F., Prata, K.L., Silva, W.A.(2015). Simvastatin modulates mesenchymal stromal cell proliferation and gene expression . PLoS ONE. 10. (4).

Arruda, L.C.M., Lorenzi, J.C.C., Sousa, A.P.A., Zanette, D.L., Palma, P.V.B., Panepucci, R.A., Brum, D.S., Barreira, A.A., Covas, D.T., Simões, B.P., et al.(2015). Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients . Bone Marrow Transplantation. 50. (3). p. 380-389.

Arruda, L. C. M., Lorenzi, J. C. C., Sousa, A. P. A., Zanette, D. L., Palma, P. V. B., Panepucci, R. A., Brum, D. S., Barreira, A. A., Covas, D. T., Simoes, B. P., et al.(2015). Autologous hematopoietic SCT normalizes miR-16,-155 and-142-3p expression in multiple sclerosis patients . Bone Marrow Transplantation. 50. (3). p. 380-389.

Caskey, Marina, Klein, Florian, Lorenzi, Julio C. C., Seaman, Michael S., West, Anthony P., Jr., Buckley, Noreen, Kremer, Gisela, Nogueira, Lilian, Braunschweig, Malte, Scheid, Johannes F., et al.(2015). Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 . Nature. 522. (7557). p. 487-+.

de Araujo, L.F., Fonseca, A.S., Muys, B.R., Plaça, J.R., Bueno, R.B.L., Lorenzi, J.C.C., Santos, A.R.D., Molfetta, G.A., Zanette, D.L., Souza, J.E.S., et al.(2015). Mitochondrial genome instability in colorectal adenoma and adenocarcinoma . Tumor Biology.

Caskey, M., Klein, F., Lorenzi, J.C.C., Seaman, M.S., West, A.P., Buckley, N., Kremer, G., Nogueira, L., Braunschweig, M., Scheid, J.F., et al.(2015). Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 . Nature. 522. (7557). p. 487-491.

Julio Cesar Cetrulo Lorenzi, Sabrina Ruhrmann, Eliane Piket, Petra Bergman, Lara Kular, Shahin Aeinehband, Roham Parsa, David Gomez-cabrero, Jesper Tegnér, Fredrik Piehl, et al.(2014). Methylome characterization of {CD}4$\mathplus$ T cells in multiple sclerosis {\textemdash} Establishing a role for {miR}-21 in autoimmune disease . Journal of Neuroimmunology. 275. (1-2). p. 112. Elsevier {BV}

Shingai, M., Donau, O.K., Plishka, R.J., Buckler-White, A., Mascola, J.R., Nabel, G.J., Nason, M.C., Montefiori, D., Moldt, B., Poignard, P., et al.(2014). Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques . Journal of Experimental Medicine. 211. (10). p. 2061-2074.

Shingai, Masashi, Donau, Olivia K., Plishka, Ronald J., Buckler-White, Alicia, Mascola, John R., Nabel, Gary J., Nason, Martha C., Montefiori, David, Moldt, Brian, Poignard, Pascal, et al.(2014). Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques . Journal of Experimental Medicine. 211. (10). p. 2061-2074.

Zanette, D.L., Lorenzi, J.C.C., Panepucci, R.A., Santos, A.R.D., Molfetta, G.A., Araujo, A.G., Silva Junior, W.A., Zago, M.A.(2013). Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling . Genetics and Molecular Research. 12. (2). p. 1691-1697.

Zanette, D. L., Lorenzi, J. C. C., Panepucci, R. A., Santos, A. R. D., Molfetta, G. A., Araujo, A. G., Silva Junior, W. A., Zago, M. A.(2013). Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling . Genetics and Molecular Research. 12. (2). p. 1691-1697.

Lorenzi, J.C.C., Brum, D.G., Zanette, D.L., De Paula Alves Souza, A., Barbuzano, F.G., Dos Santos, A.C., Barreira, A.A., Da Silva Jr., W.A.(2012). miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients . International Journal of Neuroscience. 122. (8). p. 466-471.

Rocha, C.D., Trombone, A.P.F., Lorenzi, J.C.C., Almeida, L.P., Gembre, A.F., Padilha, E., Ramos, S.G., Silva, C.L., Coelho-Castelo, A.A.M.(2012). Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis . Brazilian Journal of Medical and Biological Research. 45. (12). p. 1183-1194.

Padilha, E., Malardo, T., Moreira, B. P., Lorenzi, J. C. C., Fontoura, I. C., Silva, C. L., Coelho-Castelo, A. A. M.(2012). mRNA and plasmideal DNA stimuli for different times may change microRNA expression in murine dendritic cells. Immunology. 137. p. 119.

Padilha, E., Malardo, T., Moreira, B. P., Lorenzi, J. C. C., Fontoura, I. C., Silva, C. L., Coelho-Castelo, A. A. M.(2012). mRNA and plasmideal DNA stimuli for different times may change microRNA expression in murine dendritic cells . Immunology. 137. p. 119.

Rocha, C. D., Trombone, A. P. F., Lorenzi, J. C. C., Almeida, L. P., Gembre, A. F., Padilha, E., Ramos, S. G., Silva, C. L., Coelho-Castelo, A. A. M.(2012). Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis . Brazilian Journal of Medical and Biological Research. 45. (12). p. 1183-1194.

Lorenzi, J. C. C., Brum, D. G., Zanette, D. L., Souza, A. D. A., Barbuzano, F. G., dos Santos, A. C., Barreira, A. A., Silva, W. A.(2012). miR-15a and 16-1 Are Downregulated in CD4(+) T Cells of Multiple Sclerosis Relapsing Patients . International Journal of Neuroscience. 122. (8). p. 466-471.

Brum, D. G., Lorenzi, J. C. C., Zanette, D. L., de Paula, A., Barbuzano, F. G., Santos, A. C., Barreira, A. A., da Silva, W. A.(2011). miR-16 Is Downregulated in CD4+T Cells of Multiple Sclerosis Relapsing Patients. Neurology. 76. (9). p. A139.

Almeida, L.P., Trombone, A.P.F., Lorenzi, J.C.C., Rocha, C.D., Malardo, T., Fontoura, I.C., Gembre, A.F., Silva, R.L.L., Silva, C.L., Castelo, A.P., et al.(2011). B cells Can Modulate the CD8 Memory T Cell after DNA Vaccination Against Experimental Tuberculosis . Genetic Vaccines and Therapy. 9.

Almeida, L. P., Trombone, A. P., Lorenzi, J. C., Rocha, C. D., Malardo, T., Fontoura, I. C., Gembre, A. F., Silva, R. L., Silva, C. L., Castelo, A. P., et al.(2011). B cells Can Modulate the CD8 Memory T Cell after DNA Vaccination Against Experimental Tuberculosis . Genet Vaccines Ther. 9. p. 5.

Lorenzi, J. C. C., Trombone, A. P. F., Rocha, C. D., Almeida, L. P., Lousada, R. L., Malardo, T., Fontoura, I. C., Rossetti, R. A. M., Gembre, A. F., Silva, A. M., et al.(2010). Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis . Bmc Biotechnology. 10. p. 11.

Lorenzi, J.C.C., Trombone, A.P.F., Rocha, C.D., Almeida, L.P., Lousada, R.L., Malardo, T., Fontoura, I.C., Rossetti, R.A.M., Gembre, A.F., Silva, A.M., et al.(2010). Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis . BMC Biotechnology. 10.

Tereza Cristina Orlando, Adriene Ribeiro Lima, Ariadne Mendes da Silva, Carolina Nakau Fuzissaki, Cíntia Lacerda Ramos, Daisy Machado, Fabrício Freitas Fernandes, Júlio César C. Lorenzi, Marisa Aparecida de Lima, Sueli Gardim, et al.(2009). {PLANEJAMENTO}, {MONTAGEM} E {APLICA}{\c{C}}{\~{A}}O {DE} {MODELOS} {DID}{\'{A}}{TICOS} {PARA} {ABORDAGEM} {DE} {BIOLOGIA} {CELULAR} E {MOLECULAR} {NO} {ENSINO} M{\'{E}}{DIO} {POR} {GRADUANDOS} {DE} {CI}{\^{E}}{NCIAS} {BIOL}{\'{O}}{GICAS} . Revista de Ensino de Bioqu{\'{\i}}mica. 7. (1). p. 1. Sociedade Brasileira de Bioquimica e Biologia Molecular - {SBBq}

Rosseti, R.A.M., LORENZI, J. C. C., GIULIATTI, S., COELHO-CASTELO, A. A. M.(2008).  In Silico Prediction of the Tertiary Structure of M. leprae Hsp65 Protein Shows an Unusual Structure in Carboxy-terminal Region .  Journal of Computer Science & Systems Biology. 1. (1). p. 5.

Pelizon, A., Martins, D.R., Zorzella, S.F.G., Trombone, A.P., Lorenzi, J.C.C., Carvalho, R.F., Brandão, I.T., Coelho-Castelo, A.A.M., Silva, C.L., Sartori, A.(2007). Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage . Genetic Vaccines and Therapy. 5.

Pelizon, AC, Martins, DR, Zorzella, SF, Trombone, AP, Lorenzi, JC, Carvalho, RF, Brandão, IT, Coelho-Castelo, AA, Silva, CL, Sartori, A(2007). Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage . Genet Vaccines Ther. 5. p. 12.

OTHER

Julio C.C. Lorenzi, Pilar Mendoza, Yehuda Z. Cohen, Lilian Nogueira, Christy Lavine, Joseph Sapiente, Michael S. Seaman, Marie Wiatr, Nelly R. Mugo, Andrew Mujugira, et al.(2020). Neutralizing activity of broadly neutralizing anti-{HIV}-1 antibodies against primary African isolates . Cold Spring Harbor Laboratory

Zijun Wang, Julio C. C. Lorenzi, Frauke Muecksch, Shlomo Finkin, Charlotte Viant, Christian Gaebler, Melissa Cipolla, Hans-Heinrich Hoffman, Thiago Y. Oliveira, Deena A. Oren, et al.(2020). Enhanced {SARS}-{CoV}-2 Neutralization by Secretory {IgA} in vitro . Cold Spring Harbor Laboratory

Christian Gaebler, Julio C. C. Lorenzi, Thiago Y. Oliveira, Lilian Nogueira, Victor Ramos, Ching-Lan Lu, Joy A. Pai, Pilar Mendoza, Mila Jankovic, Marina Caskey, et al.(2019). Quadruplex {qPCR} for qualitative and quantitative analysis of the {HIV}-1 latent reservoir . Cold Spring Harbor Laboratory

Line K. Vibholm, Julio C.C. Lorenzi, Joy A. Pai, Yehuda Z. Cohen, Thiago Y. Oliveira, John P. Barton, Marco Garcia Noceda, Ching-Lan Lu, Yuria Ablanedo-Terrazas, Perla M. Del Rio Estrada, et al.(2018). Characterization of intact proviruses in blood and lymph node from {HIV}-infected individuals undergoing analytical treatment interruption . Cold Spring Harbor Laboratory

Yehuda Z. Cohen, Julio C. C. Lorenzi, Lisa Krassnig, John P. Barton, Leah Burke, Joy Pai, Ching-Lan Lu, Pilar Mendoza, Thiago Y. Oliveira, Christopher Sleckman, et al.(2018). Analysis of {HIV}-1 latent reservoir and rebound viruses in a clinical trial of anti-{HIV}-1 antibody 3BNC117 . Cold Spring Harbor Laboratory

BOOK CHAPTER

Lorenzi, J. C. C., Trombone, A. P. F., Rocha, C. D., De Almeida, L. P., Lousada, R., Malardo, T., Silva, C. L., Coelho-Castelo, A. A. M.(2010). New approaches using genetic material as a control to tuberculosis. Advances in Biomedical Research, Proceedings. p. 426-430.